Zinc picolinate

Identification

Generic Name

Zinc picolinate

DrugBank Accession Number

DB11175

Background

Zinc picolinate is a zinc salt of picolinic acid. It is available as OTC dietary supplements as a source of zinc to treat and prevent zinc deficiency. The absorption of zinc after oral administration of zinc picolinate is shown to be effective.

Type

Small Molecule

Groups

Investigational

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Zinc picolinate (DB11175)

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Weight

Average: 309.59
Monoisotopic: 307.977549

Chemical Formula

C₁₂H₈N₂O₄Zn

Synonyms

Not Available

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Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
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Carbamazepine	Zinc picolinate can cause a decrease in the absorption of Carbamazepine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ceftibuten	Zinc picolinate can cause a decrease in the absorption of Ceftibuten resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cephalexin	Zinc picolinate can cause a decrease in the absorption of Cephalexin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin	Zinc picolinate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin	Zinc picolinate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.

Food Interactions

Not Available

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Zinc cation	ionic	13S1S8SF37	23713-49-7	PTFCDOFLOPIGGS-UHFFFAOYSA-N

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Livita Adults	Zinc picolinate (2 mg/1mL) + Ascorbic acid (200 mg/1mL) + Biotin (30 ug/1mL) + Calcium citrate tetrahydrate (200 mg/1mL) + Cholecalciferol (10 ug/1mL) + Choline bitartrate (200 mg/1mL) + D-alpha-Tocopherol acetate (20.1 mg/1mL) + Inulin (500 mg/1mL) + Levomefolate calcium (1000 ug/1mL) + Magnesium citrate (100 mg/1mL) + Mecobalamin (2.4 ug/1mL) + Nicotinamide (8 mg/1mL) + Calcium pantothenate (5 mg/1mL) + Pyridoxine hydrochloride (1.7 mg/1mL) + Riboflavin (1.3 mg/1mL) + Thiamine mononitrate (1.2 mg/1mL) + Vitamin A acetate (900 ug/1mL)	Liquid	Oral	PureTek Corporation	2023-12-15	Not applicable
Livita Children	Zinc picolinate (0.67 mg/1mL) + Ascorbic acid (66.67 mg/1mL) + Biotin (10 ug/1mL) + Calcium citrate tetrahydrate (66.67 mg/1mL) + Cholecalciferol (3.33 ug/1mL) + Choline bitartrate (66.67 mg/1mL) + D-alpha-Tocopherol acetate (10 mg/1mL) + Inulin (166.67 mg/1mL) + Levomefolate calcium (333 ug/1mL) + Magnesium citrate (33.33 mg/1mL) + Mecobalamin (0.8 ug/1mL) + Nicotinamide (2.67 mg/1mL) + Calcium pantothenate (1.67 mg/1mL) + Pyridoxine hydrochloride (0.57 mg/1mL) + Riboflavin (0.43 mg/1mL) + Thiamine mononitrate (0.4 mg/1mL) + Vitamin A acetate (300 ug/1mL)	Liquid	Oral	PureTek Corporation	2023-12-18	Not applicable
Tozal	Zinc picolinate (40 mg/31) + Ascorbic acid (452 mg/31) + Cholecalciferol (1000 [iU]/31) + Copper (1.6 mg/31) + Cyanocobalamin (100 ug/31) + Folic acid (1 mg/31) + Lutein (15 mg/31) + Omega-3 fatty acids (600 mg/31) + Pyridoxine hydrochloride (20 mg/31) + Taurine (400 mg/31) + Vitamin A palmitate (10000 [iU]/31) + Vitamin E (200 [iU]/31) + Zeaxanthin (3 mg/31)	Capsule, gelatin coated	Oral	Focus Laboratories, Inc.	2013-06-01	2015-07-15

Categories

Drug Categories

• Compounds used in a research, industrial, or household setting
• Iron Chelating Agents
• Metal cations
• Metal divalent cations
• Pyridines
• Sequestering Agents
• Zinc Compounds

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pyridinecarboxylic acids and derivatives

Direct Parent

Pyridinecarboxylic acids

Alternative Parents

Heteroaromatic compounds / Carboxylic acid salts / Organic transition metal salts / Carboxylic acids / Azacyclic compounds / Organooxygen compounds / Organonitrogen compounds / Organic zwitterions / Organic oxides / Hydrocarbon derivatives

Substituents

Aromatic heteromonocyclic compound / Azacycle / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Heteroaromatic compound / Hydrocarbon derivative / Organic nitrogen compound / Organic oxide / Organic oxygen compound

Molecular Framework

Not Available

External Descriptors

Not Available

Affected organisms

Not Available

Chemical Identifiers

UNII

ALO92O31SE

CAS number

17949-65-4

InChI Key

NHVUUBRKFZWXRN-UHFFFAOYSA-L

InChI

InChI=1S/2C6H5NO2.Zn/c2*8-6(9)5-3-1-2-4-7-5;/h2*1-4H,(H,8,9);/q;;+2/p-2

IUPAC Name

zinc(2+) bis(pyridine-2-carboxylate)

SMILES

[Zn++].[O-]C(=O)C1=CC=CC=N1.[O-]C(=O)C1=CC=CC=N1

References

General References

1. Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC: Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. Agents Actions. 1987 Jun;21(1-2):223-8. [Article]

External Links

PubChem Compound

9904746

PubChem Substance

347827932

ChemSpider

8080400

RxNav

58301

Wikipedia

Zinc_picolinate

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Basic Science	Premature Births	1
Not Available	Recruiting	Basic Science	DNA Damage / Immune System Disorders	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Liquid	Oral
Capsule, gelatin coated	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	12.2 mg/mL	ALOGPS
logP	1.55	ALOGPS
logP	-0.65	Chemaxon
logS	-1.4	ALOGPS
pKa (Strongest Acidic)	1	Chemaxon
pKa (Strongest Basic)	5.52	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	3	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	53.02 Å2	Chemaxon
Rotatable Bond Count	2	Chemaxon
Refractivity	41.62 m3·mol-1	Chemaxon
Polarizability	10.94 Å3	Chemaxon
Number of Rings	2	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Not Available

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Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53