Hydronidone
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Hydronidone
- DrugBank Accession Number
- DB06299
- Background
Hydronidone has antifibrotic activity.
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 201.225
Monoisotopic: 201.078978598 - Chemical Formula
- C12H11NO2
- Synonyms
- N-(4-Hydroxyphenyl)-5-methyl-2-pyridone
- External IDs
- F 351
- F-351
- F351
Pharmacology
- Indication
Investigated for use/treatment in liver disease.
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as pyridinones. These are compounds containing a pyridine ring, which bears a ketone.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Pyridines and derivatives
- Sub Class
- Hydropyridines
- Direct Parent
- Pyridinones
- Alternative Parents
- Methylpyridines / Dihydropyridines / 1-hydroxy-2-unsubstituted benzenoids / Benzene and substituted derivatives / Heteroaromatic compounds / Lactams / Azacyclic compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides show 1 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / Aromatic heteromonocyclic compound / Azacycle / Benzenoid / Dihydropyridine / Heteroaromatic compound / Hydrocarbon derivative / Lactam / Methylpyridine / Monocyclic benzene moiety show 7 more
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- RXQ128313W
- CAS number
- 851518-71-3
- InChI Key
- NETTXQJYJRFTFS-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H11NO2/c1-9-2-7-12(15)13(8-9)10-3-5-11(14)6-4-10/h2-8,14H,1H3
- IUPAC Name
- 1-(4-hydroxyphenyl)-5-methyl-1,2-dihydropyridin-2-one
- SMILES
- CC1=CN(C(=O)C=C1)C1=CC=C(O)C=C1
References
- General References
- Not Available
- External Links
- ChemSpider
- 9392955
- ZINC
- ZINC000021981322
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 3 Recruiting Treatment Fibrosis, Liver 2 2 Completed Treatment Chronic Hepatitis B Infection 1 1 Completed Basic Science Hepatitis b & Liver Dysfunction 1 1 Completed Basic Science Hydronidone 1 1 Completed Basic Science Pharmacokinetics of Hydronidone 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 3.15 mg/mL ALOGPS logP 1.63 ALOGPS logP 1.84 Chemaxon logS -1.8 ALOGPS pKa (Strongest Acidic) 9.3 Chemaxon pKa (Strongest Basic) -1.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 40.54 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 58.98 m3·mol-1 Chemaxon Polarizability 21.3 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0udi-0090000000-f1682f45c7debe3cb8bb Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-0090000000-33bdb8975d986c698a41 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-0uk9-0940000000-3625deadc96d0e7e41b3 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-0fka-0930000000-748dffe1884b1bcd4e04 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0n29-7900000000-c32da729603639e99632 Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-05fr-2900000000-19f134dcd69c4794f6bf Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 153.1540121 predictedDarkChem Lite v0.1.0 [M+H]+ 153.7076121 predictedDarkChem Lite v0.1.0 [M+Na]+ 152.8439121 predictedDarkChem Lite v0.1.0
Drug created at March 19, 2008 16:23 / Updated at June 12, 2020 16:52