Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.

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Kainuma M, Kasuga J, Hosoda S, Wakabayashi K, Tanatani A, Nagasawa K, Miyachi H, Makishima M, Hashimoto Y

Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3213-8. Epub 2006 Apr 17.

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16617018 [ View in PubMed

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Abstract

Novel, potent farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor alpha (PPARalpha) agonists were obtained by using a diphenylmethane skeleton as a substitute for a steroid skeleton.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
Chenodeoxycholic acid	Bile acid receptor	EC 50 (nM)	11700	N/A	N/A	Details