Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.

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Zhi L, Tegley CM, Pio B, West SJ, Marschke KB, Mais DE, Jones TK

Nonsteroidal progesterone receptor antagonists based on 6-thiophenehydroquinolines.

Bioorg Med Chem Lett. 2000 Mar 6;10(5):415-8.

PubMed ID

10743938 [ View in PubMed

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Abstract

Synthesis and biological evaluation of 6-thiophene 1,2-dihydro or 1,2,3,4-tetrahydroquinoline derivatives resulted in a number of potent nonsteroidal antiprogestins.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Progesterone	Progesterone receptor	Ki (nM)	3.5	N/A	N/A	Details
Progesterone	Progesterone receptor	EC 50 (nM)	2.9	N/A	N/A	Details
Progesterone	Progesterone receptor	EC 50 (nM)	1.8	N/A	N/A	Details