NAV

Remacemide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Remacemide
DrugBank Accession Number
DB06458
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
3D
Similar Structures
Weight
Average: 268.36
Monoisotopic: 268.157563272
Chemical Formula
C17H20N2O
Synonyms
  • Remacemide
External IDs
  • AR-R-12924
  • FPL-12924
  • PR-934-423
  • PR-934423A
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Pharmacology

Indication

Investigated for use/treatment in epilepsy, huntington's disease, and parkinson's disease.

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
1,2-BenzodiazepineThe risk or severity of CNS depression can be increased when Remacemide is combined with 1,2-Benzodiazepine.
AbemaciclibThe serum concentration of Abemaciclib can be increased when it is combined with Remacemide.
AcalabrutinibThe serum concentration of Acalabrutinib can be increased when it is combined with Remacemide.
AcenocoumarolThe serum concentration of Acenocoumarol can be increased when it is combined with Remacemide.
AcetazolamideThe risk or severity of CNS depression can be increased when Acetazolamide is combined with Remacemide.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Remacemide HydrochlorideI1ST2B6HIM111686-79-4HYQMIUSWZXGTCC-UHFFFAOYSA-N

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
EH6763C1IC
CAS number
128298-28-2
InChI Key
YSGASDXSLKIKOD-UHFFFAOYSA-N
InChI
InChI=1S/C17H20N2O/c1-17(19-16(20)13-18,15-10-6-3-7-11-15)12-14-8-4-2-5-9-14/h2-11H,12-13,18H2,1H3,(H,19,20)
IUPAC Name
2-amino-N-(1,2-diphenylpropan-2-yl)acetamide
SMILES
CC(CC1=CC=CC=C1)(NC(=O)CN)C1=CC=CC=C1

References

General References
Not Available
ChemSpider
54551
BindingDB
50239381
ChEBI
91654
ChEMBL
CHEMBL25843
Wikipedia
Remacemide

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00895 mg/mLALOGPS
logP2.48ALOGPS
logP2.35Chemaxon
logS-4.5ALOGPS
pKa (Strongest Acidic)13.61Chemaxon
pKa (Strongest Basic)8.14Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area55.12 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity81.01 m3·mol-1Chemaxon
Polarizability30.15 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-03di-2490000000-25df8ea425cfb46120d5
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0296-9580000000-05839e615f6d113cb5f2
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-07vi-5930000000-bfec784b7794b44ed8d6
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0gbc-6900000000-ebf05331e97cff4c3820
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-002f-9500000000-da5fa2a7e9f39a8a4f86
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-014l-3900000000-29d0fa2feb2a4b96ae7d
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-160.99144
predicted
DeepCCS 1.0 (2019)
[M+H]+163.34944
predicted
DeepCCS 1.0 (2019)
[M+Na]+169.44258
predicted
DeepCCS 1.0 (2019)

Enzymes

Details1. Cytochrome P450 3A4
Kind
Protein
Organism
Humans
Pharmacological action
No
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Spina E, Pisani F, Perucca E: Clinically significant pharmacokinetic drug interactions with carbamazepine. An update. Clin Pharmacokinet. 1996 Sep;31(3):198-214. doi: 10.2165/00003088-199631030-00004. [Article]

Drug created at March 19, 2008 16:34 / Updated at February 21, 2021 18:52