Identification
- Summary
Panthenol is an ingredient used in skin, hair care, and nutritional products but is not an approved medication.
- Generic Name
- Panthenol
- DrugBank Accession Number
- DB11204
- Background
Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Panthenol exists as a racemic mixture containing both the dextrorotatory form (dexpanthenol) and the levorotatory form (levopanthenol). While pantothenic acid is optically active, only the dextrorotatory form (Dexpanthenol) is biologically active.
Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 1.
Due to its good penetration and high local concentrations, dexpanthanol is used in many topical products, such as ointments and lotions for treatment of dermatological conditions to relieve itching or promote healing. Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 2.
- Type
- Small Molecule
- Groups
- Approved
- Structure
Structure for Panthenol (DB11204)
- Weight
- Average: 205.254
Monoisotopic: 205.131408096 - Chemical Formula
- C9H19NO4
- Synonyms
- DL-panthenol
- DL-Pantothenol
- Pantenol
- Panthenol
- Panthenolum
Pharmacology
- Indication
Panthenol (containing a racemic mixture of dexpanthenol and levopanthenol) is not currently available in any FDA-approved products and therefore does not have an indication.
Please see Dexpanthenol for FDA-approved uses of the dextrorotatory form of Panthenol.
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Management of Dry skin ••• ••• Prophylaxis of Paralytic ileus •••••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Pantothenic acid is a precursor of coenzyme A, which serves as a cofactor for a variety of enzyme-catalyzed reactions involving transfer of acetyl groups. The final step in the synthesis of acetylcholine consists of the choline acetylase transfer of acetyl group from acetylcoenzyme A to choline. Acetylcholine is the neurohumoral transmitter in the parasympathetic system and as such maintains the normal functions of the intestine. Decrease in acetylcholine content would result in decreased peristalsis and in extreme cases adynamic ileus.
- Mechanism of action
Panthenol is an alcohol derivative of pantothenic acid, a component of the B complex vitamins and an essential component of a normally functioning epithelium. Dexpanthenol, the active form of panthenol, is enzymatically cleaved to form pantothenic acid (Vitamin B5), which is an essential component of Coenzyme A that acts as a cofactor in many enzymatic reactions that are important for protein metabolism in the epithelium 1.
Dermatological effects of the topical use of dexpanthenol include increased fibroblast proliferation and accelerated re-epithelialization in wound healing. Furthermore, it acts as a topical protectant, moisturizer, and has demonstrated anti-inflammatory properties 2.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
Hover over products below to view reaction partners
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image AAPE Hair Ampoule Liquid 0.03 g/6mL Topical Prostemics Co., Ltd. 2019-08-01 Not applicable US 
AAPE Hair Ampoule Liquid 0.5 g/100mL Topical Prostemics Co., Ltd. 2021-05-01 Not applicable US Ahc Hydra B5 Soother Liquid 0.5 g/50mL Topical Carver Korea Co.,Ltd. 2017-05-12 2018-12-01 US Ahc Hydra B5 Soother (red) Liquid 0.5 g/50mL Topical Carver Korea Co.,Ltd. 2017-05-12 2018-12-01 US Ahc Premium Hydra Soother Cellulose Mask Patch 0.081 g/27mL Topical Carver Korea Co.,Ltd. 2017-05-18 2018-12-01 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Alopecia Reliefshampoo Panthenol (0.2 g/100mL) + Menthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL) Shampoo Topical DERMA CENTRIC INC 2020-08-08 Not applicable US 574H Cell Care Panthenol (1.5 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Pyrithione zinc (3.0 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US Add More Hair Panthenol (0.5 g/100mL) + Pyrithione zinc (0.29 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2017-03-01 2018-09-04 US Add More Hair Panthenol (0.5 g/100mL) + Pyrithione zinc (0.28 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US Adeks - Dps Panthenol (3 mg / mL) + Ascorbic acid (45 mg / mL) + Beta carotene (1 mg / mL) + Biotin (15 mcg / mL) + Cyanocobalamin (4 mcg / mL) + Nicotinamide (6 mg / mL) + Phylloquinone (0.1 mg / mL) + Pyridoxine hydrochloride (0.6 mg / mL) + Riboflavin (0.6 mg / mL) + Thiamine (0.5 mg / mL) + Vitamin A palmitate (1500 unit / mL) + Vitamin D (400 unit / mL) + Vitamin E (40 unit / mL) + Zinc sulfate (5 mg / mL) Solution / drops Oral Axcan Pharma 1995-12-31 2007-10-01 Canada 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 24 Alopecia Reliefshampoo Panthenol (0.2 g/100mL) + Menthol (0.3 g/100mL) + Salicylic acid (0.25 g/100mL) Shampoo Topical DERMA CENTRIC INC 2020-08-08 Not applicable US 574H Cell Care Panthenol (1.5 g/300mL) + Biotin (0.18 g/300mL) + Nicotinamide (0.9 g/300mL) + Pyrithione zinc (3.0 g/300mL) Shampoo Topical Celino Inc. 2020-06-01 Not applicable US AAPE Hair Ampoule Panthenol (0.03 g/6mL) Liquid Topical Prostemics Co., Ltd. 2019-08-01 Not applicable US AAPE Hair Ampoule Panthenol (0.5 g/100mL) Liquid Topical Prostemics Co., Ltd. 2021-05-01 Not applicable US Add More Hair Panthenol (0.5 g/100mL) + Pyrithione zinc (0.28 g/100mL) + Salicylic acid (0.2 g/100mL) Shampoo Topical Coretree Co.,Ltd 2018-06-09 2018-09-05 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- WV9CM0O67Z
- CAS number
- 16485-10-2
- InChI Key
- SNPLKNRPJHDVJA-UHFFFAOYSA-N
- InChI
- InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)
- IUPAC Name
- 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
- SMILES
- CC(C)(CO)C(O)C(=O)NCCCO
References
- General References
- Proksch E, de Bony R, Trapp S, Boudon S: Topical use of dexpanthenol: a 70th anniversary article. J Dermatolog Treat. 2017 Dec;28(8):766-773. doi: 10.1080/09546634.2017.1325310. Epub 2017 May 14. [Article]
- Biro K, Thaci D, Ochsendorf FR, Kaufmann R, Boehncke WH: Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study. Contact Dermatitis. 2003 Aug;49(2):80-4. [Article]
- External Links
- Human Metabolome Database
- HMDB0004231
- KEGG Drug
- D03726
- ChemSpider
- 4516
- 1044977
- ChEBI
- 27373
- ChEMBL
- CHEMBL1371937
- Wikipedia
- Panthenol
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 3 Completed Treatment Allergic Disorder of Respiratory System / Cold / Flu caused by Influenza 1 3 Completed Treatment Diabetic Foot Ulcers (DFUs) 1 3 Terminated Treatment Diabetic Foot Ulcers (DFUs) 1 Not Available Not Yet Recruiting Treatment Solar Elastosis 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Liquid Topical 0.03 g/6mL Solution / drops Oral Liquid Topical 0.5 g/50mL Patch Topical 0.081 g/27mL Gel Topical Cream Topical Cream Topical 0.04875 g/50mL Lotion Topical 1.5 g/200mL Lotion Topical 1.8 mL/200mL Liquid Topical 0.75 mL/200mL Gel Topical 1.5 mL/100mL Cream Topical 0.4875 mL/50mL Cream Topical 1.5 mL/200mL Liquid Topical 0.075 mL/10mL Spray Topical 0.5 g/50mL Liquid Topical 0.45 g/30mL Lotion Topical 0.09 g/12mL Elixir Topical Liquid Topical 0.003 g/5mL Lotion Topical 0.375 g/50mL Liquid Topical 0.375 1/50mL Injection, solution Intramuscular; Intravenous Liquid Topical 0.002 mg/1mL Shampoo Topical Liquid Topical 0.19 g/100mL Lotion Topical Liquid Transdermal Liquid Topical Gel Topical 0.01 mL/100mL Liquid Topical 0.018 mL/2mL Cream Topical 0.47 g/479.39g Powder Topical Liquid Topical 3.75 g/750mL Shampoo Topical 0.02 mL/1mL Liquid Topical 0.002 mL/1mL Cream Vaginal Liquid Intravenous Kit Topical Spray Topical Solution Intravenous Syrup Oral Solution Topical 1 g/100mL Liquid Topical 0.50 g/50mL Powder Patch Topical Solution Topical Cream Topical 0.45 mL/50mL Cream Topical 1.8 mL/200mL Liquid Topical 0.3 g/30mL Lotion Topical 15 mg/1mL Liquid Topical 0.501 g/100mL Shampoo Topical 1.2 mg/240mL Liquid Topical 0.5 mg/100mL Shampoo Topical 0.002 mL/1mL Shampoo Topical 0.95 g/958.50g Gel Topical 0.95 g/958.50g Emulsion Topical Liquid Topical 0.5 g/100mL - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 121.0 mg/mL ALOGPS logP -1 ALOGPS logP -1.7 Chemaxon logS -0.23 ALOGPS pKa (Strongest Acidic) 12.69 Chemaxon pKa (Strongest Basic) -2.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 89.79 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 51.88 m3·mol-1 Chemaxon Polarizability 22.15 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4i-3690000000-f795a326de750e1ce69d Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS splash10-0udi-8790000000-6ed7330b7a5f4cd7ffbb Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS splash10-00dl-9100000000-d350b93723479d042415 Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS splash10-00di-9500000000-ef0609f53481a1cdbfdd Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS splash10-00di-9000000000-1c3304c420d96001b861 Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS splash10-0a4l-9000000000-9d3b189b80a6c90c2950 Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 149.9031028 predictedDarkChem Lite v0.1.0 [M-H]- 139.6721242 predictedDarkChem Standard v0.1.0 [M-H]- 142.32503 predictedDeepCCS 1.0 (2019) [M+H]+ 151.0761028 predictedDarkChem Lite v0.1.0 [M+H]+ 143.4010298 predictedDarkChem Standard v0.1.0 [M+H]+ 144.76866 predictedDeepCCS 1.0 (2019) [M+Na]+ 150.2621028 predictedDarkChem Lite v0.1.0 [M+Na]+ 150.2063028 predictedDarkChem Lite v0.1.0 [M+Na]+ 152.5525 predictedDeepCCS 1.0 (2019)
Drug created at December 03, 2015 16:51 / Updated at September 28, 2021 21:54