Biological activities of 2-mercaptobenzothiazole derivatives: a review.

Article Details

Citation
Copy to clipboard

Azam MA, Suresh B

Biological activities of 2-mercaptobenzothiazole derivatives: a review.

Sci Pharm. 2012 Dec;80(4):789-823. doi: 10.3797/scipharm.1204-27. Epub 2012 Jun 18.

PubMed ID
23264933 [ View in PubMed
]
Abstract

2-Mercaptobenzothiazoles are an important class of bioactive and industrially important organic compounds. These compounds are reported for their antimicrobial and antifungal activities, and are subsequently highlighted as a potent mechanism-based inhibitor of several enzymes like acyl coenzyme A cholesterol acyltransferase, monoamine oxidase, heat shock protein 90, cathepsin D, and c-Jun N-terminal kinases. These derivatives are also known to possess antitubercular, anti-inflammatory, antitumor, amoebic, antiparkinsonian, anthelmintic, antihypertensive, antihyperlipidemic, antiulcer, chemoprotective, and selective CCR3 receptor antagonist activity. This present review article focuses on the pharmacological profile of 2-mercaptobenzothiazoles with their potential activities.

DrugBank Data that Cites this Article

Drugs