Inhibition of enzymes of polyamine biosynthesis by substrate-like O-substituted hydroxylamines.

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Khomutov AR

Inhibition of enzymes of polyamine biosynthesis by substrate-like O-substituted hydroxylamines.

Biochemistry (Mosc). 2002 Oct;67(10):1159-67.

PubMed ID

12460114 [ View in PubMed

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Abstract

The biogenic amines spermine, spermidine, and putrescine are essential factors of cell growth and differentiation. To inhibit pyridoxal-5'-phosphate dependent ornithine decarboxylase and pyruvate dependent S-adenosylmethionine decarboxylase, key enzymes of polyamine biosynthesis, a system of substrate-like O-substituted hydroxylamines is suggested. The best of these compounds were active at nanomolar concentrations. High potency and specificity of this type of inhibitors are discussed in terms of structural similarity of E-I and E-S complexes.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pyridoxal phosphate	Ornithine decarboxylase	Protein	Humans	Unknown	Cofactor	Details