Iodine

Identification

Summary

Iodine is an ingredient of nutritional supplements that is also used for disinfection.

Brand Names

Sclerodine, Vitafol-one, Xylocaine With Epinephrine

Generic Name

Iodine

DrugBank Accession Number

DB05382

Background

Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.^1,2,3,4

Type

Small Molecule

Groups

Approved, Investigational

Structure

Similar Structures

Weight: Average: 253.8089
Monoisotopic: 253.80893684
Chemical Formula: I₂

Synonyms

diiodine
I2
Iodine
iodo
Jod
molecular iodine

External IDs

NSC-42355

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Pharmacology

Indication

Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic).

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Prophylaxis of	Infection in minor cuts, scrapes, or burns		••• •••			••••••••

Associated Therapies

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-nitrosourea-induced mammary carcinogenesis, to regress 7,12-dimethylbenz(a)anthracene-induced breast tumors in rats.It has also been shown to have beneficial effects in fibrocystic human breast disease.

Target	Actions	Organism
ASodium/iodide cotransporter	substrate	Humans
AMicrobial proteins	unknown

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Avoid goitrogenic foods. These include soy, cassava, cabbage, broccoli, cauliflower, and other cruciferous vegetables.

Products

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International/Other Brands

IoGen

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Lugols Solution	Liquid	0.4 g/1g	Topical	Gordon Laboratories	2010-02-01	Not applicable
Lugols Solution	Solution	1 g/5g	Transdermal	PURTEX INC	2017-01-27	Not applicable
Sky-Living Water MT Activition Liquid	Liquid	2.5 g/100mL	Oral	Wings Biomedical Technology Co., Ltd.	2015-10-15	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
Alphadine Scrub	Solution	7.5 mg/100mL	Topical	Ecolab Inc.	2000-02-05	2018-01-17
Colloidal Iodine	Solution	2 g/100mL	Topical	JCI INSTITUTE OF MEDICAL SCIENCE	2014-08-27	Not applicable
Colloidal Iodine Ophthalmic	Solution	0.1 g/100mL	Topical	JCI INSTITUTE OF MEDICAL SCIENCE	2014-08-27	Not applicable
Colloidal Iodine Solution	Solution	2 g/100mL	Oral	JCI Colloidal Iodine Laboratory Co., Ltd.	2023-05-18	Not applicable
Colloidal Iodineinjection	Solution	2 g/100mL	Subcutaneous	JCI INSTITUTE OF MEDICAL SCIENCE	2019-09-14	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
3M DURAPREP® SURGICAL SOLUTION	Iodine (0.12 % v/v) + Isopropyl alcohol (60.61 % v/v)	Solution	Topical	3M COLOMBIA S.A.	2006-11-10	2015-08-03
Adult Formula 50+	Iodine (0.15 mg) + Ascorbic acid (120 mg) + Beta carotene (3000 unit) + Biotin (30 mcg) + Calcium (220 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Manganese (2.5 mg) + Molybdenum (10 mcg) + Nicotinamide (20 mg) + Calcium pantothenate (20 mg) + Potassium (37.5 mg) + Pyridoxine hydrochloride (6 mg) + Riboflavin (3.4 mg) + Selenium (10 mcg) + Thiamine hydrochloride (4.5 mg) + Vitamin A palmitate (3000 unit) + Zinc (15 mg) + alpha-Tocopherol acetate (60 unit)	Tablet	Oral	Wn Pharmaceuticals Ltd.	2002-04-25	2009-09-28
Alkadrenergy Tablets	Iodine (0.1 mg) + Ascorbic acid (60 mg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Calcium (50 mg) + Choline (100 mg) + Chromic chloride (5 mcg) + Cyanocobalamin (45 mcg) + Folic acid (0.2 mg) + Inositol (25 mg) + Magnesium (50 mg) + Manganese (0.5 mg) + Molybdenum (3 mcg) + Nicotinamide (40 mg) + Pantothenic acid (15 mg) + Pyridoxine hydrochloride (6.25 mg) + Riboflavin (6.25 mg) + Sodium selenite (37.5 mcg) + Thiamine (6.25 mg) + Zinc (9 mg) + alpha-Tocopherol acetate (15 unit)	Tablet	Oral	Morter Healthsystem	Not applicable	Not applicable
Anaplex Tab	Iodine (.05 mg / tab) + Ascorbic acid (40 mg / tab) + Calcium (160 mg / tab) + Magnesium oxide (50 mg / tab) + Nicotinamide (30 mg / tab) + Calcium pantothenate (15 mg / tab) + Phosphorus (75.33 mg / tab) + Potassium chloride (20 mg / tab) + Pyridoxine hydrochloride (40 mg / tab) + Vitamin A palmitate (2000 unit / tab) + Vitamin D (133.33 unit / tab)	Tablet	Oral	Anabolic Laboratories Inc.	1975-12-31	1996-10-02
B.E.T. Complex	Iodine (0.15 mg) + Beta carotene (1250 unit) + Calcium ascorbate (75 mg) + Chromium (400 mcg) + Cyanocobalamin (100 mcg) + Folic acid (0.2 mg) + Magnesium (200 mg) + Manganese (5 mg) + Nicotinamide (35 mg) + Sodium metavanadate (75 mcg) + Ubidecarenone (10 mg) + Vitamin A palmitate (1250 unit) + alpha-Tocopherol succinate (50 unit)	Tablet	Oral	Abundance Naturally Ltd	2000-12-06	2004-06-30

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Bal-Care DHA	Iodine (.223 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Pru Gen Pharmaceuticals	2012-05-01	Not applicable
Bal-Care DHA Essential	Iodine (.223 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iron sucrose (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Pru Gen Pharmaceuticals	2012-05-01	Not applicable
Cavan Alpha	Iodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic acid (1 mg/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)	Kit	Oral	Seton Pharmaceuticals	2010-07-01	2013-09-30
CitraNatal Assure	Iodine (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + Doconexent (300 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.75 mg/1) + Iron (35 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc (25 mg/1)	Kit	Oral	Mission Pharmacal	2008-11-19	Not applicable
CitraNatal Assure	Iodine (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + Doconexent (300 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (0.75 mg/1) + Iron (35 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc (25 mg/1)	Capsule; Kit; Tablet, coated	Oral	Mission Pharmacal Company	2014-04-30	Not applicable

Chemical Identifiers

UNII: 9679TC07X4
CAS number: 7553-56-2
InChI Key: PNDPGZBMCMUPRI-UHFFFAOYSA-N
InChI: InChI=1S/I2/c1-2
IUPAC Name: diiodine
SMILES: II

References

General References

Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM: Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006 Jul 14;281(28):19762-71. Epub 2006 May 5. [Article]
Moreno-Vega A, Vega-Riveroll L, Ayala T, Peralta G, Torres-Martel JM, Rojas J, Mondragon P, Dominguez A, De Obaldia R, Avecilla-Guerrero C, Anguiano B, Delgado-Gonzalez E, Zambrano-Estrada X, Cuenca-Mico O, De La Puente Flores O, Varela-Echavarria A, Aceves C: Adjuvant Effect of Molecular Iodine in Conventional Chemotherapy for Breast Cancer. Randomized Pilot Study. Nutrients. 2019 Jul 17;11(7). pii: nu11071623. doi: 10.3390/nu11071623. [Article]
Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ: Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine. Int J Med Sci. 2008 Jul 8;5(4):189-96. doi: 10.7150/ijms.5.189. [Article]
Rappaport J: Changes in Dietary Iodine Explains Increasing Incidence of Breast Cancer with Distant Involvement in Young Women. J Cancer. 2017 Jan 13;8(2):174-177. doi: 10.7150/jca.17835. eCollection 2017. [Article]
McDonnell G, Russell AD: Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79. [Article]
DailyMed: CVS Iodine [Link]
Drugs.com: Iodine tincture information [Link]
Mayo Clinic: Topical iodine side effects [Link]
NIH Statpearls: Physiology, thyroid hormone [Link]
NIH StatPearls: Skin (integument) antiseptics [Link]

External Links

Human Metabolome Database: HMDB0000675
KEGG Drug: D00108
KEGG Compound: C01382
PubChem Compound: 807
PubChem Substance: 175426989
ChemSpider: 785
RxNav: 5933
ChEBI: 17606
ChEMBL: CHEMBL1201225
PDBe Ligand: I2I
Wikipedia: Iodine

PDB Entries

4r1t / 6pkg / 6uio

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Diagnostic	Coronary Artery Disease (CAD) / Coronary Stenosis	1
4	Completed	Prevention	Transient Hypothyroxinemia	1
4	Recruiting	Prevention	Aseptic Revision Total Hip Arthroplasty / Total Knee Arthroplasty With Exchange of at Least One Prosthetic Component	1
4	Recruiting	Prevention	Neurodevelopmental Disorders / Nutrition Disorder, Fetal / Pregnancy Related	1
4	Recruiting	Treatment	Hyperthyroidism, Autoimmune	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Injection, solution, concentrate	Intravenous
Solution	Topical	7.5 mg/100mL
Rinse	Oral	6.8 %
Capsule; kit; tablet, coated	Oral
Kit	Oral
Solution	Topical	0.1 g/100mL
Solution	Oral	2 g/100mL
Solution	Subcutaneous	2 g/100mL
Kit	Topical
Capsule, gelatin coated; kit; tablet	Oral
Liquid	Topical	.75 %
Liquid	Oral
Spray	Nasal
Spray	Nasal	0.9 mg/100mL
Tablet	Oral	.15 mg / tab
Solution	Topical
Tablet	Oral	0.15 mg / tab
Strip	Topical	5 %
Tincture	Topical	20 mg/1mL
Tablet	Oral	3 mg
Spray	Topical
Tincture	Topical
Solution / drops	Topical	20 mg/1mL
Ointment
Solution	Topical	7 %/5%
Solution	Topical
Solution	Oral
Liquid	Topical	20 mg/1mL
Solution	Intra-arterial; Intrathecal; Intravenous
Injection	Intracavitary; Intravascular
Injection, solution	Intrathecal; Intravascular	300 MG/ML
Injection		300 MG/ml
Injection		370 MG/ml
Insert	Vaginal	20 mg
Syrup	Oral
Solution	Topical	2 g/100mL
Injection, solution	Intra-arterial; Intravenous
Tablet	Oral	.3 mg / tab
Tablet	Oral	150 mcg
Injection	Intramuscular
Liquid	Oral	.15 mg / .04 mL
Liquid	Topical	0.4 g/1g
Solution	Transdermal	1 g/5g
Solution	Oral	350 mg
Tablet	Oral
Solution	Intravascular
Solution	Ophthalmic; Topical	5 mg
Liquid	Topical	1 %
Aerosol, spray	Topical	0.1 g/1g
Capsule, coated	Oral
Tablet, film coated	Oral
Solution	Topical	1 g
Injection, solution; kit; solution	Infiltration; Perineural; Topical
Liquid	Topical
Capsule, gelatin coated	Oral
Liquid	Intravenous
Liquid	Oral	2.5 g/100mL
Solution / drops	Oral
Tablet, extended release	Oral
Liquid	Topical	5 %
Powder, for solution	Oral
Capsule	Oral
Injection, solution	Intrathecal; Intravascular	240 mg/ml
Injection, solution	Intrathecal; Intravascular	370 mg/ml
Tablet
Liquid	Vaginal	1 %
Tablet, coated	Oral
Capsule, liquid filled; kit	Oral
Capsule, liquid filled	Oral
Tablet, chewable	Oral
Injection, solution	Intravascular
Solution

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	1.36	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	0	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	0 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	26.68 m³·mol^-1	Chemaxon
Polarizability	10.18 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Property	Value	Probability
Human Intestinal Absorption	+	0.9789
Blood Brain Barrier	+	0.9786
Caco-2 permeable	+	0.6632
P-glycoprotein substrate	Non-substrate	0.8984
P-glycoprotein inhibitor I	Non-inhibitor	0.9714
P-glycoprotein inhibitor II	Non-inhibitor	0.9923
Renal organic cation transporter	Non-inhibitor	0.921
CYP450 2C9 substrate	Non-substrate	0.8498
CYP450 2D6 substrate	Non-substrate	0.7906
CYP450 3A4 substrate	Non-substrate	0.7855
CYP450 1A2 substrate	Non-inhibitor	0.615
CYP450 2C9 inhibitor	Non-inhibitor	0.812
CYP450 2D6 inhibitor	Non-inhibitor	0.8992
CYP450 2C19 inhibitor	Non-inhibitor	0.8566
CYP450 3A4 inhibitor	Non-inhibitor	0.9008
CYP450 inhibitory promiscuity	Low CYP Inhibitory Promiscuity	0.8954
Ames test	Non AMES toxic	0.8029
Carcinogenicity	Carcinogens	0.7427
Biodegradation	Not ready biodegradable	0.7303
Rat acute toxicity	3.0004 LD50, mol/kg	Not applicable
hERG inhibition (predictor I)	Weak inhibitor	0.9452
hERG inhibition (predictor II)	Non-inhibitor	0.971

ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted GC-MS Spectrum - GC-MS	Predicted GC-MS	splash10-0udi-0090000000-0b4eb980a6d80c2892dd
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0udi-0090000000-d80218a1199b8de0e843
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0udi-0090000000-d80218a1199b8de0e843
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0udi-0090000000-d80218a1199b8de0e843

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å²)	Source type	Source
[M-H]-	125.24487	predicted	DeepCCS 1.0 (2019)
[M+H]+	127.14041	predicted	DeepCCS 1.0 (2019)
[M+Na]+	135.56676	predicted	DeepCCS 1.0 (2019)

Targets

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Details1. Sodium/iodide cotransporter

Kind: Protein
Organism: Humans
Pharmacological action: Yes
Actions: Substrate

General Function: Mediates iodide uptake in the thyroid gland.
Specific Function: Iodide transmembrane transporter activity
Gene Name: SLC5A5
Uniprot ID: Q92911
Uniprot Name: Sodium/iodide cotransporter
Molecular Weight: 68665.63 Da

References

Bizhanova A, Kopp P: Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009 Mar;150(3):1084-90. doi: 10.1210/en.2008-1437. Epub 2009 Feb 5. [Article]
NIH Statpearls: Physiology, thyroid hormone [Link]

2. Microbial proteins

Kind

Group

Organism

Not Available

Pharmacological action

Yes

Actions

Unknown

References

NIH StatPearls: Skin (integument) antiseptics [Link]

Enzymes

Details1. Thyroid peroxidase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Substrate

General Function: Peroxidase activity
Specific Function: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Gene Name: TPO
Uniprot ID: P07202
Uniprot Name: Thyroid peroxidase
Molecular Weight: 102961.63 Da

References

Magnusson RP, Taurog A, Dorris ML: Mechanisms of thyroid peroxidase- and lactoperoxidase-catalyzed reactions involving iodide. J Biol Chem. 1984 Nov 25;259(22):13783-90. [Article]
Fragu P: [Peroxidase and human thyroid hormone synthesis disorders (author's transl)]. Sem Hop. 1981 Jun 8-15;57(21-24):1130-8. [Article]

Carriers

Details1. Serum albumin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Binder

General Function: Toxic substance binding
Specific Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name: ALB
Uniprot ID: P02768
Uniprot Name: Serum albumin
Molecular Weight: 69365.94 Da

References

Acland JD: The interpretation of the serum protein-bound iodine: A review. J Clin Pathol. 1971 Apr;24(3):187-218. doi: 10.1136/jcp.24.3.187. [Article]

Details2. Thyroglobulin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Binder

General Function: Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity).
Specific Function: Hormone activity
Gene Name: TG
Uniprot ID: P01266
Uniprot Name: Thyroglobulin
Molecular Weight: 304787.525 Da

References

Acland JD: The interpretation of the serum protein-bound iodine: A review. J Clin Pathol. 1971 Apr;24(3):187-218. doi: 10.1136/jcp.24.3.187. [Article]
Ma ZF, Skeaff SA: Thyroglobulin as a biomarker of iodine deficiency: a review. Thyroid. 2014 Aug;24(8):1195-209. doi: 10.1089/thy.2014.0052. Epub 2014 Jun 12. [Article]

Transporters

Details1. Sodium/iodide cotransporter

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Mediates iodide uptake in the thyroid gland.
Specific Function: Iodide transmembrane transporter activity
Gene Name: SLC5A5
Uniprot ID: Q92911
Uniprot Name: Sodium/iodide cotransporter
Molecular Weight: 68665.63 Da

References

Pesce L, Kopp P: Iodide transport: implications for health and disease. Int J Pediatr Endocrinol. 2014;2014(1):8. doi: 10.1186/1687-9856-2014-8. Epub 2014 May 30. [Article]
Hingorani M, Spitzweg C, Vassaux G, Newbold K, Melcher A, Pandha H, Vile R, Harrington K: The biology of the sodium iodide symporter and its potential for targeted gene delivery. Curr Cancer Drug Targets. 2010 Mar;10(2):242-67. doi: 10.2174/156800910791054194. [Article]

Details2. Pendrin

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Sodium-independent transporter of chloride and iodide.
Specific Function: Anion
Gene Name: SLC26A4
Uniprot ID: O43511
Uniprot Name: Pendrin
Molecular Weight: 85722.155 Da

References

Bizhanova A, Kopp P: Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology. 2009 Mar;150(3):1084-90. doi: 10.1210/en.2008-1437. Epub 2009 Feb 5. [Article]
NIH Statpearls: Physiology, thyroid hormone [Link]

Drug created at November 18, 2007 18:24 / Updated at February 20, 2024 23:55

Iodine

Identification

Structure for Iodine (DB05382)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References

References

Enzymes

References

Carriers

References

References

Transporters

References

References