Triamcinolone

Identification

Summary

Triamcinolone is a glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.

Brand Names

Allernaze, Aristocort, Aristocort R, Juulissa Pharmapak, Kenalog, Kourzeq, Marcaine, Nasacort, Oracort, Oralone, Pediaderm Ta, Triaderm, Trianex, Triderm, Triesence, Triloan Suik, Tritocin, Viaderm Kc, Xipere, Zilretta

Generic Name

Triamcinolone

DrugBank Accession Number

DB00620

Background

Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis.¹³ Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain,¹⁶ or first line as a topical treatment of corticosteroid responsive dermatoses.¹¹ Triamcinolone is more commonly seen in the forms triamcinolone hexacetonide, triamcinolone acetonide, and triamcinolone diacetate.^{10,11,12,13,14,15,16}

Triamcinolone was granted FDA approval on 3 December 1957.⁹ In October 2021, a suspension of triamcinolone acetonide was approved for suprachoroidal injection - the first suprachoroidal injection to receive FDA approval¹⁹ - for the treatment of patients with macular edema associated with uveitis.¹⁸

Type

Small Molecule

Groups

Approved, Vet approved

Structure

Similar Structures

Weight: Average: 394.4339
Monoisotopic: 394.179166801
Chemical Formula: C₂₁H₂₇FO₆

Synonyms

11β,16α,17α,21-tetrahydroxy-9α-fluoro-1,4-pregnadiene-3,20-dione
9-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-11β,16α,17α,21-tetrahydroxypregna-1,4-diene-3,20-dione
9α-fluoro-16α-hydroxyprednisolone
Fluoxyprednisolone
Tiamcinolonum
Triamcinolona
Triamcinolone
Triamcinolonum

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Pharmacology

Indication

Triamcinolone hexacetonide injections are indicated for intralesional administration in alopecia areata, discoid lupus erythematosus, keloids, and necrobiosis lipoidica diabeticorum.¹⁰ This formulation can also be used for localized hypertrophic infiltrated inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus, and psoriatic plaques.¹⁰

Triamcinolone acetonide spray and cream are indicated for the treatment of inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.^11,14 A triamcinolone acetonide 10mg/mL or 40mg/mL injection is indicated intra-articularly for acute gouty arthritis, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, and synovitis of osteoarthritis.^12,13 The same 10mg/mL injection is indicated by the intralesional route for the treatment of alopecia areata, discoid lupus erythematosus, keloids, necrobiosis lipoidica diabeticorum, and tumors of an aponeurosis or tendon.¹² This formulation can also be used for localized hypertrophic infiltrated inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus, and psoriatic plaques.¹² The 40mg/mL injection is indicated intramuscularly for controlling severe allergic conditions such as asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity, perennial or seasonal allergic rhinitis, serum sickness, and transfusion reactions; treatment of bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, Stevens-Johnson syndrome, congenital adrenal hyperplasia, hypercalcemia in cancer, nonsuppurative thyroiditis, autoimmune hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, secondary thrombocytopenia, trichinosis, tuberculous meningitis, acute exacerbations of multiple sclerosis or cerebral edema, sympathetic ophthalmia, temporal arteritis, uveitis, ocular inflammation, berylliosis, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis, dermatomyositis, polymyositis, and systemic lupus erythematosus; adjunct treatment of adrenocortical insufficiency, regional enteritis, ulcerative colitis, fulminating or disseminated pulmonary tuberculosis, acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis; palliative management of leukemia and lymphoma; induction of diuresis or remission of proteinuria in idiopathic nephrotic syndrome or lupus erythematosus.¹³ A triamcinolone intravitreal injection is indicated for the treatment of sympathetic ophthalmia, temporal arteritis, uveitis, and ocular inflammatory conditions.¹⁵ The intravitreal injection is also used for visualization during vitrectomy.¹⁵ An extended release suspension is indicated intra-articularly for management of pain in osteoarthritis of the knee.¹⁶

A triamcinolone acetonide suspension for injection into the suprachoroidal space is indicated for the treatment of macular edema associated with uveitis.¹⁸

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Dose Form
Used in combination to treat	Acne	Combination Product in combination with: Kanamycin (DB01172)	••••••••••••	••••••••
Treatment of	Acne vulgaris		••• •••••	•••••••••
Adjunct therapy in management of	Acute gouty arthritis		••••••••••••	•••••••••
Symptomatic treatment of	Acute gouty arthritis		••••••••••••	•••••••••
Used in combination to treat	Allergic contact dermatitis	Combination Product in combination with: Salicylic acid (DB00936)	••••••••••••	••••••••

Contraindications & Blackbox Warnings

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Pharmacodynamics

Triamcinolone is a corticosteroid with anti-inflammatory properties.⁸ These properties are used to treat inflammation in conditions that affect various organs and tissues.¹⁵ Triamcinolone should not be administered as an epidural injection.^{10,12,13,15,16}

Mechanism of action

Corticosteroids like triamcinolone inhibit phospholipase A2 on cell membranes, preventing the breakdown of lysosomal membranes of leukocytes, which in turn prevent the formation of arachidonic acid, which decrease expression of cyclooxygenase and lipoxygenase, inhibiting synthesis of prostaglandins and leukotrienes.⁸ Anti-inflammatory activity occurs via reversal of vascular dilation and reducing permeability, which prevents macrophage and leukocyte migration.⁸ Triamcinolone also inhibits nuclear factor kappa-B, which decreases the production of pro-inflammatory signals such as interleukin-6, interleukin-8, and monocyte chemoattractant protein-1.⁸

Target	Actions	Organism
AGlucocorticoid receptor	agonist	Humans

Absorption

A 16mg oral dose of triamcinolone reaches a C_max of 5.23±0.84ng/mL with a T_max of 2.24±0.78h and an AUC of 36.0±6.2ng*h/mL.⁴

A 2mg intravenous dose of triamcinolone acetonide has an AUC of 57.7ng*h/mL.³ The bioavailability of 800µg of inhaled triamcinolone acetonide is 25%, with 10.4% coming from pulmonary absorption and the rest being accounted for by deposition on the oral mucosa and other underlying factors.² An inhaled dose of triamcinolone acetonide reaches a C_max of 0.92ng/mL with a T_max of 1.74h and an AUC of 5.12ng*h/mL.² The fraction of an inhaled dose that is actually absorbed via the pulmonary route reaches a C_max of 0.55ng/mL with a T_max of 0.66h and an AUC of 2.15ng*h/mL.²

A 16mg oral dose of triamcinolone diacetate reaches a C_max of 5.33±1.55ng/mL with a T_max of 1.86±0.47h and an AUC of 32.7±9.9ng*h/mL.⁴

Volume of distribution

The apparent volume of distribution of triamcinolone is 115.2±10L.⁴ The mean apparent volume of distribution of triamcinolone acetonide is 1.96L/kg.² The apparent volume of distribution of triamcinolone diacetate is 119.7±33.14L.⁴

Protein binding

Triamcinolone is mostly bound to corticosteroid-binding globulin or serum albumin.⁵ Triamcinolone acetonide is approximately 68% protein bound in plasma.⁷

Metabolism

The major metabolite of triamcinolone is 6-beta-hydroxy-triamcinolone.¹ Data regarding the metabolism of triamcinolone is not readily available.^{10,11,12,13,14,15,16,17}

Hover over products below to view reaction partners

Triamcinolone
- 6-beta-hydroxy-triamcinolone

Route of elimination

Approximately 20% of a dose of triamcinolone is recovered in the urine as the unchanged drug, 25% is recovered as 6-beta-hydroxy-triamcinolone, and 5% is recovered as unidentified metabolites.¹

Half-life

The half life of triamcinolone is 2.7h.⁴ The mean terminal elimination half life following an inhaled dose of triamcinolone acetonide is 2.4h.² The half life of triamcinolone diacetate is 2.8h.⁴

Clearance

The clearance of triamcinolone is 28.6±5.6L/h.⁴ The mean total body clearance of triamcinolone acetonide is 0.57L/h.² The clearance of triamcinolone diacetate is 34.4±10.6L/h.⁴

Adverse Effects

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Toxicity

The subcutaneous LD₅₀ of triamcinolone acetonide in rats is 13,100µg/kg and in mice is 132mg/kg.¹⁷ The oral LD₅₀ in rats is 1451mg/kg and in mice is 2168mg/kg.[LD₅₀] The intraperitoneal LD₅₀ in mice is 105mg/kg.[LD₅₀]

Patients experiencing an overdose may develop Cushing's syndrome.⁶ This overdose may be treated with supportive therapy and mifepristone for its antiglucocorticoid activity.⁶

Pathways

Not Available

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Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Abametapir	The serum concentration of Triamcinolone can be increased when it is combined with Abametapir.
Abatacept	The metabolism of Triamcinolone can be increased when combined with Abatacept.
Abciximab	The therapeutic efficacy of Abciximab can be decreased when used in combination with Triamcinolone.
Abemaciclib	The metabolism of Abemaciclib can be increased when combined with Triamcinolone.
Acalabrutinib	The metabolism of Acalabrutinib can be increased when combined with Triamcinolone.

Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Triamcinolone acetonide	F446C597KA	76-25-5	YNDXUCZADRHECN-JNQJZLCISA-N
Triamcinolone diacetate	A73MM2Q32P	67-78-7	XGMPVBXKDAHORN-RBWIMXSLSA-N
Triamcinolone hexacetonide	I7GT1U99Y9	5611-51-8	TZIZWYVVGLXXFV-FLRHRWPCSA-N

Product Images

International/Other Brands

Delphicort / Flutex / Kenacort / Omcilon-A / Oracort / Tri-Nasal / Triacet / Triacort / Triaderm / Tricortone / Trilone / Tristoject

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
AllerNaze	Spray, metered	0.5 mg/1mL	Nasal	Lupin Pharmaceuticals	2011-02-01	Not applicable
Aristocort	Injection, suspension	40 mg/1mL	Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral	Sandoz	1961-09-05	1961-09-05
Aristocort	Injection, suspension	40 mg/1mL	Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral	Physicians Total Care, Inc.	1961-09-05	2005-07-28
Aristocort - Syr Orl 0.4mg/ml	Syrup	.4 mg / mL	Oral	Glades, Division Of Stiefel Canada Inc.	1996-10-10	1997-08-05
Aristocort - Tab 4mg	Tablet	4 mg	Oral	Glades, Division Of Stiefel Canada Inc.	1998-05-11	2004-01-27

Generic Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Apo-triamcinolone AQ	Spray, metered	55 mcg / act	Nasal	Apotex Corporation	2016-06-15	Not applicable
DermacinRx Silazone Pak	Cream; Kit	1 mg/1g	Topical	PureTek Corporation	2015-12-10	2018-08-15
DermacinRx Trizapak	Kit	1 mg/1g	Topical	Pure Tek Corporation	2016-08-02	2017-08-17
Dermasorb TA Complete Kit	Kit	1 mg/1g	Topical	Crown Laboratories	2013-11-14	2019-08-30
Dermazone	Cream; Kit	1 mg/1g	Topical	Shoreline Pharmaceuticals, Inc.	2016-04-20	2018-08-15

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
24 Hour Nasal Allergy	Spray, metered	55 ug/1	Nasal	Kroger Company	2016-04-10	Not applicable
24 Hour Nasal Allergy	Spray, metered	55 ug/1	Nasal	Meijer Distribution Inc	2017-01-18	Not applicable
Allergy Nasal	Spray, metered	55 ug/1	Nasal	Walgreen Company	2016-04-10	Not applicable
Basic Care Nasal Allergy	Spray, metered	55 ug/1	Nasal	Amazon.com Services LLC	2021-07-26	Not applicable
Basic Care Nasal Allergy	Spray, metered	55 ug/1	Nasal	L. Perrigo Company	2018-04-25	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
AECORAS OINTMENT	Triamcinolone acetonide (0.1 %) + Econazole nitrate (1 %)	Ointment	Topical	DUOPHARMA (M) SDN. BHD.	2020-09-08	2022-02-08
AFTOJEL % 0,1 + %3 JEL (5 G)	Triamcinolone acetonide (1 mg/g) + Diclofenac sodium (30 mg/g)	Gel	Topical	ORVA İLAÇ SAN. VE TİC. A.Ş.	2008-04-30	Not applicable
Aristoform R Crm 0.1%	Triamcinolone acetonide (1 mg / g) + Clioquinol (30 mg / g)	Cream	Topical	Lederle Cyanamid Canada Inc.	1966-12-31	1997-01-29
Aureocort 1 mg/g + 30 mg/g Salbe	Triamcinolone acetonide (1 mg/g) + Chlortetracycline hydrochloride (30 mg/g)	Ointment	Topical	Dermapharm Gmb H	1966-09-28	Not applicable
Bt	Triamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Isopropyl alcohol (0.7 mL/1) + Povidone-iodine (0.10 g/1)	Cloth; Injection, solution; Kit; Solution	Epidural; Infiltration; Intra-articular; Intramuscular; Topical	Sa3, Llc	2015-07-01	2017-12-01

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Bupivilog Kit	Triamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Povidone-iodine (10 mg/1mL)	Kit	Epidural; Intra-articular; Intramuscular; Topical	Asclemed Usa, Inc.	2014-02-04	Not applicable
Bupivilog Kit	Triamcinolone acetonide (40 mg/1mL) + Bupivacaine hydrochloride (5 mg/1mL) + Povidone-iodine (10 mg/1mL)	Kit	Epidural; Intra-articular; Intramuscular; Topical	Advanced Rx Pharmacy of Tennessee, LLC	2023-07-31	Not applicable
Calcipotriene 0.005% / Triamcinolone Acetonide 0.1%	Triamcinolone acetonide (0.1 g/100g) + Calcipotriol (0.005 g/100g)	Ointment	Topical	Sincerus Florida, LLC	2019-05-11	Not applicable
Ellzia Pak	Triamcinolone acetonide (1 mg/1g) + Dimethicone (50 mg/1mL)	Kit	Topical	PureTek Corporation	2016-12-29	Not applicable
Hexatrione 2%	Triamcinolone hexacetonide (40 mg/2mL)	Injection, suspension	Intra-articular	Medexus Pharma, Inc.	2021-03-03	Not applicable

Chemical Identifiers

UNII: 1ZK20VI6TY
CAS number: 124-94-7
InChI Key: GFNANZIMVAIWHM-OBYCQNJPSA-N
InChI: InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
IUPAC Name: (1S,2R,3aS,3bS,9aS,9bR,10S,11aS)-9b-fluoro-1,2,10-trihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
SMILES: [H][C@@]12C[C@@H](O)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

References

Synthesis Reference

Abu Alam, "Triamcinolone formulations and methods for their preparation and use." U.S. Patent US20040186084, issued September 23, 2004.

US20040186084

General References

FLORINI JR, SMITH LL, BUYSKE DA: Metabolic fate of a synthetic corticosteroid (triamcinolone) in the dog. J Biol Chem. 1961 Apr;236:1038-42. [Article]
Argenti D, Shah B, Heald D: A pharmacokinetic study to evaluate the absolute bioavailability of triamcinolone acetonide following inhalation administration. J Clin Pharmacol. 1999 Jul;39(7):695-702. doi: 10.1177/00912709922008335. [Article]
Derendorf H, Hochhaus G, Rohatagi S, Mollmann H, Barth J, Sourgens H, Erdmann M: Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration. J Clin Pharmacol. 1995 Mar;35(3):302-5. doi: 10.1002/j.1552-4604.1995.tb04064.x. [Article]
Hochhaus G, Portner M, Barth J, Mollmann H, Rohdewald P: Oral bioavailability of triamcinolone tablets and a triamcinolone diacetate suspension. Pharm Res. 1990 May;7(5):558-60. doi: 10.1023/a:1015889305157. [Article]
FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. [Article]
Schweitzer DH, Le-Brun PP, Krishnaswami S, Derendorf H: Clinical and pharmacological aspects of accidental triamcinolone acetonide overdosage: a case study. Neth J Med. 2000 Jan;56(1):12-6. [Article]
Argenti D, Jensen BK, Hensel R, Bordeaux K, Schleimer R, Bickel C, Heald D: A mass balance study to evaluate the biotransformation and excretion of [14C]-triamcinolone acetonide following oral administration. J Clin Pharmacol. 2000 Jul;40(7):770-80. doi: 10.1177/00912700022009413. [Article]
Sidhu G, Preuss CV: Triamcinolone . [Article]
FDA Approved Drug Products: Aristocort Triamcinolone Oral Tablets (Discontinued) [Link]
FDA Approved Drug Products: Triamcinolone Hexacetonide Injection [Link]
FDA Approved Drug Products: Triamcinolone Acetonide Topical Spray [Link]
FDA Approved Drug Products: Triamcinolone Acetonide 10mg/mL Injection [Link]
FDA Approved Drug Products: Triamcinolone Acetonide 40mg/mL Injection [Link]
FDA Approved Drug Products: Triamcinolone Acetonide Topical Cream [Link]
FDA Approved Drug Products: Triamcinolone Acetonide Intravitreal Injection [Link]
FDA Approved Drug Products: Triamcinolone Acetonide Intraarticular Extended Release Suspension [Link]
Cayman Chemicals: Triamcinolone Acetonide MSDS [Link]
FDA Approved Drug Products: Xipere (triamcinolone acetonide) suspension for suprachoroidal injection [Link]
PR Newswire: Bausch + Lomb and Clearside Biomedical Announce FDA Approval of XIPERE™ (triamcinolone acetonide injectable suspension) for Suprachoroidal Use for the Treatment of Macular Edema Associated with Uveitis [Link]

External Links

Human Metabolome Database: HMDB0014758
KEGG Drug: D00385
PubChem Compound: 31307
PubChem Substance: 46507950
ChemSpider: 29046
BindingDB: 41132
RxNav: 10759
ChEBI: 9667
ChEMBL: CHEMBL1451
ZINC: ZINC000003882036
Therapeutic Targets Database: DAP000417
PharmGKB: PA451749
Guide to Pharmacology: GtP Drug Page
RxList: RxList Drug Page
Drugs.com: Drugs.com Drug Page
PDRhealth: PDRhealth Drug Page
Wikipedia: Triamcinolone

FDA label

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MSDS

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Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Treatment	Atopic Dermatitis	1
4	Active Not Recruiting	Treatment	Osteoarthritis (OA) / TMJ	1
4	Active Not Recruiting	Treatment	Osteoarthritis of the Knee	1
4	Completed	Basic Science	Rheumatoid Arthritis	1
4	Completed	Basic Science	To Assess the Changes in Bone Mineral Density / To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject	1

Pharmacoeconomics

Manufacturers

Astellas pharma us inc
Bristol myers squibb co
Barr laboratories inc
Impax laboratories inc
Ivax pharmaceuticals inc sub teva pharmaceuticals usa
Mylan pharmaceuticals inc
Purepac pharmaceutical co
Roxane laboratories inc
Sandoz inc
Teva pharmaceuticals usa inc
Watson laboratories inc
Abbott laboratories
Sanofi aventis us llc
Ivax pharmaceuticals inc
Apothecon inc div bristol myers squibb
Solvay pharmaceuticals
Actavis mid atlantic llc
Alpharma us pharmaceuticals division
Altana inc
Ambix laboratories div organics corp america
G and w laboratories inc
Morton grove pharmaceuticals inc
Perrigo new york inc
Pharmaderm div altana inc
Pharmafair inc
Taro pharmaceuticals inc
Taro pharmaceuticals usa inc
Topiderm inc
Vintage pharmaceuticals llc
Del ray laboratories inc
Savage laboratories inc div altana inc
Parnell pharmaceuticals inc
Sandoz canada inc
Allergan inc
Alcon inc
Bristol myers squibb co pharmaceutical research institute
Wockhardt eu operations (swiss) ag
Carolina medical products co
Lyne laboratories inc
Lupin atlantis holding sa switzerland
Ranbaxy laboratories inc
Akorn inc

Packagers

AAIPharma Inc.
Abbott Laboratories Ltd.
Actavis Group
Advanced Pharmaceutical Services Inc.
Aidarex Pharmacuticals LLC
Alcon Laboratories
Armstrong Pharmaceuticals Inc.
A-S Medication Solutions LLC
Blansett Pharmacal Co. Inc.
Bristol-Myers Squibb Co.
C.O. Truxton Inc.
Carlisle Laboratories Inc.
Carolina Medical Products Co.
Clint Pharmaceutical Inc.
Crown Laboratories Inc.
Darby Dental Supply Co. Inc.
Del Ray Dermatology
Dept Health Central Pharmacy
Dispensing Solutions
Diversified Healthcare Services Inc.
E. Fougera and Co.
E.R. Squibb and Sons LLC
G & W Labs
Generics Puerto Rico Inc.
Genesis Pharmaceutical Inc.
Goldline Laboratories Inc.
Group Health Cooperative
H.J. Harkins Co. Inc.
Hl Moore Drug Exchange
Ide Interstate
Innoviant Pharmacy Inc.
Inyx Usa Ltd.
Keene Pharmaceuticals Inc.
Lake Erie Medical and Surgical Supply
Major Pharmaceuticals
Martica Enterprises Inc.
Martin Surgical Supply
Medisca Inc.
Medvantx Inc.
Mericon
Merit Pharmaceuticals
National Pharmaceuticals
Nycomed Inc.
Paddock Labs
Palmetto Pharmaceuticals Inc.
Parnell Pharmaceuticals Inc.
Perrigo Co.
Pharmedix
Physicians Total Care Inc.
Preferred Pharmaceuticals Inc.
Primedics Laboratories
Princeton Pharmaceutical Products Inc.
Qualitest
Ranbaxy Laboratories
Rebel Distributors Corp.
Robar Inc.
San Jose Surgical Supply Inc.
Sandoz
Sanofi-Aventis Inc.
Savage Labs
Stat Rx Usa
Suppositoria Laboratories Inc.
Taro Pharmaceuticals USA
Topiderm Inc.
Vintage Pharmaceuticals Inc.
Watson Pharmaceuticals
Wockhardt Ltd.
X-Gen Pharmaceuticals

Dosage Forms

Form	Route	Strength
Tablet	Oral	0025 MG
Tablet, multilayer	Buccal	25 mcg
Spray, metered	Nasal	0.5 mg/1mL
Injection, suspension	Intra-articular; Intralesional; Intramuscular; Intrasynovial; Parenteral	40 mg/1mL
Syrup	Oral	.4 mg / mL
Cream	Topical	0.5 % w/w
Cream	Topical	5 mg / g
Cream	Topical	.025 %
Cream	Topical	.25 mg / g
Liquid	Intra-articular; Intramuscular; Intrasynovial	40 mg / mL
Liquid	Intra-articular; Intradermal; Intramuscular	25 mg / mL
Cream	Topical	0.1 % w/w
Ointment	Topical	0.1 % w/w
Cream	Topical	1 mg / g
Ointment	Topical	.1 %
Syrup	Oral	2 mg / 5 mL
Tablet	Oral	2 mg
Injection, suspension	Intra-articular; Parenteral	20 mg/1mL
Injection, suspension	Intralesional; Parenteral	5 mg/1mL
Suspension	Intra-articular	20 mg / mL
Injection, suspension	Intra-articular	20 mg/ml
Injection, suspension	Intra-articular	5 mg/ml
Kit	Intra-articular; Intramuscular	40 mg/1mL
Aerosol, metered	Respiratory (inhalation)	200 mcg / act
Aerosol, metered	Respiratory (inhalation)	75 ug/1
Cream		0.100 g
Cloth; injection, solution; kit; solution	Epidural; Infiltration; Intra-articular; Intramuscular; Topical
Kit	Epidural; Intra-articular; Intramuscular; Topical
Injection, solution; injection, suspension; kit	Epidural; Intra-articular; Intracaudal; Intramuscular; Intravenous; Perineural; Topical
Suspension	Intra-articular; Intramuscular	40 mg
Cream; injection, suspension; kit	Intra-articular; Intramuscular; Topical
Kit	Topical	1 mg/1g
Capsule	Oral
Paste	Oral
Cream	Topical	10 mg/g
Cream	Topical
Injection		10 mg/ml
Injection		40 mg/ml
Injection, solution
Injection, suspension	Intra-articular	40 mg/2mL
Emulsion	Topical
Kit	Infiltration; Intra-articular; Intramuscular; Respiratory (inhalation); Topical
Suspension	Intra-articular	20 mg
Inhalant; injection, solution; injection, suspension; kit; solution	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Perineural; Respiratory (inhalation); Topical
Kit	Intra-articular; Intralesional
Kit	Intra-articular; Intramuscular
Paste	Oral	0.1 %
Injection, solution	Intra-articular; Intradermal	40 mg/mL
Injection, suspension	Intra-articular; Intramuscular	40 mg
Injection, suspension	Parenteral	40 MG/ML
Suspension	Intra-articular; Intradermal	10 mg
Injection	Intra-articular; Intramuscular	40 mg
Ointment	Oral	0.1 %
Aerosol, spray	Topical	0.147 mg/1g
Lotion	Topical	0.25 mg/1mL
Ointment	Topical	5 mg/1g
Paste, dentifrice	Dental	1 mg/1g
Paste	Dental	1 mg / g
Ointment	Topical	1 mg / g
Injection, suspension	Intra-articular; Intralesional	10 mg/1mL
Suspension	Intra-articular; Intrabursal; Intradermal; Intrasynovial	10 mg / mL
Injection, suspension	Intra-articular; Intramuscular	40 mg/1mL
Injection, suspension	Intramuscular	40 mg/1mL
Suspension	Intra-articular; Intramuscular	40 mg / mL
Injection, suspension	Intra-articular; Intramuscular	80 mg/1mL
Paste	Oral	1 mg/g
Ointment
Suspension	Ophthalmic	2.00 mg
Cream	Topical	1 mg/g
Cream
Paste	Dental
Kit	Epidural; Infiltration; Intra-articular; Intramuscular; Topical
Kit	Epidural; Infiltration; Intra-articular; Intramuscular
Liquid	Buccal
Spray	Nasal	0.055 %
Implant	Subcutaneous
Aerosol, metered	Nasal	100 mcg / dose
Aerosol, metered	Nasal	55 ug/1
Spray, suspension	Nasal	55 MCG
Spray	Nasal	55 UG
Spray, metered	Nasal	55 mcg / act
Spray	Nasal	0.055 mg
Spray	Nasal	55 microgram
Spray	Nasal	55 mcg
Spray, metered	Nasal	55 mcg / dose
Spray, metered	Nasal
Cream	Topical
Ointment	Topical
Injection, solution; injection, suspension; kit	Infiltration; Intra-articular; Intramuscular; Perineural; Topical
Paste	Dental	0.1 %
Paste	Submucosal	3 % w/w
Lotion	Oral
Lotion	Topical	0.5 % w/v
Paste	Dental
Ointment	Buccal	1 mg/1g
Paste	Submucosal	1 mg/g
Ointment	Auricular (otic)
Paste	Submucosal	0.1 % w/w
Injection, suspension; kit; solution	Intra-articular; Intramuscular; Topical
Injection, solution; injection, suspension; kit; solution	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Intravenous; Perineural; Topical
Gel	Topical
Cream	Cutaneous
Kit	Epidural; Infiltration; Intra-articular; Intracaudal; Intramuscular; Perineural; Respiratory (inhalation); Topical
Cloth; injection, solution; injection, suspension; kit	Infiltration; Intra-articular; Intramuscular; Topical
Kit	Infiltration; Soft tissue; Topical
Kit	Topical
Tablet	Oral
Injection, solution	Intra-articular; Intramuscular	40 mg/1mL
Suspension	Intramuscular	40 mg / mL
Injection	Intra-articular; Intramuscular	40 mg/ml
Injection	Intradermal; Intramuscular	10 mg/ml
Kit; ointment	Topical	1 mg/1g
Cream; kit	Topical	1 mg/1g
Injection		40 mg
Paste
Injection, suspension
Injection, solution	Intravenous	200 mg/5ml
Injection, solution	Intravenous	40 mg/ml
Injection, solution	Intravenous	80 mg/2ml
Injection, suspension	Intravitreal	80 MG/ML
Suspension	Nasal	56.100 mg
Cream	Topical	1 MG
Injection, suspension	Parenteral	40 MG/1ML
Cream	Topical	0.1 %
Ointment	Topical	0.25 mg / g
Ointment	Topical	0.1 %
Cream; kit	Topical
Ointment		0.1 %
Suspension	Intra-articular	50 mg
Cream	Topical	0.1 mg/.1g
Cream	Topical	0.25 mg/1
Cream	Topical	0.25 mg/1g
Cream	Topical	1 mg/1
Cream	Topical	1 mg/1g
Cream	Topical	5 mg/1g
Cream	Topical	5 mg/1
Injection	Intra-articular; Intrabursal; Intradermal; Intralesional
Injection, suspension	Intra-articular; Intrabursal; Intradermal; Intralesional	10 mg/1mL
Injection, suspension	Intra-articular; Intramuscular	200 mg/5mL
Injection, suspension	Intra-articular; Intramuscular	400 mg/10mL
Injection, suspension	Intra-articular; Intramuscular; Soft tissue	40 mg/1mL
Lotion	Topical	1 mg/1mL
Ointment	Topical	.5 mg/1g
Ointment	Topical	0.1 mg/0.100g
Ointment	Topical	0.25 mg/1g
Ointment	Topical	1 mg/1g
Paste	Dental	1 mg/1g
Paste	Topical	1 mg/1g
Spray	Topical	0.147 mg/1g
Spray, metered	Nasal	55 ug/1
Suspension	Intra-arterial; Intramuscular	40 mg/1mL
Cream
Injection	Intramuscular	40 mg/ml
Ointment	Topical	.5 mg/1
Suspension	Intra-articular; Intrabursal; Intramuscular	40 mg / mL
Suspension	Intralesional	40 mg / mL
Suspension	Intra-articular; Intradermal; Intralesional; Intramuscular	40 mg / mL
Injection, suspension		40 mg/1ml
Injection, suspension	Ophthalmic
Suspension	Ophthalmic
Solution	Oral	0.2 %
Emulsion	Topical	0.1 %
Injection, suspension	Parenteral	80 MG/2ML
Ointment	Topical	0.5 mg/1g
Injection, suspension	Intramuscular	40 mg/mL
Injection, solution		40 mg/mL
Injection, suspension	Ophthalmic	40 mg/1mL
Suspension	Intravitreal	40 mg / mL
Injection
Suspension	Intra-articular; Intradermal	50 mg
Suspension	Intra-articular; Intrasynovial; Periarticular	20 mg / mL
Injection, suspension	Parenteral	20 mg/ml
Injection, suspension	Intra-articular; Intramuscular; Intravitreal	8 mg/0.1mL
Tablet	Oral	16 MG
Tablet	Oral	8 MG
Cream	Cutaneous	1 mg/g
Ointment	Oral	1 mg/g
Ointment	Cutaneous	1 mg/g
Solution	Topical
Injection	Parenteral	40 mg
Injection	Parenteral	80 mg
Ointment		1 mg/g
Cream	Topical	0.25 mg/g
Ointment		0.25 mg/g
Injection, solution	Intramuscular
Kit	Intra-articular	32 mg/1
Suspension		10 mg/1ml
Suspension		40 mg/1ml
Cream		0.02 %w/w
Lotion	Topical	0.1 %w/w
Solution; spray	Nasal	55 mcg/1dose
Gel	Oral	0.1 %w/w
Cream		0.5 %w/w
Tablet	Oral	4 mg
Cream		0.1 %w/w
Ointment	Topical	0.1 %w/w
Paste	Oral	0.1 %w/w

Prices

Unit description	Cost	Unit
Triesence 40 mg/ml vial	148.8USD	ml
Kenalog Aerosol 63 gm Can	118.99USD	can
Nasacort AQ 55 mcg/act Aerosol (Nasal Spray)	118.74USD	inhaler
Triamcinolone Acetonide 0.1% Paste 5 gm Tube	71.7USD	tube
Kenalog 0.5% Cream 20 gm Tube	54.99USD	tube
Kenalog 0.1% Lotion 60ml Bottle	51.99USD	bottle
Kenalog 0.025% Lotion 60ml Bottle	46.99USD	bottle
Triamcinolone Acetonide 0.025% Lotion 60ml Bottle	40.99USD	bottle
Triamcinolone diacetate powder	26.01USD	g
Triamcinolone powder	20.29USD	g
Kenalog 0.1% Cream 15 gm Tube	18.99USD	tube
Triamcinolone Acetonide 0.1% Ointment 80 gm Tube	18.99USD	tube
Triamcinolone Acetonide 0.5% Ointment 15 gm Tube	14.99USD	tube
Aristospan 20 mg/ml vial	14.19USD	ml
Oralone 0.1% paste	13.57USD	g
Triamcinolone Acetonide 0.025% Cream 80 gm Tube	12.99USD	tube
Triamcinolone Acetonide 0.1% Cream 80 gm Tube	12.99USD	tube
Triamcinolone Acetonide 0.5% Cream 15 gm Tube	12.99USD	tube
Triamcinolone Acetonide 0.025% Cream 15 gm Tube	11.99USD	tube
Triamcinolone Acetonide 0.025% Ointment 80 gm Tube	11.99USD	tube
Triamcinolone Acetonide 0.1% Cream 15 gm Tube	11.99USD	tube
Triamcinolone Acetonide 0.1% Ointment 15 gm Tube	11.99USD	tube
Kenalog-40 40 mg/ml vial	8.99USD	ml
Triamcinolone acet 40 mg/ml sus	8.42USD	ml
Kenalog-40 40 mg/ml	7.53USD	ml
Nasacort aq nasal spray	6.99USD	g
Triamcinolone 0.1% paste	6.4USD	g
Triamcinolone Acetonide 40 mg/ml	6.29USD	ml
Triamcinolone Acetonide Usp 40 mg/ml	5.76USD	ml
Aristospan 5 mg/ml vial	3.54USD	ml
Kenalog-10 10 mg/ml	3.24USD	ml
Triamcinolone Acetonide 10 mg/ml	2.71USD	ml
Kenalog-10 10 mg/ml vial	2.32USD	ml
Triamcinolone acet 10 mg/ml sus	2.18USD	ml
Aristocort C 0.5 % Cream	1.3USD	g
Oracort 0.1 % Paste	1.19USD	g
Triderm 0.1% cream	0.47USD	g
Triamcinolone 0.5% cream	0.22USD	g
Aristocort R 0.1 % Cream	0.15USD	g
Aristocort R 0.1 % Ointment	0.15USD	g
Triamcinolone Acetonide 0.1% Cream	0.07USD	gm
Triaderm Regular 0.1 % Cream	0.07USD	g
Triamcinolone 0.025% cream	0.06USD	g
Triamcinolone Acetonide 0.1% Ointment	0.05USD	gm

DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)
CA2268927	No	2003-09-23	2017-07-02
US5976573	No	1999-11-02	2016-07-03
US6143329	No	2000-11-07	2016-07-03
US7977045	No	2011-07-12	2016-07-03
US6395294	No	2002-05-28	2020-01-13
US8211880	No	2012-07-03	2029-03-10
US8128960	No	2012-03-06	2029-12-17
US8828440	No	2014-09-09	2031-08-04
US9555048	No	2017-01-31	2031-08-04
US8636713	No	2014-01-28	2027-05-02
US9636332	No	2017-05-02	2033-11-08
US9937075	No	2018-04-10	2034-05-02

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	270	Chemspider

Predicted Properties

Property	Value	Source
Water Solubility	0.847 mg/mL	ALOGPS
logP	0.84	ALOGPS
logP	0.24	Chemaxon
logS	-2.7	ALOGPS
pKa (Strongest Acidic)	11.75	Chemaxon
pKa (Strongest Basic)	-3.3	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	6	Chemaxon
Hydrogen Donor Count	4	Chemaxon
Polar Surface Area	115.06 Å²	Chemaxon
Rotatable Bond Count	2	Chemaxon
Refractivity	99.38 m³·mol^-1	Chemaxon
Polarizability	39.8 Å³	Chemaxon
Number of Rings	4	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.9823
Blood Brain Barrier	+	0.9528
Caco-2 permeable	+	0.7397
P-glycoprotein substrate	Substrate	0.8204
P-glycoprotein inhibitor I	Non-inhibitor	0.8759
P-glycoprotein inhibitor II	Non-inhibitor	0.9725
Renal organic cation transporter	Non-inhibitor	0.8178
CYP450 2C9 substrate	Non-substrate	0.8858
CYP450 2D6 substrate	Non-substrate	0.9006
CYP450 3A4 substrate	Substrate	0.7049
CYP450 1A2 substrate	Non-inhibitor	0.9144
CYP450 2C9 inhibitor	Non-inhibitor	0.8939
CYP450 2D6 inhibitor	Non-inhibitor	0.9231
CYP450 2C19 inhibitor	Non-inhibitor	0.911
CYP450 3A4 inhibitor	Non-inhibitor	0.9007
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.942
Ames test	Non AMES toxic	0.8858
Carcinogenicity	Non-carcinogens	0.9521
Biodegradation	Not ready biodegradable	0.9952
Rat acute toxicity	2.3369 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9562
hERG inhibition (predictor II)	Inhibitor	0.6125

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Download (9.24 KB)

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	splash10-05q9-4958000000-8d5e298bc84911e269f1
Mass Spectrum (Electron Ionization)	MS	splash10-00di-2931000000-ee37afbf8c285181a340
LC-MS/MS Spectrum - LC-ESI-qTof , Positive	LC-MS/MS	splash10-006t-3970000000-70c8dcf068945a18ecdd
MS/MS Spectrum - , positive	LC-MS/MS	splash10-006t-3970000000-70c8dcf068945a18ecdd
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0a6r-0009000000-2fd4b1ef247ea3bac654
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0006-0009000000-48efe802b2ef1b9c3458
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0ara-0229000000-b1121662bdf13127e4c0
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-014r-0009000000-5dcdba502b8d6de992fc
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-014i-2829000000-a16cd5a7427cd5344a35
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-03di-0390000000-1936829b24b66da677b3
1H NMR Spectrum	1D NMR	Not Applicable
13C NMR Spectrum	1D NMR	Not Applicable
Predicted 1H NMR Spectrum	1D NMR	Not Applicable
Predicted 13C NMR Spectrum	1D NMR	Not Applicable

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	197.9275218	predicted	DarkChem Lite v0.1.0
[M-H]-	196.2095218	predicted	DarkChem Lite v0.1.0
[M-H]-	191.57143	predicted	DeepCCS 1.0 (2019)
[M+H]+	198.8500218	predicted	DarkChem Lite v0.1.0
[M+H]+	196.4032218	predicted	DarkChem Lite v0.1.0
[M+H]+	193.46683	predicted	DeepCCS 1.0 (2019)
[M+Na]+	197.6947218	predicted	DarkChem Lite v0.1.0
[M+Na]+	196.6655218	predicted	DarkChem Lite v0.1.0
[M+Na]+	199.33134	predicted	DeepCCS 1.0 (2019)

Targets

Build, predict & validate machine-learning models

Use our structured and evidence-based datasets to unlock new
insights and accelerate drug research.

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Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.

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Details1. Glucocorticoid receptor

Kind: Protein
Organism: Humans
Pharmacological action: Yes
Actions: Agonist

General Function: Zinc ion binding
Specific Function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name: NR3C1
Uniprot ID: P04150
Uniprot Name: Glucocorticoid receptor
Molecular Weight: 85658.57 Da

References

Nehme A, Lobenhofer EK, Stamer WD, Edelman JL: Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. [Article]
Issar M, Sahasranaman S, Buchwald P, Hochhaus G: Differences in the glucocorticoid to progesterone receptor selectivity of inhaled glucocorticoids. Eur Respir J. 2006 Mar;27(3):511-6. [Article]
Shahin V, Ludwig Y, Schafer C, Nikova D, Oberleithner H: Glucocorticoids remodel nuclear envelope structure and permeability. J Cell Sci. 2005 Jul 1;118(Pt 13):2881-9. [Article]

Enzymes

Details1. Cytochrome P450 3A4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate
Inducer

General Function: Vitamin d3 25-hydroxylase activity
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name: CYP3A4
Uniprot ID: P08684
Uniprot Name: Cytochrome P450 3A4
Molecular Weight: 57342.67 Da

References

Dort K, Padia S, Wispelwey B, Moore CC: Adrenal suppression due to an interaction between ritonavir and injected triamcinolone: a case report. AIDS Res Ther. 2009 Jun 8;6:10. doi: 10.1186/1742-6405-6-10. [Article]
Hagan JB, Erickson D, Singh RJ: Triamcinolone acetonide induced secondary adrenal insufficiency related to impaired CYP3A4 metabolism by coadministration of nefazodone. Pain Med. 2010 Jul;11(7):1132-5. doi: 10.1111/j.1526-4637.2010.00852.x. Epub 2010 Apr 29. [Article]
Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.

Details2. Prostaglandin G/H synthase 2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Prostaglandin-endoperoxide synthase activity
Specific Function: Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
Gene Name: PTGS2
Uniprot ID: P35354
Uniprot Name: Prostaglandin G/H synthase 2
Molecular Weight: 68995.625 Da

References

Schaefer EC, Stewart AA, Durgam SS, Byron CR, Stewart MC: Effects of sodium hyaluronate and triamcinolone acetonide on glucosaminoglycan metabolism in equine articular chondrocytes treated with interleukin-1. Am J Vet Res. 2009 Dec;70(12):1494-501. doi: 10.2460/ajvr.70.12.1494. [Article]

Details3. Cholinesterase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inducer

General Function: Identical protein binding
Specific Function: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Gene Name: BCHE
Uniprot ID: P06276
Uniprot Name: Cholinesterase
Molecular Weight: 68417.575 Da

References

Ehrich M, Jortner BS, Gross WB: Types of adrenocorticoids and their effect on organophosphorus-induced delayed neuropathy in chickens. Toxicol Appl Pharmacol. 1988 Feb;92(2):214-23. [Article]

Details4. Cytochrome P450 3A5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate
Inducer

General Function: Oxygen binding
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name: CYP3A5
Uniprot ID: P20815
Uniprot Name: Cytochrome P450 3A5
Molecular Weight: 57108.065 Da

References

Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS: Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. [Article]

Details5. Cytochrome P450 3A7

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate
Inducer

General Function: Oxygen binding
Specific Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name: CYP3A7
Uniprot ID: P24462
Uniprot Name: Cytochrome P450 3A7
Molecular Weight: 57525.03 Da

References

Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS: Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. [Article]

Carriers

Details1. Corticosteroid-binding globulin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Binder

General Function: Steroid binding
Specific Function: Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name: SERPINA6
Uniprot ID: P08185
Uniprot Name: Corticosteroid-binding globulin
Molecular Weight: 45140.49 Da

References

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
Groyer A, Le Bouc Y, Joab I, Radanyi C, Renoir JM, Robel P, Baulieu EE: Chick oviduct glucocorticosteroid receptor. Specific binding of the synthetic steroid RU 486 and immunological studies with antibodies to chick oviduct progesterone receptor. Eur J Biochem. 1985 Jun 3;149(2):445-51. [Article]
Svec F, Harrison RW: Conditions affecting AtT-20 cell glucocorticoid uptake. Steroids. 1981 Feb;37(2):143-56. [Article]
Eisen HJ: An antiserum to the rat liver glucocorticoid receptor. Proc Natl Acad Sci U S A. 1980 Jul;77(7):3893-7. [Article]
Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]

Details2. Serum albumin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Binder

General Function: Toxic substance binding
Specific Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name: ALB
Uniprot ID: P02768
Uniprot Name: Serum albumin
Molecular Weight: 69365.94 Da

References

FLORINI JR, BUYSKE DA: Plasma protein binding of triamcinolone-H3 and hydrocortisone-4-C14. J Biol Chem. 1961 Jan;236:247-51. [Article]

Drug created at June 13, 2005 13:24 / Updated at February 20, 2024 23:55

Triamcinolone

Identification

Structure for Triamcinolone (DB00620)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References

Enzymes

References

References

References

References

References

Carriers

References

References