Selenomethionine

Identification

Generic Name

Selenomethionine

DrugBank Accession Number

DB11142

Background

Selenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. It can be produced from post-structural modifications. In vivo, selenomethionine plays an essential role in acting as an antioxidant, where it depletes reactive oxygen species (ROS) and aids in the formation and recycling of glutathione, another important antioxidant. In comparison to selenite, which is the inorganic form of selenium, the organic form of selenomethionine is more readily absorbed in the human body. Selenomethionin is used in biochemical laboratories where its incorporation into proteins that need to be visualized enhances the performance of X-ray crystallography.

Type

Small Molecule

Groups

Approved, Investigational

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Selenomethionine (DB11142)

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Weight

Average: 196.11
Monoisotopic: 196.995500429

Chemical Formula

C₅H₁₁NO₂Se

Synonyms

Not Available

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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Eltrombopag	The bioavailability of Selenomethionine can be decreased when combined with Eltrombopag.

Food Interactions

No interactions found.

Products

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Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Bacmin	Selenomethionine (50 ug/1) + Ascorbic acid (500 mg/1) + Biotin (150 ug/1) + Chromium Cr-51 chloride (0.1 mg/1) + Cupric oxide (3 mg/1) + Cyanocobalamin (50 ug/1) + Ferrous fumarate (27 mg/1) + Flavone (50 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Manganese gluconate (5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (25 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Thiamine mononitrate (20 mg/1) + Vitamin A acetate (2000 [iU]/1) + Zinc oxide (22.5 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet, coated	Oral	Marnel Pharmaceuticals, Llc	2000-04-01	Not applicable
RE FAC-x	Selenomethionine (100 ug/1) + Ascorbic acid (200 mg/1) + Biotin (200 ug/1) + Cholecalciferol (400 [iU]/1) + Chromium picolinate (200 ug/1) + Cupric sulfate pentahydrate (2.5 mg/1) + Cyanocobalamin (2500 ug/1) + Folic acid (2800 ug/1) + Lutein (500 ug/1) + Lycopene (500 ug/1) + Magnesium (100 mg/1) + Manganese sulfate (2.5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Thiamine mononitrate (20 mg/1) + Vitamin A (5000 [iU]/1) + Vitamin E (100 [iU]/1) + Zinc (15 mg/1)	Tablet	Oral	River’s Edge Pharmaceuticals, LLC	2007-07-01	2011-01-13
Vital-D Rx	Selenomethionine (70 ug/1) + Ascorbic acid (60 mg/1) + Biotin (300 ug/1) + Cholecalciferol (2000 [iU]/1) + Cobalamin (6 ug/1) + Folic acid (1 mg/1) + Nicotinamide (20 mg/1) + Pantothenic acid (10 mg/1) + Pyridoxine hydrochloride (10 mg/1) + Riboflavin (1.7 mg/1) + Thiamine chloride (1.5 mg/1) + Tocopherol (35 [iU]/1) + Zinc oxide (12.5 mg/1)	Tablet, coated	Oral	Nephro-Tech, Inc.	2007-11-01	Not applicable
Viva CT Prenatal	Selenomethionine (50 ug/1) + Ascorbic acid (100 mg/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate (1 mg/1) + Cyanocobalamin (15 ug/1) + Ferrous fumarate (28 mg/1) + Folic acid (1 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (20 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)	Tablet, chewable	Oral	Jaymac Pharmaceuticals Llc	2012-05-01	Not applicable

Categories

Drug Categories

• Amino Acids
• Amino Acids, Peptides, and Proteins
• Organoselenium Compounds
• Selenium Compounds

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Fatty acids and conjugates / Amino acids / Selenoethers / Monocarboxylic acids and derivatives / Carboxylic acids / Organopnictogen compounds / Organic oxides / Monoalkylamines / Hydrocarbon derivatives / Carbonyl compounds

Substituents

Aliphatic acyclic compound / Amine / Amino acid / Carbonyl group / Carboxylic acid / Fatty acid / Hydrocarbon derivative / L-alpha-amino acid / Monocarboxylic acid or derivatives / Organic nitrogen compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

amino acid zwitterion (CHEBI:62621)

Affected organisms

Not Available

Chemical Identifiers

UNII

964MRK2PEL

CAS number

3211-76-5

InChI Key

RJFAYQIBOAGBLC-BYPYZUCNSA-N

InChI

InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

IUPAC Name

(2S)-2-amino-4-(methylselanyl)butanoic acid

SMILES

C[Se]CC[C@H](N)C(O)=O

References

General References

Not Available

External Links

KEGG Compound

C05335

PubChem Compound

105024

PubChem Substance

347827917

ChemSpider

94765

RxNav

9644

ChEBI

62621

ChEMBL

CHEMBL113178

PDBe Ligand

MSE

Wikipedia

Selenomethionine

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
3	Completed	Prevention	Cataracts / Macular Degeneration	1
3	Completed	Prevention	Colorectal Cancer / Precancerous Conditions	1
3	Completed	Prevention	Lung Cancer	1
3	Completed	Prevention	Precancerous/Nonmalignant Condition / Prostate Cancer	1
3	Completed	Prevention	Prostate Cancer	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet	Oral
Tablet, coated	Oral
Tablet, chewable	Oral
Capsule	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	109.0 mg/mL	ALOGPS
logP	-2.5	ALOGPS
logP	-3.3	Chemaxon
logS	-0.25	ALOGPS
pKa (Strongest Acidic)	1.56	Chemaxon
pKa (Strongest Basic)	9.5	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	4	Chemaxon
Hydrogen Donor Count	2	Chemaxon
Polar Surface Area	63.32 Å2	Chemaxon
Rotatable Bond Count	4	Chemaxon
Refractivity	42.91 m3·mol-1	Chemaxon
Polarizability	14.64 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
GC-MS Spectrum - GC-MS (1 TMS)	GC-MS	splash10-0pc0-2910000000-c7140386a1899064bb79
GC-MS Spectrum - GC-MS (2 TMS)	GC-MS	splash10-00b9-0950000000-05c9f3aa6ccd78087856
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0udi-0900000000-3871910f0550e77f02b0
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0a59-4900000000-eaca64ea97f84c7658f4
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0006-9000000000-d6721fe6411593c100b2
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0006-9000000000-6f7ee284f69845517002
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-0a4l-9700000000-6150e74d157e38f0002d
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0006-9000000000-ad5cc953d6aafb2a446a

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å2)	Source type	Source
[M-H]-	128.8893643	predicted	DarkChem Lite v0.1.0
[M-H]-	128.8767643	predicted	DarkChem Lite v0.1.0
[M-H]-	127.76049	predicted	DeepCCS 1.0 (2019)
[M+H]+	129.6753643	predicted	DarkChem Lite v0.1.0
[M+H]+	129.4783643	predicted	DarkChem Lite v0.1.0
[M+H]+	131.51552	predicted	DeepCCS 1.0 (2019)
[M+Na]+	128.8335643	predicted	DarkChem Lite v0.1.0
[M+Na]+	128.9408643	predicted	DarkChem Lite v0.1.0
[M+Na]+	140.34157	predicted	DeepCCS 1.0 (2019)

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Drug created at December 03, 2015 16:51 / Updated at June 01, 2022 17:06