Identification
- Summary
Aluminum zirconium octachlorohydrex gly is an antiperspirant used to reduce sweating.
- Generic Name
- Aluminum zirconium octachlorohydrex gly
- DrugBank Accession Number
- DB11200
- Background
Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent 8, 9. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants 11.
Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms 2.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Aluminum zirconium octachlorohydrex gly (DB11200)
- Weight
- Average: 263.74
Monoisotopic: 261.89768 - Chemical Formula
- C2H8AlClNO4Zr
- Synonyms
- Aluminium zirconium octachlorohydrex gly
- Aluminium zirconium octachlorohydrex glycine complex
- Aluminum zirconium octachlorohydrex gly
- Aluminum zirconium octachlorohydrex glycine complex
Pharmacology
- Indication
Aluminum-based antiperspirant preparations intended for the reduction of normal underarm perspiration, and indicated for use in hyperhidrosis 12.
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Reduces perspiration and body odor 8.
- Mechanism of action
Aluminium salts in antiperspirants, such as chlorohydrates, form insoluble plugs within sweat ducts to temporarily prevent sweat reaching the surface of the skin 14, 5, 6, 8.
Target Actions Organism ASweat ducts antagonistHumans - Absorption
A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminum-26 was performed. After repeated exposure for 6 days to aluminum chlorohydrate 21 % (about 13 mg of aluminium) to each axilla under occlusive dressing in two volunteers (one man and a woman), on skin previously tape stripped twice, blood and urine samples were obtained. Aluminium was detected in the blood 6 hours after the primary application and remained detectable for 15 days therafter. The results of this study estimate that the proportion of aluminium is absorbed averaged 0.012%. The shortcomings of this study are that it was not done in accordance with good practice (GCP) and it was performed using only 2 volunteers 7.
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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The EU has published a statement of caution that antiperspirant should not be applied to damaged or irritated skin, yet it is common to shave the underarm area before applying antiperspirant 14.
The possible health risks of aluminum containing antiperspirant use are not well studied. Although it has been suggested that deodorant and/or antiperspirant use is associated with incidence or age of breast cancer diagnosis 3, a causal relationship between aluminium product use and breast cancer has not been established 2, 4.
The oral toxicity of aluminium compounds for which data are available (bromide, nitrate, chloride and sulfate) is moderate to low, with LD50 values in the range of 162 to 750 mg Al/kg in rats, and from 164 to 980 mg Al/kg in mice, depending on the type of aluminium compound studied 14.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Active Moieties
Name Kind UNII CAS InChI Key Aluminum cation ionic 3XHB1D032B 22537-23-1 REDXJYDRNCIFBQ-UHFFFAOYSA-N Chloride ion ionic Q32ZN48698 16887-00-6 VEXZGXHMUGYJMC-UHFFFAOYSA-M Aluminium unknown CPD4NFA903 7429-90-5 XAGFODPZIPBFFR-UHFFFAOYSA-N - Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 24 Hour High Performance Antiperspirant Stick 18.6 mL/100mL Topical Aramis Inc. 1984-04-01 Not applicable US 
5 Day Liquid 20 g/100mL Topical Numark Brands, Inc 1937-04-10 Not applicable US Active Antiperspirant and Deodorant for Men Cream 17.8 g/100g Topical Harrison Specialty Co., Inc. 2011-04-09 2014-03-10 US Adidas 24H Anti Perspirant Deep Energy 2.8 Stick 12.6 g/79g Topical Coty Canada Inc. 2012-10-01 Not applicable US Adidas 24H Anti Perspirant Dynamic Pulse 2.8 Stick 12.6 g/79g Topical Coty Canada Inc. 2012-10-01 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image DELTA RON 2019 AMENITY With Colgate Cavity Protection Aluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g) Kit Dental; Topical Buzz Export Services Pty., Ltd. 2019-04-01 Not applicable US Lactovit DEODORANT AND ANTIPERSPIRANT INVISIBLE ANTISTAIN Aluminum zirconium octachlorohydrex gly (8 mg/1) + Aluminum sesquichlorohydrate (1 mg/1) Liquid Topical Laboratorios Genesse Sl 2016-11-19 2017-12-31 US Lactovit DEODORANT ROLL-ON MEN INVISIBLE Aluminum zirconium octachlorohydrex gly (5.28 mg/1) + Aluminum sesquichlorohydrate (0.8 mg/1) Liquid Topical Laboratorios Genesse Sl 2017-04-06 2017-12-31 US Ron 2 Aluminum zirconium octachlorohydrex gly (15.2 g/100g) + Sodium fluorophosphate (7.6 mg/1g) Kit Dental; Topical Buzz Export Services Pty., Ltd. 2015-03-30 Not applicable US Secret Fresh For You Luxe Lavender Aluminum zirconium octachlorohydrex gly (18 g/100g) + Aluminum zirconium octachlorohydrex gly (19.2 g/100g) Kit Topical The Procter & Gamble Manufacturing Company 2019-05-01 2023-03-01 US
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- P9D3YP29MY
- CAS number
- 174514-58-0
- InChI Key
- WYANSMZYIOPJFV-UHFFFAOYSA-L
- InChI
- InChI=1S/C2H5NO2.Al.ClH.2H2O.Zr/c3-1-2(4)5;;;;;/h1,3H2,(H,4,5);;1H;2*1H2;/q;+3;;;;+4/p-2
- IUPAC Name
- zirconium(4+) aluminium(3+) 2-aminoacetate dihydrate chloride
- SMILES
- O.O.[Al+3].[Cl-].[Zr+4].NCC([O-])=O
References
- General References
- Reynolds K, Darrigrand A, Roberts D, Knapik J, Pollard J, Duplantis K, Jones B: Effects of an antiperspirant with emollients on foot-sweat accumulation and blister formation while walking in the heat. J Am Acad Dermatol. 1995 Oct;33(4):626-30. [Article]
- Urban J, Fergus DJ, Savage AM, Ehlers M, Menninger HL, Dunn RR, Horvath JE: The effect of habitual and experimental antiperspirant and deodorant product use on the armpit microbiome. PeerJ. 2016 Feb 2;4:e1605. doi: 10.7717/peerj.1605. eCollection 2016. [Article]
- Darbre PD: Aluminium, antiperspirants and breast cancer. J Inorg Biochem. 2005 Sep;99(9):1912-9. doi: 10.1016/j.jinorgbio.2005.06.001. [Article]
- Allam MF: Breast Cancer and Deodorants/Antiperspirants: a Systematic Review. Cent Eur J Public Health. 2016 Sep;24(3):245-247. doi: 10.21101/cejph.a4475. [Article]
- ALUMINUM ZIRCONIUM OCTACHLOROHYDREX GLY [Link]
- Aluminum zirconium pentachlorohydrex Gly [Link]
- Product Assessment Against Criteria: Antiperspirants [Link]
- LABEL: SECRET COOL WATERLILY CLEAR- aluminum zirconium octachlorohydrex gly gel [Link]
- SECRET ACTIVE COOL INVISIBLE- aluminum zirconium tetrachlorohydrex gly stick [Link]
- Household Product Database, NIH [Link]
- FDA CFR - Code of Federal Regulations Title 21, PART 350: ANTIPERSPIRANT DRUG PRODUCTS FOR OVER-THE-COUNTER HUMAN USE [Link]
- Health Canada Document : Chemical Substance - Aluminum zirconium octachlorohydrex glycine [Link]
- Breast Cancer Organization, UK [Link]
- Scientific Committee on Consumer Safety SCCS [File]
- ZIRKONAL® L435G [File]
- External Links
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 4 Unknown Status Treatment Gastritis, Gastric Ulcer, and Duodenal Ulcer 1 3 Completed Treatment Malaria 1 2 Completed Treatment Cystic Fibrosis (CF) 1 2 Not Yet Recruiting Treatment Cell Carcinoma 1 1 Completed Treatment Leukemias 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Stick Topical 18.6 mL/100mL Liquid Topical 20 g/100mL Stick Topical 12.6 g/79g Stick Topical 14.2 g/79g Stick Topical 18 mg/100g Stick Topical 16 g/57g Stick Topical 10.24 g/64g Stick Topical 11.39 g/64g Liquid Topical 15 g/100mL Stick Topical 6.02 g/70g Stick Topical 186 mg/1mL Gel Topical 20 g/100g Stick Topical 17.8 g/100g Gel Topical 10.08 g/63g Aerosol, spray Topical 16 g/100g Stick Topical 70 g/100g Stick Topical 10.146 g/57g Cream Topical 17 g/100g Gel Topical 16.15 g/85g Aerosol Topical 19 g/100g Liquid Topical .2 g/1mL Solution Topical 0.3 g/100mL Gel Topical 0.3 mL/100mL Solution Topical 0.3 g/100g Stick Topical 7.8 g/100g Lotion Topical 16 g/100g Lotion Topical .165 g/1g Liquid Topical 18 mg/1mL Stick Topical 18.6 g/100g Stick Topical 11.65 g/64g Stick Topical 20 g/48g Stick Topical 18.5 g/100g Stick Topical 10 g/100g Stick Topical 19.2 g/100g Stick Topical 15.2 g/100g Stick Topical 182 mg/1g Stick Topical 19.0 g/100g Stick Topical 20 g/100g Paste Topical 150 mg/1g Kit; paste Topical 150 mg/1g Stick Topical 154 mg/1mL Stick Topical 11.4 g/100g Stick Topical 14.8 g/100g Stick Topical 12.9 g/100g Stick Topical 0.204 g/1.36g Stick Topical 14.6 g/73g Liquid Topical 16.3 mL/96.1mL Stick Topical 15.4 g/73g Liquid Topical 16.3 g/96.1mL Gel Topical; Transmucosal 16.4 g/100g Liquid Topical 16.3 g/16.3g Stick Topical 13.94 g/85g Liquid Topical 16.3 g/96mL Liquid Topical 16.3 g/100mL Liquid Topical 16 g/96.1mL Gel Topical 16.4 g/100g Stick Topical 9.6 g/48g Stick Topical 17 g/85g Stick Topical 195.4 mg/1mL Stick Topical 199 mg/1mL Stick Topical 200 mg/1mL Stick Topical 13.47 g/76.5g Gel Topical 8.75 g/50g Gel Topical 0.2 g/1g Stick Topical 0.2 g/1g Gel Topical 16 % Lotion Topical 15 mL/100mL Cream Topical 20 g/100mL Lotion Topical 14.39 g/100mL Stick Topical 160 mg/100g Stick Topical 200 mg/100g Gel Topical 18 g/57g Lotion Topical 15 g/100g Cream Topical 100 mg/1mL Liquid Topical Liquid Topical 110 mg/1mL Cream Topical 99 mg/1mL Stick Topical 200 mg/1g Stick Cutaneous 250 mg/1g Stick Topical 151 mg/1g Stick Topical 15.4 g/100g Stick Topical 170 mg/1g Stick Topical 154 mg/1g Stick Topical 159 mg/1g Liquid Topical 0.20 g/1mL Stick Topical 156 mg/1g Cream Topical 80 mg/1mL Cream Topical 17.8 g/100g Stick Topical 0.15 g/1g Stick Topical 15 g/100g Stick Topical 18 g/100g Kit Topical 18 g/100g Stick Topical 0.16 g/1g Stick Topical 17 g/100g Cream Topical 19 g/100g Stick Topical 25 g/100g Stick Topical 17.5 g/100g Stick Topical 13.49 g/71g Stick Topical 10.83 1/57g Stick Topical 1.2 g/75g Liquid Topical 0.2 g/1mL Stick Topical 14.062 g/79g Stick Topical 2.0944 g/11.9g Stick Topical 14 g/100g Stick Topical 16.4 g/100g Stick Topical 48 g/48g Stick Topical 10.318 g/73.7g Stick Topical 7.14 g/51g Gel Topical 13.94 1/85g Stick Topical 14.00 g/73g Gel Topical 18.5 g/113g Stick Topical 4.902 g/57g Stick Topical 17.3 g/100g Kit Dental; Topical Stick Topical 22 g/100g Stick Topical 12.8 g/64g Gel Topical 15 g/100g Cream Topical 20 g/100g Stick Topical .028 g/1g Gel Topical 0.16 g/1g Stick Topical 13.87 g/73g Kit Topical Gel Topical 17 g/100g Gel Topical 16 g/100g Stick Topical 0.19 g/1g Stick Topical 0.192 g/1g Stick Topical 0.18 g/1g Stick Topical 10.83 g/57g Stick Topical 19 g/57g Cream Topical 18.6 g/100g Stick Topical 18.6 g/100mL Stick Topical 13. g/73g Stick Topical 13 g/65g Stick Topical 85 g/85g Stick Topical 164 mg/1g Stick Topical 153 mg/1g Stick Topical 161 mg/1g Stick Topical 172 mg/1g Stick Topical 158 mg/1g Stick Topical 100 mg/1g Stick Topical 160 mg/1g Stick Topical 14.4 g/75g Stick Topical 18.2 g/100g Stick Topical 19 g/100g Stick Topical 16 g/100g Stick Topical 152 mg/1g Stick Topical 0.17 g/1g Stick Topical 18.4 g/100g Gel Topical 19 g/100g Liquid Topical 21 g/100mL Solution Topical 20 g/100g Stick Cutaneous 17.8 1/1 Stick Cutaneous 16.0 1/1 Stick Topical 0.20 g/1g Cream Topical 0.20 g/1g Stick Topical 180 mg/1g - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 11.9 mg/mL ALOGPS logP 0.36 ALOGPS logP -3.4 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) 2.31 Chemaxon pKa (Strongest Basic) 9.24 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 66.15 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 26.84 m3·mol-1 Chemaxon Polarizability 6.25 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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1. Sweat ducts
Yes
Antagonist
References
Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54