Pharmacokinetics of oral taurine in healthy volunteers.

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Ghandforoush-Sattari M, Mashayekhi S, Krishna CV, Thompson JP, Routledge PA

Pharmacokinetics of oral taurine in healthy volunteers.

J Amino Acids. 2010;2010:346237. doi: 10.4061/2010/346237. Epub 2010 Jun 29.

PubMed ID
22331997 [ View in PubMed
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Abstract

Taurine, a sulfur-containing amino acid, is a normal constituent of the human diet. Little is known of the pharmacokinetics of taurine in man after oral administration. We studied the pharmacokinetics of 4 g taurine in eight healthy male volunteers (median age 27.5, range 22-45) following orally administration in the fasting state in the morning. Blood samples were taken at regular intervals and plasma taurine concentration was measured by a modified HPLC method. Data were subjected to noncompartmental analysis. Maximum plasma taurine concentration (C(max)) was measured at 1.5 +/- 0.6 hr after administration as 86.1 +/- 19.0 mg/L (0.69 +/- 0.15 mmol). Plasma elimination half-life (T(1/2)) and the ratio of clearance/bioavailability (Cl/F) were 1.0 +/- 0.3 hr and 21.1 +/- 7.8 L/hr, respectively. Since taurine is occasionally used in therapeutics as a medicine, the pharmacokinetics and effects of oral taurine in healthy volunteers would be useful in the future studies of taurine in pharmacology and nutrition.

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