Initial rates of pyruvate transport in mitochondria determined by an "inhibitor-stop" technique.

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Titheradge MA, Coore HG

Initial rates of pyruvate transport in mitochondria determined by an "inhibitor-stop" technique.

Biochem J. 1975 Sep;150(3):553-6.

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Abstract

An "inhibitor-stop" technique has been developed for measuring initial rates of pyruvate transport into mitochondria. The technique uses alpha-cyano-3-hydroxycinnamate as the inhibitor and separates the mitochondria from the radioactive medium by Millipore filtration. Observed rates depend on availability of hydroxyl and other exchangeable anions within the mitochondrial matrix.

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