Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine.

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Wu XR, Kenzior A, Willmot D, Scanlon S, Chen Z, Topin A, He SH, Acevedo A, Folk WR

Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine.

Plant J. 2007 May;50(4):627-36. Epub 2007 Apr 8.

PubMed ID
17425721 [ View in PubMed
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Abstract

The Arabidopsis thaliana lysyl tRNA synthetase (AtKRS) structurally and functionally resembles the well-characterized prokaryotic class IIb KRS, including the propensity to aminoacylate tRNA(Lys) with suboptimal identity elements, as well as non-cognate tRNAs. Transient expression of AtKRS in carrot cells promotes aminoacylation of such tRNAs in vivo and translational recoding of lysine at nonsense codons. Stable expression of AtKRS in Zea mays causes translational recoding of lysine into zeins, significantly enriching the lysine content of grain.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
LysineLysine--tRNA ligaseProteinHumans
Unknown
Not AvailableDetails