The structural biology of oestrogen metabolism.
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Thomas MP, Potter BV
The structural biology of oestrogen metabolism.
J Steroid Biochem Mol Biol. 2013 Sep;137:27-49. doi: 10.1016/j.jsbmb.2012.12.014. Epub 2013 Jan 4.
- PubMed ID
- 23291110 [ View in PubMed]
- Abstract
Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product. The reactions catalysed include aromatisation, oxidation, reduction, sulfonation, desulfonation, hydroxylation and methoxylation. The enzymes that catalyse these reactions must all recognise and bind oestrogen but, despite this, they have diverse structures. This review looks at each of these enzymes in turn, describing the structure and discussing the mechanism of the catalysed reaction. Since oestrogen has a role in many disease states inhibition of the enzymes of oestrogen metabolism may have an impact on the state or progression of the disease and inhibitors of these enzymes are briefly discussed. This article is part of a Special Issue entitled 'CSR 2013'.
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- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Estrone Cytochrome P450 1B1 Protein Humans UnknownSubstrateDetails - Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
Drugs Interaction Integrate drug-drug
interactions in your softwareDiethylstilbestrolButabarbital The therapeutic efficacy of Diethylstilbestrol can be decreased when used in combination with Butabarbital. EstetrolButabarbital The therapeutic efficacy of Estetrol can be decreased when used in combination with Butabarbital. EstradiolButabarbital The therapeutic efficacy of Estradiol can be decreased when used in combination with Butabarbital. Estradiol cypionateButabarbital The therapeutic efficacy of Estradiol cypionate can be decreased when used in combination with Butabarbital. Estradiol valerateButabarbital The therapeutic efficacy of Estradiol valerate can be decreased when used in combination with Butabarbital.