Identification
- Summary
Salicylic acid is an acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
- Brand Names
- Actikerall, Bensal, Bioelements Active Astringent, Cantharone Plus, Clearasil, Diprosalic, Keralyt, Salex, Saliject, Salinocaine, Salvax, Ultrasal, Virasal
- Generic Name
- Salicylic acid
- DrugBank Accession Number
- DB00936
- Background
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
- Type
- Small Molecule
- Groups
- Approved, Investigational, Vet approved
- Structure
Structure for Salicylic acid (DB00936)
- Weight
- Average: 138.1207
Monoisotopic: 138.031694058 - Chemical Formula
- C7H6O3
- Synonyms
- 2-Carboxyphenol
- 2-Hydroxybenzoic acid
- ácido salicílico
- Acidum salicylicum
- O-carboxyphenol
- O-hydroxybenzoic acid
- Salicylic acid
- External IDs
- FEMA NO. 3985
- K-557
- NSC-180
Pharmacology
- Indication
Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Acne Combination Product in combination with: Benzoic acid (DB03793), Octasulfur (DB09353) •••••••••••• •••••••• Treatment of Acne ••• ••• Used in combination to treat Actinic keratosis Combination Product in combination with: Fluorouracil (DB00544) •••••••••••• Used in combination to treat Alopecia areata (aa) Combination Product in combination with: Flumethasone (DB00663) •••••••••••• •••••••• Used in combination to treat Atopic dermatitis (ad) Combination Product in combination with: Flumethasone (DB00663) •••••••••••• •••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
- Mechanism of action
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
Target Actions Organism AProstaglandin G/H synthase 1 inhibitorHumans AProstaglandin G/H synthase 2 inhibitorHumans UAldo-keto reductase family 1 member C1 inhibitorHumans - Absorption
Not Available
- Volume of distribution
The volume of distribution is about 170 mL/kg of body weight.3
- Protein binding
Salicylic acid is about 90% plasma protein bound.3
- Metabolism
Salicylic acid is extensively metabolized.3
- Route of elimination
About 10% is excreted unchanged in the urine.3
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
- Pathways
Pathway Category Salicylic Acid Action Pathway Drug action - Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Salicylic acid may decrease the excretion rate of Abacavir which could result in a higher serum level. Abatacept The metabolism of Salicylic acid can be increased when combined with Abatacept. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Abciximab. Abrocitinib The metabolism of Abrocitinib can be decreased when combined with Salicylic acid. Acamprosate The excretion of Acamprosate can be decreased when combined with Salicylic acid. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Choline magnesium trisalicylate DJJ95FJP1H 64425-90-7 FQCQGOZEWWPOKI-UHFFFAOYSA-K Diethylamine salicylate 5V7PT38BJU 4419-92-5 JGMKRAUEFASZKH-UHFFFAOYSA-N Potassium salicylate K91YT16P5M 578-36-9 FRMWBRPWYBNAFB-UHFFFAOYSA-M Sodium salicylate WIQ1H85SYP 54-21-7 ABBQHOQBGMUPJH-UHFFFAOYSA-M - Active Moieties
Name Kind UNII CAS InChI Key Benzoic acid unknown 8SKN0B0MIM 65-85-0 WPYMKLBDIGXBTP-UHFFFAOYSA-N - Product Images
- International/Other Brands
- Dr. Scholl's Callus Removers / Dr. Scholl's Corn Removers / Dr. Scholl's Wart Remover Kit / Duofil Wart Remover / Duoplant / Ionil Plus shampoo / Salonil / Salsonin / Stridex
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 28.5% Salicylic Acid Solution 285 mg/1mL Topical Elorac, Inc. 2018-04-30 Not applicable US 
AcNesic Acne Treatment Gel 0.5 g/100g Topical Blaine Labs Inc. 2021-04-06 Not applicable US Aliclen Shampoo 60 mg/1mL Topical Prasco, Laboratories 2011-02-02 2014-01-31 US Bensal HP Ointment 30 mg/1g Topical Smg Pharmaceuticals, Llc 1998-10-01 Not applicable US Bioelements Active Astringent Liquid 0.5 mL/100mL Topical Bioelements 2009-01-01 Not applicable US - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 111MedCo 2% Salicylic Acid Cleansing Bar Soap 20 mg/1g Topical 111MedCo LLC 2022-07-01 Not applicable US 24 Hour Pimple Punisher Cream; Kit 2 g/100mL Topical KATE SOMERVILLE SKINCARE, LLC 2014-06-22 2018-11-18 US 28 Remedy Acne Pore Deep Cleanser Gel 0.6 g/120mL Topical NoTS Co.,Ltd 2016-01-02 2018-12-01 US 28 Remedy Balancing Toner 10mL Cream 0.001 mg/10mL Topical NoTS Co Ltd 2015-09-01 2018-12-01 US 3 in 1 Cleanser Liquid 1 mg/1mg Topical SGII, INC. 2018-06-29 2020-09-30 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 2% Salicylic Acid FACIAL CLEANSER Salicylic acid (20 mg/236mL) + Azelaic acid (10 mg/236mL) + Glycerin (50 mg/236mL) + Kaolin (20 mg/236mL) + Zinc pidolate (10 mg/236mL) Liquid Topical Volans Epic LLC 2023-04-06 Not applicable US 24 Alopecia Reliefshampoo Salicylic acid (0.25 g/100mL) + Menthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) Shampoo Topical DERMA CENTRIC INC 2020-08-08 Not applicable US 3 Part Acne Treatment Kit Ceela Naturaals Salicylic acid (20 mg/1mL) + Salicylic acid (20 mg/1mL) Kit Topical Ceela Naturals, Llc 2017-10-09 Not applicable US 3 Part Acne Treatment Kit Ceela Naturaals Salicylic acid (20 mg/1mL) + Salicylic acid (20 mg/1mL) Kit Topical Ceela Naturals, Llc 2017-10-09 Not applicable US 30 day Acne Treatment Kit Salicylic acid (0.5 g/100mL) + Benzoyl peroxide (5 g/100mL) Kit Topical COSMETIC ENTERPRISES LTD 2023-08-23 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Alopecia Reliefshampoo Salicylic acid (0.25 g/100mL) + Menthol (0.3 g/100mL) + Panthenol (0.2 g/100mL) Shampoo Topical DERMA CENTRIC INC 2020-08-08 Not applicable US 28 Remedy Balancing Toner 10mL Salicylic acid (0.001 mg/10mL) Cream Topical NoTS Co Ltd 2015-09-01 2018-12-01 US 28.5% Salicylic Acid Salicylic acid (285 mg/1mL) Solution Topical Elorac, Inc. 2018-04-30 Not applicable US AC Out Spot stOp Serum Salicylic acid (0.1 mg/100mL) Liquid Topical The Doctors Cosmetics Co., Ltd 2012-09-27 Not applicable US Ac7 Salicylic acid (0.000001 g/10mL) Gel Topical Micell Korea Co.,ltd 2017-03-20 Not applicable US
Categories
- ATC Codes
- D01AE12 — Salicylic acid
- D01AE — Other antifungals for topical use
- D01A — ANTIFUNGALS FOR TOPICAL USE
- D01 — ANTIFUNGALS FOR DERMATOLOGICAL USE
- D — DERMATOLOGICALS
- N02BA — Salicylic acid and derivatives
- N02B — OTHER ANALGESICS AND ANTIPYRETICS
- N02 — ANALGESICS
- N — NERVOUS SYSTEM
- N02BA — Salicylic acid and derivatives
- N02B — OTHER ANALGESICS AND ANTIPYRETICS
- N02 — ANALGESICS
- N — NERVOUS SYSTEM
- Drug Categories
- Acids, Carbocyclic
- Agents causing hyperkalemia
- Agents that produce hypertension
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Infective Agents
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Anti-Inflammatory Agents, Non-Steroidal (Non-Selective)
- Antifungal Agents
- Antifungals for Dermatological Use
- Antifungals for Topical Use
- Benzene Derivatives
- Benzoates
- Cyclooxygenase Inhibitors
- Cytochrome P-450 CYP2C9 Substrates
- Cytochrome P-450 Substrates
- Dermatologicals
- Enzyme Inhibitors
- Hydroxy Acids
- Hydroxybenzoates
- Keratolytic Agents
- Nephrotoxic agents
- Nervous System
- Non COX-2 selective NSAIDS
- OAT1/SLC22A6 inhibitors
- OAT3/SLC22A8 Inhibitors
- OATP2B1/SLCO2B1 substrates
- Ophthalmologicals
- Peripheral Nervous System Agents
- Phenols
- Salicylates
- Salicylic Acid and Derivatives
- Sclerosing Solutions
- Sensory Organs
- Sensory System Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzoic acids and derivatives
- Direct Parent
- Salicylic acids
- Alternative Parents
- Benzoic acids / Benzoyl derivatives / 1-hydroxy-4-unsubstituted benzenoids / 1-hydroxy-2-unsubstituted benzenoids / Vinylogous acids / Monocarboxylic acids and derivatives / Carboxylic acids / Organooxygen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 1-hydroxy-4-unsubstituted benzenoid / Aromatic homomonocyclic compound / Benzoic acid / Benzoyl / Carboxylic acid / Carboxylic acid derivative / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic oxide
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- monohydroxybenzoic acid (CHEBI:16914)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- O414PZ4LPZ
- CAS number
- 69-72-7
- InChI Key
- YGSDEFSMJLZEOE-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
- IUPAC Name
- 2-hydroxybenzoic acid
- SMILES
- OC(=O)C1=CC=CC=C1O
References
- Synthesis Reference
Howard Jones, Robert W. Houser, "Process for preparing 4-(2,4-difluorophenyl)-salicyclic acid." U.S. Patent US4225730, issued August, 1972.
US4225730- General References
- Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232-5. [Article]
- Flower R, Gryglewski R, Herbaczynska-Cedro K, Vane JR: Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nat New Biol. 1972 Jul 26;238(82):104-6. [Article]
- FDA Approved Drug Products: HELIDAC Therapy (bismuth subsalicylate, metronidazole, and tetracycline) [Link]
- External Links
- Human Metabolome Database
- HMDB0001895
- KEGG Drug
- D00097
- KEGG Compound
- C00805
- PubChem Compound
- 338
- PubChem Substance
- 46504942
- ChemSpider
- 331
- BindingDB
- 26193
- 9525
- ChEBI
- 16914
- ChEMBL
- CHEMBL424
- ZINC
- ZINC000000001554
- Therapeutic Targets Database
- DAP000731
- PharmGKB
- PA451299
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- SAL
- Wikipedia
- Salicylic_acid
- PDB Entries
- 1fiq / 1fo4 / 1jgs / 1m6e / 1pth / 1wyg / 1y7i / 2e1q / 2fn1 / 2i2z … show 59 more
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Active Not Recruiting Basic Science Chronic Obstructive Pulmonary Disease (COPD) 1 4 Active Not Recruiting Treatment Acute Hemorrhagic Stroke 1 4 Active Not Recruiting Treatment Adjuvant Chemotherapy / Non-Small Cell Lung Carcinoma 1 4 Completed Not Available Healthy Subjects (HS) 1 4 Completed Basic Science Type 2 Diabetes Mellitus 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- 7 Oaks Pharmaceutical Corp.
- Aeropak (Uk)
- Auriga Pharmaceuticals LLC
- Avidas Pharmaceuticals
- Breckenridge Pharmaceuticals
- Collegium Pharmaceutical Inc.
- Contract Pharm
- Coria Laboratories
- Direct Dispensing Inc.
- DPT Laboratories Ltd.
- Elorac Inc.
- EMS Acquisition Corp.
- Groupe Parima Inc.
- Harmony Laboratories Inc.
- Hi Tech Pharmacal Co. Inc.
- JSJ Pharmaceuticals Inc.
- Kaiser Foundation Hospital
- Kamins Dermatologics Inc.
- Major Pharmaceuticals
- Medtech Labs
- Murfreesboro Pharmaceutical Nursing Supply
- Nucare Pharmaceuticals Inc.
- Onset Therapeutics LLC
- PD-Rx Pharmaceuticals Inc.
- PEDiNOL
- Perrigo Co.
- Pharmedix
- Physicians Total Care Inc.
- Pliva Inc.
- Prasco Labs
- PruGen Inc. Pharmaceuticals
- Qualitest
- River's Edge Pharmaceuticals
- Seton Pharmaceuticals LLC
- Sheffield Laboratories Div Faria Limited LLC
- Sonar Products Inc.
- Southwood Pharmaceuticals
- Span Packaging Services LLC
- Stiefel Labs
- Summers Labs
- Valeant Ltd.
- Dosage Forms
Form Route Strength Cream; kit Topical 2 g/100mL Gel Topical 0.6 g/120mL Cream Topical 0.001 mg/10mL Liquid Topical 1 mg/1mg Liquid Topical 1 g/100g Swab Topical 0.024 g/1 Liquid Topical 0.1 mg/100mL Gel Topical 0.000001 g/10mL Solution Topical 22.5 mg/15mL Injection, solution Intramuscular 1000 mg Injection, solution Intramuscular; Intravenous 1 g/5ml Ointment Topical Cream Topical 14 g/100g Liquid Topical 1.2 g/240mL Disc Topical 20 g/1000g Gel Topical 7 mg/354mg Liquid Topical 3.61 g/3.61g Lotion Topical 1.18 g/1.18g Gel Topical 2 mg/100mg Liquid Topical 0.02 g/1 Cream Topical 2000 mg/100mL Soap Topical 3.4 g/168g Spray Topical 0.5 g/100mL Liquid Topical 29.2 mg/1 Lotion Topical 1 g/50mL Cream Topical 18 mg/1g Liquid Topical 0.75 mg/150mL Gel Topical 0.5 % Cream Topical 2 mg/100mg Gel Topical 20 g/100g Lotion Topical 18.6 mg/1mL Lotion Topical 0.295 g/59mL Gel Topical 21 mg/1mL Gel Topical 0.01 g/1g Cream Topical 0.5 mg/1mL Cream Topical 0.15 g/30g Solution Topical 0.2 g/40g Lotion Topical 1.0 mL/100mL Liquid Topical .5 g/.5mL Liquid Topical .5 g/100mL Cream Topical 0.5 g/100mL Gel Topical 5 mg/1g Cream Topical 2 g/1mL Patch Topical 2 g/100mL Liquid Topical 2 g/200mL Liquid Topical 2 g/100mL Swab Topical .5 g/100mL Swab Topical 5 mg/1000mg Swab Topical 5 mg/1mL Spray Topical 2.84 g/142g Solution Topical 20 mg/1 Gel Topical 2 mg/100mL Cloth Topical 5 mg/1 Gel Topical 0.6 g/30mL Lotion Topical 1.0 mg/1mL Liquid Topical 1.93 mL/96.5mL Cream Topical 1.5 % Cream Cutaneous 0.3 g/15mL Patch Topical 2 mg/100mg Cream; gel; kit Topical Soap Topical 2 g/100g Plaster Topical .4 1/1001 Plaster Topical 40 1/1 Aerosol, foam Topical 1.5 g/100g Cloth Topical 2 g/1 Cream Topical 2 g/100g Cloth Topical 2 g/101 Cloth Topical 2 g/301 Emulsion Topical 2 g/100g Lotion Topical 1 g/100g Lotion Topical 2.0 g/100g Lotion Topical 2.0 mL/100mL Cream Topical 2.0 g/100g Ointment Topical 0.1 g/g Cream Topical 10 % Spray Topical Shampoo Topical 60 mg/1mL Kit; tablet Oral Gel Topical .5 % Powder Topical 0.6 mg/1mL Liquid Topical 0.01 g/1mL Liquid Topical 2 mg/2mL Liquid Topical 0.5 mg/1mL Emulsion Topical 1 mg/1mL Powder Topical 0.002 g/1g Powder Topical 0.6 % Strip Topical 1.4 % Liquid; swab Topical .5 % Liquid Topical .5 % Liquid Topical 1.0 g/200mL Liquid Topical 0.25 g/50mL Liquid Topical 0.018 mg/1mg Lotion Topical 250 g/5g Shampoo Topical 200 g/6g Cream Topical 50 g/1g Gel Oral; Topical 2 g Gel Topical 2 g Lotion Topical 2 g Cream Topical 0.08 g/20mL Cream Topical 5 mg/1g Gel Topical 15 mg/1g Shampoo Topical 2.5 g/100mL Gel Topical 2 mL/100mL Shampoo Topical 0.2 g/100mL Liquid Topical 0.1 g/100mL Gel Topical 15 uL/1mL Swab Topical 10 uL/1mL Jelly Topical 1 % Lotion Topical 3 g/100mL Rinse Topical 2.0 g/397g Shampoo Topical 2.0 g/414g Gel Topical 0.1 g/1g Lotion Topical 2 g/100g Disc Topical 20 mg/1 Stick Topical 2 g/100g Lotion Topical 1 mg/100mL Lotion Topical 10 mg/1g Lotion Topical 5 % w/v Spray Topical 2 g/100mL Shampoo Topical 30 mg/100mL Shampoo Topical 3 mg/100mL Paste Topical 0.0401 g Cream Topical 2.6 g/130mL Swab Topical 0.0046 g/1 Lotion Topical 0.75 mg/150mL Lotion Topical 11 mg/1mL Oil Topical 18 mg/1mL Cloth Topical 20 mg/1mL Cloth Topical 176 mg/1 Lotion Topical 8 mg/1mL Cloth Topical 0.5 g/100g Cream Topical .5 mL/100mL Lotion Topical 2 mL/100mL Shampoo Topical 2 g/414g Rinse Topical 2 g/397g Patch Topical 0.5 g/100g Solution Topical 1.5 g/100mL Solution Topical 15 mg/1g Soap Topical 0.50 % Soap Topical 0.5 g/100g Cloth Topical 6 mg/1 Soap Topical .5 % Soap Topical 5 mg/1g Liquid Topical 2 mg/200mL Lotion Topical 0.7 % Jelly Topical Stick Topical Stick Topical 2 % Lotion Topical 1.5 % Liquid Topical 1.5 % Swab Topical 40 % Emulsion Topical 20 mg/1mL Emulsion Topical 10 mg/1g Powder Topical 30 mg/6g Liquid Topical 5 mg/100mL Solution Topical 0.05 g/100mL Gel Topical 1.3 g/91g Liquid Topical 2.1 g/100mL Solution Topical .5 g/100mL Lotion Topical 0.064 % w/v Ointment Topical 0.05 % w/w Lotion Topical 1 % Ointment Shampoo Topical 0.24 mg/355mL Spray Topical 2 mg/355mL Ointment Topical 2.8 g/140g Gel Topical 1.8 % Liquid Topical 0.5 mL/100mL Gel Topical 1.27 g/127g Gel Topical 2.5 g/127g Liquid Topical 4.3 g/200mL Liquid Topical 4.56 g/236mL Suspension Topical 0.5 g/100mL Gel Topical 2 g/200mL Gel Topical 1.3 g/127g Liquid Topical 2.8 g/141g Liquid Topical 2.54 g/127g Solution Topical 1.8 g/100mL Shampoo Topical 0.6 g/300mL Spray Topical 0.24 g/120mL Kit; liquid; shampoo Topical Shampoo Topical 0.4 g/200mL Gel Topical 19.4 mg/1g Rinse Topical 0.2 mg/100mg Lotion Topical 0.587 g/118mL Lotion Topical 1500 mg/29000mg Liquid Topical 15 mg/1mL Lotion Topical 2 g/120mL Cloth Topical 0.8 mg/80g Lotion Topical 1.5 g/15mL Lotion Topical 0.6 g/200mL Lotion Topical 0.6 g/100mL Lotion Topical 2 g/40mL Cloth Topical 10 mg/1 Strip Topical 0.03 mg/1 Lotion Topical 0.75 g/100mL Spray Topical 1.95 g/100mL Spray Topical 1.8 g/100mL Spray Topical 20 mg/1g Gel Topical 25 mg/1mL Gel Topical 1.25 g/250mL Liquid Topical 10 mg/1mL Powder Topical Gel Topical 0.4 g/20g Patch Transdermal 0.5 1/1 Solution Topical 20 g Solution Oral; Topical 12.6 g Ointment Topical 5 g/1g Patch Topical 0.19 mg/1 Patch Topical 11.9 mg/21 Shampoo Topical 0.3 g/100mL Liquid Topical 0.2 g/100mL Cream Topical 7.0753 g/237mL Plaster Topical 40 % Ointment Topical 10 mg/1g Liquid Transdermal Lotion Topical 2 % w/v Cream Topical 20.6 mg/1mL Liquid Oral 500 mg/5mL Powder Topical 1 g/100g Cream Topical 0.156 g/8.9mL Cream Topical 0.28 g/14g Liquid Topical 0.623 g/130mL Liquid Topical 0.691 g/133mL Paste Topical 5 mg/1g Kit; liquid; lotion Topical Liquid Topical 0.07 g/30mL Kit; liquid Topical 0.5 g/100mL Liquid Topical 2 mg/100mg Swab Topical 2 g/100mL Spray Topical 2 g/118mL Liquid Topical 14.4 mg/1mL Lotion Topical 28.8 mg/1mL Liquid Topical 28.8 mg/1mL Gel Topical 2 g/151mL Gel Topical 30 mg/1mL Lotion Topical Cream Topical 50 mg/1mL Liquid Topical 50 mg/1mL Gel Topical 1.0 g/100g Lotion Topical 0.5 g/100mL Gel Topical 0.3 g/15mL Cream Topical 0.6 g/60mL Liquid Topical 2.4 g/240mL Cloth Topical 283.5 mg/56.7g Lotion Topical 0.0053 g/100mL Lotion Topical 0.0091 g/100mL Cloth Topical 0.5 mg/90mL Gel Topical 0.5 mg/118mL Lotion Topical 2 mg/15mL Lotion Topical 0.5 mg/50mL Kit; oil Topical 0.3 g/50mL Liquid Topical 2.00 % Gel Topical 1 g/100mL Gel Topical 2 % Gel; kit; liquid Topical Solution Topical 2 g/100g Salve Topical 20 mg/1mL Liquid Topical 3.57 mg/1mL Cloth Topical 10 mg/1mL Aerosol, foam Topical 20 mg/1mL Gel Topical 2 g/100g Lotion Topical 0.01 g/1g Lotion Topical .01 g/1g Cream Topical .02 g/1g Lotion Topical 7 mg/1mL Cloth; cream; kit; lotion Topical Solution Topical 0.03 g/1 Solution Topical 0.01 g/1 Solution Topical 0.015 g/1 Lotion Topical 1 g/100mL Solution Topical 1 g/100mL Liquid Topical 2 % Solution Topical 1.25 g Kit; lotion Topical Cloth Topical 0.02 g/1 Cloth; kit; lotion Topical Cloth Topical 0.03 g/1 Lotion Topical 1.9 g/100mL Cream Topical 1.9 g/100mL Solution Topical 0.02 g/1 Solution Topical 2 g/100mL Lotion Topical 2 g/100mL Gel Topical 10 g/0.2g Cream Topical 50 g/0.5g Gel Topical 0.5 g/100g Liquid Topical 0.5 mg/100mL Gel Topical 18.4 mg/1mL Cream Topical 10 mg/1g Lotion Topical 0.5 g/59g Liquid Topical 5 mL/250mL Paste Topical 5 mg/1mL Lotion Topical 0.6 mL/30mL Liquid Topical 10 mg/1g Gel Topical 0.3 mL/15mL Cream Topical 1.5 mL/75mL Gel Topical 0.022 mL/1.1mL Cream Topical 1 mL/50mL Gel Topical 0.375 mL/75mL Gel Topical 5 mg/1mL Gel Topical 0.30 mL/15mL Liquid Topical 20 mg/1mL Kit Topical Stick Topical 2 g/2mL Spray Topical 2 % Liquid Topical 1 % Cream Topical 1 % Gel Topical 1 % Powder Topical 0.5 g/100g Liquid Topical 2.5 mg/500mL Ointment Topical 2 % w/w Liquid Topical 1.5 g/100mL Solution Topical 100 mg Gel Topical 0.17 g/7g Gel Topical 170 mg/1g Gel Topical 17 % Liquid Topical 20 % Liquid Topical 0.17 g/9g Liquid Topical 30 % Gel; kit Topical 170 mg/1g Cream Topical 2 1/100g Emulsion Topical 0.24 mg/29.6mg Emulsion Topical 1.89 mg/237mg Powder, for solution Oral Plaster Topical 40 mg/1 Ointment Topical 15 % Plaster Topical 50 %w/w Cream Topical 1 g/100g Gel Topical 0.3 mg/30mL Stick Topical 0.025 g/2.5g Gel Topical 0.1425 g/30mL Gel; kit Topical 10 mg/1mL Cream Topical 1 mg/100mL Liquid Topical 2 mg/30mg Cream Topical 1.5 g/50mL Lotion Topical 1.5 mg/100mg Stick Topical 2 mg/100mg Patch Topical 40 mg/1 Gel Topical 20 mg/1mL Soap Topical 20 mg/1mL Liquid Topical 5 mg/1mL Stick Topical 40 g/100g Soap Topical 20 mg/1g Shampoo Topical 30 mg/1mL Liquid Topical 3 g/100mL Liquid Topical 20.5 mg/1mL Kit; liquid; spray Topical Shampoo Topical 0.018 g/1mL Swab Topical 0.02 mL/1 Cream Topical 5.05 mg/1mL Solution Topical 2.4 mL/120mL Cream Topical 1 mg/1mg Lotion Topical 0.015 g/1g Liquid Topical 17.64 mg/1mL Liquid Topical 2 g/1mL Paste Topical 20 mg/1g Shampoo Topical 0.03 g/1mL Lotion Topical .5 % Gel Topical 18 mg/1g Lotion Topical 2 mg/1mL Gel Topical 2 mg/1g Liquid Topical 20 mg/1g Soap Topical Gel Topical 3 % Gel Topical 3.54 mL/118mL Liquid Topical 1.15 mg/230mL Liquid Topical 1.8 mg/180mL Cream Topical 0.5 mg/50mL Lotion Topical 0.5 g/1 Lotion Topical 2 g/1 Liquid Topical 0.5 g/100g Liquid Topical 50.5 mg/2.5mL Lotion Topical 30 mg/1.5mL Shampoo Topical 3.0 % Shampoo Topical 0.035 g/1g Soap Topical 4.8 g/240g Solution Topical 20 mg/1mL Aerosol, spray Topical 2 g/100g Solution Cutaneous Liquid Topical 0.25 g/100mL Liquid Topical 25 g/100mL Shampoo Topical 1.25 g/500mL Tablet Oral 325 mg Tablet Oral 325 mg / tab Tablet Oral 500 mg / tab Solution / drops Buccal Ointment Topical 20 mg/1mL Cream; kit Topical Cream Topical 0.75 g/150mL Gel Topical 1 g/50mL Cream Topical 0.01 g/15mL Spray Topical 0.14 g/140mL Gel Topical 0.1 g/100mL Liquid Topical 0.3 g/10mL Shampoo Topical 0.25 mg/100mL Liquid Topical 0.17 g/70mL Liquid Topical 12.64 % Solution Topical 150 mg/1mL Disc Topical 4 mg/1 Solution Topical 1.7 mg/1mL Disc Topical 0.4 g/1 Disc Topical 4.00 mg/1 Liquid Topical 0.48 mL/100mL Liquid Topical 0.48 g/100mL Liquid Cutaneous 0.5 mg/100mg Cream Cutaneous 0.5 mg/100mg Liquid Topical 1 mg/100mL Cream Topical 0.00001 g/100mL Solution Topical 16.7 % Tincture Topical Gel Topical 11 % Liquid Topical 150.28 mg/1mL Gel Topical 27 g Solution Topical 260 mg/1mL Patch Topical 3.0 mg/30mL Patch Topical 0.002 1/1 Lotion Topical 6 %w/w Cream Topical 2.0 g/100mL Powder Topical 1.0 g/100g Paste Topical 2.0 g/100g Liquid Topical 1.0 g/100g Paste Topical 1.0 g/100g Ointment Topical 1 mg/g Stick Topical 2 g/100mL Cream Topical 0.5 g/100g Lotion Topical 1.0 mg/1g Cream Topical 2.8 g/141g Ointment Cutaneous Gel Topical 0.006 g/1g Gel Topical 20 g/1000mL Liquid, extended release Topical 2 mg/100mL Paste Topical 20 mg/1mL Swab Topical 20 mg/1 Shampoo Topical 20 mg/1mL Soap Topical 2000 mg/100mL Liquid Topical 170 mL/1mL Liquid Topical 40 mg/1 Cream Topical 1 g/100mL Gel Topical 50 mg/1mL Tablet, film coated Oral Gel Topical 0.5 g/100mL Liquid Topical 17 g/100mL Patch Topical 0.012 mg/3mg Cloth Topical 2 g/100mL Disc Topical 2 g/100mL Gel Topical Soap Topical 2 % Cream Topical 2 % Liquid Topical 2.16 mg/120mL Liquid Topical 158.4 mg/1mL Solution Topical 13.4 g Cream, augmented Topical 5 mg/1mL Lotion Topical 7.2 % w/v Lotion Topical 5 mg/100mL Shampoo Topical 2 mg/100mL Oil Topical 10 mg/1mL Kit; liquid Topical 20 mg/1mL Liquid Topical 2 g/100g Solution Topical 30 mg/1mL Solution Topical 15 mg/1mL Spray Topical 20 mg/1mL Solution Topical 4.8 g/240mL Aerosol, foam Topical .5 mL/100mL Lotion Topical 10 mg/1 Liquid Topical 4 mL/200mL Gel Topical 2000 mg/1g Gel; kit Topical Gel Topical 21.2 mg/100mL Lotion Topical 3 g/100g Suspension Topical 0.56 g/29mL Liquid Topical 3 g/100g Aerosol, foam Topical 0.7 mg/1mL Cream Topical 1. g/100g Lotion / shampoo Topical 20 mg/1mL Rinse Topical 17.575 mg/1mL Rinse Topical 18.13 mg/1mL Gel Topical 2.0 % Solution Topical 1.0 mg/200mL Soap Topical 0.4 g/100g Liquid Topical 3 mg/118mL Lotion / shampoo Topical 18.5 mg/1mL Solution Patch Topical; Transdermal 0.0401 g Shampoo Topical 0.1 1/300mL Liquid Topical 0.02 kg/1kg Oil Topical 1 mg/100mL Liquid Topical 1.6 g/320mL Liquid Topical 3 % Cream Cutaneous 2 mg/100mL Gel Topical Kit; liquid Topical 10 mg/1mL Lotion Topical 1.184 mL/59.2mL Gel Topical 17 g/100g Gel Topical 0.55 g/100mL Kit; liquid; oil; patch Topical Liquid Topical 0.003 g/1mL Liquid Topical 0.0001 g/1mL Lotion Topical 2.15 g/110mL Liquid Topical 1.2 g/120mL Soap Topical 1.35 g/135g Gel Topical 20 g/1000g Cream Topical 3 % Liquid Topical 1.5 g/100g Gel Topical 2 mg/2mL Cream Topical 0.5 mg/0.5mL Liquid Topical 20 g/1L Gel Topical 0.02 mL/1mL Lotion Topical 0.02 mL/1mL Shampoo Topical Shampoo Topical 0.5 g/100mL Cream Topical 0.5 % Jelly Topical .5 % Cream Topical .5 % Cream Topical 0.0015 g/15g Shampoo Topical 28 mg/1g Rinse Topical 15 mg/1mL Cream Topical 100 mg/1g Gel Topical 6 g/100g Gel; kit; shampoo Topical Shampoo Topical 5 g/100mL Shampoo Topical 6 g/92.6mL Gel Topical 3 g/100g Gel Topical 5 g/100g Gel Topical 6 % Shampoo Topical 10 mg/1mL Shampoo Topical 19 mg/1mL Lotion Topical 15 mg/1mL Lotion Topical 12 mg/1mL Cream Topical 0.15105 g/15mL Patch Topical 0.0125 mg/0.6216mg Liquid Topical 5.88 mg/1mL Cream Topical 0.025 mg/5mL Cream Topical 2.0 mCi/100mL Solution Topical 5 mg/1mL Patch Topical 5 g/100g Liquid Topical 0.5 g/100mL Paste Topical Liquid Topical 0.6 g/100mL Ointment Topical 53.3 g Solution Topical Gel Cutaneous Patch Topical 2 g/1 Patch Topical 0.005 g/1 Patch Topical 5 g/1 Cream; suspension Topical 0.5 % Gel Topical 10 mg/1mL Shampoo Topical 1 g/100mL Spray Topical 4.72 mL/118mL Cloth Topical .6 mL/60mL Gel Topical .75 mL/50mL Gel Topical 0.425 mL/25mL Paste Topical 0.75 mL/150mL Stick Topical 36 mg/1.8g Shampoo Topical 0.1 mg/100mL Liquid Topical 0.25 mg/100mL Ointment Topical 53.33 g Liquid Topical .75 % Shampoo Topical 29 mg/1mL Aerosol, foam Topical 5 mg/1g Plaster Topical 0.4 g/1g Plaster Topical 0.40 g/1g Liquid Topical 17 mg/100mg Swab Topical .02 mL/1 Gel Topical 19.8 mg/1g Disc Topical 40 % Soap Topical 2 g/100mL Patch Topical 0.4 g/181 Shampoo Topical 1.8 g/100mL Plaster Topical 40 g/100g Patch Topical 0.056 mg/1 Plaster Topical 2.068 mg/1 Plaster Topical 3.175 mg/1 Plaster Topical 5.51 mg/1 Shampoo Topical 2 g / 100 g Liquid Topical 7 mg/100mL Solution Topical 14.8 g Shampoo Topical 0.03 g/1g Patch Topical 0.5 mg/100mg Lotion Topical Patch Topical 5 mg/1g Cream Topical 2.016 g/112g Liquid Topical 0.5 mg/100mg Lotion Topical 30 mg/1mL Solution Topical 0.15 mg/30mL Cloth Topical 1 g/100g Shampoo Topical 0.2 1/300g Liquid Topical 10 mg/100mL Liquid Topical 150 mg/1mL Plaster Topical 4 mg/1 Ointment Topical 40 % Lotion Topical 0.501 g/100mL Liquid Topical 0.3 g/120mL Solution Topical 0.10 g/25mL Lotion Topical 1.5 g/100mL Liquid Topical 0.06 g/1mL Shampoo Topical 0.06 g/1mL Emulsion Topical 1 g/100g Liquid Topical 0.75 g/100g Liquid Topical 1 g/1001 Cream Topical 30 mL/100mL Lotion Topical 10 mg/1mL Liquid Topical 1.0 mL/100mL Lotion Topical 0.5 mg/1mL Shampoo Topical 0.01 g/100mL Cream Topical 20 mg/1g Gel Topical 0.7 g/100mL Gel Topical 0.02 g/1g Swab Topical 0.5 g/100mL Swab Topical 2 mL/100mL Gel Topical 1.0 mg/1g Aerosol, foam Topical 20 mg/1g Strip Topical 20 mg/1 Cream; kit; lotion Topical Liquid Topical 1.8 % Cloth Topical 20 mg/1 Lotion Topical 5 mg/1mL Suspension Topical 20 mg/1mL Gel Topical 20 mg/1g Shampoo Topical 25 mg/1mL Lotion Topical 2.0 % Cream Topical 5.5 mg/1g Liquid Topical 5 mg/1g Gel Topical 1.5 % Cream Topical 1.0 % Powder Topical 5 mg/1g Spray Topical 5 mg/1mL Cream Topical 20 mg/1mL Ointment Topical 2 g/100g Gel Topical 1 mL/100mL Gel Topical 3 mg/15mL Liquid Topical 1 g/50g Gel Topical 0.1 g/20mL Soap Topical 0.01 g/1g Cloth Topical 0.02 g/1g Cloth Topical .05 mg/100mg Lotion Topical 5 g/1000mL Gel Topical 5 g/1000mL Gel Topical 5.5 g/1000mL Solution, gel forming / drops Topical 20 mg/1mL Cream Topical Shampoo Topical 9 mg/500g Liquid Topical 170 mg / g Cloth Topical 20.5 mg/1mL Liquid Topical 2.5 g/125g Lotion Topical 20.6 mg/1mL Lotion Topical 20 mg/1mL Liquid Topical 18 mg/1mL Gel Topical 3 g/150g Gel Topical 4 mg/177mg Cream Topical .5 mL/50mL Gel Topical 1.15 mL/115mL Gel Topical .06 mL/15mL Liquid Topical 19.6 mg/1mL Solution / drops Ophthalmic Patch Topical 0.4 g/1g Soap Topical 0.27 g/55g Soap Topical 0.50 g/100g Soap Topical 0.40 g/80g Solution Topical 10 mg/1mL Swab Topical 5 mg/1 Solution Topical 5 mg/1g Lotion Topical 5 mg/1g Suspension Topical 0.5 % Lotion Topical 2 % Swab Topical 2 % Swab Topical .5 % Patch Topical 5 mg/1 Spray Topical 2 g/100mg Cream Topical 30 mg/1g Plaster Topical 0.4 g/1 Paste Topical 0.57 g Kit Topical 5 mg/1g Kit; patch Topical 5 mg/1g Kit; lotion; solution Topical Spray Topical 20.6 mg/1mL Patch Topical 0.359 mg/1 Patch Topical 0.5 mg/1 Patch Topical 0.1575 mg/1 Patch Topical 4 mg/1 Plaster Topical 17.67 mg/44.18mg Strip Topical 4.42 mg/1 Plaster Topical 11.04 mg/1 Patch Topical Cream Topical 1 mg/20mg Rinse Topical 2 g/100g Lotion Topical 2.0 g/100mL Solution Topical 2.0 g/100mL Liquid Topical 0.025 g/1 Liquid Topical 2.0 mL/100mL Cream Topical 15 mg/1mL Concentrate Topical 2 g/100mL Gel Topical 2.0 g/100mL Liquid Topical 0.05 g/100mL Solution Topical 0.013 mg/2.5mL Liquid Topical .7 % Cream Topical 0.02 g/1mL Cream Topical 100 mg / g Solution Oral Patch Topical 40 mg/100mg Liquid Dental Solution Topical Ointment Cutaneous 0.40 g Gel Topical 0.008776 g/1mL Ointment Topical 5 % w/w Lotion Topical 1.8 mg/180mg Soap Topical 2 mg/100g Spray Topical 2 mg/100mL Lotion Topical 0.5 mg/100mL Lotion / shampoo Topical 2 g/100mL Cream Topical 0.02 g/1000mL Lotion Topical 2 mg/100mL Gel Topical 5 mg/1000mL Solution Topical 5 mg/1000mL Cream Topical 1.5 g/100g Liquid Topical 2 mg/100mL Cream Topical 0.01 g/1g Gel Topical 0.2 g/100mL Lotion / shampoo Topical 0.02 g/1000mL Gel Topical 0.5 mg/100mL Liquid Topical 0.5 % Lotion Topical 0.5 % Swab Topical 0.5 % Liquid Topical 0.02 g/45mL Gel Topical 1.77 g/59mL Gel; kit Topical 1.77 g/59mL Lotion / shampoo Topical 1.33 g/74mL Cream Topical 2.26 g/113g Cream Topical 1.1 g/56.7g Soap Topical 3 g/100g Shampoo Topical 3 g/100g Cream Topical 2.5 g/100g Cream Topical 3 g/100g Gel Topical 3 g/100mL Cream Topical 3 g/100mL Liquid Topical 1.8 g/100mL Emulsion Topical 2 g/100mL Gel Topical 0.0001 g/120g Gel Topical 0.012 g/120g Patch Topical 0.6 g/100mm Cream Topical 0.5 ug/1mL Solution Buccal Solution Intragingival; Oropharyngeal Liquid Topical 0.003 g/ml Solution Buccal; Oral Cream Topical 17 g/100g Liquid Topical 2 mg/1mL Emulsion Topical 15 mg/1mL Liquid Topical 1.5 g/1 Cream Topical 59 mg/1g Shampoo Topical 2 g/100mL Swab Topical 20 mg/1mL Spray Topical 4.8 mL/240mL Soap Topical 0.6 g/100g Cream Topical 2 mL/100mL Patch Topical 0.04 g/40mL Cream Topical 3 g/150mL Swab Topical 0.005 mg/1mL Swab Topical 0.02 mg/1mL Oil Topical 2 mg/100mL Liquid Topical 1 mL/100mL Stick Topical 1 % Soap Topical 0.3 g/100g Swab Topical 21 mg/1 Lotion Topical 0.18 g/30g Lotion Topical 0.95 % Shampoo Topical 0.25 g/100mL Ointment Topical 40 g Gel Cutaneous 0.020 g Soap Topical 1.2 g/1.2g Cream Topical 0.5 g/0.5g Gel Topical 0.72 g/0.72g Plaster Topical 14.13 mg/1 Cream Topical 24 g/400g Lotion Topical 24.84 mg/414mL Lotion Topical 60 mg/1mL Gel Topical 1.2 g/60g Gel Topical 10 mg/100mL Lotion Topical 1 g/1g Cream Topical 1 g/0.25mL Cream Topical 6 g/100g Gel Topical 0.17 g/1g Gel Topical 0.21 g/1.25g Gel Topical 60 mg/1g Kit Topical 60 mg/1mL Kit Topical 60 mg/1g Liquid Topical 0.17 mg/15mL Liquid Topical 0.17 mg/9.8g Liquid Topical 0.17 mg/9mL Liquid Topical 0.17 g/9.8mL Liquid Topical 0.17 mg/151mL Liquid Topical 0.17 mg/9.8mL Liquid Topical 0.17 g/9mL Liquid Topical 2.1 g/14.7mL Liquid Topical 260 mg/1mL Liquid Topical 275 mg/1mL Lotion Topical 0.5 g/60mL Lotion Topical 2.1 g/100g Lotion Topical 6 g/100mL Lotion Topical 6 mg/100mL Lotion Topical 60 mg/1g Ointment Topical 30 mg/1g Patch Topical 40 mg/61 Patch Topical 40 mg/141 Patch Topical 40 mg/81 Patch Topical 40 mg/121 Patch Topical 40 mg/181 Patch Topical 40 mg/91 Patch Topical 40 mg/241 Patch Topical 40 mg/41 Patch Topical 400 mg/1g Plaster Topical 0.4 g/141 Plaster Topical 0.4 g/1411 Plaster Topical 0.4 g/181 Plaster Topical 40 mg/141 Powder Not applicable 1 g/1g Shampoo Topical 2 g/100g Shampoo Topical 6 mg/100mL Shampoo Topical 60 mg/1g Solution Topical 275 mg/1mL Solution Topical 285 mg/1mL Cream Topical 2 % w/w Suspension Topical Swab Topical 0.5 mg/100mg Strip Topical 40 mg/1 Tablet Topical 2 g/1001 Soap Topical 3.5 % Gel Topical .01 mg/1g Liquid Intravenous 570 mg / mL Ointment Topical Gel Topical 15 mg/1mL Lotion Topical 1.66 g/1.66g Gel Topical 2 g/2g Cream Topical 60 mg/1g Lotion Topical 0.06 g/1mL Aerosol, foam Topical 6 g/100g Lotion Topical 20 mg Aerosol, foam Topical 3.88 g/70g Patch Topical 40 g/1001 Liquid Topical 3.4 g/20mL Soap Topical 0.54 g/100mL Gel Topical 0.54 g/100.00mL Gel Topical 2.18 g/100.00mL Solution Topical 8.85 % w/v Liquid Topical 12 g/100mL Ointment Topical 6 % w/w Shampoo Topical 3.0 g/100mL Liquid Topical 30 mg/1g Liquid Topical 0.01 mg/1mg Solution Topical 2.8 % w/w Liquid Topical 17 % Liquid Topical 1.7 mg/1mL Disc Topical 0.4 g/1g Liquid Oral Liquid Topical 1 g/100mL Liquid Topical 1.22 g/490mL Gel Topical 0.4 g/200g Gel Topical 8 g/100g Paste Topical 1 g/100g Gel Topical 1 g/100g Shampoo Topical 0.2 mg/100mL Liquid; shampoo Topical Shampoo Topical 0.02 g/1mL Lotion Topical 6.3 % w/v Gel Topical 154 mg/30mL Cream Topical 1.8 % Liquid Topical Patch Topical 32 mg/1 Patch Topical 25.6 mg/1001 Liquid Topical 1.5 mg/100mL Rinse Topical 0.50 mL/100mL Liquid Topical 20 g/2mL Liquid Topical 5 g/2mL Cream Topical 1.8 g/100g Cream Topical 1.8 mg/1g Cream; kit; liquid Topical Kit; liquid Topical 2 g/100mL Liquid Topical 4 g/100g Liquid Topical 0.2 g/1g Ointment Topical 1.8 g/50g Gel Topical .5 g/100g Cloth Topical 2 g/100g Liquid Topical 20 mg/1 Spray Topical 9.72 mg/1mL Solution Topical 17 % Shampoo Topical 18 mg/1L Liquid Topical 0.005 g/100mL Liquid Topical 0.01 g/100mL Gel Topical 0.001 g/100mL Solution Topical 170 mg/1g Liquid Topical 2 g/29mL Gel Topical 1 g/59mL Swab Topical 3 g/100g Cream Topical 2.0 % Patch Topical 1.24 g/1 Liquid Topical 0.009506 g/100mL Cream Topical 0.065 mg/13mL Solution Topical 10 % Gel Topical 10 % Emulsion Topical 0.02 g/1g Emulsion Topical 0.01 g/1g Lotion Topical 0.02 g/1g Emulsion Topical 0.01 g/1mL Emulsion Topical 0.02 mL/1mL Emulsion Topical 0.02 g/1mL Emulsion Topical 0.01 mL/1mL Liquid Topical 2.2 % Soap Topical 0.01 mL/1mL Soap Topical 0.02 mL/1mL Soap Topical 0.02 g/1g Gel Cutaneous; Topical 0.572 mg/50000mg Gel Topical 2 g/100mL Liquid Topical 0.1 g/1 Soap Cutaneous Ointment Topical 20 mg/1g Oil Topical 15 mg/1mL Lotion Topical 0.95 % w/v Cream Topical Shampoo Topical 2 % Suspension Topical 2 % Shampoo Topical 3 % Gel Topical 1.5 g/100mL Solution Topical 170 mg/1mL Ointment Topical 3 g/100g Stick Topical 12.0 g/100g Stick Topical 15.0 g/100g Lotion Topical 1.0 g/100g Lotion Topical 0.02 g/1 Liquid Cutaneous 10 mg/1mL Gel Cutaneous 5 mg/1mL Ointment Topical 0.14 g/28g Cream Topical 1 g/50g Spray Topical Shampoo Topical 18 mg/1mL Cream Topical 16 mg/1g Shampoo Topical 9 g/500g Ointment Topical 5 % w/w Liquid Topical 0.2 g/100g Liquid Topical .0024 mg/.120mg Tablet Oral Plaster Topical 15 % Patch Transdermal Ointment Extracorporeal 17 mg/100mL Shampoo Topical 3 g/100mL Soap Topical 1 g/100g Swab Topical 0.02 g/1 Liquid Topical 0.1 mg/1mL Patch Topical 40 mg/100g Solution Topical 50 mg/1mL Cream Topical 2 g/100mL Cream Topical 11.4 g/100mL Cream Topical 0.005 g/1mL Cream Topical 170 mg/1mL Emulsion Topical 20 mg/1g Tape Topical 4 mg/1 Solution Topical 8 g/100g Patch Topical 0.4 g/100g Liquid Topical 170 mg/1mL Liquid Topical 17 mL/10mL Syrup Cutaneous Liquid Topical 2 mL/100mL Disc Topical 17.67 mg/44.18mg Liquid Topical 0.15 g/100mL Spray Topical 15 mg/1mL Lotion Topical 20 mg/1g Emulsion Topical 1.2 g/120mL Lotion / shampoo Topical 30 mg/1mL Liquid Topical 30 mg/1mL Liquid Cutaneous Liquid Topical 1.7 mg/10mL Liquid Topical 12 mg/100mL Plaster Topical 40 mL/1 Liquid Topical 0.17 g/1g Solution Topical 10 g/100mL Liquid Topical 2.51 mL/14.78mL Stick Topical .4 g/1g Liquid Topical 0.02 g/1g Gel Topical 4 g/200g Swab Topical 0.5 g/100g Swab Topical 1 g/100g Swab Topical 2 g/100g Soap Topical 0.001 g/0.1g Soap Topical 1 mg/100g Solution Topical 280 mg/1g Ointment Cutaneous Shampoo Topical 10 g/325g Gel Topical 5 mg/237mg Gel Topical 0.75 mg/150mL Plaster Topical 40 g/1 Plaster Topical; Transdermal 40 g/1 Plaster Topical Plaster Topical 156 mg/1 Soap Topical 0.5 g/110g Liquid Topical 5.3 g/265mL Gel Topical 1.0 g/100mL Cloth Topical 5 mg/1mL Suspension Topical 10 mg/1g Stick Topical 1 g/100g Gel Topical 1.0 mg/100mL Strip Topical 5 mg/1mL Cream Topical 10 mg/1mL Cream Topical 5 mg/1mL Solution Topical 2.0 mg/100mL Cream Topical 0.47 g/100mL Cream Topical 0.47 mL/100mL Liquid Topical 0.47 mL/100mL Liquid Topical 0.47 g/100mL Gel Topical 0.47 g/100mL Gel Topical 0.47 mL/100mL Cloth Cutaneous 20 mg/1300mg Gel Topical 0.06 g/25mL Liquid Topical 0.4 g/100mL Kit Topical 20 mg/1mL Stick Topical 20 mg/1g Patch Topical 20 mg/1mL Kit; patch Topical 20 mg/1mL Emulsion Topical Liquid Ophthalmic Gel - Prices
Unit description Cost Unit Keralyt scalp complete kit 67.8USD kit Keralyt 6% Gel 100 gm Tube 51.99USD tube Keralyt 6% Gel 40 gm Tube 49.99USD tube Compound W 17% Liquid 9.3ml Bottle 11.99USD bottle Keralyt 3% Gel 28.4 gm Tube 11.35USD tube Sastid soap 4.32USD each Salicylic acid 6% gel 1.14USD g Salactic film solution 0.74USD ml Compound w pads 0.5USD each Keralyt 6% gel 0.5USD g Freezone corn-callus liquid 0.42USD ml Keralyt 3% gel 0.39USD g Salicylic acid 6% shampoo 0.21USD ml Ionil plus 2% shampoo 0.05USD ml Ionil t plus shampoo 0.05USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 158 °C PhysProp boiling point (°C) 211 °C at 2.00E+01 mm Hg PhysProp water solubility 2240 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) logP 2.26 HANSCH,C ET AL. (1995) logS -1.82 ADME Research, USCD Caco2 permeability -4.79 ADME Research, USCD pKa 2.97 SERJEANT,EP & DEMPSEY,B (1979) - Predicted Properties
Property Value Source Water Solubility 11.3 mg/mL ALOGPS logP 1.96 ALOGPS logP 1.98 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 2.79 Chemaxon pKa (Strongest Basic) -6.3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 57.53 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 35.3 m3·mol-1 Chemaxon Polarizability 12.81 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9756 Blood Brain Barrier + 0.6165 Caco-2 permeable + 0.8867 P-glycoprotein substrate Non-substrate 0.734 P-glycoprotein inhibitor I Non-inhibitor 0.9815 P-glycoprotein inhibitor II Non-inhibitor 0.9937 Renal organic cation transporter Non-inhibitor 0.9167 CYP450 2C9 substrate Non-substrate 0.7962 CYP450 2D6 substrate Non-substrate 0.9233 CYP450 3A4 substrate Non-substrate 0.766 CYP450 1A2 substrate Non-inhibitor 0.9517 CYP450 2C9 inhibitor Non-inhibitor 0.7984 CYP450 2D6 inhibitor Non-inhibitor 0.9659 CYP450 2C19 inhibitor Non-inhibitor 0.7644 CYP450 3A4 inhibitor Non-inhibitor 0.8675 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8525 Ames test Non AMES toxic 0.9829 Carcinogenicity Non-carcinogens 0.8627 Biodegradation Ready biodegradable 0.8086 Rat acute toxicity 2.2160 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9631 hERG inhibition (predictor II) Non-inhibitor 0.9734
Spectra
- Mass Spec (NIST)
- Download (8.17 KB)
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 125.5302905 predictedDarkChem Lite v0.1.0 [M-H]- 125.5713905 predictedDarkChem Lite v0.1.0 [M-H]- 125.7111905 predictedDarkChem Lite v0.1.0 [M-H]- 125.8811905 predictedDarkChem Lite v0.1.0 [M-H]- 126.26153 predictedDeepCCS 1.0 (2019) [M-H]- 125.5302905 predictedDarkChem Lite v0.1.0 [M-H]- 125.5713905 predictedDarkChem Lite v0.1.0 [M-H]- 125.7111905 predictedDarkChem Lite v0.1.0 [M-H]- 125.8811905 predictedDarkChem Lite v0.1.0 [M-H]- 126.26153 predictedDeepCCS 1.0 (2019) [M+H]+ 126.9397905 predictedDarkChem Lite v0.1.0 [M+H]+ 125.8362905 predictedDarkChem Lite v0.1.0 [M+H]+ 127.0415905 predictedDarkChem Lite v0.1.0 [M+H]+ 126.4772905 predictedDarkChem Lite v0.1.0 [M+H]+ 128.6421 predictedDeepCCS 1.0 (2019) [M+H]+ 126.9397905 predictedDarkChem Lite v0.1.0 [M+H]+ 125.8362905 predictedDarkChem Lite v0.1.0 [M+H]+ 127.0415905 predictedDarkChem Lite v0.1.0 [M+H]+ 126.4772905 predictedDarkChem Lite v0.1.0 [M+H]+ 128.6421 predictedDeepCCS 1.0 (2019) [M+Na]+ 125.7379905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.9270905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.8893905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.9433905 predictedDarkChem Lite v0.1.0 [M+Na]+ 137.04338 predictedDeepCCS 1.0 (2019) [M+Na]+ 125.7379905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.9270905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.8893905 predictedDarkChem Lite v0.1.0 [M+Na]+ 125.9433905 predictedDarkChem Lite v0.1.0 [M+Na]+ 137.04338 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Prostaglandin-endoperoxide synthase activity
- Specific Function
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gas...
- Gene Name
- PTGS1
- Uniprot ID
- P23219
- Uniprot Name
- Prostaglandin G/H synthase 1
- Molecular Weight
- 68685.82 Da
References
- Moon C, Ahn M, Jee Y, Heo S, Kim S, Kim H, Sim KB, Koh CS, Shin YG, Shin T: Sodium salicylate-induced amelioration of experimental autoimmune encephalomyelitis in Lewis rats is associated with the suppression of inducible nitric oxide synthase and cyclooxygenases. Neurosci Lett. 2004 Feb 12;356(2):123-6. [Article]
- Graham GG, Scott KF: Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-13. [Article]
- Sun R, Carlson NG, Hemmert AC, Kishore BK: P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Am J Physiol Renal Physiol. 2005 Sep;289(3):F585-92. Epub 2005 Apr 19. [Article]
- Celik G, Pasaoglu G, Bavbek S, Abadoglu O, Dursun B, Mungan D, Misirligil Z: Tolerability of selective cyclooxygenase inhibitor, celecoxib, in patients with analgesic intolerance. J Asthma. 2005 Mar;42(2):127-31. [Article]
- Liu X, Lee TL, Wong PT: Cyclooxygenase-1 inhibition shortens the duration of diazepam-induced loss of righting reflex in mice. Anesth Analg. 2006 Jan;102(1):135-40. [Article]
- Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232-5. [Article]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inhibitor
- General Function
- Prostaglandin-endoperoxide synthase activity
- Specific Function
- Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and...
- Gene Name
- PTGS2
- Uniprot ID
- P35354
- Uniprot Name
- Prostaglandin G/H synthase 2
- Molecular Weight
- 68995.625 Da
References
- Graham GG, Scott KF: Mechanisms of action of paracetamol and related analgesics. Inflammopharmacology. 2003;11(4):401-13. [Article]
- Fiebich BL, Chrubasik S: Effects of an ethanolic salix extract on the release of selected inflammatory mediators in vitro. Phytomedicine. 2004 Feb;11(2-3):135-8. [Article]
- Chae HJ, Chae SW, Reed JC, Kim HR: Salicylate regulates COX-2 expression through ERK and subsequent NF-kappaB activation in osteoblasts. Immunopharmacol Immunotoxicol. 2004 Feb;26(1):75-91. [Article]
- Wu KK: Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3(2):107-12. [Article]
- Elvira C, Gallardo A, Lacroix N, Schacht E, San Roman J: Incorporation of salicylic acid derivatives to hydrophilic copolymer systems with biomedical applications. J Mater Sci Mater Med. 2001 Jun;12(6):535-42. [Article]
- Vane JR: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232-5. [Article]
- Zheng L, Howell SJ, Hatala DA, Huang K, Kern TS: Salicylate-based anti-inflammatory drugs inhibit the early lesion of diabetic retinopathy. Diabetes. 2007 Feb;56(2):337-45. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- Specific Function
- Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the in...
- Gene Name
- AKR1C1
- Uniprot ID
- Q04828
- Uniprot Name
- Aldo-keto reductase family 1 member C1
- Molecular Weight
- 36788.02 Da
References
- Dhagat U, Carbone V, Chung RP, Matsunaga T, Endo S, Hara A, El-Kabbani O: A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase. Med Chem. 2007 Nov;3(6):546-50. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP2C9
- Uniprot ID
- P11712
- Uniprot Name
- Cytochrome P450 2C9
- Molecular Weight
- 55627.365 Da
References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Bojic M, Sedgeman CA, Nagy LD, Guengerich FP: Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56. doi: 10.1016/j.ejps.2015.03.015. Epub 2015 Mar 31. [Article]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Other/unknown
- General Function
- Toxic substance binding
- Specific Function
- Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
- Gene Name
- ALB
- Uniprot ID
- P02768
- Uniprot Name
- Serum albumin
- Molecular Weight
- 69365.94 Da
References
- Bertucci C, Wainer IW: Improved chromatographic performance of a modified human albumin based stationary phase. Chirality. 1997;9(4):335-40. [Article]
- Xiao HR, Sheng LQ, Shi CH, Xu XL, Xie YS, Liu QL: [Fluorescence study on the interaction of salicylic acid and bovine serum albumin]. Guang Pu Xue Yu Guang Pu Fen Xi. 2004 Jan;24(1):78-81. [Article]
- Yin T, Wei W, Yang L, Liu K, Gao X: Kinetics parameter estimation for the binding process of salicylic acid to human serum albumin (HSA) with capacitive sensing technique. J Biochem Biophys Methods. 2007 Jun 10;70(4):587-93. Epub 2007 Jan 27. [Article]
- Yu T, Tao Z: [Fluorescence study on the interaction of salicylic acid and human serum albumin]. Guang Pu Xue Yu Guang Pu Fen Xi. 1999 Jun;19(3):453-5. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one ...
- Gene Name
- SLC22A6
- Uniprot ID
- Q4U2R8
- Uniprot Name
- Solute carrier family 22 member 6
- Molecular Weight
- 61815.78 Da
References
- Cihlar T, Ho ES: Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Anal Biochem. 2000 Jul 15;283(1):49-55. [Article]
- Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [Article]
- Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [Article]
- Uwai Y, Saito H, Inui K: Interaction between methotrexate and nonsteroidal anti-inflammatory drugs in organic anion transporter. Eur J Pharmacol. 2000 Dec 1;409(1):31-6. [Article]
- Apiwattanakul N, Sekine T, Chairoungdua A, Kanai Y, Nakajima N, Sophasan S, Endou H: Transport properties of nonsteroidal anti-inflammatory drugs by organic anion transporter 1 expressed in Xenopus laevis oocytes. Mol Pharmacol. 1999 May;55(5):847-54. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Not Available
- Gene Name
- SLC22A10
- Uniprot ID
- Q63ZE4
- Uniprot Name
- Solute carrier family 22 member 10
- Molecular Weight
- 60256.57 Da
References
- Youngblood GL, Sweet DH: Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Am J Physiol Renal Physiol. 2004 Aug;287(2):F236-44. Epub 2004 Apr 6. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenad...
- Gene Name
- SLC22A8
- Uniprot ID
- Q8TCC7
- Uniprot Name
- Solute carrier family 22 member 8
- Molecular Weight
- 59855.585 Da
References
- Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [Article]
- Takeda M, Khamdang S, Narikawa S, Kimura H, Hosoyamada M, Cha SH, Sekine T, Endou H: Characterization of methotrexate transport and its drug interactions with human organic anion transporters. J Pharmacol Exp Ther. 2002 Aug;302(2):666-71. [Article]
- Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.
- Gene Name
- SLC22A11
- Uniprot ID
- Q9NSA0
- Uniprot Name
- Solute carrier family 22 member 11
- Molecular Weight
- 59970.945 Da
References
- Cha SH, Sekine T, Kusuhara H, Yu E, Kim JY, Kim DK, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. J Biol Chem. 2000 Feb 11;275(6):4507-12. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.
- Gene Name
- SLCO2B1
- Uniprot ID
- O94956
- Uniprot Name
- Solute carrier organic anion transporter family member 2B1
- Molecular Weight
- 76709.98 Da
References
- Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Symporter activity
- Specific Function
- Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucin...
- Gene Name
- SLC16A1
- Uniprot ID
- P53985
- Uniprot Name
- Monocarboxylate transporter 1
- Molecular Weight
- 53943.685 Da
References
- Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A: Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol. 1999 Oct;51(10):1113-21. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulf...
- Gene Name
- SLC22A7
- Uniprot ID
- Q9Y694
- Uniprot Name
- Solute carrier family 22 member 7
- Molecular Weight
- 60025.025 Da
References
- Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. [Article]
- Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. [Article]
- Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. [Article]
Drug created at June 13, 2005 13:24 / Updated at February 20, 2024 23:55