Selective androgen receptor modulators: in pursuit of tissue-selective androgens.
Article Details
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Omwancha J, Brown TR
Selective androgen receptor modulators: in pursuit of tissue-selective androgens.
Curr Opin Investig Drugs. 2006 Oct;7(10):873-81.
- PubMed ID
- 17086931 [ View in PubMed]
- Abstract
The androgen receptor mediates the androgenic and anabolic activity of the endogenous steroids testosterone and 5alpha-dihydrotestosterone. Current knowledge of the androgen receptor protein structure, and the molecular mechanisms surrounding the binding properties and activities of agonists and antagonists has led to the design and development of novel nonsteroidal ligands with selected tissue-specific androgen receptor agonist and antagonist activities. The activity of these compounds, termed selective androgen receptor modulators (SARMs), is directed toward the maintenance or enhancement of anabolic effects on bone and muscle with minimal androgenic effects on prostate growth. SARMs are of potential therapeutic value in the treatment of male hypogonadism, osteoporosis, frailty and muscle wasting, burn injury and would healing, anemia, mood and depression, benign prostatic hyperplasia and prostate cancer.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Calusterone Androgen receptor Protein Humans YesNot Available Details Methyltestosterone Androgen receptor Protein Humans YesAgonistDetails Testosterone Androgen receptor Protein Humans YesAgonistDetails Testosterone cypionate Androgen receptor Protein Humans YesAgonistDetails Testosterone enanthate Androgen receptor Protein Humans YesAgonistDetails Testosterone propionate Androgen receptor Protein Humans YesAgonistDetails Testosterone undecanoate Androgen receptor Protein Humans YesAgonistDetails