Restricted diffusion in Canavan disease.

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Srikanth SG, Chandrashekar HS, Nagarajan K, Jayakumar PN

Restricted diffusion in Canavan disease.

Childs Nerv Syst. 2007 Apr;23(4):465-8. Epub 2007 Jan 12.

PubMed ID
17219235 [ View in PubMed
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Abstract

INTRODUCTION: Canavan disease is a megalencephalic leukodystrophy due to deficiency of the enzyme aspartoacylase. Proton MR spectroscopy finding of elevated N-acetyl-L: -aspartate is considered diagnostic of Canavan disease. CASE REPORT: We report a case of Canavan disease, which showed restricted diffusion in diffusion-weighted imaging and discuss the cause of it.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Aspartic acidAspartoacylaseProteinHumans
Unknown
Not AvailableDetails