Fluocinonide
Identification
- Summary
Fluocinonide is a high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
- Brand Names
- Lidemol, Lidex, Lyderm, Tiamol, Vanos
- Generic Name
- Fluocinonide
- DrugBank Accession Number
- DB01047
- Background
A topical glucocorticoid used in the treatment of eczema.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
- Weight
- Average: 494.5249
Monoisotopic: 494.211609788 - Chemical Formula
- C26H32F2O7
- Synonyms
- Fluocinonida
- Fluocinonide
- Fluocinonido
- Fluocinonidum
- External IDs
- NSC-101791
Pharmacology
- Indication
A topical anti-inflammatory product for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Dermatoses •••••••••••• Used in combination to treat Inflammation Combination Product in combination with: Neomycin (DB00994), Nystatin (DB00646), Gramicidin D (DB00027) •••••••••••• Used in combination to treat Pruritus Combination Product in combination with: Neomycin (DB00994), Nystatin (DB00646), Gramicidin D (DB00027) •••••••••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Fluocinonide is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. It mediates its effects to relieve itching, redness, dryness, crusting, scaling, inflammation, and discomfort associated with inflammatory skin conditions.
- Mechanism of action
Fluocinonide is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. Fluocinonide binds to the cytosolic glucocorticoid receptor. After binding the receptor the newly formed receptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing the increase in expression of specific target genes. The anti-inflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Specifically glucocorticoids induce lipocortin-1 (annexin-1) synthesis, which then binds to cell membranes preventing the phospholipase A2 from coming into contact with its substrate arachidonic acid. This leads to diminished eicosanoid production. Cyclooxygenase (both COX-1 and COX-2) expression is also suppressed, potentiating the effect. In another words, the two main products in inflammation Prostaglandins and Leukotrienes are inhibited by the action of Glucocorticoids. Glucocorticoids also stimulate the lipocortin-1 escaping to the extracellular space, where it binds to the leukocyte membrane receptors and inhibits various inflammatory events: epithelial adhesion, emigration, chemotaxis, phagocytosis, respiratory burst and the release of various inflammatory mediators (lysosomal enzymes, cytokines, tissue plasminogen activator, chemokines etc.) from neutrophils, macrophages and mastocytes. Additionally the immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Like other glucocorticoid agents Fluocinolone acetonide acts as a physiological antagonist to insulin by decreasing glycogenesis (formation of glycogen). It also promotes the breakdown of lipids (lipolysis), and proteins, leading to the mobilization of extrahepatic amino acids and ketone bodies. This leads to increased circulating glucose concentrations (in the blood). There is also decreased glycogen formation in the liver.
Target Actions Organism AGlucocorticoid receptor agonistHumans USmoothened homolog agonistHumans - Absorption
The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. In general, percutaneous absorption is minimal.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Side effects may include acne-like eruptions, burning, dryness, excessive hair growth, infection of the skin, irritation, itching, lack of skin colour, prickly heat, skin inflammation, skin loss or softening, stretch marks.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbametapir The serum concentration of Fluocinonide can be increased when it is combined with Abametapir. Abatacept The risk or severity of adverse effects can be increased when Fluocinonide is combined with Abatacept. Abemaciclib The metabolism of Abemaciclib can be increased when combined with Fluocinonide. Acalabrutinib The metabolism of Acalabrutinib can be increased when combined with Fluocinonide. Acarbose The risk or severity of hyperglycemia can be increased when Fluocinonide is combined with Acarbose. - Food Interactions
- No interactions found.
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
- International/Other Brands
- Fluonex / Lonide / Lyderm (Taro) / Metosyn (Bioglan) / Topsymin / Topsyn (Syntex)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Fluocinol Pak Cream; Kit 1 mg/1g Topical PureTek Corporation 2020-07-02 Not applicable US Fluocinonide Solution 0.5 mg/1mL Topical County Line Pharmaceuticals, LLC 2014-02-28 2019-10-01 US Fluocinonide Cream 0.5 mg/1g Topical A S Medication Solutions 1984-06-26 Not applicable US Fluocinonide Ointment 0.5 mg/1g Topical Nucare Pharmaceuticals,inc. 2017-10-02 Not applicable US Fluocinonide Cream 0.5 mg/1g Topical Lake Erie Medical DBA Quality Care Products LLC 1984-06-26 2018-02-08 US - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Fluocinonide Cream 0.5 mg/1g Topical A-S Medication Solutions 1990-09-30 Not applicable US Fluocinonide Ointment 0.5 mg/1g Topical Nucare Pharmaceuticals,inc. 1992-05-01 Not applicable US Fluocinonide Cream 1 mg/1g Topical bryant ranch prepack 2020-04-30 Not applicable US Fluocinonide Ointment 0.5 mg/1g Topical Physicians Total Care, Inc. 1994-11-22 Not applicable US Fluocinonide Ointment 0.5 mg/1g Topical Teva Pharmaceuticals USA, Inc. 1992-05-01 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Flumethovix Fluocinonide (1 mg/1g) + Dimethicone (1.8 g/100g) + Zinc oxide (2 g/100g) Kit Topical Primary Pharmaceuticals, Inc. 2021-02-19 2024-01-31 US Hexicinide Fluocinonide (1 mg/1g) + Chlorhexidine gluconate (4 g/100mL) Kit Topical PureTek Corporation 2014-01-14 Not applicable US Lidecomb Cream Fluocinonide (0.5 mg / g) + Gramicidin D (0.25 mg / g) + Neomycin sulfate (5 mg / g) + Nystatin (100000 unit / g) Cream Topical Medicis Pharmaceutical Corporation 1980-12-31 1998-09-25 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Fluocinol Pak Fluocinonide (1 mg/1g) Cream; Kit Topical PureTek Corporation 2020-07-02 Not applicable US Fluocinonide 0.05% / Hyaluronic Acid Sodium Salt 0.5% / Niacinamide 4% Fluocinonide (0.05 g/100g) + Sodium hyaluronate (0.5 g/100g) Cream Topical Sincerus Florida, LLC 2019-05-22 Not applicable US Fluopar Fluocinonide (1 mg/1g) + Dimethicone (50 mg/1mL) Cream; Kit Topical PureTek Corporation 2014-01-14 Not applicable US
Categories
- ATC Codes
- C05AA11 — Fluocinonide
- C05AA — Corticosteroids
- C05A — AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- C05 — VASOPROTECTIVES
- C — CARDIOVASCULAR SYSTEM
- D07AC — Corticosteroids, potent (group III)
- D07A — CORTICOSTEROIDS, PLAIN
- D07 — CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
- D — DERMATOLOGICALS
- Drug Categories
- Adrenal Cortex Hormones
- Anti-Allergic Agents
- Anti-Inflammatory Agents
- Corticosteroid Hormone Receptor Agonists
- Corticosteroids
- Corticosteroids, Dermatological Preparations
- Corticosteroids, Potent (Group III)
- Cytochrome P-450 CYP3A Inducers
- Cytochrome P-450 CYP3A Substrates
- Cytochrome P-450 CYP3A4 Inducers
- Cytochrome P-450 CYP3A4 Inducers (strength unknown)
- Cytochrome P-450 CYP3A4 Substrates
- Cytochrome P-450 CYP3A5 Inducers
- Cytochrome P-450 CYP3A5 Inducers (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Cytochrome P-450 Substrates
- Dermatologicals
- Fused-Ring Compounds
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Immunosuppressive Agents
- Pregnadienes
- Pregnanes
- Steroids
- Steroids, Fluorinated
- Thyroxine-binding globulin inhibitors
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
- Kingdom
- Organic compounds
- Super Class
- Lipids and lipid-like molecules
- Class
- Steroids and steroid derivatives
- Sub Class
- Pregnane steroids
- Direct Parent
- Gluco/mineralocorticoids, progestogins and derivatives
- Alternative Parents
- 20-oxosteroids / 11-beta-hydroxysteroids / 3-oxo delta-1,4-steroids / Halogenated steroids / Delta-1,4-steroids / Alpha-acyloxy ketones / Ketals / 1,3-dioxolanes / Fluorohydrins / Cyclic ketones show 9 more
- Substituents
- 11-beta-hydroxysteroid / 11-hydroxysteroid / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / 6-halo-steroid / 9-halo-steroid / Acetal / Alcohol / Aliphatic heteropolycyclic compound show 28 more
- Molecular Framework
- Aliphatic heteropolycyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 2W4A77YPAN
- CAS number
- 356-12-7
- InChI Key
- WJOHZNCJWYWUJD-IUGZLZTKSA-N
- InChI
- InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
- IUPAC Name
- 2-[(1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-8-yl]-2-oxoethyl acetate
- SMILES
- [H][C@@]12C[C@@]3([H])[C@]4([H])C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]1(OC(C)(C)O2)C(=O)COC(C)=O
References
- Synthesis Reference
US. Patent 3,197,469.
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0015181
- KEGG Drug
- D00325
- PubChem Compound
- 9642
- PubChem Substance
- 46504523
- ChemSpider
- 9265
- 4462
- ChEBI
- 5109
- ChEMBL
- CHEMBL1501
- ZINC
- ZINC000003977978
- Therapeutic Targets Database
- DAP000421
- PharmGKB
- PA449664
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- PDRhealth
- PDRhealth Drug Page
- Wikipedia
- Fluocinonide
- FDA label
- Download (818 KB)
- MSDS
- Download (75.1 KB)
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Completed Treatment Atopic Dermatitis 2 4 Recruiting Treatment Central Centrifugal Cicatricial Alopecia (CCCA) 1 2 Completed Supportive Care Breast Carcinoma 1 2 Completed Treatment Atopic Dermatitis 1 2 Terminated Treatment Hand and Foot Skin Reaction / Rash 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Actavis Group
- Advanced Pharmaceutical Services Inc.
- A-S Medication Solutions LLC
- Contract Pharm
- Dispensing Solutions
- Diversified Healthcare Services Inc.
- E. Fougera and Co.
- Gallipot
- Innoviant Pharmacy Inc.
- Major Pharmaceuticals
- Mason Distributors
- Medicis Pharmaceutical Co.
- Nycomed Inc.
- Palmetto Pharmaceuticals Inc.
- Patheon Inc.
- Pharmedix
- Physicians Total Care Inc.
- Preferred Pharmaceuticals Inc.
- Qualitest
- Quality Care
- Rebel Distributors Corp.
- Stat Rx Usa
- Taro Pharmaceuticals USA
- Teva Pharmaceutical Industries Ltd.
- United Research Laboratories Inc.
- Dosage Forms
Form Route Strength Cream; kit Topical 1 mg/1g Cream Topical 0.5 mg/1g Gel Topical 0.5 mg/1g Ointment Topical 0.05 mg/1g Ointment Topical 0.5 mg/1g Solution Topical 0.5 mg/1mL Cream Topical Powder Not applicable 1 g/1g Cream; kit Topical Kit Topical 1 mg/1g Kit Topical Cream Topical 0.05 % w/w Cream; emulsion Topical .05 % Gel Topical 0.05 % w/w Ointment Topical 0.05 % w/w Cream Topical 0.01 % Ointment Topical 0.01 % Ointment Topical .05 % Gel Topical 0.05 % Ointment Topical 0.05 % Cream Topical .05 % Cream Topical 0.05 % Solution Nasal; Respiratory (inhalation) 0.05 g Solution Oral 0.05 % Cream Topical 15 MG/30G Gel Cutaneous 50.000 mg Gel Topical 15 MG/30G Ointment Topical 0.05 g/100g Solution Cutaneous 15 MG/30G Jelly Topical .5 mg / g Gel Topical Cream Topical 1 mg/1g - Prices
Unit description Cost Unit Vanos 0.1% Cream 60 gm Tube 275.75USD tube Fluocinonide powder 176.0USD g Vanos 0.1% Cream 30 gm Tube 155.34USD tube Fluocinonide 0.05% Ointment 60 gm Tube 50.96USD tube Fluocinonide 0.05% Gel 60 gm Tube 50.78USD tube Fluocinonide-E 0.05% Cream 60 gm Tube 47.84USD tube Fluocinonide 0.05% Gel 30 gm Tube 30.1USD tube Fluocinonide 0.05% Ointment 30 gm Tube 28.61USD tube Fluocinonide-E 0.05% Cream 30 gm Tube 28.6USD tube Fluocinonide 0.05% Solution 60ml Bottle 27.23USD bottle Fluocinonide 0.05% Cream 60 gm Tube 22.71USD tube Fluocinonide 0.05% Solution 20ml Bottle 21.99USD bottle Fluocinonide 0.05% Ointment 15 gm Tube 21.88USD tube Fluocinonide 0.05% Gel 15 gm Tube 21.85USD tube Fluocinonide-E 0.05% Cream 15 gm Tube 20.18USD tube Fluocinonide 0.05% Cream 30 gm Tube 13.54USD tube Fluocinonide 0.05% Cream 15 gm Tube 11.99USD tube Vanos 0.1% cream 4.13USD g Lidex 0.05% cream 3.57USD g Fluocinonide-e 0.05% cream 1.33USD g Fluocinonide 0.05% cream 0.6USD g Fluocinonide-emol 0.05% cream 0.4USD g Lyderm 0.05 % Gel 0.38USD g Lyderm 0.05 % Ointment 0.37USD g Lyderm 0.05 % Cream 0.29USD g Tiamol 0.05 % Emollient Cream 0.27USD g DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US7220424 No 2007-05-22 2023-01-07 US US7794738 No 2010-09-14 2022-09-11 US US8232264 No 2012-07-31 2023-03-09 US US6765001 No 2004-07-20 2021-12-21 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 309 °C PhysProp water solubility 4.74 mg/L Not Available logP 3.19 HANSCH,C ET AL. (1995) - Predicted Properties
Property Value Source Water Solubility 0.0168 mg/mL ALOGPS logP 2.93 ALOGPS logP 2.05 Chemaxon logS -4.5 ALOGPS pKa (Strongest Acidic) 13.6 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 99.13 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 120.56 m3·mol-1 Chemaxon Polarizability 48.97 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.9823 Blood Brain Barrier + 0.981 Caco-2 permeable - 0.5804 P-glycoprotein substrate Substrate 0.7813 P-glycoprotein inhibitor I Inhibitor 0.8103 P-glycoprotein inhibitor II Non-inhibitor 0.5782 Renal organic cation transporter Non-inhibitor 0.8178 CYP450 2C9 substrate Non-substrate 0.8667 CYP450 2D6 substrate Non-substrate 0.8951 CYP450 3A4 substrate Substrate 0.7219 CYP450 1A2 substrate Non-inhibitor 0.9045 CYP450 2C9 inhibitor Non-inhibitor 0.9071 CYP450 2D6 inhibitor Non-inhibitor 0.9482 CYP450 2C19 inhibitor Non-inhibitor 0.9025 CYP450 3A4 inhibitor Non-inhibitor 0.8309 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8455 Ames test Non AMES toxic 0.7768 Carcinogenicity Non-carcinogens 0.9166 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 3.1492 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9835 hERG inhibition (predictor II) Non-inhibitor 0.6907
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 216.898939 predictedDarkChem Lite v0.1.0 [M-H]- 208.06499 predictedDeepCCS 1.0 (2019) [M+H]+ 216.475839 predictedDarkChem Lite v0.1.0 [M+H]+ 210.14445 predictedDeepCCS 1.0 (2019) [M+Na]+ 217.046239 predictedDarkChem Lite v0.1.0 [M+Na]+ 216.1546 predictedDeepCCS 1.0 (2019)
Targets
![](https://go.drugbank.com/assets/locked/DrugTargets2-682eb846d210ae4bf33ca03febccfb57bb1c61318e699b729e5df4dfab2c5b67.png)
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Zinc ion binding
- Specific Function
- Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
- Gene Name
- NR3C1
- Uniprot ID
- P04150
- Uniprot Name
- Glucocorticoid receptor
- Molecular Weight
- 85658.57 Da
References
- Jessop S, Whitelaw D, Jordaan F: Drugs for discoid lupus erythematosus. Cochrane Database Syst Rev. 2001;(1):CD002954. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Agonist
- General Function
- Wnt-protein binding
- Specific Function
- G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought t...
- Gene Name
- SMO
- Uniprot ID
- Q99835
- Uniprot Name
- Smoothened homolog
- Molecular Weight
- 86395.95 Da
References
- Wang J, Lu J, Bond MC, Chen M, Ren XR, Lyerly HK, Barak LS, Chen W: Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9323-8. doi: 10.1073/pnas.0910712107. Epub 2010 May 3. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- SubstrateInducer
- General Function
- Vitamin d3 25-hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
- Gene Name
- CYP3A4
- Uniprot ID
- P08684
- Uniprot Name
- Cytochrome P450 3A4
- Molecular Weight
- 57342.67 Da
References
- Moore CD, Roberts JK, Orton CR, Murai T, Fidler TP, Reilly CA, Ward RM, Yost GS: Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes. Drug Metab Dispos. 2013 Feb;41(2):379-89. doi: 10.1124/dmd.112.046318. Epub 2012 Nov 9. [Article]
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Oxygen binding
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
- Gene Name
- CYP3A5
- Uniprot ID
- P20815
- Uniprot Name
- Cytochrome P450 3A5
- Molecular Weight
- 57108.065 Da
References
- Dvorak Z, Pavek P: Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metab Rev. 2010 Nov;42(4):621-35. doi: 10.3109/03602532.2010.484462. [Article]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Steroid binding
- Specific Function
- Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
- Gene Name
- SERPINA6
- Uniprot ID
- P08185
- Uniprot Name
- Corticosteroid-binding globulin
- Molecular Weight
- 45140.49 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [Article]
Drug created at June 13, 2005 13:24 / Updated at February 20, 2024 23:55