Etofenamate
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Identification
- Summary
Etofenamate is an NSAID used to treat muscle and joint pain.
- Generic Name
- Etofenamate
- DrugBank Accession Number
- DB08984
- Background
Etofenamate is used to treat muscle and joint paint. It is a non-steroidal anti-inflammatory drug (NSAID).
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 369.335
Monoisotopic: 369.118792684 - Chemical Formula
- C18H18F3NO4
- Synonyms
- Etofenamate
- Etofenamato
- Etofenamatum
- External IDs
- BAY D 1107
- BAY-D-1107
- TVX 485
- TVX-485
- TVX485
- WHR-5020
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning models
with evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Treatment of Acute musculoskeletal pain •••••••••••• ••••••••• Treatment of Ankylosing spondylitis (as) •••••••••••• ••••••••• Treatment of Bursitis •••••••••••• ••••• Treatment of Gonarthrosis •••••••••••• •••• ••••• Treatment of Menstrual cramps •••••••••••• ••••••••• - Contraindications & Blackbox Warnings
- Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbacavir Etofenamate may decrease the excretion rate of Abacavir which could result in a higher serum level. Abciximab The risk or severity of bleeding and hemorrhage can be increased when Etofenamate is combined with Abciximab. Acebutolol Etofenamate may decrease the antihypertensive activities of Acebutolol. Aceclofenac The risk or severity of adverse effects can be increased when Aceclofenac is combined with Etofenamate. Acemetacin The risk or severity of adverse effects can be increased when Etofenamate is combined with Acemetacin. - Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions. - International/Other Brands
- Activon (Meda) / Aspitopic (Bayer) / Bayagel (Bayer) / Bayro (Bayer) / Etobay (Bayer) / Gemadol (Meda) / Glasel (Meda) / Rheumon (Bayer) / Ticatrop (Meda)
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image HOTFİX 100 MG/G + 10 MG/G KREM , 50 GRAM Etofenamate (100 mg/g) + Benzyl nicotinate (10 mg/g) Cream Topical KARFARMA İLAÇ SAN. VE TİC. A.Ş. 2020-08-14 Not applicable Turkey RESTAFEN PLUS 5G /0,5G KREM Etofenamate (100 mg/g) + Benzyl nicotinate (10 mg/g) Cream Topical VEM İLAÇ SAN. VE TİC. A.Ş. 2012-02-09 Not applicable Turkey THER-MERAM KREM ,50 G Etofenamate (100 mg/g) + Benzyl nicotinate (10 mg/g) Cream Topical HUMANİS SAĞLIK A.Ş. 2014-04-16 Not applicable Turkey THERMO EFAMAT %10+%1 KREM, 50 G Etofenamate (10 %) + Benzyl nicotinate (1 %) Cream Topical Deva Holding A.S. 2015-03-03 Not applicable Turkey THERMO ETOX 50 G KREM Etofenamate (100 mg/g) + Benzyl nicotinate (10 mg/g) Cream Topical TRİOZER İLAÇ KİM. KOZMETİK SAĞ. HİZM. SAN. VE TİC. LTD. ŞTİ. 2011-11-30 Not applicable Turkey
Categories
- ATC Codes
- M02AA06 — Etofenamate
- Drug Categories
- Acids, Carbocyclic
- Agents causing hyperkalemia
- Agents that produce hypertension
- Aminobenzoates
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antiinflammatory Preparations, Non-Steroids for Topical Use
- Antirheumatic Agents
- Benzene Derivatives
- Benzoates
- Fenamates
- Musculo-Skeletal System
- Nephrotoxic agents
- Non COX-2 selective NSAIDS
- ortho-Aminobenzoates
- Peripheral Nervous System Agents
- Sensory System Agents
- Thyroxine-binding globulin substrates
- Topical Products for Joint and Muscular Pain
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as benzoic acid esters. These are ester derivatives of benzoic acid.
- Kingdom
- Organic compounds
- Super Class
- Benzenoids
- Class
- Benzene and substituted derivatives
- Sub Class
- Benzoic acids and derivatives
- Direct Parent
- Benzoic acid esters
- Alternative Parents
- Trifluoromethylbenzenes / Aminobenzoic acids and derivatives / Aniline and substituted anilines / Benzoyl derivatives / Vinylogous amides / Amino acids and derivatives / Carboxylic acid esters / Secondary amines / Dialkyl ethers / Monocarboxylic acids and derivatives show 6 more
- Substituents
- Alcohol / Alkyl fluoride / Alkyl halide / Amine / Amino acid or derivatives / Aminobenzoic acid or derivatives / Aniline or substituted anilines / Aromatic homomonocyclic compound / Benzoate ester / Benzoyl show 18 more
- Molecular Framework
- Aromatic homomonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- KZF0XM66JC
- CAS number
- 30544-47-9
- InChI Key
- XILVEPYQJIOVNB-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2
- IUPAC Name
- 2-(2-hydroxyethoxy)ethyl 2-{[3-(trifluoromethyl)phenyl]amino}benzoate
- SMILES
- OCCOCCOC(=O)C1=CC=CC=C1NC1=CC=CC(=C1)C(F)(F)F
References
- Synthesis Reference
U.S. Patent 3,692,818.
- General References
- Not Available
- External Links
- KEGG Drug
- D04102
- PubChem Compound
- 35375
- PubChem Substance
- 310264945
- ChemSpider
- 32560
- 24608
- ChEBI
- 94731
- ChEMBL
- CHEMBL1451633
- ZINC
- ZINC000002034516
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Etofenamate
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count Not Available Completed Diagnostic Dermatitis, Photocontact 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Cream Topical 10 % Spray Topical 10 % Solution Intramuscular 1 g/2ml Patch Topical Injection, solution Intramuscular 1 g/2ml Injection, solution Intramuscular Injection, solution Intramuscular 1 gr/2ml Solution Intramuscular 1000 mg Spray Topical Spray Topical 100 mg/ml Injection Intramuscular 1 g Solution Intramuscular 1.0000 g Gel Cutaneous 5.000 g Solution Intramuscular 1.000 g Plaster Topical 70 mg Cream Cutaneous 10.000 g Gel Topical Cream Topical 100 mg/g Cream Topical Injection, solution Intramuscular 1 g Gel Topical 50 mg/g Gel Topical 10 g Injection Intramuscular 1000 mg/2ml Cream Topical 10 g Solution Intramuscular 1.0 g Cream Topical Cream Topical 50 gr Solution Intramuscular 1 g Spray Oral 100 mg/mL Gel Topical 100 mg/g Gel Topical 10 % Gel Topical 5 % Gel Topical 5 g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.00936 mg/mL ALOGPS logP 3.53 ALOGPS logP 4.86 Chemaxon logS -4.6 ALOGPS pKa (Strongest Acidic) 15.12 Chemaxon pKa (Strongest Basic) -2.2 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 67.79 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 89.88 m3·mol-1 Chemaxon Polarizability 35.57 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0090000000-db9745021c7ac25c01cd Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-001r-1091000000-86309f85cda414b4178d Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-03di-0090000000-85c25d26d2a696a32f23 Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-000i-1090000000-e8a37f9f1cd9d405006e Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-03dr-0090000000-ef79892f789d7e7c500b Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-000i-0190000000-454136130b7c3ef30f02 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 181.8397 predictedDeepCCS 1.0 (2019) [M+H]+ 184.19772 predictedDeepCCS 1.0 (2019) [M+Na]+ 192.30394 predictedDeepCCS 1.0 (2019)
Carriers
1. DetailsThyroxine-binding globulin
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- No
- Actions
- Substrate
- General Function
- Serine-type endopeptidase inhibitor activity
- Specific Function
- Major thyroid hormone transport protein in serum.
- Gene Name
- SERPINA7
- Uniprot ID
- P05543
- Uniprot Name
- Thyroxine-binding globulin
- Molecular Weight
- 46324.12 Da
References
- CYTOMEL (liothyronine) FDA label [File]
Drug created at June 10, 2014 17:10 / Updated at June 02, 2021 20:03