Identification
- Summary
Diazoxide is a non diuretic benzothiadiazine indicated for the management of hypoglycemia in patients who produce an excess of insulin caused by a variety of conditions.
- Brand Names
- Proglycem
- Generic Name
- Diazoxide
- DrugBank Accession Number
- DB01119
- Background
Diazoxide is a non-diuretic benzothiadiazine derivative that activates ATP-sensitive potassium channels.5,7 It is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity.1 Diazoxide is commonly used in the treatment of hyperinsulinaemic hypoglycemia due to its ability to inhibit insulin release.5 Diazoxide also exhibits hypotensive activity and reduces arteriolar smooth muscle and vascular resistance.1 When administered intravenously, diazoxide can be used to treat hypertensive emergencies;9 however, this specific form of diazoxide is no longer available in the US. Diazoxide is usually well tolerated, and some of its more common side effects include fluid retention and electrolyte disturbances. In September 2015, the FDA issued a safety alert regarding post-marketing reports of pulmonary hypertension occurring in infants and neonates.5,7
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Diazoxide (DB01119)
- Weight
- Average: 230.671
Monoisotopic: 229.991675875 - Chemical Formula
- C8H7ClN2O2S
- Synonyms
- 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
- Diazossido
- Diazoxide
- Diazoxido
- Diazoxidum
- External IDs
- NSC-64198
- NSC-76130
- SCH 6783
- SCH-6783
- SRG 95213
- SRG-95213
Pharmacology
- Indication
Oral diazoxide is indicated to manage hypoglycemia due to hyperinsulinism associated with conditions such as inoperable islet cell adenoma or carcinoma, and extrapancreatic malignancy in adults, or leucine sensitivity, islet cell hyperplasia, nesidioblastosis, extrapancreatic malignancy, islet cell adenoma, and adenomatosis in infants and children. In infants and children oral diazoxide may be used preoperatively as a temporary measure, and postoperatively, if hypoglycemia persists.7 Diazoxide may also be used parentally or intravenously to treat hypertensive emergencies.4,9
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Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Management of Hyperinsulinemic hypoglycemia •••••••••••• ••••••••• •••••••• •••••••••• Management of Hyperinsulinemic hypoglycemia •••••••••••• ••••••••• •••••••• •••••••••• Management of Hyperinsulinemic hypoglycemia •••••••••••• ••••••••• •••••••• •••••••••• Management of Hyperinsulinemic hypoglycemia •••••••••••• ••••••••• •••••••• •••••••••• Management of Hyperinsulinemic hypoglycemia •••••••••••• ••••••••• •••••••• •••••••••• - Contraindications & Blackbox Warnings
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Diazoxide is a potassium channel activator that enhances cell membrane permeability to potassium ions. By promoting a vasodilatory effect on the smooth muscle in peripheral arterioles, diazoxide lowers blood pressure and peripheral vascular resistance. Diazoxide-induced decreases in blood pressure lead to reflex increases in heart rate and cardiac output.9 The oral administration of diazoxide increases blood glucose in a dose-dependent manner. In patients with normal renal function, this effect is observed within an hour and lasts no more than eight hours. The hypotensive effects of diazoxide are usually not detected when administered orally.7
Diazoxide administered intravenously may lead to sodium and water retention, severe hypotension, transient myocardial or cerebral ischaemia and gastrointestinal upsets such as nausea, vomiting and abdominal discomfort.9 Diazoxide administered orally may cause ketoacidosis and nonketotic hyperosmolar coma, especially in patients with other concurrent conditions.7 The use of intravenous or oral diazoxide may lead to the development of pulmonary hypertension in infants and neonates.7,9
- Mechanism of action
Diazoxide is a nondiuretic benzothiadiazine derivative used for the management of symptomatic hypoglycemia. By binding to the sulfonylurea receptor (SUR) subunit of the ATP-sensitive potassium channel (KATP) channel on the membrane of pancreatic beta‐cells, diazoxide promotes a potassium efflux from beta-cells. This hyperpolarizes the cell membrane and prevents the influx of calcium to the pancreatic beta‐cells. Without a sufficient amount of calcium in the cell, insulin release is inhibited.5 Therefore, the use of diazoxide produces an increase in glucose levels.7 Diazoxide is chemically related to thiazide diuretics but does not inhibit carbonic anhydrase and does not have chloriuretic or natriuretic activity.1 It also exhibits hypotensive activity by reducing arteriolar smooth muscle and vascular resistance.1 The mechanism of action of its hypotensive effect has not been fully elucidated; however, it is possible that it involves the antagonism of calcium.9
Target Actions Organism AATP-sensitive inward rectifier potassium channel 11 inducerHumans UMitochondrial ATP synthase F1 domain inhibitorHumans - Absorption
Diazoxide is readily absorbed following oral administration; however, its absorption depends on the dissolution rate of the dosage form.3 Diazoxide has a bioavailability of 91%.2
- Volume of distribution
The apparent volume of distribution of diazoxide in adults with normal renal function is 13 L (21% of body weight), while in children with normal renal function, it is 2 L (33% of body weight).3 Other sources show that the volume of distribution of diazoxide is 0.21 L/kg.2
- Protein binding
The protein binding of diazoxide in normal adults can range from 77% to 94%, depending on the administered dose. In patients with renal failure, protein binding ranges between 77% and 87%. This reduction can be related to the lower levels of albumin in patients with renal failure.3
- Metabolism
Diazoxide is metabolized in the liver through oxidation of the 3-methyl group, producing hydroxymethyl (MI) and carboxy (M2) derivatives.3,6 The MI derivatives undergo subsequent sulphate conjugation. It is estimated that, in subjects with normal renal function, 54-60% of diazoxide is metabolized. Diazoxide metabolites are inactive and do not contribute to its cardiovascular activity. Additionally, diazoxide metabolites do not displace diazoxide from protein binding sites.3
- Route of elimination
Diazoxide and its metabolites are mainly eliminated through urine. Since diazoxide is extensively protein-bond, it has a slow excretion and a prolonged half-life. In subjects with normal renal function, the urinary excretion rates of diazoxide peak on the first day after oral administration.3
- Half-life
Following oral administration, the plasma half-life of diazoxide varies from 9.5 to 24 hours in children with normal renal function and from 20 to 72 hours in adults with normal renal function.3
- Clearance
In subjects with normal renal function given 300 mg of diazoxide intravenously, renal clearance was 4 ml/min.3 Other sources show that the clearance of diazoxide is 0.06 ml/min/kg.2
- Adverse Effects
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The oral LD50 of diazoxide in rats and mice are 980 mg/kg and 444 mg/kg, respectively.8 In the mouse, rat, rabbit, dog, pig, and monkey, the oral administration of diazoxide leads to a rapid and transient rise in blood glucose levels. In rats given 400 mg/kg of diazoxide orally during subacute toxicity studies, growth retardation, edema, increases in liver and kidney weights, and adrenal hypertrophy were observed. Rats given doses up to 1080 mg/kg for three months developed hyperglycemia, an increase in liver weight and an increase in mortality.7 Toxicity is increased when diazoxide was administered at high dosages concomitantly with either chlorothiazide to rats or trichlormethiazide to dogs. Reproduction and teratology studies in different animal species suggest that diazoxide may interfere with normal fetal development, possibly due to the alteration of glucose metabolism.7
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbaloparatide The risk or severity of adverse effects can be increased when Diazoxide is combined with Abaloparatide. Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Diazoxide. Acebutolol Diazoxide may increase the hypotensive activities of Acebutolol. Aceclofenac The therapeutic efficacy of Diazoxide can be decreased when used in combination with Aceclofenac. Acemetacin The therapeutic efficacy of Diazoxide can be decreased when used in combination with Acemetacin. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Diazoxide choline 2U8NRZ7P8L 1098065-76-9 Not applicable - International/Other Brands
- Eudemine (Mercury)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Hyperstat Injection 300 mg/20mL Intravenous Merck Sharp & Dohme Limited 1973-01-22 2006-07-31 US 
Hyperstat Inj 15mg/ml Liquid 15 mg / mL Intravenous Schering Plough 1973-12-31 2003-07-14 Canada 
Proglycem Capsule 100 mg Oral Merck Ltd. 1985-12-31 Not applicable Canada Proglycem Suspension 50 mg/1mL Oral Teva Pharmaceuticals USA, Inc. 1990-09-30 Not applicable US Proglycem Susp 50mg/ml Suspension 50 mg / mL Oral Schering Plough 1984-12-31 2006-03-23 Canada - Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Diazoxide Suspension 50 mg/1mL Oral E5 Pharma, Llc 2019-12-11 Not applicable US Diazoxide Suspension 50 mg/1mL Oral Par Pharmaceutical, Inc 2020-07-21 Not applicable US Diazoxide Oral Solution Suspension 50 mg/1mL Oral TriRx Huntsville Pharmaceutical Services LLC 2023-01-06 Not applicable US
Categories
- ATC Codes
- G01AE10 — Combinations of sulfonamides
- G01AE — Sulfonamides
- G01A — ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
- G01 — GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
- G — GENITO URINARY SYSTEM AND SEX HORMONES
- C02DA — Thiazide derivatives
- C02D — ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
- C02 — ANTIHYPERTENSIVES
- C — CARDIOVASCULAR SYSTEM
- Drug Categories
- Antihypertensive Agents
- Arteriolar Smooth Muscle, Agents Acting On
- Benzothiadiazines
- Cardiovascular Agents
- Direct Vasodilators
- Heterocyclic Compounds, Fused-Ring
- Hyperglycemia-Associated Agents
- Hypoglycemia-Treating Agents
- Hypotensive Agents
- Potassium Channel Opener
- Sulfonamides
- Sulfones
- Sulfur Compounds
- Thiazide Derivatives
- Vasodilating Agents
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as 1,2,4-benzothiadiazine-1,1-dioxides. These are aromatic heterocyclic compounds containing a 1,2,4-benzothiadiazine ring system with two S=O bonds at the 1-position.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Thiadiazines
- Sub Class
- Benzothiadiazines
- Direct Parent
- 1,2,4-benzothiadiazine-1,1-dioxides
- Alternative Parents
- Imidolactams / Benzenoids / Aryl chlorides / Organosulfonic acids and derivatives / Azacyclic compounds / Amidines / Organopnictogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives
- Substituents
- 1,2,4-benzothiadiazine-1,1-dioxide / Amidine / Aromatic heteropolycyclic compound / Aryl chloride / Aryl halide / Azacycle / Benzenoid / Hydrocarbon derivative / Imidolactam / Organic nitrogen compound
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- sulfone, organochlorine compound, benzothiadiazine (CHEBI:4495)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- O5CB12L4FN
- CAS number
- 364-98-7
- InChI Key
- GDLBFKVLRPITMI-UHFFFAOYSA-N
- InChI
- InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
- IUPAC Name
- 7-chloro-3-methyl-4H-1lambda6,2,4-benzothiadiazine-1,1-dione
- SMILES
- CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2
References
- Synthesis Reference
Topliss, J.G., Sperber, N. and Rubin, A.A. U.S. Patent 2,986,573; May 30, 1961; assigned to Schering Corporation. https://patentimages.storage.googleapis.com/a7/52/ac/b4aae51fc2087d/US2986573.pdf Topliss, J.G., Sperber, N. and Rubin, A.A.; U.S. Patent 3,345,365; October 3, 1967; assigned to Schering Corporation.
- General References
- Koch-Weser J: Diazoxide. N Engl J Med. 1976 Jun 3;294(23):1271-3. doi: 10.1056/NEJM197606032942306. [Article]
- Kirsten R, Nelson K, Kirsten D, Heintz B: Clinical pharmacokinetics of vasodilators. Part I. Clin Pharmacokinet. 1998 Jun;34(6):457-82. [Article]
- Pearson RM: Pharmacokinetics and response to diazoxide in renal failure. Clin Pharmacokinet. 1977 May-Jun;2(3):198-204. doi: 10.2165/00003088-197702030-00004. [Article]
- Vidt DG: Diazoxide for hypertensive crisis. Am Fam Physician. 1975 May;11(5):128-30. [Article]
- Chen SC, Dastamani A, Pintus D, Yau D, Aftab S, Bath L, Swinburne C, Hunter L, Giardini A, Christov G, Senniappan S, Banerjee I, Shaikh MG, Shah P: Diazoxide-induced pulmonary hypertension in hyperinsulinaemic hypoglycaemia: Recommendations from a multicentre study in the United Kingdom. Clin Endocrinol (Oxf). 2019 Dec;91(6):770-775. doi: 10.1111/cen.14096. Epub 2019 Oct 1. [Article]
- Dayton PG, Pruitt AW, Faraj BA, Israili ZH: Metabolism and disposition of diazoxide. A mini-review. Drug Metab Dispos. 1975 May-Jun;3(3):226-9. [Article]
- FDA Approved Drug Products: Proglycem (diazoxide) oral capsules, suspension [Link]
- MSD: Diazoxide (<15%) formulation SDS [Link]
- New Zealand Drug Data Sheet: DBL (diazoxide) injection for intravenous use [Link]
- External Links
- Human Metabolome Database
- HMDB0015251
- KEGG Drug
- D00294
- KEGG Compound
- C06949
- PubChem Compound
- 3019
- PubChem Substance
- 46508027
- ChemSpider
- 2911
- BindingDB
- 86248
- 3327
- ChEBI
- 4495
- ChEMBL
- CHEMBL181
- ZINC
- ZINC000003872277
- Therapeutic Targets Database
- DAP000956
- PharmGKB
- PA449285
- Guide to Pharmacology
- GtP Drug Page
- PDBe Ligand
- 20J
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Diazoxide
- PDB Entries
- 4lv9
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Active Not Recruiting Basic Science Hyperglycemia / Metabolism Disorder, Glucose / Type 2 Diabetes Mellitus 1 4 Active Not Recruiting Prevention Hypoglycemia / Hypoglycemia Unawareness / Type 1 Diabetes Mellitus 1 4 Completed Prevention Type 1 Diabetes Mellitus 1 4 Completed Treatment Type 1 Diabetes Mellitus 1 4 Withdrawn Treatment Gastroenteropancreatic Neuroendocrine Tumors 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Ivax Pharmaceuticals
- Medisca Inc.
- Teva Pharmaceutical Industries Ltd.
- Dosage Forms
Form Route Strength Powder Not applicable 1 g/1g Suspension Oral 50 mg Solution Intravenous 300.000 mg Injection Intravenous 300 mg/20mL Liquid Intravenous 15 mg / mL Capsule Oral 25 MG Capsule Oral 100 mg Suspension Oral 50 mg/1mL Suspension Oral 50 mg / mL Injection, powder, for solution Intramuscular 300 mg/1 Suspension Oral 5 g - Prices
Unit description Cost Unit Proglycem 50 mg/ml Suspension 30ml Bottle 197.05USD bottle Diazoxide powder 85.07USD g Proglycem 100 mg Capsule 1.65USD capsule DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 330ºC Topliss, J.G., Sperber, N. and Rubin, A.A.; U.S. Patent 2,986,573; May 30, 1961; assigned to Schering Corporation. Topliss, J.G., Sperber, N. and Rubin, A.A.; U.S. Patent 3,345,365; October 3, 1967; assigned to Schering Corporation. water solubility 2850 mg/L Not Available logP 1.20 HANSCH,C ET AL. (1995) pKa 8.74 SANGSTER (1994) - Predicted Properties
Property Value Source Water Solubility 0.552 mg/mL ALOGPS logP 1.09 ALOGPS logP 1 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 14.48 Chemaxon pKa (Strongest Basic) -2.6 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 58.53 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 54.84 m3·mol-1 Chemaxon Polarizability 20.98 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 1.0 Blood Brain Barrier + 0.5923 Caco-2 permeable - 0.5765 P-glycoprotein substrate Non-substrate 0.6817 P-glycoprotein inhibitor I Non-inhibitor 0.6924 P-glycoprotein inhibitor II Non-inhibitor 0.6927 Renal organic cation transporter Non-inhibitor 0.8107 CYP450 2C9 substrate Non-substrate 0.5606 CYP450 2D6 substrate Non-substrate 0.8064 CYP450 3A4 substrate Non-substrate 0.5774 CYP450 1A2 substrate Inhibitor 0.9108 CYP450 2C9 inhibitor Non-inhibitor 0.9071 CYP450 2D6 inhibitor Inhibitor 0.8932 CYP450 2C19 inhibitor Non-inhibitor 0.9025 CYP450 3A4 inhibitor Non-inhibitor 0.831 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.7977 Ames test Non AMES toxic 0.7888 Carcinogenicity Non-carcinogens 0.8304 Biodegradation Not ready biodegradable 1.0 Rat acute toxicity 2.3408 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9233 hERG inhibition (predictor II) Non-inhibitor 0.9271
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 142.7307676 predictedDarkChem Lite v0.1.0 [M-H]- 141.30731 predictedDeepCCS 1.0 (2019) [M+H]+ 143.7884676 predictedDarkChem Lite v0.1.0 [M+H]+ 143.69765 predictedDeepCCS 1.0 (2019) [M+Na]+ 142.9699676 predictedDarkChem Lite v0.1.0 [M+Na]+ 149.75845 predictedDeepCCS 1.0 (2019)
Targets
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Inducer
- Curator comments
- Diazoxide binds to the Kir6.2 subunit of the ATP-sensitive K+ channel present in both plasma and mitochondrial membranes.
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage ...
- Gene Name
- KCNJ11
- Uniprot ID
- Q14654
- Uniprot Name
- ATP-sensitive inward rectifier potassium channel 11
- Molecular Weight
- 43540.375 Da
References
- D'hahan N, Moreau C, Prost AL, Jacquet H, Alekseev AE, Terzic A, Vivaudou M: Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12162-7. [Article]
- Sakura H, Trapp S, Liss B, Ashcroft FM: Altered functional properties of KATP channel conferred by a novel splice variant of SUR1. J Physiol. 1999 Dec 1;521 Pt 2:337-50. [Article]
- Shindo T, Katayama Y, Horio Y, Kurachi Y: MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel. J Pharmacol Exp Ther. 2000 Jan;292(1):131-5. [Article]
- de Lonlay P, Fournet JC, Touati G, Groos MS, Martin D, Sevin C, Delagne V, Mayaud C, Chigot V, Sempoux C, Brusset MC, Laborde K, Bellane-Chantelot C, Vassault A, Rahier J, Junien C, Brunelle F, Nihoul-Fekete C, Saudubray JM, Robert JJ: Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases. Eur J Pediatr. 2002 Jan;161(1):37-48. [Article]
- Russ U, Lange U, Loffler-Walz C, Hambrock A, Quast U: Binding and effect of K ATP channel openers in the absence of Mg2+. Br J Pharmacol. 2003 May;139(2):368-80. [Article]
- Guo W, Chen N, Chen Y, Xia Q, Shen Y: Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation. Conf Proc IEEE Eng Med Biol Soc. 2005;4:4027-30. [Article]
- Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ: Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res. 1997 Dec;81(6):1072-82. doi: 10.1161/01.res.81.6.1072. [Article]
- Kind
- Protein group
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Transmembrane transporter activity
- Specific Function
- Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport comp...
Components:
References
- Comelli M, Metelli G, Mavelli I: Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug. Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H820-9. [Article]
- Jasova M, Kancirova I, Murarikova M, Farkasova V, Waczulikova I, Ravingerova T, Ziegelhoffer A, Ferko M: Stimulation of mitochondrial ATP synthase activity - a new diazoxide-mediated mechanism of cardioprotection. Physiol Res. 2016 Sep 19;65 Suppl 1:S119-27. doi: 10.33549/physiolres.933411. [Article]
Carriers
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Toxic substance binding
- Specific Function
- Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
- Gene Name
- ALB
- Uniprot ID
- P02768
- Uniprot Name
- Serum albumin
- Molecular Weight
- 69365.94 Da
References
- Pearson RM: Pharmacokinetics and response to diazoxide in renal failure. Clin Pharmacokinet. 1977 May-Jun;2(3):198-204. doi: 10.2165/00003088-197702030-00004. [Article]
Drug created at June 13, 2005 13:24 / Updated at February 20, 2024 23:55