This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Poloxamer 407
- DrugBank Accession Number
- DB11252
- Background
Poloxamer 407 is a polyoxyethylene polymer and hydrophilic non-ionic surfactant. It consists of a central hydrophobic block of polypropylene glycol that is flanked on each side by polyethylene glycol blocks, both hydrophilic in nature. Poloxamer 407 is used as an emulsifying agent and solubilizing agent in cosmetic and personal products such as contact lens cleaning solutions.
- Type
- Small Molecule
- Groups
- Investigational
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Dream Eye Liquid 0.1 mL/1mL Ophthalmic K&J.C Co., Ltd 2010-10-13 Not applicable US 
Dream Eye Liquid 0.1 mL/1mL Ophthalmic K&J.C Co., Ltd 2010-06-17 Not applicable US K-MOM Baby Tooth Paste, dentifrice 2 g/100g Dental MOTHER-K CO.,LTD 2019-10-01 Not applicable US Natural Care Liquid 0.1 mL/1mL Ophthalmic K&J.C Co., Ltd 2010-10-05 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image อลิซ คอมฟอร์ท มัลติ-เพอพัส โซลูชั่น Poloxamer 407 (0.05 g/100ml) + Boric acid (0.175 g/100ml) + Edetate disodium (0.1 g/100ml) + Hypromellose (0.15 g/100ml) + Polyaminopropyl biguanide (0.00015 g/100ml) + Sodium borate (0.079 g/100ml) + Sodium chloride (0.83 g/100ml) Solution Ophthalmic บริษัท อลิซไลฟ์ จำกัด จำกัด 2017-02-02 2020-09-29 Thailand 
- Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Dream Eye Poloxamer 407 (0.1 mL/1mL) Liquid Ophthalmic K&J.C Co., Ltd 2010-10-13 Not applicable US Dream Eye Poloxamer 407 (0.1 mL/1mL) Liquid Ophthalmic K&J.C Co., Ltd 2010-06-17 Not applicable US K-MOM Baby Tooth Poloxamer 407 (2 g/100g) Paste, dentifrice Dental MOTHER-K CO.,LTD 2019-10-01 Not applicable US Natural Care Poloxamer 407 (0.1 mL/1mL) Liquid Ophthalmic K&J.C Co., Ltd 2010-10-05 Not applicable US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- TUF2IVW3M2
- CAS number
- 691397-13-4
References
- General References
- Not Available
- External Links
- PubChem Substance
- 347911166
- 155155
- Wikipedia
- Poloxamer_407
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count 2 Completed Supportive Care Oral Mucositis 1 2 Terminated Treatment Persistent Corneal Epithelial Defects 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Paste, dentifrice Dental 2 g/100g Liquid Ophthalmic 0.1 mL/1mL Solution Ophthalmic - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at June 12, 2020 16:53