NAV

Attapulgite

Identification

Summary

Attapulgite is a veterinary antidiarrheal agent used to treat non-infectious diarrhea in animals.

Generic Name
Attapulgite
DrugBank Accession Number
DB01574
Background

Attapulgite is a magnesium aluminium phyllosilicate which occurs in a type of clay soil common to the Southeastern United States. When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Until 2003, it was the active ingredient used in Kaopectate, before that product was reformulated with bismuth subsalicylate.

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Similar Structures
Weight
Average: 412.684
Monoisotopic: 411.8684309
Chemical Formula
AlH9MgO15Si4
Synonyms
  • Activated attapulgite
  • Aluminium magnesium silicate (attapulgite)
  • Attapulgite (activated)
  • Attapulgite, activated
  • Attapulgite,activated
  • Attapulgus clay
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Pharmacology

Indication

When used in medicine, it physically binds to acids and toxic substances in the stomach and digestive tract. For that reason, it has often been used in antidiarrheal medications. Attapulgite is an adsorbent.

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for symptomatic treatment ofAcute diarrhoeaCombination Product in combination with: Pectin (DB11158)••••••••••••
Treatment ofDiarrhea••••••••••••••••••••••• ••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Attapulgite is an adsorptive magnesium aluminium phyllosilicate which binds to toxins, bacteria and water.

Mechanism of action

Attapulgite adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
  • Take with or without food.

Products

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Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Children's Kaopectate Sus 600mg/15mlSuspension600 mg / 15 mLOralUpjohn1992-12-312001-07-27Canada flag
Extra Strength Kaopectate Tablets 750mgTablet750 mgOralJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1998-04-062005-07-14Canada flag
Kaopectate Chewable Tab 300mgTablet300 mgOralUpjohn1990-12-312001-07-27Canada flag
Kaopectate Chewable Tablets 300mgTablet300 mgOralJohnson & Johnson Merck Consumer Pharmaceuticals Of Canada1998-09-182002-07-18Canada flag
Kaopectate Extra Strength SusSuspension750 mg / 15 mLOralUpjohn1992-12-312001-07-27Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Diaret TabAttapulgite (350 mg / tab) + Aluminum hydroxide (70 mg / tab) + Pectin (45 mg / tab) + Zinc phenolsulfonate (30 mg / tab)TabletOralProduits Francais Labs Inc.1981-12-311997-05-30Canada flag
Diarex TabAttapulgite (350 mg / tab) + Aluminum hydroxide (70 mg / tab) + Pectin (45 mg / tab) + Zinc phenolsulfonate (30 mg / tab)TabletOralNutribon (1986) Inc.1995-12-311996-09-30Canada flag
Diban CapAttapulgite (300 mg) + Atropine sulfate (9.7 mcg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg)CapsuleOralAyerst Laboratories1992-12-311999-04-12Canada flag
Diban CapAttapulgite (300 mg) + Atropine sulfate (9.7 mcg) + Hyoscyamine sulfate (0.0519 mg) + Opium (12 mg) + Pectin (71.4 mg) + Scopolamine (3.3 mcg)CapsuleOralWyeth Ayerst Canada Inc.1998-02-182001-01-30Canada flag
Donnagel-PG CapAttapulgite (300 mg / cap) + Opium (12 mg / cap) + Pectin (71.4 mg / cap)CapsuleOralWyeth Ayerst Canada Inc.1994-12-312002-03-20Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
DIASORB 100 ML SUSPANSIYONAttapulgite (100 ml)SuspensionOralRECORDATİ İLAÇ SAN. VE TİC. A.Ş.2013-03-122021-02-15Turkey flag

Categories

ATC Codes
A07BC54 — Attapulgite, combinationsA07BC04 — Attapulgite
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of inorganic compounds known as post-transition metal hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a post-transition metal.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Post-transition metal oxoanionic compounds
Sub Class
Post-transition metal hydroxides
Direct Parent
Post-transition metal hydroxides
Alternative Parents
Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides / Inorganic hydrides
Substituents
Inorganic hydride / Inorganic metalloid salt / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal hydroxide
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
U6V729APAM
CAS number
12174-11-7
InChI Key
IXWIAFSBWGYQOE-UHFFFAOYSA-M
InChI
InChI=1S/Al.Mg.5H2O.10O.4Si/h;;5*1H2;;;;;;;;;;;;;;/q+3;+2;;;;;;10*-2;4*+4/p-1
IUPAC Name
tetrasilicon(4+) ion aluminium(3+) ion magnesium(2+) ion tetrahydrate hydroxide decaoxidandiide
SMILES
[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[O--].[Mg++].[Al+3].[Si+4].[Si+4].[Si+4].[Si+4].[O-][H].[H]O[H].[H]O[H].[H]O[H].[H]O[H]

References

General References
  1. Zaid MR, Hasan M, Khan AA: Attapulgite in the treatment of acute diarrhoea: a double-blind placebo-controlled study. J Diarrhoeal Dis Res. 1995 Mar;13(1):44-6. [Article]
  2. Nwachukwu CE, Okebe JU: Antimotility agents for chronic diarrhoea in people with HIV/AIDS. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD005644. doi: 10.1002/14651858.CD005644.pub2. [Article]
PubChem Compound
73415752
PubChem Substance
46505928
ChemSpider
32701176
RxNav
133050
PharmGKB
PA164781017
Drugs.com
Drugs.com Drug Page
Wikipedia
Palygorskite

Clinical Trials

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PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Tablet
Suspension
SuspensionOral600 mg / 15 mL
TabletOral
SuspensionOral100 ml
CapsuleOral
TabletOral750 mg
TabletOral300 mg
SuspensionOral750 mg / 15 mL
TabletOral750 mg / tab
LiquidOral600 mg / 15 mL
TabletOral600 mg
TabletOral600 mg / tab
TabletOral
SuspensionOral500 mg/5ml
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP-0.65Chemaxon
pKa (Strongest Acidic)15.7Chemaxon
pKa (Strongest Basic)-1.8Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area25.3 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity3.7 m3·mol-1Chemaxon
Polarizability1.51 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at August 29, 2007 14:48 / Updated at May 05, 2021 20:30