Chromium picolinate

Identification

Generic Name

Chromium picolinate

DrugBank Accession Number

DB11255

Background

Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are shown to regulate insulin by promoting glucose utilization and increasing the sensitivity of the insulin receptor ¹.

Type

Small Molecule

Groups

Approved

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Chromium picolinate (DB11255)

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Weight

Average: 418.3005
Monoisotopic: 418.013122035

Chemical Formula

C₁₈H₁₂CrN₃O₆

Synonyms

• Chromium(III) picolinate

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Pharmacology

Indication

Not Available

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Associated Therapies

• Nutritional supplementation

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">

Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">

This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drug	Interaction
Integrate drug-drug interactions in your software
Betibeglogene autotemcel	The risk or severity of adverse effects can be increased when Chromium picolinate is combined with Betibeglogene autotemcel.
Exagamglogene autotemcel	The risk or severity of myelosuppression can be increased when Exagamglogene autotemcel is combined with Chromium picolinate.

Food Interactions

• Administer vitamin supplements. Foods or supplements containing niacin (Vitamin B3) may improve the absorption of chromium.
• Take with foods containing vitamin C. Foods rich in vitamin C increase the absorption of chromium.

Products

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Active Moieties

Name	Kind	UNII	CAS	InChI Key
Chromium	unknown	0R0008Q3JB	7440-47-3	VYZAMTAEIAYCRO-UHFFFAOYSA-N
Chromic cation	ionic	X1N4508KF1	16065-83-1	BFGKITSFLPAWGI-UHFFFAOYSA-N

Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
MENOPACE KAPSUL, 30 ADET	Chromium picolinate (50 mcg) + Aminobenzoic acid (30 mg) + Ascorbic acid (45 mg) + Biotin (30 mcg) + Boron (2 mg) + Copper (1 mg) + Cyanocobalamin (9 mcg) + Folic acid (400 mcg) + Iodine (225 mcg) + Iron (12 mg) + Magnesium (100 mg) + Manganese (2 mg) + Niacin (20 mg) + Pantothenic acid (30 mg) + Pyridoxine (40 mg) + Riboflavin (5 mg) + Selenium (100 mcg) + Thiamine (10 mg) + Vitamin A (750 mcg) + Vitamin D (2.5 mcg) + Vitamin E (30 mg) + Zinc (15 mg)	Capsule	Oral	NOBEL İLAÇ SAN. VE TİC. A.Ş.	1999-07-22	2020-05-28

Unapproved/Other Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
Divista	Chromium picolinate (1000 ug/1) + Biotin (2 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Omega-3-acid ethyl esters (300 mg/1) + Pyridoxine (25 mg/1)	Capsule	Oral	Us Pharmaceutical Corporation	2010-07-10	2011-09-30
Medi-10	Chromium picolinate (1 mg/1) + Acetylcysteine (200 mg/1) + Cholecalciferol (1000 [iU]/1) + Levomefolate calcium (2.5 mg/1) + Lipoic acid (200 mg/1) + Mecobalamin (2.5 mg/1) + Nicotinamide (10 mg/1) + Pyridoxal phosphate (20 mg/1) + Resveratrol (83 mg/1) + Ubidecarenone (16 mg/1)	Capsule	Oral	Medicap Laboratories Inc.	2015-05-01	2016-01-12
RE FAC-x	Chromium picolinate (200 ug/1) + Ascorbic acid (200 mg/1) + Biotin (200 ug/1) + Cholecalciferol (400 [iU]/1) + Cupric sulfate pentahydrate (2.5 mg/1) + Cyanocobalamin (2500 ug/1) + Folic acid (2800 ug/1) + Lutein (500 ug/1) + Lycopene (500 ug/1) + Magnesium (100 mg/1) + Manganese sulfate (2.5 mg/1) + Nicotinamide (100 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (20 mg/1) + Selenomethionine (100 ug/1) + Thiamine mononitrate (20 mg/1) + Vitamin A (5000 [iU]/1) + Vitamin E (100 [iU]/1) + Zinc (15 mg/1)	Tablet	Oral	River’s Edge Pharmaceuticals, LLC	2007-07-01	2011-01-13
Vita-Rx Diabetic Vitamin	Chromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic acid (0.8 mg/1) + Lipoic acid (150 mg/1) + Mecobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)	Capsule, gelatin coated	Oral	Mas Management Group Inc.	2015-08-11	Not applicable
Vita-Rx Diabetic Vitamin	Chromium picolinate (0.465 mg/1) + Ascorbic acid (120 mg/1) + Biotin (2.5 mg/1) + Cholecalciferol (0.0625 mg/1) + Folic acid (0.8 mg/1) + Lipoic acid (150 mg/1) + Mecobalamin (0.0025 mg/1) + Niacin (20 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxal phosphate (12.5 mg/1) + Riboflavin (1.7 mg/1) + Thiamine mononitrate (1.5 mg/1) + Ubidecarenone (50 mg/1) + alpha-Tocopherol acetate (10 mg/1)	Capsule, gelatin coated	Oral	Pure Source, Llc	2015-08-11	Not applicable

Categories

Drug Categories

• Compounds used in a research, industrial, or household setting
• Iron Chelating Agents
• Pyridines
• Sequestering Agents
• Standardized Chemical Allergen

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Pyridines and derivatives

Sub Class

Pyridinecarboxylic acids and derivatives

Direct Parent

Pyridinecarboxylic acids

Alternative Parents

Heteroaromatic compounds / Carboxylic acid salts / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic zwitterions / Organic oxides / Organic chromium salts / Hydrocarbon derivatives

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Substituents

Aromatic heteromonocyclic compound / Azacycle / Carboxylic acid / Carboxylic acid derivative / Carboxylic acid salt / Heteroaromatic compound / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic chromium salt / Organic nitrogen compound / Organic oxide / Organic oxygen compound / Organic salt / Organic transition metal salt / Organic zwitterion / Organonitrogen compound / Organooxygen compound / Organopnictogen compound / Pyridine carboxylic acid

show 9 more

Molecular Framework

Not Available

External Descriptors

chromium coordination entity (CHEBI:50369)

Affected organisms

Not Available

Chemical Identifiers

UNII

S71T8B8Z6P

CAS number

14639-25-9

InChI Key

CBDQOLKNTOMMTL-UHFFFAOYSA-K

InChI

InChI=1S/3C6H5NO2.Cr/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

IUPAC Name

chromium(3+) tris(pyridine-2-carboxylate)

SMILES

[Cr+3].[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C1=NC=CC=C1

References

General References

1. Broadhurst CL, Domenico P: Clinical studies on chromium picolinate supplementation in diabetes mellitus--a review. Diabetes Technol Ther. 2006 Dec;8(6):677-87. [Article]

External Links

PubChem Compound

625469

PubChem Substance

347827953

ChemSpider

133913

RxNav

59308

ChEBI

50369

Wikipedia

Chromium(III)_picolinate

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Completed	Treatment	Type 2 Diabetes Mellitus	1
1	Terminated	Treatment	Type 2 Diabetes Mellitus	1
Not Available	Completed	Prevention	Atypical Depression / Obesity	1
Not Available	Completed	Treatment	Impaired Glucose Tolerance / Metabolic Diseases / Obesity / Resistance, Insulin / Syndrome, Metabolic	1
Not Available	Completed	Treatment	Type 2 Diabetes Mellitus	2

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, coated	Oral
Capsule	Oral
Tablet	Oral
Tablet, film coated	Oral
Capsule, gelatin coated	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0312 mg/mL	ALOGPS
logP	2.9	ALOGPS
logP	-0.65	Chemaxon
logS	-4.1	ALOGPS
pKa (Strongest Acidic)	1	Chemaxon
pKa (Strongest Basic)	5.52	Chemaxon
Physiological Charge	-1	Chemaxon
Hydrogen Acceptor Count	3	Chemaxon
Hydrogen Donor Count	0	Chemaxon
Polar Surface Area	53.02 Å2	Chemaxon
Rotatable Bond Count	3	Chemaxon
Refractivity	41.62 m3·mol-1	Chemaxon
Polarizability	10.94 Å3	Chemaxon
Number of Rings	3	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å2)	Source type	Source
[M-H]-	120.8559436	predicted	DarkChem Lite v0.1.0
[M+H]+	121.3658436	predicted	DarkChem Lite v0.1.0
[M+Na]+	121.1226436	predicted	DarkChem Lite v0.1.0

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Drug created at December 03, 2015 16:51 / Updated at September 28, 2023 05:40