(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).
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Michaelides MR, Hong Y, DiDomenico S Jr, Asin KE, Britton DR, Lin CW, Williams M, Shiosaki K
(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).
J Med Chem. 1995 Sep 1;38(18):3445-7.
- PubMed ID
- 7658429 [ View in PubMed]
- Abstract
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- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Dopamine Dopamine D1 receptor Ki (nM) 130 N/A N/A Details Dopamine Dopamine D1 receptor EC 50 (nM) 100 N/A N/A Details Dopamine Dopamine D2 receptor Ki (nM) 260 N/A N/A Details Dopamine Dopamine D2 receptor EC 50 (nM) 170 N/A N/A Details