Dimethicone

Identification

Summary

Dimethicone is an ingredient used to treat dry and irritated eyes.

Brand Names

A+d Diaper Rash, Alka-seltzer Heartburn Plus Gas Relief, Almacone, Carlesta, Dyna1199 with Dimethicone, Dynashield, Gelusil, Gold Bond Maximum Relief, Imodium Multi-symptom Relief, Maalox Plus, Mi-acid, Mi-acid Double Strength, Mintox Plus, Mylanta, Mylanta Tonight, Pediacare Gas Relief, Phazyme, Rash Relief Antibacterial, Rash Relief Antifungal, Rash Relief With Zinc Oxide, Rolaids Advanced, Titralac Plus

Generic Name

Dimethicone

DrugBank Accession Number

DB11074

Background

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions ^6,8.

A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products ³.

Type

Small Molecule

Groups

Approved

Synonyms

• Dimethicone
• Dimeticona
• Dimeticone
• Dimeticonum

External IDs

• Dow Corning 1664

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Pharmacology

Indication

Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent ², ⁷.

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Used in combination for symptomatic treatment of	Acute diarrhoea	Combination Product in combination with: Loperamide (DB00836)	••• •••			••••••
Used in combination to treat	Aerophagy	Combination Product in combination with: Pancrelipase (DB00085)	••••••••••••			••••••• •••• ••••••
Used in combination for symptomatic treatment of	Duodenal ulcer	Combination Product in combination with: Magaldrate (DB08938)	••••••••••••			•••
Used in combination for symptomatic treatment of	Dyspepsia	Combination Product in combination with: Magaldrate (DB08938)	••••••••••••			•••
Used in combination to manage	Dyspepsia	Combination Product in combination with: Magaldrate (DB08938)	••••••••••••		••••••••• •• •••••••• ••••••• •••••••	•••

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Associated Therapies

• Bowel preparation therapy
• Carbohydrate Digestion
• Digestive Aid
• Fat Digestion
• Protein Digestion

Contraindications & Blackbox Warnings

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Pharmacodynamics

This drug acts as a skin protectant by helping to treat and prevent minor skin irritation due to diaper rash and seals out moisture from the diaper area. This drug temporarily protects and helps prevent chafed, chapped, cracked or windburned skin. ⁷.

Mechanism of action

When applied topically, dimethicone forms a layer to delay the evaporation of water ⁸. In the treatment of head lice dimethicone 100, the respiratory systems of head lice are targeted. NYDA works by suffocating the lice, nymphs and the embryos. The physical properties of this drug, including the viscosity and spreading property of the solution allow it to easily flow into the respiratory system of all developmental stages of the insect, causing suffocation and death of the organisms. It diffuses through the stigmata (spiracles) of the lice, into the tracheae of the head lice as well as through the aeropyles of the egg operculum. The solution then displaces oxygen. The low viscosity, volatile dimethicone enables the NYDA head lice solution to penetrate into the breathing system. Its evaporation causes the thickening of the NYDA solution. The remaining high viscosity dimethicone ultimately encloses the respiratory system and thus leading to suffocation of all stages of head lice (adult lice, larvae and eggs). This mode of action prevents the development of lice resistance by preventing the formation of new progency ⁹.

Studies performed using house crickets and lice suggest a close correlation between the death of the lice and the influx of the solution into the insect head tracheae. These data strongly suggest that the total filling of the head tracheae immediately blocks the oxygen supply to the insect central nervous system. Death, following numerous stages of disability after the entrance of dimethicones into the abdominal tracheal system, demonstrates the sequence of oxygen deprivation. NYDA was applied directly to the head and mouth of the organism, and was found to have no effect when applied solely to the outside of the head/mouth ⁹.

Absorption

This drug is not believed to be absorbed when used in quantities from 1-30% ^Label.

Volume of distribution

Following injection of [14C]dimethicone fluid in the hind limb of rats, the radioactivity was distributed primarily in the gastrointestinal tract, and no evidence of metabolism was observed. When [14C]dimethicone was administered through i.p. injection in rats, the following distribution of radioactivity was observed at 25 days after dosing: 51% in adipose tissue, 27% in gastrointestinal tissues, and 15% in liver ⁵.

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

The minimum lethal oral dose of dimethicone 200 (50 cs), dimethicone 550 (75 cs), dimethicone in rats ⁵.

A 76-week dietary toxicity study of a silicone antifoam compound (94% polydimethylsiloxane silicone oil and 6% silicone dioxide) was performed in mice. Three groups were given diet containing 0, 0.25%, or 2.5% of the test article. The dose levels in the treatment groups were estimated to be 580 and 5800 mg/kg/day. Mortality was increased in the 5800 mg/kg/day females. No target organs of toxicity were observed. The no-effect dose was 580 mg/kg/day. This study is of limited usefulness for assessing the toxicity of dimethicones, due to the small number of organs/tissues that were examined ⁵.

In one clinical study, 145 subjects were treated with either NYDA (dimethicone )or with a permethrin-based lice product. The number of subjects experiencing any adverse events was similar in both groups. In the NYDA group, 29 adverse events were reported in 25 subjects. All except two adverse events were categorized as being unrelated to the lice treatment (e.g., superficial wound after a fall, otitis externa following swimming in a pool). Two patients in the NYDA group experienced ocular irritation after treatment when the product entered the eyes. The irritation resolved spontaneously in both cases after rinsing the eyes with clean water ⁹.

Pathways

Not Available

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Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Segesterone acetate	The serum concentration of Segesterone acetate can be increased when it is combined with Dimethicone.

Food Interactions

No interactions found.

Products

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Product Ingredients

Ingredient	UNII	CAS	InChI Key
Dimethicone 100	RO266O364U	9006-65-9	Not applicable

Over the Counter Products

Name	Dosage	Strength	Route	Labeller	Marketing Start	Marketing End	Region	Image
28 Remedy Balancing Day Moisturizer	Cream	0.45 mg/45mL	Topical	NoTS Co.,Ltd	2015-03-01	2018-12-01
28 Remedy Repair	Cream	0.3 g/30g	Topical	NoTS Co Ltd	2015-03-01	2018-12-01
28 Remedy Repair 30g	Cream	0.3 g/30g	Topical	NoTS Co.,Ltd	2016-01-02	2018-12-01
3ce Lip Lacquer Backstage	Lipstick	0.76 g/6.4g	Topical	Nanda Co., Ltd	2016-08-01	2018-12-01
3ce Lip Lacquer Bon Bon	Lipstick	0.76 g/6.4g	Topical	Nanda Co., Ltd	2016-08-01	2018-12-01

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
A + D Diaper Rash Cream	Dimethicone (1 % w/w) + Zinc oxide (10 % w/w)	Cream	Topical	Schering Plough	2010-04-05	2014-07-31
A AND A Diaper Rash cream	Dimethicone (10 mg/1g) + Zinc oxide (100 mg/1g)	Cream	Topical	BioZone Laboratories, Inc.	2013-06-15	Not applicable
A and D	Dimethicone (11.09 mg/1g) + Zinc oxide (110.09 mg/1g)	Cream	Topical	Bayer Healthcare Llc.	2009-12-25	Not applicable
ABC Arbonne Baby Care Diaper Rash	Dimethicone (1 g/100g) + Zinc oxide (12 g/100g)	Cream	Topical	Arbonne International Llc	2014-09-20	Not applicable
Abc Arbonne Baby Care Diaper Rash Cream	Dimethicone (1 % w/w) + Zinc oxide (12 % w/w)	Cream	Topical	Arbonne International Llc	2014-09-25	Not applicable

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
3ce Matte Lip Crayon Dubious	Dimethicone (0.006 g/1g)	Lipstick	Topical	Nanda Co., Ltd.	2016-08-10	Not applicable
AQUTOP Moisturizing Signature Tone-up Cream	Dimethicone (0.53 g/50mL) + Adenosine (0.02 g/50mL) + Nicotinamide (1 g/50mL)	Cream	Topical	Alable Co., Ltd.	2018-07-09	Not applicable
BEYOND THE SHAVE For Men	Dimethicone (2.9 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.7 g/100mL)	Kit	Topical	Rodan & Fields	2017-06-01	Not applicable
Biellee Pollen Hydra Pure Brightening Cream	Dimethicone (0.4 mg/50mL)	Cream	Topical	Nsb Co., Ltd.	2016-06-21	Not applicable
CALSODORE kit	Dimethicone (5 g/100mL) + Calcipotriol (50 ug/1g)	Kit	Topical	Forreal Pharmaceuticals LLC	2023-09-11	Not applicable

Categories

ATC Codes

P03AX05 — Dimeticone

• P03AX — Other ectoparasiticides, incl. scabicides
• P03A — ECTOPARASITICIDES, INCL. SCABICIDES
• P03 — ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
• P — ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS

Drug Categories

• Antifoaming Agents
• Antiparasitic Products, Insecticides and Repellents
• Basic Ointments and Protectants
• Compounds used in a research, industrial, or household setting
• Ectoparasiticides, Incl. Scabicides
• Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents
• Macromolecular Substances
• Misc. Skin and Mucous Membrane Agents
• Organosilicon Compounds
• Polymers
• Scabicides and Pediculicides
• Silicones
• Siloxanes
• Skin Barrier Activity

Classification

Not classified

Affected organisms

Not Available

Chemical Identifiers

UNII

92RU3N3Y1O

CAS number

63148-62-9

InChI Key

Not Available

InChI

Not Available

IUPAC Name

Not Available

SMILES

Not Available

References

General References

1. Ingram RJ, Bartlett A, Brown MB, Marriott C, Whiffield RJ: Dimethicone barrier cream prevents infection of human skin by schistosome cercariae: evidence from Franz cell studies. J Parasitol. 2002 Apr;88(2):399-402. doi: 10.1645/0022-3395(2002)088[0399:DBCPIO]2.0.CO;2. [Article]
2. Dimethicone [Link]
3. Safety and efficacy of a 100 % dimethicone pediculocide in school-age children [Link]
4. Public Assessment Report, Dimethicone [Link]
5. CENTER FOR DRUG EVALUATION AND RESEARCH- 20755 [Link]
6. Dimethicone [Link]
7. Moisturel, Daily Med monograph [Link]
8. Guidelines of care for the management of atopic dermatitis [Link]
9. Product Monograph, NYDA [Link]
10. POLYDIMETHYLSILOXANE [Link]
11. Dimethicone [Link]
12. DailyMed Label: DIMETHICONE, skin protectant cream [Link]

External Links

PubChem Substance

347911104

RxNav

324072

Wikipedia

Polydimethylsiloxane

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Diagnostic	Bowel preparation therapy / Colonoscopy	1
4	Completed	Treatment	Dentin Sensitivity / Periodontal Disease	1
4	Completed	Treatment	Gastro-esophageal Reflux Disease (GERD)	1
4	Terminated	Treatment	Relapsing Remitting Multiple Sclerosis (RRMS)	1
3	Completed	Treatment	Dyspepsia	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Lipstick	Topical	0.76 g/6.4g
Lipstick	Topical	0.006 g/1g
Cream	Topical	0.93 g/30mL
Cream	Topical	0.75 g/50mL
Stick	Topical	0.1 g/100g
Stick	Topical	0.85 g/100g
Cream	Topical	13000 mg/1L
Cream; kit; lotion	Topical
Suspension	Intra-articular; Oral
Cream	Cutaneous	0.5 mg/50mL
Cream	Cutaneous	2 mg/100mL
Cream	Cutaneous	1.2 mg/30mL
Cream	Topical	1.375 g/55mL
Cream	Topical	0.3 g/25mL
Cream	Topical	1.32 g/120mL
Cream	Topical	0.48 g/40mL
Lotion	Topical	10 mg/1g
Capsule, liquid filled	Not applicable	125 mg/1
Cream	Topical	1.95 g/150mL
Cream	Topical	4 mg/1mL
Cream	Cutaneous	0.9 g/45g
Cream	Cutaneous	0.45 g/45g
Cream	Cutaneous	0.45 mL/45mL
Gel	Oral	8.000 g
Cream	Topical	1.35 g/50mL
Cream	Topical	0.75 g/25mL
Tablet, chewable	Oral
Lotion	Topical	30 mg/1mL
Lotion	Topical	3.54 g/118mL
Lotion	Topical	7.08 g/236mL
Lotion	Topical	1.77 g/59mL
Lotion	Topical	.03 mg/1mL
Cloth	Topical	0.352 g/1
Cream	Topical	2.1 g/100mL
Cream	Topical	0.65 g/50g
Cream	Cutaneous	0.51 mL/50mL
Patch	Topical	0.6 g/20g
Liquid	Oral	21 mg/100mL
Capsule	Oral	125 mg/1
Lotion	Topical	4.55 g/130mL
Cream	Topical	0.2 g/20g
Oil	Topical	249.2 mg/1mL
Cream	Topical	1 g/100mL
Cream	Topical	0.01 g/100mL
Solution	Topical	30 mg/300mL
Cream	Topical	20 mg/200mL
Stick	Topical	0.9 g/10g
Cream	Topical	0.60 mg/60g
Lotion	Topical	13 mg/1g
Cream	Topical	12.5 mg/1g
Cream	Topical	13 mg/1g
Kit	Topical	12 mg/1mL
Lotion	Topical	12 mg/1mL
Kit; lotion	Topical	12 mg/1g
Kit; lotion	Topical	12 mg/1mL
Cream	Topical	12 mg/1mL
Kit; lotion	Topical
Cream	Topical	125 mg/1g
Emulsion	Topical	50 mg/1g
Tablet	Oral	200 mg
Spray, suspension	Topical
Cream	Topical	3 g/100g
Lotion	Topical	1.2 g/100mL
Lotion	Topical	0.5 g/100mL
Lotion	Topical	1 %
Lotion	Topical	1.2 g/100g
Suspension	Oral	40 mg / mL
Cream	Topical	1.5 %
Cream	Topical	0.2 g/1g
Cream	Topical	20 %/1
Lotion	Topical	2 g/100mL
Lotion	Topical	2 % w/w
Cloth	Topical	3 g/100g
Lotion	Topical	20 mg/1g
Cream	Topical	1 g/50g
Cream	Topical	1.6 g/160g
Lotion	Topical	1.25 g/100mL
Liquid	Topical	2.5 g/50mL
Cream	Topical	0.5 g/50mL
Cream	Topical	2.93 g/125mL
Cream	Topical	1.5 g/30mL
Aerosol	Topical	2.7 g/100g
Jelly	Topical	2 g/100g
Cream	Topical	2.25 g/150mL
Cream	Topical	1.25 g/50mL
Cream	Topical	0.3 g/30mL
Cream	Cutaneous	2.72 g/50g
Tablet	Oral	125 mg/1
Cream	Topical	0.4 mg/50mL
Cream	Topical	1.02 mg/40mL
Tablet
Cream	Cutaneous	0.5 mL/50mL
Cream	Topical	4.27 g/95g
Patch	Topical	0.96 mg/32mL
Cream	Topical	0.015 g/1mL
Cream	Topical	0.15 g/15mL
Stick	Topical	10 mg/1g
Ointment; stick	Topical
Kit; ointment; stick	Topical
Kit	Topical
Cream	Topical	5.88 mg/5.88mL
Cream	Topical	4.4 g/44g
Ointment	Topical	1 g/113g
Stick	Topical	0.01 g/1g
Liquid	Topical	2.5 g/100mL
Cream	Topical	0.5 g/50g
Cream	Topical	0.6 g/20g
Capsule	Oral
Liquid	Topical	32 mg/100g
Liquid	Topical	3.2 g/100g
Cream	Topical	1.3 % w/w
Cream	Topical	0.82 mg/55mL
Emulsion	Topical	1.20 mg/120mL
Cream	Topical	0.55 mg/55mL
Cream	Topical	1.65 g/55mL
Cream	Topical	2.2 g/55mL
Cream	Topical	1.2 g/60mL
Cream	Topical	2.4 g/60mL
Cream	Topical	0.2 mg/20mL
Cream	Topical	0.7 mg/70mL
Lotion	Topical	1.50 g/150mL
Cream	Topical	1.50 g/150mL
Cream	Topical	2.8 mg/140mL
Cream	Topical	0.51 mg/15mL
Cream	Topical	0.9 g/35mL
Cream	Topical	1.14 g/55mL
Cream	Topical	10.04 g/200mL
Cream	Topical	0.9 g/30mL
Cream	Topical	2.3 g/50mL
Ointment	Topical	0.36 g/30g
Cream	Topical	0.4 mg/40mL
Cream	Topical	0.3 mg/30mL
Cream	Topical	12 mg/1g
Lotion	Topical	10 mg/1mL
Lotion	Topical	20 mg/1mL
Cream	Topical	3.90 g/65mL
Stick	Topical
Gel	Topical	20 mg/1g
Cream	Topical	9 % w/w
Cream	Topical	6.0 mg/30mL
Liquid; spray	Topical	1.5 %
Liquid	Topical	1.52 mg/1mL
Lotion	Topical	1.5 % w/w
Cream	Topical	1 % w/w
Lotion	Topical	1.25 % w/w
Lotion	Topical	1.25 mg/100mL
Lotion	Topical	3.0 % w/w
Cloth	Topical	3 %
Cloth	Topical	30 mg/1g
Gel	Topical	2.5 g/50mL
Liquid	Topical	3.6 g/120mL
Cream	Topical	0.57 g/57g
Stick	Topical	0.66 g/8.5g
Stick	Topical	1 g/100g
Capsule	Oral	100 MG
Liquid	Topical	12 mg/1mL
Cream	Topical	12.5 mg/1mL
Spray	Topical	1 g/100mL
Lotion	Topical	12.12 mg/1mL
Lotion	Topical	13.1 mg/1g
Lotion	Topical	1.3 kg/100mL
Lotion	Topical	1.3 g/100g
Lotion	Topical	13.13 mg/1mL
Lotion	Topical	1.2500 mL/100mL
Cream	Topical	0.2 g/100g
Cream	Topical	2.92 g/75mL
Suspension	Oral	21 mg/2.5ml
Cream; kit; solution	Topical
Cream; kit; patch	Cutaneous; Topical
Lotion	Topical	0.01 g/1mL
Kit	Cutaneous; Topical
Cream	Topical	3 g/100mL
Cream	Topical	.01 mg/1g
Lotion	Topical	0.5 g/100g
Lotion	Topical	1.0 g/100g
Capsule, coated	Oral
Cream	Topical	17.5 ug/1mg
Cream	Topical	50 ug/1mg
Liquid	Topical	17.5 ug/1mg
Patch	Topical	48 g/100g
Ointment	Topical
Cream	Topical	5.0 %
Cream	Topical	5.0 % w/w
Disc	Topical
Suspension	Oral	10.000 g
Lotion	Topical	4.50 mg/300mL
Cream	Topical	5.5 g/110mL
Liquid	Topical	1.5 g/30mL
Cream	Topical	6.0 g/100mL
Lotion	Topical	1.1 g/100mL
Cream	Topical
Cream	Topical	0.9 g/30g
Oil	Topical	26 1/100mL
Oil	Topical	1.5 1/150mL
Cream	Topical	11.5 g/50g
Cream	Topical	15 mg/1g
Gel	Topical	1.27 g/100mL
Cream	Topical	6.0192 g/100mL
Cream	Topical	0.5 g/100mL
Cream	Topical	0.75 g/100mL
Gel	Topical	0.01 g/100mL
Liquid	Topical	0.01 g/100mL
Liquid	Topical	1.2 g/100mL
Cream	Topical	4.0 g/400mL
Granule, effervescent	Oral
Tablet	Oral	40 mg/1
Solution	Topical	12.0 mg/200mL
Liquid	Topical	9.60 g/200mL
Liquid	Topical	2.88 g/60mL
Cream	Topical	0.9 g/60mL
Cream	Topical	0.46 mg/40mL
Cream	Topical	0.9 g/45g
Emulsion	Topical	2 mg/1g
Suspension	Oral	1.000 g
Cream	Topical	20 g/1000g
Kit; stick	Topical
Solution	Oral
Tablet, coated	Oral
Lotion	Topical	13 mg/1mL
Suspension / drops	Oral	20 mg/0.3mL
Gel	Topical	30 g/100mL
Cream	Cutaneous	0.55 g/55g
Capsule	Oral	10 g
Tablet, chewable	Oral	40 mg
Kit	Topical	5 g/100g
Liquid	Oral	125 mg/5mL
Tablet	Oral	150 mg / tab
Capsule, gelatin coated	Oral	125 mg/1
Cream	Cutaneous
Tablet, chewable	Oral	80 mg/80mg
Cream	Topical	0.8 g/80mL
Cream	Topical	0.62 mg/20mL
Patch	Cutaneous	4 g/100g
Capsule, coated pellets	Oral
Gel	Topical	2 g/100mL
Liquid	Topical	3.1 mg/155mL
Lotion	Topical	0.5 mg/1mL
Gel	Topical	3.2 g/100g
Aerosol, foam	Topical	1 g/100g
Cream	Topical	5.45 g/125mL
Cream	Topical	0.46 g/20mL
Cream	Topical	0.605 g/55mL
Kit	Topical	1.5 g/100mL
Cream	Topical	2.5 mg/50mL
Cream	Cutaneous	0.5 g/50g
Cream	Cutaneous	2.65 mL/50mL
Cream	Cutaneous	2.25 g/50g
Cream	Topical	1.39 g/55g
Cream	Topical	2.64 g/55g
Cream	Topical	1.88 g/50g
Cream	Topical	0.71 g/50g
Cream	Topical	1.54 g/55g
Lotion	Topical	2.40 mg/130mL
Tablet, chewable	Oral	125 mg/1
Tablet, chewable	Oral	80 mg/1
Tablet, chewable	Oral	250 mg/1
Capsule	Oral	180 mg/1
Strip	Oral	62.5 mg/1
Gel	Oral	125 mg/1
Tablet	Oral	50 mg
Gel	Oral
Lotion	Topical	17.5 mg/1mL
Cream	Topical	17.5 mg/1mL
Cream	Topical	15 mg/1mL
Liquid	Topical	0.4 mg/40mL
Cream	Topical	0.46 g/23mL
Cream	Cutaneous	1.8 mL/45mL
Cream	Cutaneous	3.51 mL/45mL
Cream	Cutaneous	3.69 g/55g
Cream	Topical	10 mg/1g
Cream	Topical	0.2 g/50mL
Cream	Topical	2.0 g/50mL
Cream	Topical	0.2 g/40mL
Cream	Topical	1.0 g/50mL
Cream	Topical	0.83 mg/50mL
Cream	Topical	1.63 mg/40mL
Shampoo	Topical	0.6 g/100mL
Shampoo	Topical	4 mg/400mL
Shampoo	Topical	2.4 mg/240mL
Cream	Topical	0.8 g/80g
Gel	Topical
Gel	Topical	1 g/100mL
Cream	Topical	1.5 mL/100mL
Cream	Topical	1.0 % w/w
Cream	Topical	1.50 g/60mL
Cream	Topical	1.01 g/30mL
Gel	Topical	2 g/300g
Gel	Topical	1.0 g/300g
Cream	Topical	0.6 g/30mL
Cream	Topical	9.98 mg/1mL
Cream	Topical	0.5 g/100g
Liquid	Topical	3 g/100mL
Cream	Topical	1.04 g/50g
Cream	Topical	12.5 g/100mL
Ointment	Topical	17 g/56.69g
Lotion / shampoo	Topical
Cream	Topical	2.99 g/50mL
Cream	Topical	2.08 g/50mL
Cream	Cutaneous	1.39 g/30mL
Tablet, chewable	Oral	80 mg
Lotion	Topical	2.0 g/200mL
Lotion	Topical	12.5 mg/1mL
Suspension	Oral	20 mg/0.3mL
Liquid	Oral	20 mg/0.3mL
Lotion	Topical
Liquid	Topical	0.15 g/100g
Lotion	Topical	2.0 mg/200mL
Cream	Topical	0.96 mg/30mL
Cream	Topical	0.95 mg/30mL
Suspension
Shampoo	Topical	1 g/100mL
Shampoo	Topical	1.666667 g/100mL
Liquid	Topical	1 g/100mL
Liquid	Topical	0.06 g/1.5mL
Cream	Topical	0.04 g/1.5mL
Liquid	Topical	1.5 g/100mL
Kit; liquid; ointment	Buccal; Topical
Liquid	Topical	1.5 mL/100mL
Cream	Topical	5.0 mL/100mL
Lotion	Topical	1.5 mL/100mL
Spray	Topical	10.2 mg/1mL
Liquid	Topical	5 g/100mL
Gel	Topical	0.2 g/10mL
Cream	Topical	0.75 mg/1mL
Lipstick	Topical
Kit; liquid	Oral
Cream; kit; liquid	Oral; Topical
Lipstick	Topical	6 g/100g
Tablet, chewable	Oral	200 MG
Tablet, chewable	Oral	60 mg/1
Tablet	Oral	80 mg
Cream	Topical	0.58 g/50mL
Cream	Topical	1.02 g/50mL
Tablet	Oral	800.00 mg
Lotion	Topical	20 %
Aerosol, foam	Topical	1 g/100mL
Patch	Topical
Capsule, liquid filled	Oral	250 mg/1
Cream	Topical	0.1 g/100g
Cream	Topical	10 g/100g
Cream	Topical	20 mg/1g
Cream	Topical	125 mg/1mL
Cloth	Topical	3.6 % v/v
Cream	Topical	1.5 g/50g
Gel	Topical	1.05 g/50mL
Tablet	Oral	200.000 mg
Suspension	Oral
Lipstick	Topical	7.4 g/100g
Cream	Topical	1.62 mg/65mL
Patch	Topical	0.16 g/8g
Capsule, delayed release	Oral	25 mg / ecc
Cream	Topical	0.3 g/75mL
Cream	Topical	3 mg/300mL
Emulsion	Topical	2 mg/200mL
Patch	Topical	0.22 mg/22mL
Cream	Topical	0.35 g/35g
Cream	Topical	2 mg/200mL
Cream	Topical	7.5 g/150mL
Lotion	Topical	30 g/1g
Lotion	Topical	40 mg/1mL
Solution / drops	Oral	20 mg/0.3mL
Gel	Topical	1.2 g/100g
Gel	Topical	12 mg/1g
Cream	Topical	1 g/50mL
Cream	Topical	1.5 g/50mL
Cream	Topical	10 mg/1mL
Lotion	Topical	4.8 mg/400mL
Cream	Topical	0.8 g/50mL
Gel	Oral	80.0000 mg
Cream	Topical	45 mg/1g
Patch	Topical	0.50 g/20g
Stick	Topical	0.03 g/3.2g
Lotion	Topical	.02 mL/1mL
Cream	Topical	.02 mL/1mL
Cream	Topical	50 mg/1mL
Cream	Topical	1.7 mg/118mg
Cream; kit; ointment; solution	Topical
Cream	Topical	1.0 %
Solution	Topical	50 %
Liquid	Topical	1 mg/100mL
Lotion	Topical	0.15 g/100g
Lotion	Topical	1 g/100g
Lotion	Topical	12 mg/1g
Lotion	Topical	3 g/227g
Cream	Cutaneous	2 g/50g
Liquid	Topical	0.03 mg/2.8mL
Solution	Topical
Gel	Topical	0.024 g/1mL
Tablet	Oral	160 mg
Tablet	Oral	40 mg
Cream	Topical	7.06 g/50mL
Stick	Topical	0.09 g/9g
Tablet, sugar coated	Oral
Granule	Oral
Lotion	Topical	2.70 g/180mL
Liquid	Oral
Emulsion	Oral
Liquid	Topical	1.10 g/110mL
Powder, for solution	Oral
Cream	Topical	1.675 g/50g
Swab	Topical	3.2 g/100g
Cloth	Topical	32 mg/1mL
Capsule, gelatin coated	Oral	180 mg/1
Capsule, gelatin coated	Oral	250 mg/1
Solution / drops	Oral	40 mg / .6 mL
Liquid	Oral	40 mg / .6 mL
Capsule, liquid filled	Oral	500 mg/1
Cream	Topical	0.6 g/60g
Cream	Topical	1.0 g/20mL
Lotion		15 mg/1mL
Cream		15 mg/1mL
Cream		25 mg/1mL
Capsule, gelatin coated	Rectal; Vaginal	0.324 g/1.2g
Cream	Topical	2.38 g/140mL
Cream	Topical	0.4 g/40mL
Cream	Topical	0.36 g/30mL
Cream	Topical	6.75 g/50mL
Cream	Topical	1.4 g/140mL
Cream	Topical	1 g/100g
Cream	Topical	1.6 g/80g
Cream	Topical	2 g/100g
Lotion	Topical	3 mg/150mL
Cream	Cutaneous	1.8 mL/130mL
Cream	Topical	1.1 g/55mL
Cream	Topical	0.55 g/50mL
Capsule	Oral	40 mg
Solution	Topical	0.72 g/40mL
Swab	Topical	32 mg/1g
Cream	Topical	1.5 mg/30mL
Emulsion	Topical	2.6 mg/130mL
Cream	Topical	2.1 mg/60mL
Cream	Topical	3.05 g/30mL
Powder	Topical	2.16 g/12g
Cream	Topical	0.9 mg/30mL
Powder	Topical	1.85 g/12g
Cream	Topical	20 mg/1mL
Cream	Topical	0.01 g/1g
Ointment	Topical	1 % w/w
Ointment	Topical	0.01 g/1g
Cream	Topical	1.6 g/80mL
Cream	Topical	5.41 g/50g
Cream	Topical	1.25 g/50g
Liquid	Topical	0.9 g/45mL
Cream	Topical	8 g/100mL
Liquid	Topical	8 g/100mL
Cream; kit	Topical
Liquid	Topical	53.1 g/100mL
Cream	Topical	0.3 g/100mL
Spray	Topical
Liquid	Topical
Cloth	Topical	0.608 g/1
Cloth	Topical	3.2 %
Cloth	Topical	0.544 g/1
Cloth	Topical	0.294 g/1
Cloth	Topical	3.2 g/100mL
Cream	Topical	0.5 mg/100mL
Cream	Topical	0.4 g/100mL
Shampoo	Topical	2 g/100mL
Oil	Topical	1.2 g/30mL
Cream	Topical	2.66 g/140mL
Cream	Topical	1.6 g/40mL
Cream	Topical	2 g/80mL
Cloth	Topical	3.6 g/100mL
Lotion	Topical	1.5 g/100mL
Lotion	Topical	1.5 mg/100mL
Lotion	Topical	0.01 g/1g
Cream	Topical	0.05 g/100g
Cream	Topical	0.015 g/100g
Cream	Topical	1.5 g/100mL
Cream	Topical	1.61 mg/50mL
Cream	Topical	0.32 g/10mL
Cream	Topical	1.75 mg/70mL
Emulsion	Topical	1.3 mg/130mL
Cream	Topical	0.25 mg/25mL
Cream	Topical	0.75 mg/50mL
Cream	Topical	0.15 g/10mL
Emulsion	Topical	0.2 g/20mL
Cream	Topical	0.15 mg/15mL
Cream	Topical	0.03 g/3mL
Liquid	Topical	1.1 mg/110mL
Patch	Topical	0.6 g/30mL
Liquid	Topical	12.5 mg/1mL
Bar, chewable	Oral
Cream	Topical	0.3 g/30g
Cream	Topical	0.6 g/30g
Cream	Topical	2.49 g/120mL
Liquid	Topical	2.49 g/120mL
Cream	Topical	0.54 g/50mL
Cream	Topical	1.8 g/100mL
Stick	Topical	2 g/100g
Gel	Topical	1 mg/100mg
Lotion	Topical	1.25 mL/100mL
Cream	Topical	1.133 g/113g
Cream	Topical	960 mg/96g
Cream	Topical	0.4988 mg/21mL
Cream	Topical	0.42 mg/21mL
Cloth	Topical
Lotion	Topical	50 mg/1mL
Powder	Topical	0.02 g/10g
Cream	Topical	0.24 mg/80mL
Cream	Topical	50 mg/1g
Tablet	Oral	125 MG
Cream	Topical	1.0 g/100mL
Cream	Topical	1.0 mg/100mL
Powder	Topical	0.08 g/4.5g
Powder	Topical	0.07 g/4.5g
Gel	Topical	2.1 g/7.5mL
Powder	Topical	1.05 g/10g
Cream	Topical	20 %
Cream	Topical	2.5 g/100mL
Suspension	Oral	66.6 mg
Capsule, liquid filled	Oral	125 mg/1
Capsule, liquid filled	Oral	180 mg/1
Solution / drops	Oral
Tablet	Oral	80 mg/1
Gel	Oral	180 mg/1
Gel	Topical	.0024 mg/.024mg
Gel	Topical	.00119 mg/.119mg
Gel	Topical	0.6 mg/60mg
Cream	Topical	1.04 mg/50mL
Lotion	Topical	1 mL/100mL
Lotion	Topical	1.0000 mL/100mL
Lotion	Topical	1200 mg/100mL
Liquid	Topical	1.3 mL/100mL
Lotion	Topical	5 mg/354mg
Ointment	Topical	2.272 g/113.6g
Stick	Topical	1 mg/100mg
Gel	Topical	1.61 g/50mL
Cream	Topical	0.5 mg/50mL
Emulsion	Topical	1.30 mg/120mL
Cream	Topical	1.07 mg/40mL
Emulsion	Topical	1.5 g/150mL
Cream	Topical	0.60 mg/30mL
Cream	Topical	0.99 g/55mL
Emulsion	Topical	1.30 g/120mL
Cream	Topical	1.07 g/40mL
Gel	Topical	1.6 g/100mL
Cream	Topical	1.04 mg/55mL
Cream	Topical	1.6 g/100mL
Cream	Topical	0.968 g/40mL
Solution	Topical	0.3 g/30mL
Cream	Topical	1.296 g/120mL
Cream	Topical	1.2 g/120mL
Cream	Topical	0.76 g/40mL
Cream	Topical	0.375 g/25mL
Stick	Topical	20 mg/1g
Cream	Topical	5 g/100mL
Cream	Topical	0.77 g/55mL
Cream	Topical	9.75 g/150mL
Cream	Topical	1.35 g/30mL
Liquid	Topical	5.4 g/135mL
Cream	Topical	5.0 g/100mL
Cream	Topical	1.5 g/75mL
Powder	Topical	0.12 g/6g
Powder	Topical	0.06 g/6g
Stick	Topical	0.18 g/1.5g
Cream	Topical	1.2 g/60g
Cream	Topical	1.44 g/120g
Cream	Topical	2.56 g/160mL
Cream	Topical	4 g/100mL
Cream	Topical	13 mg/1mL
Emulsion	Oral	20 mg/0.3mL
Cream	Topical	1.6 mg/80mL
Cream	Topical	2 g/100mL
Cream	Topical	6.8 mg/80mL
Cream	Topical	0.3 g/20mL
Cream	Topical	1.575 g/35mL
Cream	Topical	1.5 g/150mL
Cream	Cutaneous	0.58 mL/45mL
Cream	Cutaneous	0.7 mL/35mL
Cream	Topical	6 % w/w
Cream	Topical	60 mg/1g
Cream	Topical	.01 g/100mL
Cream	Topical	.012 g/100mL
Lotion	Topical	1 % w/w
Lotion	Topical	1.5 g/150mL
Cream	Topical	0.5 g/25mL
Gel	Topical	1.5 g/100mL
Cream	Topical	1.55 g/50mL
Cream	Topical	0.81 g/30mL
Cream	Topical	50 uL/1mL
Cream	Topical	17.5 uL/1mL
Liquid	Topical	17.5 uL/1mL
Cream	Topical	1.7 g/170.10g
Cream	Topical	0.044 g/4mL
Cream	Topical	0.77 g/70mL
Cream	Topical	1.5 mg/50mL
Cream	Topical	1.4 mg/140mL
Cream	Topical	7 mg/35mL
Cream	Topical	0.6 mg/30mL
Tablet	Oral
Gel	Topical	30 mg/1mL
Cream	Topical	0.45 mg/45mL
Injectable foam	Topical
Cream	Topical	0.6 g/60mL
Cream	Topical	2.10 g/60mL
Emulsion	Topical
Spray	Topical	20 g/100g
Shampoo	Topical	11.4 mg/380mL
Solution	Topical	15.2 mg/380mL
Cream	Topical	1 mg/50mL
Lotion	Topical	2 g/100g
Cream	Topical	5 g/100g
Cream	Topical	0.64 g/40mL
Cream	Topical	1.65 g/150mL
Cream	Topical	2 g/40mL
Cream	Topical	0.75 g/30mL
Cream	Topical	3.6 g/90mL
Cream	Topical	7 g/100mL
Cream	Topical	3.81 g/50mL
Emulsion	Topical	0.937 mg/50mL
Ointment	Topical	10 mg/1g
Ointment	Topical	20 mg/1g
Lotion	Topical	1 g/100mL
Patch	Topical	2.0 g/100mL
Liquid	Topical	3.0 g/100mL
Lotion	Topical	15 mg/1mL
Cream	Topical	25 mg/1g
Emulsion	Topical	1.50 g/150mL
Cream	Topical	1.57 g/35mL
Lipstick	Topical	0.91 g/4.5g
Liquid	Topical	0.05 g/7g
Liquid	Topical	3.77 g/7g
Kit	Oral
Cream	Topical	0.32 g/30mL
Cream	Topical	1.12 g/50mL
Cream	Cutaneous	0.35 mL/35mL
Liquid	Topical	99.97 g/100mL
Cream	Cutaneous	0.3 g/30g
Tablet, film coated	Oral
Paste	Topical

Prices

Not Available

Patents

Patent Number	Pediatric Extension	Approved	Expires (estimated)	Region
US6103260	No	2000-08-15	2017-07-17

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Not Available

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Not Available

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Drug created at December 03, 2015 16:51 / Updated at February 20, 2024 23:55