Identification
- Brand Names
- Clear Eyes Cooling Comfort, Clear Eyes Redness Relief Reformulated Nov 2011, Fleet Mineral Oil, Genteal Tears, Glycerolyte 57, Pedia-lax Liquid, Preparation H Cream, Procalamine 3, Refresh Optive Advanced, Refresh Optive Extended Therapy, Synovisol, Tears Lubricant
- Generic Name
- Glycerin
- DrugBank Accession Number
- DB09462
- Background
A trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Glycerin (DB09462)
- Weight
- Average: 92.0938
Monoisotopic: 92.047344122 - Chemical Formula
- C3H8O3
- Synonyms
- 1,2,3-propanetriol
- 1,2,3-trihydroxypropane
- Glycerin
- Glycerin, anhydrous
- Glycerin,anhydrous
- Glycerine
- glycérine
- Glycerinum
- Glycerol
- glycérol
- Glyzerin
- Monoctanoin component D
- Ölsüß
- Propanetriol
- Trihydroxypropane
- External IDs
- E-422
- Fema no. 2525
- INS No.422
- INS-422
- M 314429
- NSC-9230
- PZN 7474853
Pharmacology
- Indication
It is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Symptomatic treatment of Cold sore •••••••••••• •••••••• Used in combination to treat Constipation Combination Product in combination with: Sorbitol (DB01638), Sodium citrate (DB09154) •••••••••••• ••••• Symptomatic treatment of Constipation ••• ••• ••••••••••• Treatment of Dry mouth ••• ••• •••• Symptomatic treatment of Dry throat ••• ••• ••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Glycerin is commonly classified as an osmotic laxative but may act additionally or alternatively through its local irritant effects; it may also have lubricating and fecal softening actions. Glycerin suppositories usually work within 15 to 30 minutes.
- Mechanism of action
When administered rectally, glycerin exerts a hygroscopic and/or local irritant action, drawing water from the tissues into the feces and reflexively stimulating evacuation. Glycerin decreases intraocular pressure by creating an osmotic gradient between the blood and intraocular fluid, causing fluid to move out of the aqueous and vitreous humors into the bloodstream.
Target Actions Organism APeroxisome proliferator-activated receptor delta agonistHumans UGroup IIE secretory phospholipase A2 Not Available Humans UInositol-3-phosphate synthase 1 Not Available Humans UAlcohol dehydrogenase 1B Not Available Humans UInositol 1,4,5-trisphosphate receptor type 1 Not Available Humans UGlycodelin Not Available Humans UAlpha-N-acetylgalactosaminidase Not Available Humans UADP-ribosylation factor 1 Not Available Humans UBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 Not Available Humans UDNA mismatch repair protein MutL Not Available Escherichia coli (strain K12) URibonucleoside-diphosphate reductase 1 subunit beta Not Available Escherichia coli (strain K12) UA/G-specific adenine glycosylase Not Available Escherichia coli (strain K12) UtRNA (cytosine(38)-C(5))-methyltransferase Not Available Humans UMaleylacetoacetate isomerase Not Available Humans - Absorption
Well absorbed orally, poorly absorbed rectally. Studies in humans and animals indicate glycerol is rapidly absorbed in the intestine and the stomach
- Volume of distribution
Glycerin is distributed throughout the blood. Although glycerin generally does not appear in ocular fluids, it may enter the orbital sac when the eye is inflamed, with a consequent decrease in osmotic effect.
- Protein binding
Not Available
- Metabolism
Glycerin is a substrate for synthesis of triacylglycerols and of phospholipids in the liver and adipose tissue. When fat metabolized as a source of energy, glycerol and fatty acids are released into the bloodstream. Circulating glycerin does not glycate proteins and does not lead to the formation of advanced glycation endproducts (AGEs). In some organisms, the glycerin component can enter the glycolysis pathway directly to provide a substrate for energy or glucose production. Glycerol must be converted to their intermediate glyceraldehyde 3-phosphate before being used in glycolysis or gluconeogenesis. Glycerol metabolism is regulated by the enzymes glycerol kinase, (cytosolic) NAD+-dependent G3P dehydrogenase and (mitochondrial) FAD-linked G3P dehydrogenase.
- Route of elimination
Approx 7-14% of dose is excreted unchanged in the urine within 2.5 hr.
- Half-life
30 - 45 minutes
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Glycerol has very low toxicity when ingested ; Rat LD50 (oral)-12600mg/kg Mice LD50 (oral )-4090mg/kg Human TDLo (oral) - 1428mg/kg
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAcetaminophen Glycerin may increase the hepatotoxic activities of Acetaminophen. Acetazolamide The risk or severity of dehydration can be increased when Acetazolamide is combined with Glycerin. Aclidinium The therapeutic efficacy of Glycerin can be decreased when used in combination with Aclidinium. Alfentanil The therapeutic efficacy of Glycerin can be decreased when used in combination with Alfentanil. Alloin The risk or severity of adverse effects can be increased when Glycerin is combined with Alloin. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Coca-Glycerine Control Injection, solution 0.525 mL/1mL Intradermal Antigen Laboratories, Inc. 1974-03-23 Not applicable US 
Glycerol-Saline Control Injection 0.53 g/1mL Cutaneous; Intradermal; Subcutaneous Allermed Laboratories, Inc. 1974-03-12 Not applicable US Negative Skin Test Control - Glycerin Liquid 50 % v/v Percutaneous Jubilant Hollisterstier Llc Not applicable Not applicable Canada 
Sterile Diluent for Allergenic Extract Injection, solution 0.5 mL/1mL Intradermal; Subcutaneous Antigen Laboratories, Inc. 1974-03-23 Not applicable US Synovisol Irrigation Solution 2.6% Solution 2.6 % Irrigation Baxter Laboratories 1996-09-26 Not applicable Canada - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 2x First Essence Cream 4.0 g/200mL Topical Tonymoly Co., Ltd. 2016-05-01 Not applicable US 3 en 1 Cleanser. Deep Cleansing Liquid 13 mg/1mL Topical Casmara Cosmetics, Sa 2016-06-06 Not applicable US 3 en 1 Cleanser. Deep Cleansing Liquid 13 mg/1mL Topical Casmara Cosmetics, Sa 2016-06-06 Not applicable US 3ce Liqu Id Eye Liner Black Liquid 0.19 g/6.5g Topical Nanda Co., Ltd. 2016-08-01 Not applicable US 3ce Liqu Id Eye Liner Brown Liquid 0.19 g/6.5g Topical Nanda Co., Ltd. 2016-08-01 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 10% กลีเซอริล Glycerin (100 g) + D-glucose monohydrate (27.5 g) + Sodium chloride (4.5 g) Solution Intravenous บริษัท มิลลิเมด จำกัด จำกัด 2011-09-22 2020-09-29 Thailand 
2% Salicylic Acid FACIAL CLEANSER Glycerin (50 mg/236mL) + Azelaic acid (10 mg/236mL) + Kaolin (20 mg/236mL) + Zinc pidolate (10 mg/236mL) + Salicylic acid (20 mg/236mL) Liquid Topical Volans Epic LLC 2023-04-06 Not applicable US 5% Oat Facial Cleanser Glycerin (50 mg/236mL) + Ceramide NG (1 mg/236mL) + Colloidal oatmeal (50 mg/236mL) Liquid Topical Volans Epic LLC 2023-04-06 Not applicable US 7 Select Redness Relief Glycerin (0.0025 mg/1mL) + Naphazoline hydrochloride (0.00012 mg/1mL) Solution / drops Ophthalmic 7-Select, Inc 2017-03-28 Not applicable US ABREVA Rapid Pain Relief Glycerin (200 mg/1g) + Lidocaine hydrochloride (40 mg/1g) Gel Topical GlaxoSmithKline Consumer Healthcare Holdings (US) LLC 2023-06-01 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 2x First Essence Glycerin (4.0 g/200mL) Cream Topical Tonymoly Co., Ltd. 2016-05-01 Not applicable US 3ce Liqu Id Eye Liner Black Glycerin (0.19 g/6.5g) Liquid Topical Nanda Co., Ltd. 2016-08-01 Not applicable US 3ce Liqu Id Eye Liner Brown Glycerin (0.19 g/6.5g) Liquid Topical Nanda Co., Ltd. 2016-08-01 Not applicable US 3D Lifting Glycerin (0.067 mL/2mL) Liquid Topical Babor Cosmetics America, Corp. 2009-06-01 2017-02-17 US AC Clear Sheet Mask Glycerin (1.84 g/23mL) Patch Topical Miguhara 2016-01-02 Not applicable US
Categories
- ATC Codes
- A06AX01 — Glycerol
- A06AX — Other drugs for constipation
- A06A — DRUGS FOR CONSTIPATION
- A06 — DRUGS FOR CONSTIPATION
- A — ALIMENTARY TRACT AND METABOLISM
- Drug Categories
- Alcohols
- Alimentary Tract and Metabolism
- Basic Ointments and Protectants
- Carbohydrates
- Cell-mediated Immunity
- Compounds used in a research, industrial, or household setting
- Cryoprotective Agents
- Cytochrome P-450 CYP2E1 Inducers
- Cytochrome P-450 CYP2E1 Inducers (strength unknown)
- Cytochrome P-450 Enzyme Inducers
- Drugs for Constipation
- Enemas
- Increased Histamine Release
- Increased IgG Production
- Irrigating Solutions
- Laxatives
- Non-Standardized Chemical Allergen
- Osmotic Laxatives
- Other Cold and Cough Preparations
- Other Diagnostics
- Protective Agents
- Solvents
- Sugar Alcohols
- Triose Sugar Alcohols
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as sugar alcohols. These are hydrogenated forms of carbohydrate in which the carbonyl group (aldehyde or ketone, reducing sugar) has been reduced to a primary or secondary hydroxyl group.
- Kingdom
- Organic compounds
- Super Class
- Organic oxygen compounds
- Class
- Organooxygen compounds
- Sub Class
- Carbohydrates and carbohydrate conjugates
- Direct Parent
- Sugar alcohols
- Alternative Parents
- Secondary alcohols / Polyols / Primary alcohols / Hydrocarbon derivatives
- Substituents
- Alcohol / Aliphatic acyclic compound / Hydrocarbon derivative / Polyol / Primary alcohol / Secondary alcohol / Sugar alcohol
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- triol, alditol (CHEBI:17754) / Glycerols (C00116) / a sugar alcohol (GLYCEROL)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- PDC6A3C0OX
- CAS number
- 56-81-5
- InChI Key
- PEDCQBHIVMGVHV-UHFFFAOYSA-N
- InChI
- InChI=1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
- IUPAC Name
- propane-1,2,3-triol
- SMILES
- OCC(O)CO
References
- General References
- External Links
- PDB Entries
- 1ah8 / 1ahp / 1ayf / 1b4e / 1b6g / 1b8f / 1bcs / 1bf6 / 1bg4 / 1bhp … show 22556 more
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Completed Prevention Pancreatitis 1 4 Completed Prevention Visceral Obesity 1 4 Completed Supportive Care Fecal Incontinence / Neurogenic Bowel Dysfunction 1 4 Completed Treatment Cataracts / Dry Eye Syndrome (DES) 1 4 Completed Treatment Dry Eye Syndrome (DES) 4
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Intravenous Cream Topical 4.0 g/200mL Liquid Topical 13 mg/1mL Liquid Topical 0.19 g/6.5g Liquid Topical 0.067 mL/2mL Soap Topical 15 g/100g Solution Topical 10 g/100mL Solution Topical 1.8 g/101 Cream Cutaneous 28 mg/140mL Cream Topical 0.08 g/1g Liquid Topical 0.08 mg/1mL Cream Topical 11.55 g/55mL Cream Topical 24.6 g/120mL Cream Topical 12.1 g/55mL Solution / drops Ophthalmic 10 mg/1mL Cream Topical 31.5 g/150mL Emulsion Oral Cream Topical 4 mg/1mL Patch Topical 3 g/101 Liquid Topical 6.8 g/100mL Gel Topical 6 mg/150mL Gel Vaginal 2 g/100mL Emulsion Topical 2.55 g/50mL Liquid Topical 1.9 g/50mL Gel Topical 6.2 g/31mL Liquid Topical 5.2 g/200mL Gel Topical 16.0 g/200mL Aerosol, foam Topical 0.54 mg/1mL Cream Topical 2.85 g/50g Solution Topical 6.22 g/100mL Cream Topical 10.0 g/100mL Patch Topical 1.3 g/26mL Cream Topical 1.8 g/60mL Liquid Topical 4.5 g/150mL Cream Topical 5 g/25g Cream Topical 8.81 g/25g Cream Topical 8.006 g/100mL Cream Topical 5.0 g/50mL Solution Topical 2.8 g/35mL Cream Topical 1.2 g/20mL Solution Topical 1.65 g/120mL Cream Topical 3 g/30mL Liquid Topical 0.5 g/100mL Patch Topical 1.89 g/27g Patch Topical 2.7 g/27g Patch Topical 7.0 g/100g Patch Topical 1.65 g/22mL Injectable foam Topical 12 g/120mL Patch Topical 0.8 g/8g Patch Topical 1.5 g/25g Cream Topical 1.8 g/9g Patch Topical 1.7 g/8.5g Cream Topical 0.084 g/1mL Powder Topical 0.0000167 g/1g Solution / drops Auricular (otic) Lotion Topical 6 g/100mL Lotion Topical 13 g/100mL Cream Topical 11 g/100mL Swab Topical 0.08 g/1 Cream Topical 5 mg/50mL Cream Topical 4 mg/40mL Shampoo Topical 3.075 g/100g Cream Topical 8.06 g/100g Gel Topical 11.985 g/100g Liquid Topical 3.075 g/100mL Shampoo Topical 3.845 g/100g Cream Topical 6.46 mg/100mL Spray Topical 0.075 g/75mL Liquid Topical 10 g/100g Liquid Topical 3.1406 mL/200mL Cream Topical 4.9947 mL/50mL Solution Topical 9.5 g/100mL Solution Topical 11 g/100mL Liquid Topical 2.5 g/100g Liquid Topical 0.002035 g/100mL Liquid Topical 3 g/100g Liquid Dental Patch Topical 1.75 g/25g Emulsion Topical 9.6 mg/120mL Solution Topical 41.85 mg/150mL Solution Topical 8.13 mg/150mL Cream Topical 1.21 mg/30mL Gel Topical .2 g/1g Cream Topical 1.0 g/100mL Cream Topical 0.9 g/30g Cream Topical 1.2 mg/10mL Liquid Topical 10.82 g/100mL Liquid Topical 15 g/100g Cream Topical 10.03 g/100g Solution / drops Ophthalmic 5 mg/1mL Solution / drops Ophthalmic 0.75 mg/1mL Patch Topical 1.92 mg/32mL Patch Topical 0.6 g/20g Patch Topical 1.8 mg/30mL Liquid Topical 8.13 g/100g Gel Topical 13.5 g/45g Cream Topical 0.08 g/1mL Liquid Topical 25 g/100mL Liquid Topical 6.0 mg/150mL Cream Topical 2.7 mg/90mL Solution Topical 19.60 g/200mL Spray Topical 0.5 g/50mL Solution Rectal 2.25 G/3G Solution Rectal 6.75 G/9G Patch Topical 0.50 g/25mL Patch Topical 0.5 g/25mL Cream Topical 18 g/100g Liquid Topical 4 g/100g Powder Topical 1.8 g/100mL Cream Topical 0.15 g/100mL Patch Topical 3.04264 g/100mL Cream Topical 5.0613 g/100mL Lotion Topical 6.502 g/100mL Cream Topical 2.3315 g/100mL Cream Topical 0.1535 g/100mL Liquid Topical 0.1535 g/100mL Shampoo Topical 0.01 g/1mL Liquid Topical 0.01 g/1mL Patch Topical 9 g/51 Cream Topical 10 g/50g Lotion Topical 2 g/100mL Liquid Topical 4.5 g/4.5mL Gel Topical 5 g/100g Liquid Topical 40 g/100mL Gel Topical 0.01 g/100mL Patch Topical 4.72 g/105mL Gel Topical 0.16 g/160mL Cream Topical 30.75 g/150mL Cream Topical 31.2 g/150mL Lotion Topical 32.12 g/400mL Cream Topical 12.9 g/150mL Liquid Topical 0.05 g/1mL Ointment Topical 5 g/100mL Liquid Oral Cream Topical 0.012 g/100mL Cream Topical 0.7675 g/100g Cream Topical 6.5 g/100g Gel Topical 15.0 g/150mL Cream Topical 3 mg/1mL Liquid Topical 4.8 g/120mL Soap Topical Cream Topical 1.5 mg/30mL Solution / drops Ophthalmic 2.5 mg/1mL Liquid Ophthalmic Cream Topical 200 mg/1mL Lotion Topical 0.09 g/1mL Cream Topical 0.0433 g/1mL Cream Topical 0.0279 g/1mL Patch Topical 2.1 g/101 Patch Topical 2.94 g/101 Patch Topical 2.1 g/7.5g Cream Topical 6.88 mg/160mL Gel Topical 5.6 mg/80mL Kit Topical Injection, solution Intradermal 0.525 mL/1mL Patch Topical 0.22 g/22g Soap Topical 0.1 g/100g Cream Topical 7 mg/35mL Jelly Enteral 19.312 g/48.28g Shampoo Topical 0.001 g/100mL Emulsion Topical 10 g/100mL Gel Topical 0.2 g/100mL Solution / drops Ophthalmic Liquid Rectal 2.8 g/1 Liquid Rectal 5.4 g/1 Liquid Topical 1.0300049 g/100mL Oil Topical 8.0075 g/100mL Liquid Topical 1 kg/20kg Cream Topical 15.585 g/100mL Liquid Topical 11.3 g/100mL Liquid Topical 20.009 g/100mL Cream Topical 11.0005 g/100mL Liquid Topical 10.05 g/100mL Cream Topical 10.0002 g/100mL Gel Topical 91.16098 g/100mL Liquid Topical 26 g/200mL Gel Topical 37.5 g/150mL Liquid Topical 30.78 mL/100mL Liquid Topical 1.6 g/100mL Cream Topical 4.073 g/100mL Gel Rectal; Topical; Vaginal 50 mg/1g Liquid Topical 2.53 g/100g Cream Topical 1.77 g/50g Spray Topical 0.13 g/100mL Cream Topical 1.90 g/30g Cream Topical 1 U/1U Liquid Topical 20 g/100g Liquid Topical 6 g/100g Liquid Topical 0.877 g/100mL Liquid Topical 0.045 g/100mL Cloth Extracorporeal Liquid Topical 10.01 g/100mL Solution / drops Ophthalmic 13 mg/1mL Lotion Topical 2 mL/40mL Gel Topical 3.75 g/15g Gel Topical 0.5 g/2g Powder Topical 8 g/100g Lotion Topical 0.0015 mg/150mL Soap Topical 0.45 g/90g Shampoo Topical 15 g/300mL Lotion Topical 5 mg/50mg Paste, dentifrice Dental 7.68 g/120g Cream Topical 3.25 g/50mL Cream Topical 1.5 g/50mL Shampoo Topical 6 g/300mL Soap Topical 21 g/300mL Solution / drops Topical Cream Topical Liquid Topical 20 g/100mL Gel Topical 9.6 g/120mL Gel Topical 0.57 g/100mL Gel Topical 5.088 mL/100mL Cream Topical 1.729 g/100g Liquid Topical 5.006 g/100mL Cream Topical 0.05 g/1mL Cream Topical 0.04 g/1mL Liquid Topical 2.53045 g/100g Cream Topical 7.05 g/100mL Liquid Topical 8.05 g/100mL Cream Topical 4.07 g/100mL Liquid Topical 4.04 g/100mL Gel Topical 4 g/100mL Liquid Topical 3 g/100mL Cream Topical 3 g/100mL Cream Topical 5 g/100g Cream Topical 6.1000565 g/100mL Liquid Topical 7.1270547 g/100mL Liquid Topical 4.044 g/100mL Liquid Topical 0.0125 g/1mL Cream Topical 6.3 g/18g Liquid Topical 5.021 g/100g Cream Topical 5.105 g/100mL Patch Topical 1 g/100g Kit; liquid; solution; swab Oral; Topical Kit Oral Swab Topical 200 mg/0.5mL Liquid Auricular (otic) Patch Topical 1.3 g/25mL Liquid Topical 4.8 g/160mL Gel Topical 14.4 g/120mL Gel Topical 24.0 g/120mL Solution Topical 4.97 mg/1mL Cream Topical 1.0 g/25mL Patch Topical 1.75 mg/101 Liquid Topical 10.87 g/100mL Liquid Topical 4.102 g/100mL Lotion Topical 10.2 g/100mL Liquid Topical 12 g/100g Lotion Topical 5 g/100mL Cream Topical 0.025 g/100g Patch Topical 10 g/100g Suspension Conjunctival; Ophthalmic Gel Topical 2.65 g/100g Gel Topical 30 g/100mL Spray Topical 5 g/100mL Liquid Topical 0.935 g/100mL Cream Topical 53.67 g/250mL Jelly Topical 200 mg/1g Lotion Topical 35 mg/1mL Kit Intrauterine Stick Topical Cream Cutaneous Solution / drops Ophthalmic 2 mg/1mL Liquid Topical 12 g/100mL Liquid Topical 0.01 g/100mL Cream Topical 0.01 g/100mL Liquid Topical 0.0798 g/1mL Liquid Topical 11 g/100mL Cream Topical 10 g/100mL Liquid Topical 1 g/100g Cloth Topical Suppository Rectal 79.85 % Solution Rectal 4.036 g Cream Topical 4 g/100mL Cream Topical 26 mg/130mL Cream Topical 10.5 mg/1mL Cream Topical 31.65 g/155mL Cream Topical 8.15 g/40mL Cream Rectal; Topical 25 g/100mL Gel Topical 30 mL/150mL Liquid Topical 0.02 g/2mL Cream Topical 29 mg/145mL Gel Topical 20 g/100g Patch Topical 70.4 mg/1 Cream Topical 1.25 mg/25mL Gel Topical 41.85 g/150mL Patch Topical 3.36 g/51 Patch Topical 3.36 g/101 Patch Topical 3.36 mg/32mL Liquid Topical 0.08 g/1g Cream Topical 4.83 g/23mL Cream Topical 4.6 g/23mL Suppository Rectal 1237.7 mg Suppository Rectal 2.393 g Suppository Rectal 0.908 g Suppository Rectal 1.375 G Suppository Rectal 2.25 g Suppository Rectal 2.250 G Solution Rectal 2.3 g Solution Rectal 6.9 g Suppository Parenteral 1375 MG Suppository Parenteral 2250 MG Injection, solution Parenteral Suppository Parenteral Injection, solution Parenteral Injection, solution Intravenous Solution Rectal 6.75 G Suppository Parenteral 1000 MG Suppository Parenteral 1500 MG Suppository Parenteral 2500 MG Suppository Parenteral 750 MG Suppository Parenteral 2.25 G Solution Rectal 2.25 G Solution Rectal 4.5 G Suppository Rectal 3300 mg Suppository Rectal 1400 mg Spray Topical 0.5 mg/1mL Suppository Rectal 91 % / sup Liquid Oral Liquid Topical 995 mg/1mL Suppository Rectal 1 g/1.21 Suppository Rectal 1.614 g/1 Suppository Rectal 2 g/1 Suppository Rectal 1.2 g/1 Suppository Rectal 2.1 g/1 Liquid Topical 100 % Liquid Oral; Topical Liquid Rectal 12.5 g/1 Solution, concentrate Oral Suppository Rectal 2.09 g / sup Suppository Rectal 1 g / sup Suppository Rectal 90 % Liquid Oral; Topical 100 % Cream Rectal; Topical Liquid Intradermal; Subcutaneous Liquid Oral 100 % Enema Rectal Suppository Rectal 1.4 g Injection Cutaneous; Intradermal; Subcutaneous 0.53 g/1mL Solution Other 57 g/100ml Solution Unknown Solution Topical Solution Extracorporeal Gel Topical 0.5 mg/1mL Liquid Topical 6 g/100mL Liquid Topical 100 mg/1mL Cream Topical 10.20052486 g/100g Liquid Topical 0.04 mg/1mL Solution Ophthalmic Solution Ophthalmic 10 mg Solution Ophthalmic 1000000 mg Solution Topical 8.7 g/145mL Cream Topical 6.5 g/130mL Cream Topical 11.7 g/130mL Cream Topical 1.07 g/20mL Lotion Topical 3 g/100mL Liquid Topical 7 g/100mL Solution Topical 4 mg/1mL Shampoo Topical 3.88 mg/1mL Cream Topical 28 % Liquid Topical 30 g/150mL Liquid Topical 9.0 g/300mL Ointment Rectal; Topical Solution Topical 15.96 g/120mL Gel Topical 15.0 g/150g Spray Topical 0.4 g/40mL Enema Rectal 6 g/20ml Cream Topical 5 g/100mL Liquid Topical 5 g/100mL Cream Topical 0.1 g/100mL Cream Topical 0.1 g/100g Shampoo Topical 0.2 g/100mL Cream Topical 4.0 g/50mL Emulsion Topical 12.0 g/120mL Lotion Topical 10.5 g/150mL Spray Topical 12 g/150mL Spray Topical 7.2 g/120mL Cream Topical 3.5 g/50mL Cream Topical 2.5 g/50mL Liquid Topical 2.00008 g/100mL Cream Topical 8 mg/1mL Cream Topical 11 mg/1mL Cream Topical 13 mg/1mL Cream Topical 5.00008 g/100mL Liquid Topical 5.007 g/100mL Liquid Topical 5.740794 g/100mL Liquid Ophthalmic 0.3 mg/100mL Liquid Topical 0.0001 g/1mL Emulsion Topical 0.034 g/1mL Liquid Topical 0.04 g/1mL Emulsion Topical 0.02 g/1mL Solution / drops Ophthalmic 1 g/100mL Liquid Topical 2.5 g/250mL Lotion Topical 8.0 g/200mL Cream Topical 1.67 mg/33mL Cream Topical 0.66 mg/33mL Patch Topical 20 g/100g Suppository Gel Vaginal 0.04 g/1g Suppository Rectal 1.3 g/1 Liquid Topical 15 g/100mL Solution Vaginal 6.0 g/100g Liquid Topical 1.5 g/100mL Cream Topical 31 mg/155mL Cream Topical 11.57 mg/50mL Cream Topical 9 mg/45mL Liquid Topical 0.8 mg/81 Lotion Topical 28 mg/140mL Cream Topical 5 mg/25mL Patch Topical 5 g/25g Liquid Topical 11 g/100g Liquid Topical 9 g/100g Liquid Topical 8 g/100g Cream Topical 8 g/100g Powder Topical 0.1 g/1g Liquid Topical 0.002 g/1mL Swab Topical 0.25 g/2.5mL Patch Topical 2.50 g/25mL Liquid Topical 0.30 g/1.5mL Patch Topical 1.08 g/27mL Liquid Topical 0.1 g/1.5mL Cream Topical 0.06 g/1.5mL Patch Topical 1.61 g/30mL Emulsion Topical 15.62 g/130mL Liquid Topical 7.80 g/130mL Patch Topical 1.37 g/25mL Patch Topical 1.87 g/25mL Cream Topical 1.75 g/50mL Cream Topical 2.50 g/50mL Liquid Topical 0.10 g/1.5mL Patch Topical 1.06 g/25mL Patch Topical 0.81 g/27mL Patch Topical 1.50 g/25mL Liquid Topical 0.2 g/1.5mL Patch Topical 1.0 g/25mL Emulsion Topical 9.10 g/130mL Liquid Topical 0.98 g/130mL Gel Topical 5.5 g/100mL Liquid Topical 10.013 g/100mL Cream Topical 8.013 g/100mL Liquid Topical 3.2 g/100mL Liquid Topical 4.001 g/100mL Cream Topical 8.001 g/100mL Gel Topical 11 g/100mL Liquid Topical 3.02 g/100mL Liquid Topical 5.5 g/100mL Liquid Vaginal 7 g/100mL Liquid Topical 0.3 g/100mL Gel Topical 2 g/100g Gel Rectal Cloth Extracorporeal 0.21 1/701 Shampoo Topical 4 g/100mL Gel Topical 10 mg/1mL Cream Topical 1.5 g/100mL Liquid Topical 4.2 g/100mL Gel Topical 1.5 g/100mL Oil Topical 1 g/100mL Suppository Rectal 2.3896 g Gel Topical 2.0 g/10mL Gel Topical 6.59 g/10mL Gel Topical 8.99 g/10mL Gel Topical 2.01 g/10mL Gel Topical 8.95 g/100mL Cream Topical 0.579998 g/100mL Swab Oral 7.5 1/1 Swab Oral 0.3 g/4g Swab Oral 7.5 g/100g Swab Oral 7.5 mL/100mL Swab Topical 0.43 mL/10mL Swab Topical 0.500 mg/1mL Swab Topical 500 mg/1mL Swab Topical 7.5 g/100g Syrup Oral Solution Topical 1.94 mg/60mL Cream Topical 30 mg/1mL Gel Topical 1 U/1U Injection Intravenous 12 g/1000ml Injection, emulsion Intravenous Injection Intravenous 12 g/L Cream Topical 0.4 mg/40mL Cream Topical 20 g/100g Cream Topical 10 mg/1mL Ointment Topical 40 mg/1g Solution Topical 5 g/100mL Soap Topical 12 g/60g Liquid Topical 8.7675 g/100g Patch Topical 0.34 g/17g Gel Topical 3 g/100mL Liquid Topical 4.001 g/100g Cream Topical 0.00007 g/1mL Cream Topical 0.02 g/1mL Cream Topical 0.00001 mg/1mL Patch Topical 2.0 g/10g Liquid Topical 0.24 g/8mL Liquid Topical 0.5 mg/1mL Liquid Topical 0.03 g/1g Spray Oral 29.5 mg/1mL Cream Topical 3 g/100g Powder Topical Liquid Topical 0.08 g/1mL Cream Topical 0.10295 g/1mL Shampoo Topical 2 g/100mL Cream Topical 1.222 g/100mL Gel Topical 1.222 g/100mL Liquid Topical 2.185 g/100mL Cream Topical 4.555 g/100mL Liquid Topical 5 g/100g Swab Oral 0.075 g/1 Swab Topical 0.5 g/1 Patch Topical 0.13 g/3g Gel Topical 4.8 g/120mL Patch Topical 0.14 g/7g Solution Ophthalmic 4 mg/1mL Liquid Topical 3.97 g/100mL Solution Topical Injection, emulsion Topical Enema Rectal 12.5 % w/w Enema Rectal 80 mL/100mL Cream Topical 2 g/100mL Soap Topical 1 g/100g Liquid Topical 0.0224 g/1mL Patch Topical 0.16 g/1.6g Patch Topical 3.0 g/101 Liquid Topical 0.01 g/1g Cream Topical 4.2 g/100g Spray Topical 4.8 g/80mL Liquid Topical 25 g/100g Lotion Topical 15 g/300mL Cream Topical 2.005 g/100mL Gel Vaginal 4 g/100g Liquid Topical 0.05205 g/1mL Emulsion Topical 0.075205 g/1mL Cream Topical 11.45 g/50mL Liquid Topical 2 g/100g Cream Topical 0.175 mg/5mL Paste Oral Solution Topical 6 g/100mL Gel Topical 10.0 g/200mL Cream Topical 8.6 g/200mL Emulsion Topical 9 g/150mL Liquid Topical 0.15 g/150mL Liquid Topical 2.5 g/100mL Liquid Percutaneous 50 % v/v Cream Topical 16 mg/80mL Gel Topical Gel Dental Liquid Topical 8.75 g/100g Emulsion Topical 0.8 g/100mL Cream Topical 0.29 g/30mL Cream Topical 1.4 g/50mL Cream Topical 1.97 g/30mL Cream Topical 3.14 g/50mL Shampoo Topical 7.5 g/300g Solution / drops Ophthalmic 2 g/1000mL Solution / drops Ophthalmic 0.25 g/100mL Solution / drops Ophthalmic 0.22 g/100mL Solution / drops Ophthalmic .22 g/100mL Lotion Topical 16 mg/200mL Liquid Topical 10.5 g/100g Liquid Topical 19.91 g/100g Liquid Topical 4.975 g/100mL Soap Topical 12 g/100g Emulsion Parenteral Liquid Topical 1.01 mg/2.8mL Liquid Topical 0.57 mg/2.8mL Patch Topical 5.55 mg/27mL Liquid Topical 0.58 mg/2.8mL Patch Topical 5.56 mg/27mL Solution / drops Ophthalmic 0.25 mg/1mL Solution / drops Ophthalmic 9 mg/1mL Spray Ophthalmic 1 mg/1mL Gel Ophthalmic 2 mg/1mL Solution Conjunctival; Ophthalmic Ointment Ophthalmic; Topical Gel Topical 1 g/100mL Gel Topical 180 mg/1g Soap Topical 8 g/100g Patch Topical 1.84 g/23mL Cream Topical 0.00012 mg/120mL Solution Auricular (otic) Liquid Topical 4.80 g/20mL Solution Topical 69.8 g/100mL Solution Ophthalmic 10.000 mg Liquid Rectal 2.8 g/4mL Suppository Rectal 1 g/1 Cream Topical 0.5 mg/1mL Liquid Topical 0.29 g/5mL Emulsion Topical 3.5 mg/35mL Liquid Topical 30 g/100g Liquid Topical 2.145 g/100g Liquid Topical 3.055 g/100g Liquid Topical 3.005 g/100g Cream Topical 10 g/100g Solution Topical 7.35 g/30mL Liquid Oral 5 g/100g Liquid Oral 2 g/100mL Cream Oral 5.05 g/100mL Lotion Topical 20 mg/100mL Cream Topical 24 g/120g Lotion Topical 0.5 g/200mL Lotion Topical 3.38 g/200mL Lotion Topical 1.22 g/200mL Lotion Topical 6.84 g/180mL Cream Topical 37.8 g/180mL Cream Topical 7 g/35mL Liquid Topical 7 g/100g Solution Topical 2.37 g/40mL Ointment Topical Suppository Rectal 83 g/100g Gel Topical 9 g/100mL Liquid Oral 4.5 mg/100mL Enema Rectal Enema Rectal 25 % w/v Cream Topical 7 g/100mL Emulsion Topical 6 g/100mL Liquid Topical 4 g/100mL Injection Intravenous Injection Intravenous 0.21 g/100ml Solution Parenteral Kit Oral; Topical Spray Topical 0.5 g/100mL Patch Topical 7.5 g/30g Lotion Topical 4 g/100mL Cream Topical 1 g/100mL Liquid Topical 1 g/100mL Cream Topical 1.2 g/100mL Cream Topical 4.0015 g/100mL Gel Topical 6.459996 g/100mL Shampoo Topical 0.02 mg/1mL Cream Topical 3 mg/100mL Cream Topical 5 mg/100mL Liquid Topical 0.19 g/8g Liquid Topical 8 g/100mL Liquid Topical 0.8 g/100g Cream Topical Cream Topical 18 g/100mL Cream Topical 0.05 g/100g Liquid Topical 6.25 g/250mL Cream Topical 12.5 g/50mL Lotion Topical 1.45 g/15mL Cream Topical 2.92 mg/50mL Emulsion Topical 2.35 mg/125mL Cream Topical 2.55 mg/50mL Gel Topical 9.6 mg/160mL Liquid Topical 7.81 mg/150mL Soap Topical 5 g/100g Cloth; cream; kit Topical Cream Topical 28 g/140mL Gel Topical 15 g/150g Emulsion Ophthalmic Solution / drops Ophthalmic 12 mg/3mL Solution / drops Ophthalmic 15 mg/3mL Solution / drops Ophthalmic 0.4 1/1 Solution / drops Ophthalmic 0.5 1/1 Injection Topical Liquid Topical 2 g/100mL Solution Topical 2.6 g/40mL Solution Topical 0.21 mg/121 Cream Topical 2.53 mg/150mL Cream Topical 1.87 mg/150mL Cream Topical 0.25 g/20mL Cream Topical 7.8 mg/1mL Cream Topical 1.98 mg/1mL Cream Topical 0.25 mg/1mL Patch Topical 0.8 g/16mL Patch Topical 0.56 g/14mL Patch Topical 0.33 g/3mL Patch Topical 2 g/25mL Liquid Topical 0.7426 g/100mL Liquid Topical 3.6201 g/100mL Cream Topical 2.04 g/30mL Gel Topical 3.002 g/100mL Liquid Topical 0.100005 g/1g Liquid Topical 0.03 mg/1mL Lotion Cutaneous Liquid Nasal Liquid Topical 4.0 g/200mL Patch Topical 1.50 g/50g Cream Topical 0.03 g/1mL Liquid Topical 0.06 g/1mL Cream Topical 0.03 g/1g Patch Topical 0.05 g/1mL Liquid Topical 0.07 g/1mL Enema Rectal 0.35 g Cream Topical 0.9 g/9g Cream Topical 3.1545 g/100g Lotion Topical 4.305 g/100mL Cream Topical 1.9345 g/100g Cream Topical 0.02 g/1g Liquid Topical 0.018 mg/1mL Cream Topical 0.000001 g/1g Cream Rectal Soap Topical 0.5 g/100g Lotion Topical 0.4 g/100mL Soap Topical 0.4 g/100g Cream Topical 15 mg/100mL Cream Topical 10 mg/100mL Patch Topical 6 g/100g Gel Topical 5 mg/1mL Gel Topical 13.8 mg/100mL Gel Topical 2.661 g/100mL Lotion Topical 5.75 g/100mL Cream Topical 2 g/100g Gel Topical 0.02 g/100mL Liquid Topical 0.1 g/100mL Cream Topical 5.05 g/100g Patch Topical 2.1 g/7g Cream Topical 1.33 mg/30mL Spray Topical Cream Topical 7 mg/100mL Lotion Topical 1.4 mg/100mL Gel Topical 1 mg/100mL Cream Cutaneous 19.2 g/48g Cream Cutaneous 16.8 g/48g Cream Topical 2.49 mL/50mL Spray Topical 1.5 g/150mL Cream Topical 9.0 g/75mL Lotion Topical 7.5 g/150mL Lotion Topical 6.0 g/120mL Cream Topical 1.69 mg/60mL Patch Topical 0.8 g/101 Liquid Topical 5.92 g/150mL Cream Topical 3.3 g/50g Cream Topical 5.82 g/60mL Patch Topical 1.96 g/28g Liquid Topical 13.50 g/150mL Cream Topical 0.07 mg/1mL Patch Topical 1.2 g/20g Cream Topical 3.5 g/70g Cream Topical 4.2 g/20g Cream Topical 6 g/30mL Gel Topical 5 g/25g Cream Topical 4 g/20mL Patch Topical 1.37 mg/101 Cream Topical 10 g/50mL Powder Oral Cream Topical 36 g/160mL Gel Topical 60 g/300mL Gel Topical 146.88 g/300mL Cream Topical 6 g/100mL Cream Topical 5.15 mL/100mL Patch Topical 0.27 g/27g Cream Topical 5.6 g/50g Injection, solution Intradermal; Subcutaneous Injection, solution Intradermal; Subcutaneous 0.5 mL/1mL Gel Topical 5 g/100mL Liquid Topical 0.16 g/1mL Cream Topical 1.6 mg/80mL Gel Topical 4.65 mg/155mL Cream Topical 8 g/40mL Liquid Topical 0.03 g/1mL Suppository Rectal 1.3672 g Suspension Oral; Rectal 2.3896 g Capsule Rectal 87 % Suppository Rectal 2.38958 g Suppository Rectal 2.76 g Suppository Rectal 1.365 g Suppository Rectal 1380.00 mg Liquid Topical Emulsion Topical Solution Irrigation 2.6 % Patch Topical 1.84 g/23g Patch Topical Shampoo Topical 0.04 g/1mL Cream Topical 6 g/30g Cream Topical 4.03 g/100mL Liquid Topical 1.001 g/100mL Solution Topical 0.12 mg/101 Liquid Topical 6.0 g/200mL Injectable foam Topical 16.5 g/150mL Cream Topical 30 g/150mL Emulsion Topical 2 g/100mL Lotion Topical 5 mg/100mL Cream Topical 10.16 g/40mL Cream Topical 18 g/90mL Liquid Topical 0.02 g/1mL Liquid Topical 4.4 g/100mL Liquid Topical 28 mg/140mL Shampoo Topical 2 g/100g Cream Topical 24 g/80g Lotion Topical 12742.339 mg/145mL Cream Topical 5926.7425 mg/35mL Cream Topical 5.05 g/50g Lotion Topical 8377.386 mg/60mL Lotion Topical Injectable foam Topical Cream Topical 1.0 g/45g Cream Topical 78.1 g/95g Gel Topical 0.252 g/45g Cream Topical 5.04 g/30mL Liquid Topical 5287.8 mg/140mL Cream Topical 2.1 g/70g Cream Topical 3147.5 mg/50mL Patch Topical 1.5 g/30g Cream Topical 4910.1 mg/50mL Emulsion Topical 9694.3 mg/140mL Lotion Topical 503 mg/50mL Cream Topical 1510.8 mg/140mL Liquid Topical 1762.6 mg/140mL Liquid Topical 14100.8 mg/140mL Enema Rectal 3 g/100mL Oil Cutaneous; Extracorporeal; Vaginal 48 g/240mL Lotion Topical 0.008 g/100mL Liquid Topical 3.5 g/100mL Cream Topical 32.7 g/150mL Cream Topical 0.1 g/1g Liquid Topical 0.1 g/1mL Liquid Topical 0.02 mg/1mL Liquid Topical 0.015 g/1mL Solution Topical 12.3 g/100mL Cream Topical 0.06 g/1mL Liquid Topical 0.04 g/5mL Liquid Topical 1.005 g/100g Liquid Topical 0.01 mg/1mL Gel Topical 25 g Cream Topical 8 g/100mL Gel Topical 2 g/100mL Gel Topical 15 g/100mL Solution Rectal Suppository 1.375 G Suppository Rectal 0.675 g Spray Oral Solution Ophthalmic 1 g/100g Lotion Topical 8.28 g/180mL Liquid Topical 0.001 g/1mL Cream Topical 0.04 g/1g Gel Topical 0.015 g/1mL Cream Topical 5 mg/1mL Cream Topical 3.43 g/50mL Liquid Topical 2.59 g/150mL Liquid Topical 0.06 g/1g Liquid Topical 0.04 g/1g Gel Topical 91.16 g/100mL Gel Topical 91.16098 g/100g Cream Topical 4 g/100g Cream Topical 6 mg/150mL Patch Topical 2.3 g/23mL Extract Topical 13.226 g/100mL Cream Topical 0.2 g/100mL Liquid Topical 10 g/100mL Liquid Topical 0.2 g/100mL Emulsion Topical 2.04 g/100mL Cream Topical 6.2 g/100mL Patch Topical 10 g/100mL Concentrate Topical 7 g/100mL Swab Topical Gel Vaginal 0.17 g/1g Gel Vaginal 0.306 g/101 Gel Vaginal 0.11 g/101 Patch Topical 1.57 g/35g Lotion Topical 23 % Rinse Oral Suppository Rectal 2.145 g / sup Cream Topical 3.55 g/100mL Gel Topical 3.55 g/100mL Cream Topical 12.6 g/100mL Gel Topical 9.7 g/100mL Gel Topical 8.752 g/100mL Gel Vaginal 0.1 g/100mL Liquid Topical 16 g/100mL Liquid Vaginal 0.5 g/100mL Shampoo Topical 2.5 g/100mL Suppository Rectal Solution Topical 0.25 g/5mL Cream Topical 0.16 g/8g Solution Topical 20 g/100mL Suppository Rectal 2.55 g Suppository Rectal 1.50 g Suppository 2.55 g Suppository 1.50 g Suppository Rectal 1365 mg Suppository Rectal 2320 mg - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US9717852 No 2017-08-01 2033-04-08 US US9034300 No 2015-05-19 2030-10-15 US US9259494 No 2016-02-16 2035-05-04 US US9849199 No 2017-12-26 2036-02-11 US
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 1170.0 mg/mL ALOGPS logP -1.9 ALOGPS logP -1.8 Chemaxon logS 1.1 ALOGPS pKa (Strongest Acidic) 13.61 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 60.69 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 20.52 m3·mol-1 Chemaxon Polarizability 8.93 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 108.6017602 predictedDarkChem Lite v0.1.0 [M-H]- 108.5340602 predictedDarkChem Lite v0.1.0 [M-H]- 108.5118602 predictedDarkChem Lite v0.1.0 [M-H]- 108.4987602 predictedDarkChem Lite v0.1.0 [M-H]- 122.083244 predictedDeepCCS 1.0 (2019) [M+H]+ 108.4809602 predictedDarkChem Lite v0.1.0 [M+H]+ 109.8136602 predictedDarkChem Lite v0.1.0 [M+H]+ 108.7717602 predictedDarkChem Lite v0.1.0 [M+H]+ 109.5629602 predictedDarkChem Lite v0.1.0 [M+H]+ 124.27176 predictedDeepCCS 1.0 (2019) [M+Na]+ 108.6535602 predictedDarkChem Lite v0.1.0 [M+Na]+ 108.6834602 predictedDarkChem Lite v0.1.0 [M+Na]+ 108.8114602 predictedDarkChem Lite v0.1.0 [M+Na]+ 132.4601 predictedDeepCCS 1.0 (2019)
Targets
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- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Agonist
- General Function
- Zinc ion binding
- Specific Function
- Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-lin...
- Gene Name
- PPARD
- Uniprot ID
- Q03181
- Uniprot Name
- Peroxisome proliferator-activated receptor delta
- Molecular Weight
- 49902.99 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phospholipase a2 activity
- Specific Function
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
- Gene Name
- PLA2G2E
- Uniprot ID
- Q9NZK7
- Uniprot Name
- Group IIE secretory phospholipase A2
- Molecular Weight
- 15988.525 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Inositol-3-phosphate synthase activity
- Specific Function
- Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis o...
- Gene Name
- ISYNA1
- Uniprot ID
- Q9NPH2
- Uniprot Name
- Inositol-3-phosphate synthase 1
- Molecular Weight
- 61067.285 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Not Available
- Gene Name
- ADH1B
- Uniprot ID
- P00325
- Uniprot Name
- Alcohol dehydrogenase 1B
- Molecular Weight
- 39854.21 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Phosphatidylinositol binding
- Specific Function
- Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of elect...
- Gene Name
- ITPR1
- Uniprot ID
- Q14643
- Uniprot Name
- Inositol 1,4,5-trisphosphate receptor type 1
- Molecular Weight
- 313926.375 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Small molecule binding
- Specific Function
- This protein is, quantitatively, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy.
- Gene Name
- PAEP
- Uniprot ID
- P09466
- Uniprot Name
- Glycodelin
- Molecular Weight
- 20624.015 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Protein homodimerization activity
- Specific Function
- Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids.
- Gene Name
- NAGA
- Uniprot ID
- P17050
- Uniprot Name
- Alpha-N-acetylgalactosaminidase
- Molecular Weight
- 46564.15 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Receptor signaling protein activity
- Specific Function
- GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modula...
- Gene Name
- ARF1
- Uniprot ID
- P84077
- Uniprot Name
- ADP-ribosylation factor 1
- Molecular Weight
- 20696.62 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Sulfate adenylyltransferase (atp) activity
- Specific Function
- Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield ...
- Gene Name
- PAPSS1
- Uniprot ID
- O43252
- Uniprot Name
- Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
- Molecular Weight
- 70832.725 Da
References
- Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [Article]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [Article]
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Mismatched dna binding
- Specific Function
- This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the f...
- Gene Name
- mutL
- Uniprot ID
- P23367
- Uniprot Name
- DNA mismatch repair protein MutL
- Molecular Weight
- 67923.04 Da
References
- Protein Data Bank: 1X9Z Crystal structure of the MutL C-terminal domain [Link]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
- Specific Function
- Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis.
- Gene Name
- nrdB
- Uniprot ID
- P69924
- Uniprot Name
- Ribonucleoside-diphosphate reductase 1 subunit beta
- Molecular Weight
- 43516.885 Da
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Metal ion binding
- Specific Function
- Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dG...
- Gene Name
- mutY
- Uniprot ID
- P17802
- Uniprot Name
- Adenine DNA glycosylase
- Molecular Weight
- 39148.835 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Trna methyltransferase activity
- Specific Function
- Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
- Gene Name
- TRDMT1
- Uniprot ID
- O14717
- Uniprot Name
- tRNA (cytosine(38)-C(5))-methyltransferase
- Molecular Weight
- 44596.17 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Curator comments
- Literature referenced found the drug increased target activity in the organism of Saccharomyces cerevisiae.
- General Function
- Protein homodimerization activity
- Specific Function
- Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathi...
- Gene Name
- GSTZ1
- Uniprot ID
- O43708
- Uniprot Name
- Maleylacetoacetate isomerase
- Molecular Weight
- 24212.005 Da
References
- Jia XD, Chen XW, Chen DF, Chen J: [Expression of glutathione S-transferase zeta class genes in Saccharomyces cerevisiae]. Yi Chuan. 2006 May;28(5):551-6. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Retinal dehydrogenase activity
- Specific Function
- Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
- Gene Name
- ALDH1A1
- Uniprot ID
- P00352
- Uniprot Name
- Retinal dehydrogenase 1
- Molecular Weight
- 54861.44 Da
References
- Hong SH, Ngo HP, Nam HK, Kim KR, Kang LW, Oh DK: Alternative Biotransformation of Retinal to Retinoic Acid or Retinol by an Aldehyde Dehydrogenase from Bacillus cereus. Appl Environ Microbiol. 2016 Jun 13;82(13):3940-3946. doi: 10.1128/AEM.00848-16. Print 2016 Jul 1. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Inducer
- General Function
- Steroid hydroxylase activity
- Specific Function
- Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic ...
- Gene Name
- CYP2E1
- Uniprot ID
- P05181
- Uniprot Name
- Cytochrome P450 2E1
- Molecular Weight
- 56848.42 Da
References
- Yang MX, Cederbaum AI: Glycerol increases content and activity of human cytochrome P-4502E1 in a transduced HepG2 cell line by protein stabilization. Alcohol Clin Exp Res. 1997 Apr;21(2):340-7. [Article]
Transporters
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Forms a channel that mediates water and glycerol transport across cell membranes at neutral pH (PubMed:9405233, PubMed:11952783, PubMed:30423801, PubMed:30420639). The channel is also permeable to urea (PubMed:9405233). Plays an important role in body energy homeostasis under conditions that promote lipid catabolism, giving rise to glycerol and free fatty acids. Mediates glycerol export from adipocytes. After release into the blood stream, glycerol is used for gluconeogenesis in the liver to maintain normal blood glucose levels and prevent fasting hypoglycemia. Required for normal glycerol reabsorption in the kidney (By similarity).
- Specific Function
- Glycerol channel activity
- Gene Name
- AQP7
- Uniprot ID
- O14520
- Uniprot Name
- Aquaporin-7
- Molecular Weight
- 37231.325 Da
References
- Hirako S, Wakayama Y, Kim H, Iizuka Y, Matsumoto A, Wada N, Kimura A, Okabe M, Sakagami J, Suzuki M, Takenoya F, Shioda S: The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice. Obes Res Clin Pract. 2016 Nov - Dec;10(6):710-718. doi: 10.1016/j.orcp.2015.12.001. Epub 2015 Dec 30. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines.
- Specific Function
- Amine transmembrane transporter activity
- Gene Name
- AQP9
- Uniprot ID
- O43315
- Uniprot Name
- Aquaporin-9
- Molecular Weight
- 31430.77 Da
References
- Hirako S, Wakayama Y, Kim H, Iizuka Y, Matsumoto A, Wada N, Kimura A, Okabe M, Sakagami J, Suzuki M, Takenoya F, Shioda S: The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice. Obes Res Clin Pract. 2016 Nov - Dec;10(6):710-718. doi: 10.1016/j.orcp.2015.12.001. Epub 2015 Dec 30. [Article]
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Water channel activity
- Specific Function
- Transporter of glycerol across the cytoplasmic membrane, with limited permeability to water and small uncharged compounds such as polyols.
- Gene Name
- glpF
- Uniprot ID
- P0AER0
- Uniprot Name
- Glycerol uptake facilitator protein
- Molecular Weight
- 29779.71 Da
References
- Wang Y, Schulten K, Tajkhorshid E: What makes an aquaporin a glycerol channel? A comparative study of AqpZ and GlpF. Structure. 2005 Aug;13(8):1107-18. doi: 10.1016/j.str.2005.05.005. [Article]
Drug created at November 30, 2015 19:10 / Updated at February 20, 2024 23:55