The evolution of progesterone receptor ligands.
Article Details
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Madauss KP, Stewart EL, Williams SP
The evolution of progesterone receptor ligands.
Med Res Rev. 2007 May;27(3):374-400.
- PubMed ID
- 17013809 [ View in PubMed]
- Abstract
Progesterone is one of the first nuclear receptor hormones to be described functionally and subsequently approached as a drug target. Because progesterone (1) affects both menstruation and gestation via the progesterone receptor (PR), research aimed at modulating its activity is usually surrounded by controversy. However, ligands for PR were developed into drugs, and their evolution can be crudely divided into three periods: (1) drug-like steroids that mimic the gestational properties of progesterone; (2) drug-like steroids with different properties from progesterone and expanded therapeutic applications; and (3) non-steroidal PR ligands with improved selectivity and modulator properties and further expanded therapeutic applications. Although the latter have yet to see widespread clinical applications, their development is founded on a half century of research, and they represent the future for this drug target.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Allylestrenol Progesterone receptor Protein Humans YesAgonistDetails Medroxyprogesterone acetate Progesterone receptor Protein Humans YesAgonistDetails Progesterone Progesterone receptor Protein Humans YesAgonistDetails