The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.

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Roll DM, Barbieri LR, Bigelis R, McDonald LA, Arias DA, Chang LP, Singh MP, Luckman SW, Berrodin TJ, Yudt MR

The lecanindoles, nonsteroidal progestins from the terrestrial fungus Verticillium lecanii 6144.

J Nat Prod. 2009 Nov;72(11):1944-8. doi: 10.1021/np9004882.

PubMed ID
19863083 [ View in PubMed
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Abstract

Four new indolosesquiterpenes, lecanindoles A-D (1-4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1-4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5. Compound 4 was found to be a potent and selective progesterone receptor agonist with an EC50 of 1.1 +/- 0.4 nM in a cell-based luciferase reporter assay.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
AldosteroneMineralocorticoid receptorEC 50 (nM)3.8N/AN/ADetails
DexamethasoneGlucocorticoid receptorEC 50 (nM)7.2N/AN/ADetails
EstradiolEstrogen receptor alphaEC 50 (nM)3.2N/AN/ADetails
EstradiolEstrogen receptor betaEC 50 (nM)11N/AN/ADetails
FulvestrantEstrogen receptor alphaIC 50 (nM)4N/AN/ADetails
MifepristoneGlucocorticoid receptorIC 50 (nM)3.2N/AN/ADetails
ProgesteroneProgesterone receptorEC 50 (nM)0.1N/AN/ADetails
SpironolactoneMineralocorticoid receptorIC 50 (nM)1.6N/AN/ADetails
StanoloneAndrogen receptorEC 50 (nM)20N/AN/ADetails