Identification
- Brand Names
- A+d Diaper Rash, Anbesol Cold Sore Therapy, Calazime Skin Protectant, Calmoseptine Ointment, DermaCerin, Flanders, Lubrifresh P.M., Periguard, Preparation H Cream, Preparation H Reformulated Jun 2013, Refresh Lacri-lube, Refresh PM, Resinol, Soothe & Cool Skin Paste, Soothe Night Time, Stye, Systane, Systane Nighttime, Tears Again Ointment, Vusion, Zincofax
- Generic Name
- Petrolatum
- DrugBank Accession Number
- DB11058
- Background
A colloidal system of semisolid hydrocarbons obtained from petroleum. It is used as an ointment base, topical protectant, and lubricant.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Synonyms
- Multi-hydrocarbon
- Paraffinum album
- Paraffinum flavum
- Petrolatum
- Petrolatum base
- Petrolatum, white
- Petrolatum,amber
- Petrolatum,white
- Petroleum jelly
- Soft paraffin
- White petrolatum
- White, soft paraffin
- Yellow soft paraffin
Pharmacology
- Indication
For use as an over the counter skin protectant Label. Commonly used to treat diaper rash and chapped lips Label 1.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Dermabrasion Combination Product in combination with: Zinc oxide (DB09321) ••• ••• ••••• Used in combination to treat Diaper rash Combination Product in combination with: Zinc oxide (DB09321) ••• ••• ••••• Used in combination to treat Itching of the perianal area Combination Product in combination with: Lanolin (DB11112), Levomenthol (DB00825), Zinc oxide (DB09321) ••• ••• •••••••• Used in combination to treat Pain Combination Product in combination with: Zinc oxide (DB09321), Lanolin (DB11112), Levomenthol (DB00825) ••• ••• •••••••• Used in combination to treat Skin irritation Combination Product in combination with: Lanolin (DB11112), Zinc oxide (DB09321), Levomenthol (DB00825) ••• ••• •••••••• - Associated Therapies
- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Displaces water and acts as a barrier against harsh environmental conditions like wind Label 1.
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image A and D Ointment 937.5 mg/1g Topical H&H Laboratories, Inc. 2012-05-14 Not applicable US 
A and D Ointment 937.5 mg/1g Topical Henry Schein, Inc. 2011-12-04 2024-09-01 US A and D Ointment 0.93 g/1g Topical Gentell, Inc. 2019-05-25 Not applicable US A and D Ointment 76 g/100g Topical Safetec of America, Inc. 2019-11-01 Not applicable US A and D plus E Ointment 937.5 mg/1g Topical H&H Laboratories, Inc. 2012-05-14 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 7 Select Hemorrhoidal Original Strength Petrolatum (749 mg/1g) + Mineral oil (140 mg/1g) + Phenylephrine hydrochloride (2.5 mg/1g) Ointment Topical 7-ELEVEN, INC. 2016-12-07 Not applicable US A and D Diaper Rash and Skin Protectant Petrolatum (0.53 mg/1g) + Lanolin (0.15 mg/1g) Cream Topical Natureplex, LLC 2014-11-12 Not applicable US A and D First Aid Petrolatum (469.9 mg/1g) + Lanolin (136.4 mg/1g) Ointment Topical Bayer HealthCare LLC 2003-06-04 Not applicable US A and D First Aid Petrolatum (469.9 mg/1g) + Lanolin (136.4 mg/1g) Ointment Topical Delpharm Montreal Inc. 2003-06-04 Not applicable US A and D Original Petrolatum (469.9 mg/1g) + Lanolin (136.4 mg/1g) Ointment Topical Delpharm Montreal Inc. 2003-06-04 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Antiscar Petrolatum (3 g/100g) + 13-cis-12-(3'-Carboxyphenyl)retinoic acid (2 g/100g) + Allantoin (2 g/100g) + Epigallocatechin gallate (.3 g/100g) + Onion (.5 g/100g) Patch Topical Basiem 2015-04-01 2015-04-20 US Elgoalin HISENG Petrolatum (35 g/100g) + Mineral oil (55 g/100g) Liquid Topical Elgoalin Bio Co.,Ltd 2022-04-18 Not applicable US Elite Petrolatum (30 g/100g) + Allantoin (2 g/100g) + Lidocaine (4 g/100g) Patch Topical Meds Direct Rx Of Ny Llc 2015-01-31 2015-06-08 US Hemorrhoid Petrolatum (77.99 g/100g) + Zinc oxide (7.6 g/100g) Cream Topical Zhengzhou Zhuoqing Trading Co., Ltd. 2023-10-21 Not applicable US Herpetrol Petrolatum (970 mg/1g) + Benzalkonium chloride (1.3 mg/1g) + Menthol (10 mg/1g) Ointment Topical Alva-Amco Pharmacal Companies, Inc. 2005-06-30 2018-01-31 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- B6E5W8RQJ4
- CAS number
- 8009-03-8
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- FDA Monograph: Petrolatum [Link]
- External Links
- KEGG Drug
- D05304
- PubChem Substance
- 347911097
- 8091
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Petroleum_jelly
- FDA label
- Download (230 KB)
- MSDS
- Download (47.7 KB)
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Active Not Recruiting Treatment Atopic Dermatitis 1 4 Completed Basic Science Inflammation 1 4 Completed Prevention Skin Diseases 1 4 Completed Supportive Care Surgical Wounds 1 4 Completed Treatment Atopic Dermatitis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Ointment Topical 0.93 g/1g Ointment Topical 937.5 mg/1g Ointment Topical 0.9985 g/1g Ointment Topical 0.340 g/1g Ointment Topical 340 mg/100g Cream Topical 54 g/100g Jelly Topical 99.35 g/100g Ointment Topical 43 g/100g Spray Topical 36 g/100g Ointment Topical 430 mg/1g Spray Topical 360 mg/1g Jelly Topical 99.8 g/100g Jelly Topical 99.5 g/100g Ointment Topical 0.42 g/1g Ointment Topical 100 g/44.28g Lotion Topical Ointment Topical 41 % Ointment Topical 0.934 g/1g Ointment Topical 540 mg/1g Ointment Topical 703 mg/1g Ointment Topical 54 mg/1g Ointment Topical 60.1 % Paste Topical 74.69 % Ointment Topical 46.5 % w/w Cream Topical 99 g/100g Ointment Topical 99.93 % w/w Ointment Topical 84.3 g/100g Ointment Topical 84.3 % w/w Ointment Topical 84.3 % Ointment Topical 0.511 g/1g Ointment Topical 511 mg/1g Cream Topical 430 g/1000g Ointment Topical 960 mg/1g Ointment Topical 620 mg/1g Stick Topical Cream Topical 30 % Ointment Topical 34.85 g/85g Stick Topical 41 mg/1g Ointment Topical 43.75 mg/1g Ointment Topical .96 g/1g Ointment Topical .97 g/1g Kit; salve Topical Salve Topical 453 mg/1g Salve Topical Salve Topical 412.5 mg/1g Cream Topical 0.61 g/1g Ointment Topical 46.5 g/100g Ointment Topical 715 mg/1g Cream Topical 13.2 % Lipstick Topical 619.3 mg/1g Kit; stick Topical Kit; stick Topical 450 mg/1g Stick Topical 450 mg/1g Kit Topical Gel Topical Stick Oral Jelly Topical Jelly Topical 1 g/1g Jelly Topical 998 mg/1g Salve Topical 27.6 g/28.4g Lotion Topical 5 g/100g Cream Topical 30 g/100mL Paste Topical Jelly Topical 30 g/100g Jelly Topical .30 g/100g Jelly Topical .30 mg/100g Cream Topical 30 g/100g Ointment Topical 710 mg/1g Ointment Topical 71.5 % w/w Ointment Topical 865 mg/1g Ointment Topical 98.3 % w/w Cream Topical 300 mg/1mL Ointment Topical 410 mg/1g Ointment Topical .041 g/.1g Cream Topical 33 g/100g Ointment Topical 70.3 % w/w Jelly Topical 99 g/100g Jelly Topical 98.3 g/100g Cream Topical 85 % Ointment Topical 85 g/100g Ointment Topical 33 g/100g Ointment Topical 44 g/100g Ointment Topical 713 mg/1g Ointment Topical 703.2 mg/1g Cream Topical 30 % w/w Ointment Topical 30 % Jelly Topical 226 g/226g Ointment Topical 124 g/207mL Ointment Ophthalmic Lotion Topical 20.5 g/50g Lotion Topical 41 g/100g Emulsion Topical 56.8 mg/1g Lotion Topical 28.4 g/50g Cream Topical 28.4 g/50g Cream Topical 56.8 mg/1g Gel Topical 1 g/85g Ointment Topical 600 g/1000g Ointment Topical 77.6 g/1000g Ointment Topical 0.41 g/1g Stick Topical 45.0 mg/1g Kit Ophthalmic Ointment Topical 40 g/100g Lipstick Topical Gel Topical 70.9787 g/71g Ointment Topical 87.32 g/118g Cream Rectal; Topical Ointment Topical 45 g/100g Ointment Topical 30 g/100g Ointment Topical 450 mg/1mL Cream Topical 50.74 g/100g Ointment Topical 340 mg/1g Ointment Topical 41 kg/1g Ointment Topical 41 kg/100kg Ointment Topical 46.5 % Stick Topical 670 mg/1g Ointment Rectal 93.3 g/100g Lipstick Topical 47.95 g/100g Liquid Topical 89.5 g/100g Ointment Topical 41.000 g/100g Ointment Topical 41 % w/w Cream Topical 20 g/100g Cream Topical 45 g/100g Cream Topical 52.2 g/100g Gel Topical 300 mg/1mL Cream Topical 430 mg/1g Ointment Topical 430 mg/1mL Kit Not applicable Ointment Topical 76 g/100g Ointment Topical 48 g/100mL Stick Topical 32.3 g/100g Jelly Topical 1000 mg/1g Stick Topical 59.79 % Ointment Topical 935 mg/1g Ointment Topical 934 mg/1g Ointment Topical 983 mg/1g Ointment Topical 95 g/100g Ointment Rectal; Topical Ointment Topical 60.3 % w/w Ointment Topical 604 mg/1mL Ointment Topical 60.3 mL/100mL Spray Topical 36 mL/120mL Spray Topical 36 g/120mL Ointment Topical 69 % w/w Ointment Topical 99.397 g/100g Ointment Topical 99.9 g/100g Ointment Topical 774 mg/1g Cream Topical 95.96 % Ointment Topical 95.7 % w/w Stick Topical 30 g/100g Stick Topical 1.26 g/4.2g Stick Topical 45 mg/1g Ointment Topical 0.41 mg/1g Ointment Topical 600 mg/1mL Kit Oral Ointment Topical 49.9 g/100g Jelly Topical 170 g/170g Gel Topical 100 g/1g Cream Topical 69 mg/1g Ointment Topical 10 g/10g Ointment Topical 600 mg/1g Ointment Topical 100 % w/w Jelly Topical 1 mg/1g Jelly Topical 100 g/100g Jelly Topical 1000 mg/100g Jelly Topical 82.32 mg/1g Jelly Topical 838 g/1g Jelly Topical 99.8 g/100kg Jelly Topical Ointment Topical Ointment Topical 15 g/30g Ointment Topical 99.99 % w/w Jelly Topical 99.9 g/100g Jelly Topical 99.9 1/100g Jelly Topical 100 % Ointment Topical 99.6 % w/w Gel Topical 99.9 g/100g Paste 650 mg/1mL Ointment Topical 14 % Cream Topical 67 % Ointment Topical 99.5 g/100g Ointment Topical 93.4 g/100g Ointment Topical 75 g/100g Ointment Topical 98.79 % w/w Ointment Topical 98.85 % w/w Ointment Topical 0.99 g/1g Cream Topical 0.6 g/1g Jelly Topical 0.99 g/1g Liquid Topical Cloth; cream; kit Topical Ointment Topical 500 mg/1g Paste Topical 59 g/100g Paste Topical 57 g/100g Stick Topical 45 % w/w Stick Topical 45 g/100g Ointment Topical 83 mg/1g Ointment Topical 86 mg/1g Cream Topical 41 g/100g Jelly Topical 410 mg/1g Ointment Topical 41 g/100g Ointment Topical 420 mg/1g Jelly Topical 41.0 g/100g Ointment Topical 987.89 mg/1g Cream Rectal Cream Topical Gel Topical 99.98 mg/1g Cream Topical 43 g/100g Lotion Topical 39.9 g/133mL Ointment Topical 93.5 g/100g Cream Topical 43 g/1000g Ointment Topical 44.28 g/100g Ointment Topical 23 g/71g Jelly Topical 225 g/225g Jelly Topical 110 g/110g Solution Topical 200 ml Ointment Topical 92.8 % Ointment Topical 92.8 g/100g Ointment Topical 98.3 g/100g Gel Ophthalmic Cream Topical 55 % Jelly Topical 99.7 g/100g Cream Cutaneous 65 g/100g Ointment Rectal Jelly Topical 99.6 g/100g Ointment Topical 99.96 % w/w Ointment Topical 100 g/100g Gel Topical 100 % Jelly Topical 99.96 g/100g Patch Topical Ointment Topical .948 g/1g Ointment Topical .948 mL/1mL Ointment Topical 0.948 mL/1mL Ointment Topical 30.8 g/56g Ointment Topical 929.3 mg/1g Ointment Topical .75 g/1g Ointment Topical .76 g/1g Ointment Topical 0.76 g/1g Ointment Topical .93 g/1g Ointment Topical 930 mg/1g Ointment Topical Ointment Topical 93 g/100g Ointment Topical 465 mg/1mL Lotion Topical 0.41 g/1g Ointment Topical 42 g/100g Cream Topical 100 g/100g Ointment Topical 1 g/1g Ointment Topical 5 [USP'U]/5g Ointment Topical 50 g/100g Ointment Topical 100 % Ointment Topical 99.9 % Ointment Topical 1000 mg/1g Stick Topical 30.0 mg/1g Cream Topical 99.7 g/100g Jelly Topical 38 g/127g Cream Topical 59 g/198g Jelly Topical 100 kg/100kg - Prices
- Not Available
- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region US8147852 No 2012-04-03 2028-03-30 US
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 38-60 MSDS water solubility Insoluble MSDS - Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at February 20, 2024 23:55