Titanium dioxide

Identification

Summary

Titanium dioxide is a sunscreen agent found in sunscreens that absorbs UV rays.

Brand Names

Eucerin

Generic Name

Titanium dioxide

DrugBank Accession Number

DB09536

Background

Titanium dioxide, also known as titanium(IV) oxide or titania, is the naturally occurring oxide of titanium. It is used as a pigment under the names titanium white, Pigment White 6 (PW6), or CI 77891. It is typically extracted from ilmenite, rutile and anatase.

Type

Small Molecule

Groups

Approved

Structure

Similar Structures

Weight: Average: 79.865
Monoisotopic: 79.937771
Chemical Formula: O₂Ti

Synonyms

dióxido de titanio
óxido de titanio(4)
Titanium dioxide

External IDs

C.I. 77891
CI 77891
CI-77891
E 171
E-171
INS NO.171
INS-171
NSC-15204
NSC-200C

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Pharmacology

Indication

Titanium dioxide is used in most sunscreens to block UVA and UVB rays, similar to zinc oxide.

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Dose Form
Used in combination to treat	Dermatitis, eczematous	Combination Product in combination with: Witch hazel (DB11111), Ichthammol (DB11341), Zinc oxide (DB09321)	••• •••	••••••••
Used in combination for prophylaxis of	Sunburn		••• •••
Used in combination to treat	Wounds	Combination Product in combination with: Witch hazel (DB11111), Zinc oxide (DB09321), Ichthammol (DB11341)	••• •••	••••••••
Used in combination to treat	Abrasions	Combination Product in combination with: Ichthammol (DB11341), Zinc oxide (DB09321), Witch hazel (DB11111)	••• •••	••••••••
Used in combination to treat	Blistering	Combination Product in combination with: Ichthammol (DB11341), Zinc oxide (DB09321), Witch hazel (DB11111)	••• •••	••••••••

Associated Therapies

UV protection therapy

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range. The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.

Target	Actions	Organism
UMacrophage receptor MARCO	Not Available	Humans

Absorption

When male and female rats were fed a diet containing titanium dioxide (100 g/kg) for a period of about 32 days, a significant retention of titanium of 0.06 and 0.11 mg/kg wet weight was found only in the muscles; no retention was observed in the liver, spleen, kidney, bone, plasma, or erythrocytes

Volume of distribution

Six hours after titanium dioxide was administered to rats through IV injection at 250 mg/kg body weight, the highest concentration appeared in the liver; after 24 hours, the highest concentration was detected in the celiac lymph nodes, which filter the lymph from the liver.

Protein binding

The researchers/ determined blood levels of titanium dioxide (anatase) following oral ingestion of titanium-dioxide capsules and/or powder in six adult men (24-66 years of age). Titanium dioxide was absorbed by the gastrointestinal tract in a size dependent manner: smaller particles (0.16 um) were more readily absorbed than larger ones (0.38 um). Before the experiment, the background blood levels of titanium dioxide in these men ranged from approximately 6 to 18 ug/L. Blood levels reached up to approximately 50 ug/L or 100 ug/L between 4 and 12 hours after intake of 23 mg or 46 mg titanium dioxide, respectively

Metabolism

Rats were intraperitoneal injected with 1.60 g/100 g body wt of TiO(2) in saline solution. Organs (liver, spleen, lung) were processed for histological evaluation. Reactive oxygen species (ROS) in alveolar macrophages obtained by bronchoalveolar lavage (BAL) were evaluated using the nitroblue tetrazolium test and quantitative evaluation by digital image analysis. The histological analysis of organs revealed the presence of titanium in the parenchyma of these organs with no associated tissue damage. Although in lung alveolar macrophages TiO(2) induced a significant rise in ROS generation, it failed to cause tissue alteration. This finding may be attributed to an adaptive response.

Route of elimination

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days.The retention half-time was 14 days for the first clearance phase and 88 days thereafter.

Half-life

The kinetics of TiO2 elimination in the rat lung following its deposition after 7 hr exposure at 10 and 50 mg/cu m were determined for periods up to 140 days...The retention half-time was 14 days for the first clearance phase and 88 days thereafter.

Clearance

The clearance of titanium dioxide from the lungs was studied in rats after inhalation of 15 or 100 mg/cu m. The average median aerodynamic diameter of the titanium dioxide particles was 1.48 um. After a single exposure, about 40-45% of the deposited particles were cleared from the lung in 25 days. At 15 mg/cu m, 0.7% was found in the hilar lymph nodes indicating penetration of titanium dioxide particles from alveoli into the lymphatic system and partial clearance by the lymphatic route. The clearance rate was similar after intra-tracheal administration of titanium dioxide. At an exposure of 100 mg/cu m, the clearance rate decreased drastically. /Other researchers/ demonstrated the presence of titanium dioxide in the lymphatic systems of 3 workers employed in processing titanium dioxide pigments.

Adverse Effects

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Toxicity

Rat - LD50 Intratracheal (>100ug/kg ) Effects: Structural or functional changes in bronchi and trachea. There is inadequate evidence in humans for the carcinogenicity of titanium dioxide. Cancer in experimental animals: There is sufficient evidence in experimental animals for the carcinogenicity of titanium dioxide. Overall evaluation: Titanium dioxide is possibly carcinogenic to humans (Group 2B).

Pathways

Not Available

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Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
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Padeliporfin	Titanium dioxide may increase the photosensitizing activities of Padeliporfin.
Porfimer sodium	Titanium dioxide may increase the photosensitizing activities of Porfimer sodium.
Tretinoin	The risk or severity of adverse effects can be increased when Tretinoin is combined with Titanium dioxide.
Verteporfin	Titanium dioxide may increase the photosensitizing activities of Verteporfin.

Food Interactions

No interactions found.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Titanium	unknown	D1JT611TNE	7440-32-6	RTAQQCXQSZGOHL-UHFFFAOYSA-N

Brand Name Prescription Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
AV3712501 Mineral Sunscreen SPF 18	Cream	7.0 g/100g	Topical	The Hain Celestial Group	2006-03-01	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End
3 Concept Eyes Glossing Waterful Foundation Milk Ivory	Cream	1.44 g/40g	Topical	Nanda Co., Ltd.	2013-08-01	Not applicable
3 Concept Eyes Glossing Waterful Foundation Natural Ivory	Cream	1.44 g/40g	Topical	Nanda Co., Ltd.	2013-08-01	Not applicable
3 Concept Eyes Glossing Waterful Foundation Nude Beige	Cream	1.44 g/40g	Topical	Nanda Co., Ltd.	2013-08-01	Not applicable
3 Concept Eyes Glossing Waterful Foundation Soft Beige	Cream	1.44 g/40g	Topical	Nanda Co., Ltd.	2013-08-01	Not applicable
3 Concept Eyes Honey Face Chiffon Fluid 001	Cream	3.71 mg/40mL	Topical	Nanda Co., Ltd.	2013-08-01	Not applicable

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
01 Balancing Foundation SPF 15	Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)	Emulsion	Topical	The Body Shop, Wake Forest	2009-09-06	2017-10-05
02 Balancing Foundation SPF 15	Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)	Emulsion	Topical	The Body Shop, Wake Forest	2009-09-06	2017-10-05
02 Cushion Spf45 Sunscreen	Titanium dioxide (13.5 g/100mL) + Octinoxate (5 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.5 g/100mL) + Zinc oxide (8 g/100mL)	Liquid	Topical	COIZ CO LTD	2019-06-30	Not applicable
03 Balancing Foundation SPF 15	Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)	Emulsion	Topical	The Body Shop, Wake Forest	2009-09-06	2017-10-05
04 Balancing Foundation SPF 15	Titanium dioxide (1.45 mg/0.5mL) + Octinoxate (3.75 mg/0.5mL) + Octisalate (2.5 mg/0.5mL)	Emulsion	Topical	The Body Shop, Wake Forest	2009-09-06	2017-10-05

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Abalone Crystaldouble EX Bb	Titanium dioxide (9.9 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octinoxate (2 g/100mL) + Octocrylene (3 g/100mL)	Cream	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable
Abalone Crystaldouble EX Cc	Titanium dioxide (4.694 g/100mL) + Adenosine (0.04 g/100mL) + Nicotinamide (2 g/100mL) + Octinoxate (7 g/100mL)	Cream	Topical	C&bcosmetic Co.,ltd.	2017-03-10	Not applicable
AHC Premium Intense Contour Balm	Titanium dioxide (3.96 g/50mL) + Adenosine (0.02 g/50mL) + Aluminium tristearate (0.04 g/50mL) + Aluminum hydroxide (0.45 g/50mL) + Arbutin (1 g/50mL) + Methicone (20 CST) (1.3 g/50mL) + Octinoxate (1.5 g/50mL) + Talc (2.05 g/50mL) + Zinc oxide (0.96 g/50mL)	Cream	Topical	Carver Korea Co.,Ltd.	2014-01-15	2017-11-22
Antibacterial PE film	Titanium dioxide (0.3 g/100g)	Film	Topical	DH Investment Co Ltd	2020-06-27	Not applicable
Beaute de Cell Perfect Sun-Shield SPF 50 PA	Titanium dioxide (3.85 g/100mL)	Cream	Topical	Dracell Cosmetics Co., Ltd	2016-02-04	Not applicable

Chemical Identifiers

UNII: 15FIX9V2JP
CAS number: 13463-67-7
InChI Key: GWEVSGVZZGPLCZ-UHFFFAOYSA-N
InChI: InChI=1S/2O.Ti
IUPAC Name: dioxotitanium
SMILES: O=[Ti]=O

References

General References

Olmedo DG, Tasat DR, Guglielmotti MB, Cabrini RL: Effect of titanium dioxide on the oxidative metabolism of alveolar macrophages: an experimental study in rats. J Biomed Mater Res A. 2005 May 1;73(2):142-9. [Article]
Drugs.com [Link]
ChemIDplus [Link]
Pubchem [Link]

External Links

KEGG Compound: C13409
PubChem Compound: 26042
PubChem Substance: 347827875
ChemSpider: 24256
RxNav: 38323
ChEBI: 32234
Wikipedia: Titanium_dioxide

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Not Available	Sunburn	1
4	Completed	Treatment	Melasma	1
3	Completed	Treatment	Caries / Caries Class I / Dental Decay / Dentin Caries / Pulpitis - Reversible / Pulpitis dental	1
3	Unknown Status	Treatment	Bleeding / Infection / Postoperative Complications	1
2	Completed	Supportive Care	Advanced Malignant Neoplasm / Dermatologic Complications	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Cream	Topical	1.44 g/40g
Cream	Topical	3.71 mg/40mL
Cream	Topical	2.78 mg/30mL
Powder	Topical	0.57 g/8g
Lipstick	Topical	0.02 g/4.5g
Lipstick	Topical	0.11 g/4.5g
Lipstick	Topical	0.15 g/4.5g
Lipstick	Topical	0.16 g/4.5g
Lipstick	Topical	0.17 g/4.5g
Lipstick	Topical	0.22 g/4.5g
Lipstick	Topical	0.13 g/4.5g
Lipstick	Topical	0.03 g/4.5g
Lipstick	Topical	0.18 g/4.5g
Lipstick	Topical	0.09 g/4.5g
Lipstick	Topical	0.01 g/1.1g
Lipstick	Topical	0.23 g/1.1g
Lipstick	Topical	0.26 g/1.1g
Lipstick	Topical	0.04 g/1.1g
Lipstick	Topical	0.22 g/1.1g
Lipstick	Topical	0.08 g/1.1g
Powder	Topical	0.07 g/5g
Powder	Topical	0.31 g/5g
Powder	Topical	0.37 g/5g
Powder	Topical	0.12 g/5g
Powder	Topical	0.67 g/8g
Powder	Topical	0.68 g/8g
Powder	Topical	0.47 g/8g
Powder	Topical	0.52 g/8g
Liquid	Topical	0.16 g/6g
Liquid	Topical	0.19 g/6g
Liquid	Topical	0.06 g/6g
Liquid	Topical	0.65 g/5mL
Lipstick	Topical	0.02 g/3.5g
Lipstick	Topical	0.12 g/3.5g
Lipstick	Topical	0.05 g/3.5g
Lipstick	Topical	0.17 g/3.5g
Lipstick	Topical	0.04 g/3.5g
Lipstick	Topical	0.07 g/3.5g
Lipstick	Topical	0.10 g/3.5g
Lipstick	Topical	0.20 g/3.5g
Lipstick	Topical	0.15 g/3.5g
Lipstick	Topical	0.29 g/3.5g
Lipstick	Topical	0.14 g/3.5g
Lipstick	Topical	0.13 g/3.5g
Lipstick	Topical	0.014 g/3.5g
Lipstick	Topical	0.010 g/3.5g
Lipstick	Topical	0.01 g/3.5g
Powder	Topical	1.03 g/11g
Powder	Topical	1.63 g/11g
Lipstick	Topical	0.129 g/1g
Lipstick	Topical	0.03 g/1g
Lipstick	Topical	0.097 g/1g
Lipstick	Topical	0.107 g/1g
Lipstick	Topical	0.005 g/1g
Lipstick	Topical	0.11 g/1g
Lipstick	Topical	0.081 g/1g
Powder	Topical	0.12 g/25g
Stick	Topical	0.47 g/10g
Stick	Topical	0.4 g/10g
Stick	Topical	0.85 mg/0.085g
Stick	Topical	0.015 g/0.085g
Stick	Topical	0.017 g/0.085g
Stick	Topical	0.005 g/0.085g
Powder	Topical	0.42 g/3.5g
Powder	Topical	0.30 g/3.5g
Powder	Topical	0.36 g/3.5g
Powder	Topical	0.23 g/3.5g
Cream	Topical	78.6 mg/1mL
Cream	Topical	121.6 mg/1mL
Cream	Topical	77.2 mg/1mL
Powder	Topical	0.387 g/4.3g
Cream	Topical	5 %
Lotion	Topical	2.4 %
Liquid	Topical	11.18 g/140mL
Cream	Topical	1.8 %
Powder	Topical	1.7 g/12g
Emulsion; kit	Topical
Cream	Topical	9.072 g/40g
Cream	Topical	1.7 g/7.5g
Lotion	Topical	42 mg/1mL
Spray	Topical
Cream	Topical	2.46 g/30mL
Stick	Topical	0.234 g/100g
Stick	Topical	8.8 %
Liquid	Topical	8.9 %
Powder	Topical	9.8 g/100g
Liquid	Topical	45 mL/100mL
Cream	Topical	6.4 %
Cream	Topical	8 %
Cream	Topical	7.3 %
Cream	Topical	7.6 %
Powder	Topical	6.9 g/100g
Cream	Topical	1.72 g/50g
Cream	Topical	2.6 g/50g
Cream	Topical	115.2 mg/1mL
Film	Topical	0.3 g/100g
Cream	Topical	0.0934 g/1g
Cream	Cutaneous	4.64 mL/50mL
Cream	Topical	40.25 mg/1mL
Liquid	Topical	7.5 %
Stick	Topical	1.41 g/16g
Cream	Topical	7.0 g/100g
Cream	Topical	4.4 %
Cream	Topical	18.8 mg/1mL
Cream	Topical	4.8 %
Cream	Topical	2.5 %
Stick	Topical	2.5 %
Lotion	Topical	2.2 %
Lotion	Topical	6.48 %
Lotion	Topical	8.1 %
Lotion	Topical	9.72 %
Lotion	Topical	6 g/100mL
Cream	Topical	8.46 g/100g
Cream	Topical	170 mg/1mL
Lotion	Topical	60 mg/1mL
Liquid	Topical	33.2 mg/1mL
Liquid	Topical	110 mg/1mL
Liquid	Topical	0.065 g/10mL
Liquid	Topical	62 mg/1mL
Stick	Topical	415 mg/10g
Gel	Topical	62 mg/1mL
Powder	Topical	25 g/100g
Poultice	Topical
Powder	Topical	488 mg/2g
Powder	Topical	12 g/100g
Powder	Topical	2000 mg/8g
Liquid	Topical	0.747 mg/1mL
Cream	Topical	0.3 g/2g
Cream	Topical	0.1 g/2g
Powder	Topical	20 g/100g
Cream	Topical	3.42 g/30mL
Cream	Topical	3.85 g/100mL
Liquid	Topical	0.038 mg / g
Cloth	Topical	0.56 g/301
Powder	Topical	8.56 g/100g
Cream	Topical	3.25 g/35mL
Cream	Topical	3.69 g/40g
Oil	Topical	18 mg/1mL
Cream	Topical	159 mg/1mL
Powder	Topical	24 g/100g
Cream	Topical	4.33 %
Lotion	Topical	10.145 %
Cream	Topical	69 mg/1mL
Lotion	Topical	3.75 mg/50mL
Cream	Topical	6.45 g/100g
Cream	Topical	6.4 g/100g
Cream	Topical	12.1 mg/100mL
Powder	Topical	6 g/100g
Powder	Topical	8.4 g/100g
Powder	Topical	11.4072 g/100g
Lotion	Topical	5 g/100mL
Cream	Topical	15.8 g / 100 g
Cream	Topical	19.8 g / 100 g
Liquid	Topical	6.2 g / 100 g
Liquid	Topical	5.7 g / 100 g
Liquid	Topical	7.7 g / 100 g
Liquid	Topical	8.2 g / 100 g
Liquid	Topical	8.4 g / 100 g
Liquid	Topical	7.5 g / 100 g
Powder	Topical	7.3 g / 100 g
Powder	Topical	7 g / 100 g
Powder	Topical	6.2 g / 100 g
Powder	Topical	11.1 g / 100 g
Powder	Topical	5.6 g / 100 g
Cream	Topical	2.3 g/100mL
Lotion	Topical	501 mg/6g
Lotion	Topical	930 mg/6g
Cream	Topical	9.8525 g/100mL
Powder	Topical	0.89 g/5g
Powder	Topical	0.98 g/5g
Powder	Topical	0.55 g/5g
Powder	Topical	0.67 g/5g
Powder	Topical	0.28 g/5g
Solution	Topical
Cream	Topical	120 mg/1mL
Cream	Topical	8.5 g/100mL
Cream	Topical	36.5 mg/1mL
Powder	Topical	2.10 g/14g
Lotion	Topical	10.157 g/100g
Lotion	Topical	10.622 g/100g
Cream	Topical	106.22 mg/1g
Cream	Topical	5.8 %
Paste	Topical	5.8 g/100g
Cream	Topical	11.2 %
Cream	Topical	8.8 %
Cream	Topical	8.2 %
Cream	Topical	14.85 %
Cream	Topical	9.9 %
Powder	Topical	15 g/100g
Stick	Topical	10.0 %
Stick	Topical	4 %
Stick	Topical	4.0 g/100g
Stick	Topical	7.5 %
Liquid	Topical	28 mg/1mL
Cream	Topical	47 mg/1mL
Liquid	Topical	47 mg/1mL
Liquid	Topical	20 mg/1mL
Liquid	Topical	25 mg/1mL
Cream	Topical	70 mg/1mL
Cream	Topical	68 mg/1mL
Cream	Topical	63 mg/1mL
Cream	Topical	23 mg/1mL
Emulsion	Topical	62 mg/1mL
Emulsion	Topical	28 mg/1mL
Liquid	Topical	19 mg/1mL
Emulsion	Topical	30 mg/1mL
Solution	Topical	94.5 mg/1mL
Cream	Topical	84 mg/1mL
Cream	Topical	28 mg/1mL
Solution	Topical	18.9 mg/1mL
Liquid	Topical	18.9 mg/1mL
Cream	Topical	81 mg/1mL
Liquid	Topical	81 mg/1mL
Liquid	Topical	70 mg/1mL
Solution	Topical	70 mg/1mL
Solution	Topical	81 mg/1mL
Stick	Topical	80 mg/5g
Paste	Topical	684 mg/12g
Paste	Topical	1.896 g/12g
Cream	Topical	0.65625 g/31.25g
Cream	Topical	656 mg/31.25g
Emulsion	Topical	2.72118 g/35mL
Cream	Topical	3960 mg/40g
Stick	Topical	1.31 g/8g
Powder	Topical	12.1 %
Cream	Topical	24 %
Cream	Topical	13.8 %
Powder	Topical	2.4 g/21g
Powder	Topical	0.87 g/6.25g
Cream	Topical	1.26 g/30g
Powder	Topical	4.2 %
Cream	Topical	75 mg/1mL
Cream	Topical	0.0273 g/1mL
Cream	Topical	2.0 mL/100mL
Cream	Topical	20 %
Suspension	Topical	11.8 %
Suspension	Topical	8.5 %
Suspension	Topical	4.0 %
Liquid	Topical	1.80 g/15mL
Cream	Topical	1.00 g/4.2g
Cream	Topical	1.49 g/6.5g
Cream	Topical	1.52 g/6.5g
Lipstick	Topical	1.8 g/100g
Cream	Topical	9 g/100g
Cream	Topical	4.9 mg/0.1g
Cream	Topical	49 mg/1g
Cream	Topical	4.95 g/100mL
Cream	Topical	17 mg/100mg
Gel	Topical	7.8 mL/100mL
Cream	Topical	3.225 %
Lotion	Topical	2 %
Cream	Topical	50 mg/1mL
Cream	Topical	30 mg/1g
Lotion	Topical	10 mg/1mL
Lotion	Topical	104 mg/1mL
Lotion	Topical	9.7 mg/1mL
Lotion	Topical	68 mg/1mL
Lotion	Topical	61 mg/1mL
Powder	Topical	3 %
Cream	Topical	71 mg/1mL
Lotion	Topical	210 mg/2mL
Powder	Topical	5.53 g/100g
Cream	Topical	21.9 mg/1mL
Cream	Topical	1 mg/1mL
Aerosol	Topical
Cream	Topical	1.38 g/50mL
Cream	Topical	2.905 g/100mL
Powder	Topical	7 g/100g
Liquid	Topical	99 mg/1mL
Powder	Topical	5.8 %
Powder	Topical	0.494 g/13g
Liquid	Topical	5.0 mL/100mL
Cream	Topical	14 mg/1mL
Powder	Topical	2.2 g/100g
Liquid	Topical	4.2 mL/100mL
Liquid	Topical	1.0 mL/100mL
Powder	Topical	4.0 g/100g
Cream	Topical	10.08 g/100g
Cream	Cutaneous	4.2 mg/100mg
Liquid	Cutaneous
Cream	Topical	4.05 g/50g
Lotion	Topical	2.14 g/60mL
Lotion	Topical	5 g/100g
Powder	Topical	1.80 g/15g
Cream	Topical	9 %
Powder	Topical	4 g/100g
Powder	Topical
Cream	Topical	80 mg/1g
Lotion	Topical	2 mL/100mL
Lotion	Topical	189.16 mg/1mL
Lotion	Topical	192.39 mg/1mL
Stick	Topical	0.04 g/1g
Cream	Cutaneous	3.5 g/35g
Powder	Topical	3.7 %
Liquid	Topical	3.5 %
Lotion	Topical	7.2 %
Lotion	Topical	12 %
Suspension	Topical	3 %
Powder	Topical	10 g/100g
Cream	Topical	3.8 g/100g
Cream	Topical	19 mg/1mL
Cream	Topical	2.075 g/100g
Stick	Topical	5 g / 100 g
Lotion	Topical	53.9 mg/1mL
Liquid	Topical	97 mg/1mL
Liquid	Topical	83 mg/1mL
Liquid	Topical	84 mg/1mL
Liquid	Topical	78 mg/1mL
Lotion	Topical	4.03 g / g
Cream	Topical	5.6601 g/100mL
Cream	Topical	4.2 g/100mL
Cream	Topical	10 mL/100mL
Oil	Topical	5 g/100mL
Cream	Topical	35 mg/1mL
Cream	Topical	40 mg/1mL
Cream	Topical	5 g/100mL
Cream	Topical	7.5 g/100mL
Cream	Topical	1.3500 g/45.0000g
Cream	Topical	3 g/100g
Cream	Topical	3.1500 g/45.0000g
Cream	Topical	7 g/100g
Cream	Topical	3.1680 g/45.0000g
Cream	Topical	6.8 %
Cream	Topical	3.4 %
Paste	Topical	4.2 g/100g
Cream	Cutaneous	4.01 mL/35mL
Cream	Cutaneous	2.35 g/10g
Powder	Cutaneous	2.35 g/10g
Stick	Topical	20 mg/1g
Liquid	Topical	4 %
Stick	Topical	23 g/100g
Emulsion	Topical	10.4 %
Emulsion	Topical	5.68 %
Lotion	Topical	15.9 g/100mL
Emulsion	Topical	6.37 %
Powder	Topical	1.96 g/100g
Lotion	Topical	0.504 g/12g
Lotion	Topical	30 mg/1mL
Cream	Topical	20.78 %
Liquid	Topical	29.2 mg/1mL
Stick	Cutaneous
Cream	Topical	2.886 g/60g
Cream	Cutaneous	1.77 mg/100mL
Cream	Topical	765 mg/9g
Lotion	Topical	41.1 mg/1mL
Cream	Topical	124 mg/1mL
Cream	Topical	73 mg/1mL
Cream	Topical	2.478 g/59g
Liquid	Oral	2 g/100mL
Cream	Cutaneous	4.48 g/45g
Patch	Topical
Powder	Topical	5 %
Cream	Topical	54 mg/1mL
Lotion	Topical	25.8 mg/1mL
Lotion	Topical	37.4 mg/1mL
Lotion	Topical	1.78 g/50mL
Lotion	Topical	1.785 g/50mL
Lotion	Topical	1.784 g/40mL
Powder	Topical	10.5 g/100g
Cream	Topical	0.38 mg/45mL
Kit; stick	Topical
Liquid	Topical	0.1 g/20L
Cream	Topical	1.5 g/50g
Cream, augmented	Topical
Oil	Topical
Lotion	Topical	120 mg/1g
Lotion	Topical	78.5 mg/1mL
Lotion	Topical	150 mg/1mL
Spray, suspension	Topical	7.8 g/100mL
Spray	Topical	0.078 mg/1mL
Spray	Topical	78 mg/1mL
Liquid	Topical	5 %
Powder	Topical	1.179423 g/9g
Powder	Topical	0.895536 g/9g
Powder	Topical	0.9558 g/12g
Powder	Topical	13.1 g/100g
Cream	Topical	86.4 mg/1mL
Lotion	Topical	6.5 g/100g
Lotion	Topical	250 mg/1mL
Cream	Topical	106.6 mg/1mL
Cream	Topical	155 mg/1mL
Cream	Topical	11 %
Cream	Topical	2.4 g/30g
Lipstick	Topical
Powder	Topical	0.05 g/1g
Powder	Topical	0.55 g/11g
Lotion / shampoo	Topical
Emulsion	Topical	17.6 mg/1mL
Lotion	Topical	8 %
Emulsion	Topical	70 mg/1mL
Cream	Topical	2.522 g/25mL
Liquid	Topical	2.31 g/20mL
Liquid	Topical	3.09 g/30mL
Cream	Topical	115.2 g/1mL
Cream	Topical	153.2 mg/1mL
Cream	Topical	154.3 mg/1mL
Cream	Topical	151.4 mg/1mL
Cream	Topical	5.35 g/100mL
Powder	Topical	3.0 %
Powder	Topical	100 mg/1g
Liquid	Topical	32.6 mg/1mL
Cream	Topical	61 mg/1g
Cream	Topical	12.1 g/100g
Powder	Cutaneous	0.92 g/13g
Cream	Topical	11.8 g / 100 g
Cream	Topical	5.269 g/100mL
Suspension	Topical
Lotion	Topical	33.9 mg/1mL
Lotion	Topical	46.3 mg/1mL
Spray	Topical	4.9 %
Emulsion	Topical	60 mg/1mL
Cream	Topical	31.6 mg/1mL
Lotion	Topical	2.7 %
Cream	Topical	19.90 mL/100mL
Powder	Topical	5.77 g/100g
Cream	Topical	11.5 mg/1mL
Lotion	Topical	15.3 mg/1mL
Stick	Topical
Gel	Topical
Shampoo	Topical	3 g/100mL
Cream	Topical	80 mg/1mL
Lotion	Topical	70 mg/1mL
Cream	Topical	2 %
Lotion	Topical	11.3 g/100mL
Lotion	Topical	4.2 g/100mL
Lotion	Topical	0.04601 g/1mL
Lotion	Topical	4.30 mL/100mL
Cream	Topical	16 g/100g
Powder	Topical	7.0 g/100g
Cream	Cutaneous	7.5 mg/1g
Cream	Cutaneous	3.77 mL/50mL
Cream	Cutaneous	9.3 mg/1g
Powder	Cutaneous	0.98 g/11g
Cream	Cutaneous	3.5 mL/50mL
Cream	Cutaneous	3.57 mL/50mL
Cream	Topical	2.28 g/10g
Cream	Topical	4 %
Lotion	Topical	5.4 mL/100mL
Cream	Topical	1 g/100mL
Cream	Topical	5.9 g/100mL
Cream	Cutaneous	1.19 mL/35mL
Powder	Cutaneous
Liquid	Topical
Cream	Topical	12 %
Lotion	Topical	750 mg/118mL
Cream	Cutaneous	1.36 mL/50mL
Liquid	Topical	1.98 g/17g
Cream	Topical	0.1175 1/50mL
Cream	Topical	5.85 g/50mL
Cream	Cutaneous	1.45 mL/50mL
Cream	Topical	95 mg/1g
Cream	Topical	92 mg/1g
Cream	Topical	25.2 mg/1g
Cream	Topical	18.8 mg/1g
Cream	Topical	36 mg/1mL
Liquid	Topical	24 mg/1mL
Liquid	Topical	66 mg/1mL
Powder	Topical	75 mg/1g
Powder	Topical	41.1 mg/1g
Lotion	Topical	28 mg/1mL
Lotion	Topical	29 mg/1mL
Liquid	Topical	32 mg/1mL
Lotion	Topical	9.1 %
Lotion	Topical	7.25 %
Cream	Topical	20 mg/1mL
Lotion	Topical	480 mg/1mL
Emulsion	Topical
Lotion	Topical	80 mg/1mL
Lotion	Topical	130 mg/1mL
Lotion	Topical	120 mg/1mL
Lotion	Topical	90 mg/1mL
Cream	Topical	77 mg/1mL
Lotion	Topical	7.6 mL/100mL
Powder	Topical	2.1 g/100g
Liquid	Topical	2.4 mL/100mL
Cream	Cutaneous	1.18 mL/60mL
Cream	Cutaneous	2.10 mL/60mL
Cream	Topical	121.6 mg/1g
Kit; liquid; lotion	Topical
Cream	Topical	88 mg/88mL
Lotion	Topical	88 mg/1mL
Emulsion	Topical	0.65 g/1g
Emulsion	Topical	0.66 g/1g
Emulsion	Topical	85 mg/1g
Emulsion	Topical	100.8 mg/1g
Lotion	Topical	22 %
Cream	Topical	0.8 g/35mL
Cream	Topical	0.87 mL/35mL
Cream	Topical	3.95 g/100g
Lotion	Topical	102 mg/1mL
Lotion	Topical	76.5 mg/1mL
Lotion	Cutaneous
Cream	Topical	2.94 g/70mL
Cream	Topical	120 mg/1g
Powder	Topical	2.06 g/12g
Cream	Topical	39 mg/1mL
Emulsion	Topical	31 mg/1mL
Lotion	Topical	0.2625 mg/2.5mL
Cream	Topical	7.2 g / 100 g
Cream	Topical	1.52 g/7g
Cream	Cutaneous	3.25 mL/35mL
Cream	Cutaneous
Cream	Cutaneous	1.68 g/12g
Powder	Cutaneous	1.68 g/12g
Cream	Topical	3.26 g/35mL
Lotion	Topical	8.8 g/100mL
Liquid	Topical	4.7 mL/100mL
Powder	Topical	8.0 %
Cream	Topical	16 %
Cream	Topical	0.02 g/20g
Cream	Topical	4 mg/100mL
Lotion	Topical	4 g/100mL
Lotion	Topical	4.7 mL/100mL
Powder	Topical	0.24 g/10g
Powder	Topical	0.21 g/1g
Powder	Topical	0.07 g/1g
Powder	Topical	2.38 g/10g
Powder	Topical	1.43 g/6g
Powder	Topical	0.358 g/8.33g
Powder	Topical	0.72 g/8g
Powder	Topical	0.38 g/4.25g
Cream	Topical	6 mg/100mL
Cream	Topical	2.6 mg/100mL
Cream	Topical	2.96 mg/100mL
Cream	Cutaneous	2.59 g/50g
Powder	Topical	0.84 g/12g
Cream	Topical	1.4 mL/100mL
Kit; lotion	Topical
Cream	Topical	956.25 mg/4.25g
Lotion	Topical	4 g/100g
Cream	Cutaneous	2.32 g/25g
Lotion	Topical	0.024 mg/1mL
Cream	Topical	12.5 %
Powder	Topical	2 %
Cream	Topical	11.5 %
Liquid	Topical	7.4 %
Liquid	Topical	5.2 %
Stick	Topical	4.8 %
Liquid	Topical	6 %
Liquid	Topical	8.60 %
Powder	Topical	11.00 %
Powder	Topical	14.3 %
Powder	Topical	3.5 %
Paste	Topical	4 mg/1mL
Cream	Topical	52.8 mg/1mL
Cream	Topical	61.6 mg/1mL
Cream	Topical	9.1 %
Lotion	Topical	5.6 g/100mL
Liquid	Topical	5.6 g/100mL
Cream	Topical	0.5 g/100g
Cream	Topical	100 mg/1mL
Lotion	Topical	40 uL/1mL
Lotion	Topical	2.91 mg/30mL
Cream	Topical	6.96 %
Lotion	Topical	2.866 g/44.4mL
Powder	Topical	12.9 g/100g
Cream	Topical	4 g/100mL
Liquid	Topical	13 g/100mL
Cream	Topical	2.25 g/13g
Cream	Topical	42 mg/1mL
Liquid	Topical	5 g/100mL
Cream	Topical
Powder	Topical	0.54 g/12g
Powder	Topical	540 mg/12g
Powder	Topical	864 mg/12g
Powder	Topical	22.7 %
Powder	Topical	24.6 %
Cream	Topical	10.7 %
Emulsion	Topical	12.7 %
Emulsion	Topical	11.45 %
Emulsion	Topical	11.1 %
Cream	Topical	1488 mg/36.3g
Liquid	Topical	13.9 %
Stick	Topical	250 mg/10g
Stick	Topical	400 mg/10g
Stick	Topical	410 mg/10g
Aerosol, foam	Topical
Stick	Topical	0.60 g/9g
Stick	Topical	0.55 g/9g
Stick	Topical	208 mg/1g
Cream	Topical	0.04 g/5.5g
Cream	Topical	13 g/13g
Cream; kit	Topical
Lotion	Topical	6.7 g/100g
Cream; kit; liquid	Topical
Lotion	Topical	54.9 mg/1mL
Lotion	Topical	6.90 g/100mL
Kit	Topical
Powder	Topical	3 g/100g
Powder	Oral
Cream	Topical	9.7 %
Cream	Topical	8.86 %
Cream	Topical	3.1 g / 100 g
Powder	Topical	0.7 g/10g
Lotion / shampoo	Topical	80 mg/1mL
Liquid	Topical	2.9445 g/44.4mL
Lotion	Topical	8.46 %
Stick	Topical	3.3 g/100mL
Spray, suspension	Topical
Cream	Cutaneous; Topical
Stick	Topical	170 mg/1g
Lotion / shampoo	Topical	120 mg/1g
Aerosol, spray	Topical
Powder	Topical	4.5 %
Lotion	Topical	1 g/66mL
Lotion	Topical	1 g/88mL
Cream	Topical	12 mg/1mL
Paste	Topical
Sponge	Topical
Cream	Topical	8.1 %
Cream	Topical	9.72 %
Lotion	Topical	10 %
Lotion	Topical
Lotion	Topical	5.67 %
Cream	Topical	6.1 %
Cream	Topical	3.9 %
Cream	Topical	8.9 %
Cream	Topical	6.5 %
Lotion	Topical	5.6 %
Lotion	Topical	10.4 %
Aerosol; lotion	Topical	4.86 %
Lotion	Topical	4.1 %
Kit; lotion; stick	Topical
Aerosol; lotion	Topical	3.9 %
Cream	Topical	1.26 g/50mL
Lotion	Topical	4.82 %
Cream	Cutaneous	1.6 mL/30mL
Cream	Topical	25 mg/1mL
Cream	Topical	74 mg/1mL
Powder	Topical	6.3 g/100g
Cream	Topical	17.5 %
Paste	Topical	17 %
Liquid	Topical	25.5 mg/1mL
Emulsion	Topical	29.2 mg/1mL
Powder	Topical	1.5 g/100g
Cream	Topical	7.99 mg/100mL
Cream	Topical	88 mg/1mL
Cream	Topical	3.5 g/100g
Cream	Topical	4.65 g/100g
Cream	Cutaneous	0.81 g/45g
Lotion	Topical	4 %
Powder	Topical	1510 mg/11000mg
Powder	Topical	3984 mg/30000mg
Patch	Topical	0.001 g/30g
Liquid	Not applicable	1 kg/1kg
Cream	Topical	99 mg/1mL
Lotion	Topical	5.4 mg/100mg
Powder	Topical	2.381 g/10g
Cream	Topical	8.3 g/100g
Lotion	Topical	45 mg/1mL
Lotion	Topical	50 mg/1mL
Cream	Topical	10.4 g/100g
Cream; kit; lotion	Topical
Emulsion	Topical	68 mg / mL
Cream	Topical	1.5 g / 100 g
Lotion	Topical	4.8 %
Lotion	Topical	6.83 %
Lotion	Topical	4000 mg/50mL
Lotion	Topical	110 mg/1mL
Cream	Topical	74.7 mg/1mL
Emulsion	Topical	81 mg/1mL
Lotion	Topical	81 mg/1mL
Powder	Not applicable	0.73 kg/1kg
Powder	Not applicable	0.83 kg/1kg
Powder	Not applicable	0.8 kg/1kg
Powder	Not applicable	0.82 kg/1kg
Powder	Not applicable	0.81 kg/1kg
Powder	Not applicable	0.93 kg/1kg
Powder	Not applicable	0.92 kg/1kg
Powder	Not applicable	0.85 kg/1kg
Powder	Not applicable	0.88 kg/1kg
Ointment	Topical
Lotion	Topical	6.8 %
Ointment	Topical	6 % w/w
Lotion	Topical	6 %
Stick	Topical	24.15 g/100g
Lotion	Topical	148 mg/1mL
Liquid	Topical	156.752 mg/1mL
Emulsion	Topical	64 mg/1mL
Cream	Topical	2.48 g/59g
Stick	Topical	0.002 g/3.5g
Cream	Topical	4.3 %
Cream	Topical	25 g/100g
Cream	Topical	3.8 g/100mL
Cream	Topical	2.05 mg/100mL
Cream	Topical	1.02 mg/50mL
Cream	Topical	0.5 mL/100mL
Powder	Topical	87 mg/1g
Soap	Topical
Powder	Topical	2 g/100g
Lotion	Topical	60.3 mg/1mL
Lotion	Topical	0.08 g/1g
Kit	Topical	0.08 g/1g
Kit	Topical	82 mg/1mL
Kit; lotion	Topical	82 mg/1mL
Lotion	Topical	82 mg/1mL

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
logP	-0.7	Chemaxon
pKa (Strongest Basic)	-7.7	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	2	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	34.14 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	2.89 m³·mol^-1	Chemaxon
Polarizability	4.19 Å³	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	Yes	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST): Not Available
Spectra: Not Available
Chromatographic Properties: Collision Cross Sections (CCS)
Not Available

Targets

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Details1. Macrophage receptor MARCO

Kind: Protein
Organism: Humans
Pharmacological action: Unknown

General Function: Pattern recognition receptor (PRR). Binds Gram-positive and Gram-negative bacteria.
Specific Function: Scavenger receptor activity
Gene Name: MARCO
Uniprot ID: Q9UEW3
Uniprot Name: Macrophage receptor MARCO
Molecular Weight: 52657.905 Da

References

Thakur SA, Hamilton R Jr, Pikkarainen T, Holian A: Differential binding of inorganic particles to MARCO. Toxicol Sci. 2009 Jan;107(1):238-46. doi: 10.1093/toxsci/kfn210. Epub 2008 Oct 4. [Article]

Drug created at November 30, 2015 19:10 / Updated at February 20, 2024 23:55

Titanium dioxide

Identification

Structure for Titanium dioxide (DB09536)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

References