Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.

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Bertucci A, Innocenti A, Zoccola D, Scozzafava A, Allemand D, Tambutte S, Supuran CT

Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):650-3. doi: 10.1016/j.bmcl.2008.12.056. Epub 2008 Dec 24.

PubMed ID

19121582 [ View in PubMed

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Abstract

The inhibition of a coral carbonic anhydrase (CA, EC 4.2.1.1) has been investigated with a series of inorganic anions such as halogenides, pseudohalogenides, bicarbonate, carbonate, nitrate, nitrite, hydrogen sulfide, bisulfite, perchlorate, sulfate. The full-length scleractinian coral Stylophora pistillata CA, STPCA, has a significant catalytic activity for the physiological reaction of CO(2) hydration to bicarbonate, similarly to the ubiquitous human isoforms hCA I (cytosolic) and hCA VI (secreted). The best STPCA anion inhibitors were bromide, iodide, carbonate, and sulfamate, with inhibition constants of 9.0-10.0 microM.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Acetazolamide	Carbonic anhydrase 1	Ki (nM)	250	N/A	N/A	Details
Acetazolamide	Carbonic anhydrase 2	Ki (nM)	12	N/A	N/A	Details
Acetazolamide	Carbonic anhydrase 4	Ki (nM)	11	N/A	N/A	Details