Identification
- Summary
Manganese is a transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).
- Brand Names
- Concept Ob, Multitrace-4, Multitrace-5, Multrys, Tandem Plus
- Generic Name
- Manganese
- DrugBank Accession Number
- DB06757
- Background
Manganese is a transition metal with a molar mass of 54.94g/mol. Manganese is considered critical for human health, and plays important roles in development, metabolism, and the antioxidant system. That said, excessive manganese intake is associated with manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms.
- Type
- Small Molecule
- Groups
- Approved, Nutraceutical
- Structure
Structure for Manganese (DB06757)
- Weight
- Average: 54.938
Monoisotopic: 54.938049636 - Chemical Formula
- Mn
- Synonyms
- Not Available
Pharmacology
- Indication
Indicated for use as a supplement to intravenous solutions given for Total Parenteral Nutrition (TPN). Administration helps to maintain plasma levels and to prevent depletion of endogenous stores and subsequent deficiency symptoms.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UIsocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Not Available Humans UIsocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Not Available Humans UTGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Not Available Humans UArginase-1 Not Available Humans USerotransferrin Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Manganese chloride 6YB4901Y90 7773-01-5 GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride tetrahydrate QQE170PANO 13446-34-9 CNFDGXZLMLFIJV-UHFFFAOYSA-L Manganese sulfate W00LYS4T26 10034-96-5 ISPYRSDWRDQNSW-UHFFFAOYSA-L - Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Manganese Injection, solution 0.1 mg/1mL Intravenous Hospira, Inc. 2005-01-31 Not applicable US 
Manganese Sulfate Injection, solution 0.1 mg/1mL Intravenous AMERICAN REGENT, INC. 1990-09-30 Not applicable US Micro Mn Solution 0.5 mg / mL Intravenous Sandoz Canada Incorporated 1992-12-31 2018-08-01 Canada 
Micro Mn Solution 0.1 mg / mL Intravenous Sandoz Canada Incorporated 1992-12-31 Not applicable Canada - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Bio-plex Tab 0.95mg Tablet .95 mg / tab Oral Therapeutic Foods Co. 1988-12-31 2001-07-31 Canada Chelated Manganese Tablets - 5mg Tablet 5 mg Oral Albion 1996-09-06 2002-07-12 Canada Chelazome Manganese Cap 15mg Capsule 15 mg Oral Trophic Canada Ltd. 1987-12-31 2008-08-28 Canada Hvp Chelated Manganese 30mg Tablet 30 mg / tab Oral Swiss Herbal Remedies Ltd. 1999-09-16 2003-09-10 Canada Manganese Capsule 30 mg Oral Seroyal International Inc. 1993-12-31 2009-07-06 Canada - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Multivitamins + Minerals Manganese (2 mg) + Ascorbic acid (150 mg) + Beta carotene (10000 unit) + Biotin (25 mcg) + Calcium (130 mg) + Cholecalciferol (400 unit) + Choline bitartrate (25 mg) + Chromium (20 mcg) + Copper (1 mg) + Cyanocobalamin (25 mcg) + Ferrous fumarate (15 mg) + Folic acid (.8 mg) + Inositol (25 mg) + Magnesium (65 mg) + Molybdenum (20 mcg) + Niacin (25 mg) + Calcium pantothenate (25 mg) + Potassium (15 mg) + Potassium Iodide (.1 mg) + Pyridoxine hydrochloride (25 mg) + Racemethionine (25 mg) + Riboflavin (25 mg) + Selenium (20 mcg) + Thiamine hydrochloride (25 mg) + Vanadium (20 mcg) + Vitamin A palmitate (5000 unit) + Vitamin E (50 unit) + Zinc (10 mg) Tablet Oral Stanley Pharmaceuticals, A Division Of Vita Health Products Inc. 1997-04-30 2002-07-31 Canada 50 Plus Multiple Vitamins & Minerals Manganese (5 mg) + Ascorbic acid (90 mg) + Biotin (45 mcg) + Calcium (200 mg) + Cholecalciferol (400 unit) + Chromium (10 mcg) + Copper (2 mg) + Cyanocobalamin (25 mcg) + Folic acid (0.4 mg) + Magnesium (100 mg) + Molybdenum (25 mcg) + Nicotinamide (40 mg) + Pantothenic acid (10 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (3 mg) + Riboflavin (3.2 mg) + Selenium (25 mcg) + Thiamine mononitrate (2.25 mg) + Vanadium (10 mcg) + Vitamin A palmitate (6000 unit) + Zinc (15 mg) Tablet Oral Gfr Pharma Ltd. 2002-10-20 2004-06-15 Canada A.R.T.H. Away Formula Manganese (0.58 mg) + Calcium (24 mg) + Cholecalciferol (45 unit) + Copper (0.232 mg) + Folic acid (0.025 mg) + Pyridoxine hydrochloride (0.5 mg) + Selenium (1.54 mcg) + Zinc (0.63 mg) Capsule Oral Abundance Naturally Ltd 1999-02-01 2006-06-16 Canada A/o-26 - Caplet Manganese (2.5 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Calcium ascorbate (250 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg) Tablet Oral Enviro Tech International Canada 1996-12-19 1999-07-26 Canada Acti-MN + B1 + C Caplet Manganese (30.0 mg) + Calcium ascorbate (100 mg) + Thiamine hydrochloride (20 mg) Tablet Oral Acti Form Ltd. 1991-12-31 2005-03-21 Canada - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Addamel N Manganese chloride tetrahydrate (0.027 mg/1mL) + Chromic chloride hexahydrate (1 ug/1mL) + Cuprous chloride (0.13 mg/1mL) + Ferric chloride (0.11 mg/1mL) + Potassium Iodide (0.013 mg/1mL) + Sodium selenite (3.2 ug/1mL) + Sodium fluoride (0.095 mg/1mL) + Sodium molybdate dihydrate (1.9 ug/1mL) + Zinc chloride (0.65 mg/1mL) Injection, solution Intravenous Fresenius Kabi USA, LLC 2013-05-07 2017-03-31 US ADDAMEL N 20 AMPUL Manganese chloride (990 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (3.4 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (69 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (13.6 mg/10mL) Injection, solution Intravenous FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ. 2019-04-30 Not applicable Turkey 
ADDAVEN IV INFUZYON ICIN KONSANTRE SOLUSYON Manganese chloride (198 mcg/10mL) + Chromic chloride (53.3 mcg/10mL) + Cupric Chloride (1.02 mg/10mL) + Ferric chloride (5.4 mg/10mL) + Potassium Iodide (166 mcg/10mL) + Sodium selenite (173 mcg/10mL) + Sodium fluoride (2.1 mg/10mL) + Sodium molybdate (48.5 mcg/10mL) + Zinc chloride (10.5 mg/10mL) Injection, solution Intravenous FRESENİUS KABİ İLAÇ SAN. VE TİC. LTD. ŞTİ. 2016-09-06 2022-11-10 Turkey Centratex Manganese sulfate (1.3 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Sodium ascorbate (200 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1) Capsule Oral Centurion Labs, LLC 2009-06-14 Not applicable US Concept OB Manganese sulfate (1.3 mg/1) + Ascorbic acid (210 mg/1) + Biotin (300 ug/1) + Cupric sulfate pentahydrate (800 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous fumarate (42.5 mg/1) + Folic acid (1 mg/1) + Iron (42.5 mg/1) + Magnesium sulfate (6.9 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (5 mg/1) + Thiamine mononitrate (5 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1) Capsule Oral U.S. Pharmaceutical Corporation 2009-01-01 Not applicable US
Categories
- Drug Categories
- Anions
- Chlorine Compounds
- Diet, Food, and Nutrition
- Electrolytes
- Elements
- Food
- Ions
- Magnetic Resonance Contrast Activity
- Metals
- Metals, Heavy
- Micronutrients
- Minerals
- Paramagnetic Contrast Agent
- Physiological Phenomena
- Replacement Preparations
- Sulfur Acids
- Sulfur Compounds
- Sulfuric Acids
- Trace Elements
- Transition Elements
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.
- Kingdom
- Inorganic compounds
- Super Class
- Homogeneous metal compounds
- Class
- Homogeneous transition metal compounds
- Sub Class
- Not Available
- Direct Parent
- Homogeneous transition metal compounds
- Alternative Parents
- Not Available
- Substituents
- Homogeneous transition metal
- Molecular Framework
- Not Available
- External Descriptors
- monoatomic dication, divalent metal cation, manganese cation (CHEBI:29035) / a cation (MN+2)
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- H6EP7W5457
- CAS number
- 7439-96-5
- InChI Key
- WAEMQWOKJMHJLA-UHFFFAOYSA-N
- InChI
- InChI=1S/Mn/q+2
- IUPAC Name
- manganese(2+) ion
- SMILES
- [Mn++]
References
- General References
- Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [Article]
- External Links
- Human Metabolome Database
- HMDB0001333
- KEGG Drug
- D04854
- KEGG Compound
- C19610
- PubChem Compound
- 27854
- PubChem Substance
- 310264880
- ChemSpider
- 25916
- 6623
- ChEBI
- 29035
- ChEMBL
- CHEMBL2103742
- PDBe Ligand
- MN
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Manganese
- PDB Entries
- 117e / 1a0d / 1a0o / 1a16 / 1a3w / 1a3x / 1a5v / 1a6q / 1a76 / 1a9x … show 4404 more
- MSDS
- Download (61.4 KB)
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Not Yet Recruiting Treatment Manganese Safety in Adults 1 4 Not Yet Recruiting Treatment Manganese Safety in Pediatric Patients 1 2 Completed Treatment Central Serous Chorioretinopathy (CSC) 1 2 Completed Treatment Ovarian Cancer 1 2, 3 Completed Treatment Substance Abuse / Substance Dependence 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Injection Intravenous 5.33 mcg/ml Injection, solution Intravenous drip Solution Intravenous 5.33 mcg/ml Tablet Oral .95 mg / tab Tablet Oral 5 mg Capsule Oral 15 mg Tablet, extended release Oral Tablet, film coated Tablet, coated Oral Tablet Capsule Capsule Cutaneous; Oral Liquid Oral Tablet, delayed release Oral Capsule Oral Powder Oral Tablet, effervescent Oral Capsule, coated Oral Capsule Oral 30 mg Tablet Oral 30 mg / tab Tablet Oral 15 mg / tab Tablet Oral 50 mg / tab Injection, solution Intravenous 0.1 mg/1mL Kit Oral Tablet, film coated Oral Solution Intravenous 0.1 mg / mL Solution Intravenous 0.5 mg / mL Liquid Intravenous Injection, solution, concentrate Intravenous Injection, solution Intravenous Capsule, liquid filled Oral Solution Intravenous 0.053 mg/10ml Solution Oral Tablet Oral 6 mg / tab Tablet Oral 4 mg / tab Injection, solution, concentrate Intravenous; Parenteral Injection, solution, concentrate Parenteral Solution, concentrate Intravenous Injection Intravenous Tablet, chewable Oral Tablet Oral Capsule, gelatin coated Oral Solution Intravenous Injection, solution Parenteral Powder, for solution Oral Tablet Oral 300.000 mg Tablet, sugar coated Oral - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US11786548 No 2021-07-01 2041-07-01 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 1246 Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72 boiling point (°C) 2061 Lide, D.R. CRC Handbook of Chemistry and Physics 86TH Edition 2005-2006. CRC Press, Taylor & Francis, Boca Raton, FL 2005, p. 4-72 - Predicted Properties
Property Value Source logP -0.16 Chemaxon pKa (Strongest Acidic) 3.09 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 0 m3·mol-1 Chemaxon Polarizability 1.78 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Nad binding
- Specific Function
- Not Available
- Gene Name
- IDH3A
- Uniprot ID
- P50213
- Uniprot Name
- Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
- Molecular Weight
- 39591.365 Da
References
- Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Nad binding
- Specific Function
- Not Available
- Gene Name
- IDH3G
- Uniprot ID
- P51553
- Uniprot Name
- Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
- Molecular Weight
- 42793.97 Da
References
- Soundar S, O'hagan M, Fomulu KS, Colman RF: Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase. J Biol Chem. 2006 Jul 28;281(30):21073-81. Epub 2006 May 31. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein serine/threonine phosphatase activity
- Specific Function
- May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
- Gene Name
- TAB1
- Uniprot ID
- Q15750
- Uniprot Name
- TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
- Molecular Weight
- 54643.655 Da
References
- Conner SH, Kular G, Peggie M, Shepherd S, Schuttelkopf AW, Cohen P, Van Aalten DM: TAK1-binding protein 1 is a pseudophosphatase. Biochem J. 2006 Nov 1;399(3):427-34. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Manganese ion binding
- Specific Function
- Not Available
- Gene Name
- ARG1
- Uniprot ID
- P05089
- Uniprot Name
- Arginase-1
- Molecular Weight
- 34734.655 Da
References
- Zakharian TY, Di Costanzo L, Christianson DW: Synthesis of (2S)-2-amino-7,8-epoxyoctanoic acid and structure of its metal-bridging complex with human arginase I. Org Biomol Chem. 2008 Sep 21;6(18):3240-3. doi: 10.1039/b811797g. Epub 2008 Aug 6. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transferrin receptor binding
- Specific Function
- Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from si...
- Gene Name
- TF
- Uniprot ID
- P02787
- Uniprot Name
- Serotransferrin
- Molecular Weight
- 77063.195 Da
References
- Golub MS, Han B, Keen CL: Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte cultures. Brain Res. 1996 May 6;719(1-2):72-7. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inhibitor
- General Function
- Rna binding
- Specific Function
- Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron whe...
- Gene Name
- ACO1
- Uniprot ID
- P21399
- Uniprot Name
- Cytoplasmic aconitate hydratase
- Molecular Weight
- 98398.14 Da
References
- Crooks DR, Ghosh MC, Braun-Sommargren M, Rouault TA, Smith DR: Manganese targets m-aconitase and activates iron regulatory protein 2 in AF5 GABAergic cells. J Neurosci Res. 2007 Jun;85(8):1797-809. [Article]
Drug created at September 14, 2010 16:21 / Updated at February 21, 2024 02:38