A novel estrogen receptor ligand template.

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Sibley R, Hatoum-Mokdad H, Schoenleber R, Musza L, Stirtan W, Marrero D, Carley W, Xiao H, Dumas J

A novel estrogen receptor ligand template.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1919-22.

PubMed ID
12749898 [ View in PubMed
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Abstract

Three synthetic routes towards a novel estrogen receptor ligand template based on a rigid bicyclo-[3.3.1]-nonene core have been investigated. The prototype compound exhibits potent binding at the ERbeta receptor and promising estrogen receptor subtype selectivity.

DrugBank Data that Cites this Article

Binding Properties
DrugTargetPropertyMeasurementpHTemperature (°C)
EstradiolEstrogen receptor alphaIC 50 (nM)2N/AN/ADetails
EstradiolEstrogen receptor betaIC 50 (nM)2N/AN/ADetails
RaloxifeneEstrogen receptor alphaIC 50 (nM)7N/AN/ADetails
RaloxifeneEstrogen receptor betaIC 50 (nM)470N/AN/ADetails