This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Serotonin
- DrugBank Accession Number
- DB08839
- Background
For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product.
- Type
- Small Molecule
- Groups
- Investigational, Nutraceutical
- Structure
Structure for Serotonin (DB08839)
- Weight
- Average: 176.2151
Monoisotopic: 176.094963016 - Chemical Formula
- C10H12N2O
- Synonyms
- 3-(2-Aminoethyl)-1H-indol-5-ol
- 5-HT
- 5-Hydroxytryptamine
- Enteramine
- sérotonine
- thrombocytin
- thrombotonin
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism USodium-dependent serotonin transporter Not Available Humans U5-hydroxytryptamine receptor 2A Not Available Humans U5-hydroxytryptamine receptor 3A Not Available Humans U5-hydroxytryptamine receptor 3B Not Available Humans USynaptic vesicular amine transporter Not Available Humans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when Serotonin is combined with 1,2-Benzodiazepine. Acenocoumarol The risk or severity of adverse effects can be increased when Serotonin is combined with Acenocoumarol. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Serotonin. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Serotonin. Agomelatine The risk or severity of CNS depression can be increased when Agomelatine is combined with Serotonin. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Serotonin hydrochloride GKN429M9VS 153-98-0 MDIGAZPGKJFIAH-UHFFFAOYSA-N - International/Other Brands
- 5-HTP (Natural Factors) / HTP Calm (Natural Balance) / Natural 5-HTP (Healthy Origins) / Seotonin (Apotheca Company) / Super 5-HTP (Action Labs)
Categories
- Drug Categories
- Amines
- Antidepressive Agents
- Autacoids
- Biogenic Amines
- Biogenic Monoamines
- Biological Factors
- Central Nervous System Depressants
- Complex Mixtures
- Endopeptidases
- Heterocyclic Compounds, Fused-Ring
- Indoles
- Inflammation Mediators
- Neurotransmitter Agents
- Serine Proteases
- Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome
- Serotonin Agents
- Serotonin Receptor Agonists
- Snake Venoms
- Toxins, Biological
- Tryptamines
- Venoms
- Viper Venoms
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as serotonins. These are compounds containing a serotonin moiety, which consists of an indole that bears an aminoethyl a position 2 and a hydroxyl group at position 5.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Indoles and derivatives
- Sub Class
- Tryptamines and derivatives
- Direct Parent
- Serotonins
- Alternative Parents
- Hydroxyindoles / 3-alkylindoles / 2-arylethylamines / Aralkylamines / 1-hydroxy-2-unsubstituted benzenoids / Substituted pyrroles / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds show 2 more
- Substituents
- 1-hydroxy-2-unsubstituted benzenoid / 2-arylethylamine / 3-alkylindole / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Heteroaromatic compound / Hydrocarbon derivative show 12 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- phenols, monoamine molecular messenger, primary amino compound, tryptamines (CHEBI:28790) / Biogenic amines, Indole alkaloids (C00780)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 333DO1RDJY
- CAS number
- 50-67-9
- InChI Key
- QZAYGJVTTNCVMB-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
- IUPAC Name
- 3-(2-aminoethyl)-1H-indol-5-ol
- SMILES
- NCCC1=CNC2=CC=C(O)C=C12
References
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0000259
- KEGG Compound
- C00780
- ChemSpider
- 5013
- BindingDB
- 10755
- 1311214
- ChEBI
- 28790
- ChEMBL
- CHEMBL39
- ZINC
- ZINC000000057058
- PDBe Ligand
- SRO
- Wikipedia
- Serotonin
- PDB Entries
- 2qeh / 2ymd / 3adv / 3brn / 3q6k / 4dtw / 4due / 4duf / 5mam / 5mt3 … show 31 more
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Active Not Recruiting Other Obsessive Compulsive Disorder (OCD) 1 4 Active Not Recruiting Treatment Post Traumatic Stress Disorder (PTSD) 1 4 Completed Diagnostic Bipolar Disorder (BD) / Major Depressive Disorder (MDD) 1 4 Completed Health Services Research Asthma / Depression 1 4 Completed Treatment Anxiety Disorders 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 2.5 mg/mL ALOGPS logP 0.56 ALOGPS logP 0.48 Chemaxon logS -1.8 ALOGPS pKa (Strongest Acidic) 9.31 Chemaxon pKa (Strongest Basic) 10 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 62.04 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 52.35 m3·mol-1 Chemaxon Polarizability 19.31 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 143.6670563 predictedDarkChem Lite v0.1.0 [M-H]- 144.3331754 predictedDarkChem Standard v0.1.0 [M-H]- 143.8719563 predictedDarkChem Lite v0.1.0 [M-H]- 143.8613563 predictedDarkChem Lite v0.1.0 [M-H]- 135.62567 predictedDeepCCS 1.0 (2019) [M+H]+ 144.7051563 predictedDarkChem Lite v0.1.0 [M+H]+ 144.4131563 predictedDarkChem Lite v0.1.0 [M+H]+ 144.3039563 predictedDarkChem Lite v0.1.0 [M+H]+ 144.4271563 predictedDarkChem Lite v0.1.0 [M+H]+ 139.45302 predictedDeepCCS 1.0 (2019) [M+Na]+ 143.8467563 predictedDarkChem Lite v0.1.0 [M+Na]+ 143.8438563 predictedDarkChem Lite v0.1.0 [M+Na]+ 143.8620563 predictedDarkChem Lite v0.1.0 [M+Na]+ 148.5003 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serotonin:sodium symporter activity
- Specific Function
- Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into t...
- Gene Name
- SLC6A4
- Uniprot ID
- P31645
- Uniprot Name
- Sodium-dependent serotonin transporter
- Molecular Weight
- 70324.165 Da
References
- Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD: Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. J Biol Chem. 2006 Jan 27;281(4):2012-23. Epub 2005 Nov 3. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Virus receptor activity
- Specific Function
- G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodop...
- Gene Name
- HTR2A
- Uniprot ID
- P28223
- Uniprot Name
- 5-hydroxytryptamine receptor 2A
- Molecular Weight
- 52602.58 Da
References
- Peroutka SJ, Lebovitz RM, Snyder SH: Two distinct central serotonin receptors with different physiological functions. Science. 1981 May 15;212(4496):827-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Voltage-gated potassium channel activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gate...
- Gene Name
- HTR3A
- Uniprot ID
- P46098
- Uniprot Name
- 5-hydroxytryptamine receptor 3A
- Molecular Weight
- 55279.835 Da
References
- Rusch D, Musset B, Wulf H, Schuster A, Raines DE: Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols. J Pharmacol Exp Ther. 2007 Jun;321(3):1069-74. Epub 2007 Mar 7. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Serotonin-activated cation-selective channel activity
- Specific Function
- This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gate...
- Gene Name
- HTR3B
- Uniprot ID
- O95264
- Uniprot Name
- 5-hydroxytryptamine receptor 3B
- Molecular Weight
- 50291.3 Da
References
- Rusch D, Musset B, Wulf H, Schuster A, Raines DE: Subunit-dependent modulation of the 5-hydroxytryptamine type 3 receptor open-close equilibrium by n-alcohols. J Pharmacol Exp Ther. 2007 Jun;321(3):1069-74. Epub 2007 Mar 7. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Monoamine transmembrane transporter activity
- Specific Function
- Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles...
- Gene Name
- SLC18A2
- Uniprot ID
- Q05940
- Uniprot Name
- Synaptic vesicular amine transporter
- Molecular Weight
- 55712.075 Da
References
- Gonzalez AM, Walther D, Pazos A, Uhl GR: Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile. Brain Res Mol Brain Res. 1994 Mar;22(1-4):219-26. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Quaternary ammonium group transmembrane transporter activity
- Specific Function
- Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creat...
- Gene Name
- SLC22A2
- Uniprot ID
- O15244
- Uniprot Name
- Solute carrier family 22 member 2
- Molecular Weight
- 62579.99 Da
References
- Grundemann D, Koster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermuller N, Schomig E: Transport of monoamine transmitters by the organic cation transporter type 2, OCT2. J Biol Chem. 1998 Nov 20;273(47):30915-20. [Article]
Drug created at February 21, 2013 23:40 / Updated at June 12, 2020 16:52