Identification
- Summary
Flavin mononucleotide is a form of vitamin B2 used to restore riboflavin in anemia, migraine, alcoholism, and hyperhomocysteinemia.
- Brand Names
- Fortaplex, Infuvite, Infuvite Pediatric, Mvi Pediatric, Neo-bex, Photrexa
- Generic Name
- Flavin mononucleotide
- DrugBank Accession Number
- DB03247
- Background
A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Flavin mononucleotide (DB03247)
- Weight
- Average: 456.3438
Monoisotopic: 456.104614802 - Chemical Formula
- C17H21N4O9P
- Synonyms
- FMN
- riboflavin 5'-(dihydrogen phosphate)
- riboflavin 5'-monophosphate
- riboflavin 5'-phosphate
- Riboflavin monophosphate
- Riboflavin phosphate
- Riboflavin-5-phosphate
- riboflavine dihydrogen phosphate
- Vitamin B2 (riboflavin-5-phosphate)
- Vitamin B2 phosphate
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Iron deficiency anemia (ida) Combination Product in combination with: Ferrous gluconate (DB14488), Pyridoxine (DB00165), Thiamine (DB00152), Nicotinamide (DB02701) •••••••••••• ••••• Prophylaxis of Migraine ••• •••••• ••• ••• Used in combination to treat Vitamin b complex deficiency Combination Product in combination with: Nicotinamide (DB02701), Pyridoxine (DB00165), Ferrous gluconate (DB14488), Thiamine (DB00152) •••••••••••• ••••• Used in combination to prevent Vitamin deficiency •••••••••••• ••••••••• Used in combination to prevent Vitamin deficiency •••••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UFlavin reductase (NADPH) Not Available Humans UHydroxyacid oxidase 1 Not Available Humans UPyridoxine-5'-phosphate oxidase Not Available Humans UMajor NAD(P)H-flavin oxidoreductase Not Available Vibrio fischeri URiboflavin kinase Not Available Humans UOxygen-insensitive NADPH nitroreductase Not Available Escherichia coli (strain K12) UNitric oxide synthase, brain Not Available Humans UDihydroorotate dehydrogenase (quinone) Not Available Escherichia coli (strain K12) UDihydropyrimidine dehydrogenase [NADP(+)] Not Available Humans UDihydroorotate dehydrogenase (quinone), mitochondrial Not Available Humans UFlavodoxin Not Available Clostridium beijerinckii UOxygen-insensitive NAD(P)H nitroreductase Not Available Escherichia coli (strain K12) UChorismate synthase Not Available Streptococcus pneumoniae (strain ATCC BAA-255 / R6) U2,4-dienoyl-CoA reductase [NADPH] Not Available Escherichia coli (strain K12) UDihydroorotate dehydrogenase A (fumarate) Not Available Lactococcus lactis subsp. cremoris UPyridoxine/pyridoxamine 5'-phosphate oxidase Not Available Escherichia coli (strain K12) UPentaerythritol tetranitrate reductase Not Available Enterobacter cloacae UFMN-dependent NADH-azoreductase Not Available Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) UEpidermin decarboxylase Not Available Staphylococcus epidermidis UFMN-dependent NADH-azoreductase Not Available Escherichia coli (strain K12) UChorismate synthase Not Available Helicobacter pylori (strain ATCC 700392 / 26695) UFlavodoxin Not Available Nostoc sp. (strain PCC 7120 / UTEX 2576) UFlavodoxin Not Available Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) UFlavodoxin Not Available Synechococcus elongatus (strain PCC 7942) UPutative uncharacterized protein Not Available Streptococcus mutans serotype c (strain ATCC 700610 / UA159) UPutative monooxygenase MoxC Not Available Bacillus subtilis (strain 168) UtRNA-dihydrouridine synthase Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UProtein NrdI Not Available Bacillus subtilis (strain 168) UProbable aromatic acid decarboxylase Not Available Escherichia coli O157:H7 U(S)-mandelate dehydrogenase Not Available Pseudomonas putida UFMN-dependent NADPH-azoreductase Not Available Bacillus subtilis (strain 168) UFlavodoxin Not Available Helicobacter pylori (strain J99 / ATCC 700824) USerine/threonine-protein kinase Sgk1 Not Available Humans UOxygen-insensitive NAD(P)H nitroreductase Not Available Enterobacter cloacae UNitric oxide reductase Not Available Moorella thermoacetica (strain ATCC 39073) UIsopentenyl-diphosphate delta-isomerase Not Available Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) UTrimethylamine dehydrogenase Not Available Methylophilus methylotrophus URubredoxin-oxygen oxidoreductase Not Available Desulfovibrio gigas URiboflavin biosynthesis protein RibF Not Available Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) UMorphinone reductase Not Available Pseudomonas putida UNADPH-flavin oxidoreductase Not Available Vibrio harveyi URibosomal protein S6 kinase alpha-4 Not Available Humans UPhenazine biosynthesis protein PhzG Not Available Pseudomonas fluorescens UHydroxyacid oxidase 2 Not Available Humans UNAD(P)H dehydrogenase (quinone) Not Available Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) UFlavodoxin-1 Not Available Escherichia coli (strain K12) UIsopentenyl-diphosphate delta-isomerase Not Available Bacillus subtilis (strain 168) UNADH dehydrogenase Not Available Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) UFMN-binding protein Not Available Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637) UNitroreductase family protein Not Available Bacillus cereus (strain ATCC 14579 / DSM 31) UNADPH--cytochrome P450 reductase Not Available Humans UPhosphopantothenoylcysteine decarboxylase Not Available Humans UPhzG Not Available Pseudomonas aeruginosa UFerredoxin-dependent glutamate synthase 2 Not Available Synechocystis sp. (strain PCC 6803 / Kazusa) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Avoid alcohol. Ingesting alcohol may reduce the absorption of FMN.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Riboflavin 5'-phosphate sodium anhydrous 957E53WV42 130-40-5 OHSHFZJLPYLRIP-BMZHGHOISA-M Riboflavin sodium phosphate Not Available 130-40-5 Not applicable Riboflavin-5'-phosphate sodium salt dihydrate 20RD1DZH99 6184-17-4 LQVGUKOCMOKKJU-QPVGXXQTSA-M - Active Moieties
Name Kind UNII CAS InChI Key Riboflavin unknown TLM2976OFR 83-88-5 AUNGANRZJHBGPY-SCRDCRAPSA-N - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Photrexa Solution / drops 1.46 mg/1mL Ophthalmic Glaukos Corporation 2016-04-15 2022-10-01 US 
Photrexa Viscous Solution / drops 1.56 mg/1mL Ophthalmic Glaukos Corporation 2016-04-15 2022-10-01 US Riboflavin Inj 50mg/ml Solution 50 mg / mL Intramuscular; Intravenous Kripps Pharmacy Ltd. 1979-12-31 Not applicable Canada 
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Adult Infuvite Multiple Vitamins Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Dexpanthenol (15 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2005-05-18 Not applicable US Adult Infuvite Multiple Vitamins Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Dexpanthenol (15 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2003-06-16 Not applicable US Adult Infuvite Multiple Vitamins Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Dexpanthenol (15 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2003-06-16 Not applicable US Adult Infuvite Multiple Vitamins Riboflavin-5'-phosphate sodium salt dihydrate (3.6 mg/10mL) + Ascorbic acid (200 mg/10mL) + Biotin (60 ug/10mL) + Cholecalciferol (200 [iU]/10mL) + Cyanocobalamin (5 ug/10mL) + Dexpanthenol (15 mg/10mL) + Folic acid (600 ug/10mL) + Nicotinamide (40 mg/10mL) + Phylloquinone (150 ug/10mL) + Pyridoxine hydrochloride (6 mg/10mL) + Thiamine hydrochloride (6 mg/10mL) + Vitamin A palmitate (3300 [iU]/10mL) + alpha-Tocopherol acetate (10 [iU]/10mL) Injection, solution Intravenous Sandoz Inc 2005-05-18 Not applicable US Alsimine W Vitamins A D Riboflavin-5'-phosphate sodium salt dihydrate (2 mg / amp) + Calcium glycerophosphate (13 mg / amp) + Cyanocobalamin (10 mcg / amp) + Dexpanthenol (5 mg / amp) + Dexpanthenol (400 unit / amp) + Ferrous gluconate (16 mg / amp) + Nicotinamide (40 mg / amp) + Pyridoxine hydrochloride (3 mg / amp) + Thiamine hydrochloride (4.5 mg / amp) + Vitamin A (10000 unit / amp) Capsule; Liquid Oral Alsi Cie Ltee 1978-12-31 2003-05-21 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image B-plex 100 Riboflavin-5'-phosphate sodium salt dihydrate (2 mg/1mL) + Dexpanthenol (2 mg/1mL) + Nicotinamide (100 mg/1mL) + Pyridoxine hydrochloride (2 mg/1mL) + Thiamine hydrochloride (100 mg/1mL) Injection, solution Intramuscular; Intravenous Merit Pharmaceutical 2012-01-01 Not applicable US BumP DHA Flavin mononucleotide (2 mg/1) + Cobamamide (500 mg/1) + Flavin adenine dinucleotide (1 mg/1) + Iron (15 mg/1) + Leucovorin (1 mg/1) + Levomefolate magnesium (1 mg/1) + Magnesium oxide (125 mg/1) + NADH (25 ug/1) + Omega-3 fatty acids (300 mg/1) + Potassium Iodide (250 ug/1) + Pyridoxal phosphate (5 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Zinc glycinate (15 1/1) Capsule Oral Centurion Labs 2017-03-24 2017-04-17 US Floriva Plus Riboflavin-5'-phosphate sodium salt dihydrate (0.6 mg/1mL) + Ascorbic acid (32 mg/1mL) + Biotin (3 ug/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Levomefolate glucosamine (29.7 ug/1mL) + Nicotinamide (2 mg/1mL) + Pantothenic acid (1 mg/1mL) + Pyridoxine hydrochloride (0.4 mg/1mL) + Sodium fluoride (0.25 mg/1mL) + Thiamine hydrochloride (0.5 mg/1mL) + Vitamin A acetate (1150 [iU]/1mL) + Vitamin E (5 [iU]/1mL) Solution / drops Oral BonGeo Pharmaceuticals, Inc. 2016-06-20 2020-01-21 US Multi Vitamin and Fluoride Riboflavin-5'-phosphate sodium salt dihydrate (0.6 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Nicotinamide (8 mg/1mL) + Pyridoxine hydrochloride (0.4 mg/1mL) + Sodium fluoride (0.5 mg/1mL) + Thiamine hydrochloride (0.5 mg/1mL) + Vitamin A palmitate (1500 [iU]/1mL) + Vitamin E (5 [iU]/1mL) Solution / drops Oral Mayne Pharma 2011-05-21 2019-10-31 US Multi Vitamin and Fluoride Riboflavin-5'-phosphate sodium salt dihydrate (0.6 mg/1mL) + Ascorbic acid (35 mg/1mL) + Cholecalciferol (400 [iU]/1mL) + Cyanocobalamin (2 ug/1mL) + Nicotinamide (8 mg/1mL) + Pyridoxine hydrochloride (0.4 mg/1mL) + Sodium fluoride (0.25 mg/1mL) + Thiamine hydrochloride (0.5 mg/1mL) + Vitamin A palmitate (1500 [iU]/1mL) + Vitamin E (5 [iU]/1mL) Solution / drops Oral Mayne Pharma 2011-05-21 2019-10-31 US
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions.
- Kingdom
- Organic compounds
- Super Class
- Nucleosides, nucleotides, and analogues
- Class
- Flavin nucleotides
- Sub Class
- Not Available
- Direct Parent
- Flavin nucleotides
- Alternative Parents
- Flavins / Quinoxalines / Pyrimidones / Monoalkyl phosphates / Pyrazines / Benzenoids / Vinylogous amides / Heteroaromatic compounds / Secondary alcohols / Lactams show 6 more
- Substituents
- Alcohol / Alkyl phosphate / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Diazanaphthalene / Flavin / Flavin nucleotide / Heteroaromatic compound / Hydrocarbon derivative show 20 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- flavin mononucleotide (CHEBI:17621)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 7N464URE7E
- CAS number
- 146-17-8
- InChI Key
- FVTCRASFADXXNN-SCRDCRAPSA-N
- InChI
- InChI=1S/C17H21N4O9P/c1-7-3-9-10(4-8(7)2)21(15-13(18-9)16(25)20-17(26)19-15)5-11(22)14(24)12(23)6-30-31(27,28)29/h3-4,11-12,14,22-24H,5-6H2,1-2H3,(H,20,25,26)(H2,27,28,29)/t11-,12+,14-/m0/s1
- IUPAC Name
- {[(2R,3S,4S)-5-{7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl}-2,3,4-trihydroxypentyl]oxy}phosphonic acid
- SMILES
- CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0001520
- KEGG Compound
- C00061
- PubChem Compound
- 643976
- PubChem Substance
- 46507603
- ChemSpider
- 559060
- BindingDB
- 50421345
- ChEBI
- 17621
- ChEMBL
- CHEMBL1201794
- ZINC
- ZINC000003831425
- PDBe Ligand
- FMN
- Wikipedia
- Flavin_mononucleotide
- PDB Entries
- 1ag9 / 1ahn / 1akq / 1akr / 1akt / 1aku / 1akv / 1akw / 1al7 / 1al8 … show 1622 more
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Completed Treatment Keratoconus / Keratoconus, Unstable 1 4 Recruiting Treatment Acute Kidney Injury (AKI) 1 4 Terminated Treatment Myocardial Stunning 1 3 Completed Treatment Appetite; Lack or Loss, Nonorganic Origin 1 3 Completed Treatment HbA1c Level / Plasma Homocysteine 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Capsule; liquid Oral Tablet, coated Powder, for solution Intravenous Granule Oral Granule, effervescent Oral Injection, powder, for solution Intramuscular Injection, solution Intramuscular Suppository Rectal Capsule Oral Injection, powder, for solution Intramuscular; Intravenous Injection, powder, for solution Parenteral Injection, powder, for solution Intravenous Powder Oral Liquid Intramuscular; Intravenous Injection Intramuscular Tablet Oral Tablet, effervescent Oral Injection, solution, concentrate; kit Intravenous Injection, powder, lyophilized, for solution Intravenous Kit Intravenous Elixir Oral Solution / drops Oral Liquid Oral Solution Intravenous Solution Oral Liquid Intravenous Solution Intramuscular; Intravenous Powder Syrup Oral Injection, solution; kit Intravenous Injection, solution Intravenous Solution / drops Ophthalmic 1.46 mg/1mL Kit Ophthalmic Solution / drops Ophthalmic 1.56 mg/1mL Solution Intramuscular; Intravenous 50 mg / mL Tablet Oral 200.00 mg Liquid; tablet Oral Powder, for solution Oral Injection Intramuscular; Intravenous Injection Intravenous Injection, solution Intramuscular; Intravenous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.668 mg/mL ALOGPS logP -0.78 ALOGPS logP -1 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 1.5 Chemaxon pKa (Strongest Basic) -0.31 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 6 Chemaxon Polar Surface Area 201.58 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 107.14 m3·mol-1 Chemaxon Polarizability 42.19 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.9125 Blood Brain Barrier - 0.7057 Caco-2 permeable - 0.6779 P-glycoprotein substrate Substrate 0.7661 P-glycoprotein inhibitor I Non-inhibitor 0.7188 P-glycoprotein inhibitor II Non-inhibitor 0.9704 Renal organic cation transporter Non-inhibitor 0.9373 CYP450 2C9 substrate Non-substrate 0.7163 CYP450 2D6 substrate Non-substrate 0.821 CYP450 3A4 substrate Substrate 0.523 CYP450 1A2 substrate Non-inhibitor 0.6006 CYP450 2C9 inhibitor Non-inhibitor 0.8359 CYP450 2D6 inhibitor Non-inhibitor 0.8907 CYP450 2C19 inhibitor Non-inhibitor 0.6667 CYP450 3A4 inhibitor Non-inhibitor 0.7421 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.8922 Ames test Non AMES toxic 0.716 Carcinogenicity Non-carcinogens 0.8096 Biodegradation Not ready biodegradable 0.9737 Rat acute toxicity 2.4314 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9468 hERG inhibition (predictor II) Inhibitor 0.584
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 219.5184894 predictedDarkChem Lite v0.1.0 [M-H]- 221.2389894 predictedDarkChem Lite v0.1.0 [M-H]- 219.1865894 predictedDarkChem Lite v0.1.0 [M-H]- 220.8647894 predictedDarkChem Lite v0.1.0 [M-H]- 185.859 predictedDeepCCS 1.0 (2019) [M+H]+ 217.5823894 predictedDarkChem Lite v0.1.0 [M+H]+ 218.5692894 predictedDarkChem Lite v0.1.0 [M+H]+ 215.5575894 predictedDarkChem Lite v0.1.0 [M+H]+ 217.0184894 predictedDarkChem Lite v0.1.0 [M+H]+ 188.25455 predictedDeepCCS 1.0 (2019) [M+Na]+ 217.0201894 predictedDarkChem Lite v0.1.0 [M+Na]+ 218.1843894 predictedDarkChem Lite v0.1.0 [M+Na]+ 214.9935894 predictedDarkChem Lite v0.1.0 [M+Na]+ 195.0179 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Riboflavin reductase (nadph) activity
- Specific Function
- Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone)....
- Gene Name
- BLVRB
- Uniprot ID
- P30043
- Uniprot Name
- Flavin reductase (NADPH)
- Molecular Weight
- 22119.215 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Very-long-chain-(s)-2-hydroxy-acid oxidase activity
- Specific Function
- Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octano...
- Gene Name
- HAO1
- Uniprot ID
- Q9UJM8
- Uniprot Name
- Hydroxyacid oxidase 1
- Molecular Weight
- 40923.945 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Pyridoxamine-phosphate oxidase activity
- Specific Function
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name
- PNPO
- Uniprot ID
- Q9NVS9
- Uniprot Name
- Pyridoxine-5'-phosphate oxidase
- Molecular Weight
- 29987.79 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Vibrio fischeri
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Major FMN reductase. It is capable of using both NADH and NADPH as elect...
- Gene Name
- Not Available
- Uniprot ID
- P46072
- Uniprot Name
- Major NAD(P)H-flavin oxidoreductase
- Molecular Weight
- 24720.685 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Riboflavin kinase activity
- Specific Function
- Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (...
- Gene Name
- RFK
- Uniprot ID
- Q969G6
- Uniprot Name
- Riboflavin kinase
- Molecular Weight
- 17623.08 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on nad(p)h, nitrogenous group as acceptor
- Specific Function
- Reduction of nitroaromatic compounds using NADH. Reduces nitrofurazone by a ping-pong bi-bi mechanism possibly to generate a two-electron transfer product. Major component of the oxygen-insensitive...
- Gene Name
- nfsA
- Uniprot ID
- P17117
- Uniprot Name
- Oxygen-insensitive NADPH nitroreductase
- Molecular Weight
- 26800.375 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Tetrahydrobiopterin binding
- Specific Function
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. P...
- Gene Name
- NOS1
- Uniprot ID
- P29475
- Uniprot Name
- Nitric oxide synthase, brain
- Molecular Weight
- 160969.095 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name
- pyrD
- Uniprot ID
- P0A7E1
- Uniprot Name
- Dihydroorotate dehydrogenase (quinone)
- Molecular Weight
- 36774.185 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein homodimerization activity
- Specific Function
- Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
- Gene Name
- DPYD
- Uniprot ID
- Q12882
- Uniprot Name
- Dihydropyrimidine dehydrogenase [NADP(+)]
- Molecular Weight
- 111400.32 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ubiquinone binding
- Specific Function
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Gene Name
- DHODH
- Uniprot ID
- Q02127
- Uniprot Name
- Dihydroorotate dehydrogenase (quinone), mitochondrial
- Molecular Weight
- 42866.93 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Clostridium beijerinckii
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes.
- Gene Name
- Not Available
- Uniprot ID
- P00322
- Uniprot Name
- Flavodoxin
- Molecular Weight
- 15332.225 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Nad(p)h nitroreductase activity
- Specific Function
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinon...
- Gene Name
- nfsB
- Uniprot ID
- P38489
- Uniprot Name
- Oxygen-insensitive NAD(P)H nitroreductase
- Molecular Weight
- 23904.99 Da
References
- Kind
- Protein
- Organism
- Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
- Pharmacological action
- Unknown
- General Function
- Chorismate synthase activity
- Specific Function
- Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves ...
- Gene Name
- aroC
- Uniprot ID
- P0A2Y7
- Uniprot Name
- Chorismate synthase
- Molecular Weight
- 42871.475 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Nadph dehydrogenase activity
- Specific Function
- Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-2- enoyl-CoA.
- Gene Name
- fadH
- Uniprot ID
- P42593
- Uniprot Name
- 2,4-dienoyl-CoA reductase [NADPH]
- Molecular Weight
- 72677.545 Da
References
- Kind
- Protein
- Organism
- Lactococcus lactis subsp. cremoris
- Pharmacological action
- Unknown
- General Function
- Dihydroorotate dehydrogenase (fumarate) activity
- Specific Function
- Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
- Gene Name
- pyrDA
- Uniprot ID
- Q53ZE5
- Uniprot Name
- Dihydroorotate dehydrogenase A (fumarate)
- Molecular Weight
- 34209.99 Da
References
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Pyridoxamine-phosphate oxidase activity
- Specific Function
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name
- pdxH
- Uniprot ID
- P0AFI7
- Uniprot Name
- Pyridoxine/pyridoxamine 5'-phosphate oxidase
- Molecular Weight
- 25544.975 Da
References
- Kind
- Protein
- Organism
- Enterobacter cloacae
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- onr
- Uniprot ID
- P71278
- Uniprot Name
- Pentaerythritol tetranitrate reductase
- Molecular Weight
- 39488.93 Da
- Kind
- Protein
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on other nitrogenous compounds as donors
- Specific Function
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity.
- Gene Name
- azoR
- Uniprot ID
- P63462
- Uniprot Name
- FMN-dependent NADH-azoreductase
- Molecular Weight
- 21627.63 Da
- Kind
- Protein
- Organism
- Staphylococcus epidermidis
- Pharmacological action
- Unknown
- General Function
- Lyase activity
- Specific Function
- Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond.
- Gene Name
- epiD
- Uniprot ID
- P30197
- Uniprot Name
- Epidermin decarboxylase
- Molecular Weight
- 20824.89 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on nad(p)h, quinone or similar compound as acceptor
- Specific Function
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity. The enzyme can reduce ethyl ...
- Gene Name
- azoR
- Uniprot ID
- P41407
- Uniprot Name
- FMN-dependent NADH-azoreductase
- Molecular Weight
- 21657.47 Da
- Kind
- Protein
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves ...
- Gene Name
- aroC
- Uniprot ID
- P56122
- Uniprot Name
- Chorismate synthase
- Molecular Weight
- 40099.6 Da
- Kind
- Protein
- Organism
- Nostoc sp. (strain PCC 7120 / UTEX 2576)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes.
- Gene Name
- isiB
- Uniprot ID
- P0A3D9
- Uniprot Name
- Flavodoxin
- Molecular Weight
- 18963.675 Da
- Kind
- Protein
- Organism
- Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
- Pharmacological action
- Unknown
- General Function
- Iron ion binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes.
- Gene Name
- Not Available
- Uniprot ID
- P00323
- Uniprot Name
- Flavodoxin
- Molecular Weight
- 15823.215 Da
- Kind
- Protein
- Organism
- Synechococcus elongatus (strain PCC 7942)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes.
- Gene Name
- isiB
- Uniprot ID
- P10340
- Uniprot Name
- Flavodoxin
- Molecular Weight
- 18777.495 Da
- Kind
- Protein
- Organism
- Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q8DW21
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 22384.165 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific Function
- May play a role in methionine degradation. May play a role in a sulfur salvage pathway.
- Gene Name
- moxC
- Uniprot ID
- O34974
- Uniprot Name
- Putative monooxygenase MoxC
- Molecular Weight
- 49410.955 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Trna dihydrouridine synthase activity
- Specific Function
- Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.
- Gene Name
- Not Available
- Uniprot ID
- Q9WXV1
- Uniprot Name
- tRNA-dihydrouridine synthase
- Molecular Weight
- 35149.495 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Probably involved in ribonucleotide reductase function.
- Gene Name
- nrdI
- Uniprot ID
- P50618
- Uniprot Name
- Protein NrdI
- Molecular Weight
- 14602.575 Da
- Kind
- Protein
- Organism
- Escherichia coli O157:H7
- Pharmacological action
- Unknown
- General Function
- Prenyltransferase activity
- Specific Function
- Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for phenolic acid decarboxylase C (By similarity). Involved in the decarboxylation and detoxificati...
- Gene Name
- ecdB
- Uniprot ID
- P69772
- Uniprot Name
- Probable UbiX-like flavin prenyltransferase
- Molecular Weight
- 21469.72 Da
- Kind
- Protein
- Organism
- Pseudomonas putida
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Reduction of (S)-mandelate to benzoylformate.
- Gene Name
- mdlB
- Uniprot ID
- P20932
- Uniprot Name
- (S)-mandelate dehydrogenase
- Molecular Weight
- 43436.53 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADPH, but not NADH, as an electron donor for its activity.
- Gene Name
- azr
- Uniprot ID
- O07529
- Uniprot Name
- FMN-dependent NADPH-azoreductase
- Molecular Weight
- 18903.755 Da
- Kind
- Protein
- Organism
- Helicobacter pylori (strain J99 / ATCC 700824)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes.
- Gene Name
- fldA
- Uniprot ID
- Q9ZK53
- Uniprot Name
- Flavodoxin
- Molecular Weight
- 17473.305 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Sodium channel regulator activity
- Specific Function
- Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell gr...
- Gene Name
- SGK1
- Uniprot ID
- O00141
- Uniprot Name
- Serine/threonine-protein kinase Sgk1
- Molecular Weight
- 48941.96 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Enterobacter cloacae
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred.
- Gene Name
- nfsB
- Uniprot ID
- Q01234
- Uniprot Name
- Oxygen-insensitive NAD(P)H nitroreductase
- Molecular Weight
- 23949.98 Da
- Kind
- Protein
- Organism
- Moorella thermoacetica (strain ATCC 39073)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Has nitric oxide reductase activity in combination with Hrb; probably involved in nitrosative stress protection.
- Gene Name
- fprA
- Uniprot ID
- Q9FDN7
- Uniprot Name
- Nitric oxide reductase
- Molecular Weight
- 44296.64 Da
- Kind
- Protein
- Organism
- Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
- Gene Name
- fni
- Uniprot ID
- Q746I8
- Uniprot Name
- Isopentenyl-diphosphate delta-isomerase
- Molecular Weight
- 35900.305 Da
- Kind
- Protein
- Organism
- Methylophilus methylotrophus
- Pharmacological action
- Unknown
- General Function
- Trimethylamine dehydrogenase activity
- Specific Function
- Not Available
- Gene Name
- tmd
- Uniprot ID
- P16099
- Uniprot Name
- Trimethylamine dehydrogenase
- Molecular Weight
- 81628.615 Da
- Kind
- Protein
- Organism
- Desulfovibrio gigas
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Catalyzes the four-electron reduction of one oxygen molecule to two water molecules.
- Gene Name
- roo
- Uniprot ID
- Q9F0J6
- Uniprot Name
- Rubredoxin-oxygen oxidoreductase
- Molecular Weight
- 44796.045 Da
- Kind
- Protein
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Pharmacological action
- Unknown
- General Function
- Riboflavin kinase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9WZW1
- Uniprot Name
- Riboflavin biosynthesis protein
- Molecular Weight
- 33613.56 Da
- Kind
- Protein
- Organism
- Pseudomonas putida
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- morB
- Uniprot ID
- Q51990
- Uniprot Name
- Morphinone reductase
- Molecular Weight
- 41249.71 Da
- Kind
- Protein
- Organism
- Vibrio harveyi
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction.
- Gene Name
- frp
- Uniprot ID
- Q56691
- Uniprot Name
- NADPH-flavin oxidoreductase
- Molecular Weight
- 26309.475 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Ribosomal protein s6 kinase activity
- Specific Function
- Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor REL...
- Gene Name
- RPS6KA4
- Uniprot ID
- O75676
- Uniprot Name
- Ribosomal protein S6 kinase alpha-4
- Molecular Weight
- 85605.025 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Pseudomonas fluorescens
- Pharmacological action
- Unknown
- General Function
- Pyridoxamine-phosphate oxidase activity
- Specific Function
- Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. Probably catalyzes the...
- Gene Name
- phzG
- Uniprot ID
- Q51793
- Uniprot Name
- Phenazine biosynthesis protein PhzG
- Molecular Weight
- 24934.955 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Very-long-chain-(s)-2-hydroxy-acid oxidase activity
- Specific Function
- Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.
- Gene Name
- HAO2
- Uniprot ID
- Q9NYQ3
- Uniprot Name
- Hydroxyacid oxidase 2
- Molecular Weight
- 38838.35 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Pharmacological action
- Unknown
- General Function
- Nad(p)h dehydrogenase (quinone) activity
- Specific Function
- It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone stat...
- Gene Name
- Not Available
- Uniprot ID
- Q9RYU4
- Uniprot Name
- NAD(P)H dehydrogenase (quinone)
- Molecular Weight
- 21297.875 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Fmn binding
- Specific Function
- Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.
- Gene Name
- fldA
- Uniprot ID
- P61949
- Uniprot Name
- Flavodoxin-1
- Molecular Weight
- 19736.735 Da
- Kind
- Protein
- Organism
- Bacillus subtilis (strain 168)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
- Gene Name
- fni
- Uniprot ID
- P50740
- Uniprot Name
- Isopentenyl-diphosphate delta-isomerase
- Molecular Weight
- 37220.19 Da
- Kind
- Protein
- Organism
- Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
- Pharmacological action
- Unknown
- General Function
- Nadh dehydrogenase activity
- Specific Function
- Can oxidize either NADH or NADPH with a preference for NADH. Can catalyze electron transfer from NADH to various electron acceptors which include, in addition to molecular oxygen, cytochrome c, 2,6...
- Gene Name
- nox
- Uniprot ID
- Q60049
- Uniprot Name
- NADH dehydrogenase
- Molecular Weight
- 22730.15 Da
- Kind
- Protein
- Organism
- Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
- Pharmacological action
- Unknown
- General Function
- Pyridoxamine-phosphate oxidase activity
- Specific Function
- Functions as a redox protein with a potential of -325 mV.
- Gene Name
- Not Available
- Uniprot ID
- Q46604
- Uniprot Name
- FMN-binding protein
- Molecular Weight
- 13137.025 Da
- Kind
- Protein
- Organism
- Bacillus cereus (strain ATCC 14579 / DSM 31)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q81EW9
- Uniprot Name
- Nitroreductase family protein
- Molecular Weight
- 22822.865 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
- Specific Function
- This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
- Gene Name
- POR
- Uniprot ID
- P16435
- Uniprot Name
- NADPH--cytochrome P450 reductase
- Molecular Weight
- 76689.12 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phosphopantothenoylcysteine decarboxylase activity
- Specific Function
- Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
- Gene Name
- PPCDC
- Uniprot ID
- Q96CD2
- Uniprot Name
- Phosphopantothenoylcysteine decarboxylase
- Molecular Weight
- 22394.965 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa
- Pharmacological action
- Unknown
- General Function
- Pyridoxamine-phosphate oxidase activity
- Specific Function
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name
- phzG
- Uniprot ID
- O69755
- Uniprot Name
- Phenazine biosynthesis protein
- Molecular Weight
- 24268.005 Da
- Kind
- Protein
- Organism
- Synechocystis sp. (strain PCC 6803 / Kazusa)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Not Available
- Gene Name
- gltS
- Uniprot ID
- P55038
- Uniprot Name
- Ferredoxin-dependent glutamate synthase 2
- Molecular Weight
- 169497.705 Da
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Ligand
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
- Specific Function
- This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
- Gene Name
- POR
- Uniprot ID
- P16435
- Uniprot Name
- NADPH--cytochrome P450 reductase
- Molecular Weight
- 76689.12 Da
References
- Narayanasami R, Horowitz PM, Masters BS: Flavin-binding and protein structural integrity studies on NADPH-cytochrome P450 reductase are consistent with the presence of distinct domains. Arch Biochem Biophys. 1995 Jan 10;316(1):267-74. doi: 10.1006/abbi.1995.1037. [Article]
- Makovec T, Breskvar K: Purification and characterization of NADPH-cytochrome P450 reductase from filamentous fungus Rhizopus nigricans. Arch Biochem Biophys. 1998 Sep 15;357(2):310-6. doi: 10.1006/abbi.1998.0824. [Article]
- Wang M, Roberts DL, Paschke R, Shea TM, Masters BS, Kim JJ: Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8411-6. doi: 10.1073/pnas.94.16.8411. [Article]
Drug created at June 13, 2005 13:24 / Updated at February 20, 2024 23:55