Identification
- Summary
Kaolin is a natural ingredient used for the short-term symptomatic treatment of various conditions including diarrhea, skin dryness, and minor skin bleeding.
- Brand Names
- Gold Bond Baby Cornstarch Plus
- Generic Name
- Kaolin
- DrugBank Accession Number
- DB01575
- Background
Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Kaolin (DB01575)
- Weight
- Average: 258.156
Monoisotopic: 257.9024618 - Chemical Formula
- Al2H4O9Si2
- Synonyms
- Kaolin
- Kaolin, light
Pharmacology
- Indication
Used for upset stomach and diarrhea, a traditional medicine used in China, South America and Africa. Kaolin is also used to treat AIDs-related diarrhea. Kaolin based bandages are also under investigation.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Diaper rash ••• ••• Used in combination for symptomatic treatment of Diarrhea Combination Product in combination with: Pectin (DB11158) ••• ••• •••••••••• Used in combination to treat Diarrhea Combination Product in combination with: Neomycin (DB00994), Furazolidone (DB00614) •••••••••••• •••••••••• Used in combination to treat Dysentery Combination Product in combination with: Furazolidone (DB00614), Neomycin (DB00994) •••••••••••• •••••••••• Used in combination to treat Enteritis infectious Combination Product in combination with: Neomycin (DB00994), Furazolidone (DB00614) •••••••••••• •••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Kaolin is an adsorptive agent.
- Mechanism of action
Kaolin adsorbs water, toxins and bacteria, contributing to firmer stools, reducing fluid loss from diarrhea.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetyldigitoxin The serum concentration of Acetyldigitoxin can be decreased when it is combined with Kaolin. Carbamazepine Kaolin can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy. Chenodeoxycholic acid Kaolin can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy. Chloroquine Kaolin can cause a decrease in the absorption of Chloroquine resulting in a reduced serum concentration and potentially a decrease in efficacy. Cholic Acid Kaolin can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Derladie Vegan Pink Clay Mask Deep Pore Tightening Cream 25 g/100g Topical LAON COMMERCE co ltd 2023-12-01 Not applicable US 
Dr Pore Tightening GLACIAL CLAY FACIAL MASK Cream 8.0 g/100mL Topical Lab & Company Inc. 2017-11-01 Not applicable US Dr Pore Tightening PINK CLAY FACIAL MASK Cream 4.0 g/100g Topical Lab & Company Inc. 2017-11-01 Not applicable US Druide Biolove for Diaper Rash Paste 4 g/100g Topical Laboratoires Druide Inc 2019-12-16 Not applicable US Look At Me Mud Face Mask Mini Pack Aloe Paste 4.5 g/30mL Topical Youngwon Costech Co., Ltd. 2018-03-30 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 2% Salicylic Acid FACIAL CLEANSER Kaolin (20 mg/236mL) + Azelaic acid (10 mg/236mL) + Glycerin (50 mg/236mL) + Zinc pidolate (10 mg/236mL) + Salicylic acid (20 mg/236mL) Liquid Topical Volans Epic LLC 2023-04-06 Not applicable US AXCEL KAOPEC SUSPENSION Kaolin (1 g/5ml) + Pectin (5 mg/5ml) Suspension Oral KOTRA PHARMA MARKETING 1991-08-19 Not applicable Singapore 
AXCEL KAOPEC SUSPENSION Kaolin (1 g/5ml) + Pectin (20 mg/5ml) Suspension Oral KOTRA PHARMA (M) SDN. BHD. 2020-09-08 Not applicable Malaysia 
BEAKOPECTIN SUSPENSION Kaolin (6000 mg/30ml) + Pectin (130 mg/30ml) Suspension Oral BEACONS PHARMACEUTICALS PTE. LTD. 1991-05-23 Not applicable Singapore BIOGASTRIN TOZ, 60 G Kaolin (300 mg) + Anise oil (5 mg) + Belladonna (20 mg) + Calcium carbonate (500 mg) + Sodium bicarbonate (250 mg) Oral BİOFARMA İLAÇ SAN. VE TİC. A.Ş. 1968-05-24 Not applicable Turkey 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Derladie Vegan Pink Clay Mask Deep Pore Tightening Kaolin (25 g/100g) Cream Topical LAON COMMERCE co ltd 2023-12-01 Not applicable US Mefactory Pig Collagen 1step Piggy Nose Pack Kaolin (0.002 g/0.2g) Patch Topical MeFactory Co., Ltd. 2016-12-01 Not applicable US Pore Tightening Pearl Clay Mask Kaolin (30.8 g/110g) Cream Topical Racce Co., Ltd. 2018-10-01 2018-12-01 US Sonatural Facial Design Deep Black Clay Mask Kaolin (3.5 g/14g) Patch Topical Sonatural Global Co.,ltd 2017-10-01 2018-12-01 US Sonatural Facial Design Pink Mud Mask Kaolin (2.8 g/14g) Patch Topical Sonatural Global Co.,ltd 2017-03-02 2018-12-01 US
Categories
- ATC Codes
- A07BC02 — Kaolin
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as post-transition metal silicates. These are inorganic compounds in which the largest oxoanion is silicate, and in which the heaviest atom not in an oxoanion is a post-transition metal.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Post-transition metal oxoanionic compounds
- Sub Class
- Post-transition metal silicates
- Direct Parent
- Post-transition metal silicates
- Alternative Parents
- Miscellaneous silicates / Post-transition metal salts / Metalloid salts / Inorganic salts / Inorganic oxides
- Substituents
- Inorganic metalloid salt / Inorganic oxide / Inorganic post-transition metal salt / Inorganic salt / Post-transition metal silicate / Silicate
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 24H4NWX5CO
- CAS number
- 1332-58-7
- InChI Key
- KGOIAFZMMLWXLM-UHFFFAOYSA-N
- InChI
- InChI=1S/2Al.O7Si2.2H2O/c;;1-8(2,3)7-9(4,5)6;;/h;;;2*1H2/q2*+3;-6;;
- IUPAC Name
- dialuminium(3+) ion [(trioxidosilyl)oxy]silanetris(olate) dihydrate
- SMILES
- O.O.[Al+3].[Al+3].[O-][Si]([O-])([O-])O[Si]([O-])([O-])[O-]
References
- Synthesis Reference
Joseph C. Muhler, Mark S. Putt, "Dentifrice preparation comprising purified, calcined kaolin abrasives." U.S. Patent US4122163, issued April, 1948.
US4122163- General References
- Trabattoni D, Gatto P, Bartorelli AL: A new kaolin-based hemostatic bandage use after coronary diagnostic and interventional procedures. Int J Cardiol. 2012 Apr 5;156(1):53-4. doi: 10.1016/j.ijcard.2010.10.030. Epub 2010 Nov 18. [Article]
- External Links
- MSDS
- Download (74.1 KB)
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Chattem Chemicals Inc.
- Mallinckrodt Inc.
- Pharmacia Inc.
- Dosage Forms
Form Route Strength Liquid Topical Suspension Oral Suspension Oral 1 g/5ml Suspension Oral 6000 mg/30ml Gel Topical Cream Topical 25 g/100g Cream Topical 8.0 g/100mL Cream Topical 4.0 g/100g Paste Topical 4 g/100g Liquid Oral Ointment Topical Paste Topical 4.5 g/30mL Patch Topical 0.002 g/0.2g Tablet, chewable Oral Tablet Oral Spray Topical Cream Topical 30.8 g/110g Powder Topical Cream Topical Paste Topical 5 g/100mL Solution Oral Patch Topical 3.5 g/14g Patch Topical 2.8 g/14g Cream Topical 45.5 g/130g Cream Topical 15 g/100mL Powder Tablet - Prices
Unit description Cost Unit Kaopectate 262 mg caplet 0.37USD each Kaopectate 240 mg softgel 0.25USD each Kaolin powder 0.03USD g Kaopectate children's susp 0.02USD ml DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -3.9 Chemaxon pKa (Strongest Acidic) 8.24 Chemaxon pKa (Strongest Basic) -4.7 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 147.59 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 10.01 m3·mol-1 Chemaxon Polarizability 9.46 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at August 29, 2007 14:49 / Updated at September 28, 2021 21:54