This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Brilliant green is an ingredient used in topical medications to prevent infections of the umbilical cord.
- Generic Name
- Brilliant green cation
Commonly known or available as Brilliant green - DrugBank Accession Number
- DB11279
- Background
Brilliant green, or ethanaminium, is a derivative of triarylmethane dye that has been used as a dye to color silk and wool. Due to its inhibitory actions against Gram positive microorganisms, brilliant green can be found in antiseptic products such as solutions and swabs used to prevent infection.
- Type
- Small Molecule
- Groups
- Approved, Vet approved
- Structure
Structure for Brilliant green cation (DB11279)
- Weight
- Average: 385.574
Monoisotopic: 385.263825491 - Chemical Formula
- C27H33N2
- Synonyms
- Brilliant green ion
- Brilliant green, free form
- Brilliant green(1+)
- External IDs
- NSC-5011
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Used in combination to treat Hansen's disease Combination Product in combination with: Ethanol (DB00898), Gentian violet cation (DB00406) •••••••••••• •••••••• Used in combination to prevent Infection of the umbilical cord area Combination Product in combination with: Acriflavine (DB13373), Gentian violet cation (DB00406) ••• ••• •••••••• Used in combination to prevent Infection of the umbilical cord area Combination Product in combination with: Proflavine (DB01123), Gentian violet cation (DB00406) ••• ••• ••••••••• •••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Brilliant green G0L543D370 633-03-4 NNBFNNNWANBMTI-UHFFFAOYSA-M - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image Kerr 100 Triple Dye Dispos-A Brilliant green (2.29 mg/1mL) + Gentian violet (2.2 mg/1mL) + Proflavine hemisulfate (1.14 mg/1mL) Swab Topical VistaPharm, LLC 2004-05-01 Not applicable US 
Perineze Triple Dye Brilliant green (2.29 mg/0.61mL) + Gentian violet (2.29 mg/0.61mL) + Proflavine hemisulfate (1.14 mg/0.61mL) Solution Topical Peace Medical Inc. 2011-09-28 Not applicable US Triple Dye Brilliant green (2.29 mg / mL) + Gentian violet (2.29 mg / mL) + Proflavine hemisulfate (1.14 mg / mL) Liquid Topical Frank W. Kerr Chemical Company 1983-12-31 2004-10-27 Canada 
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- S85JD8CLBH
- CAS number
- 18198-35-1
- InChI Key
- HXCILVUBKWANLN-UHFFFAOYSA-N
- InChI
- InChI=1S/C27H33N2/c1-5-28(6-2)25-18-14-23(15-19-25)27(22-12-10-9-11-13-22)24-16-20-26(21-17-24)29(7-3)8-4/h9-21H,5-8H2,1-4H3/q+1
- IUPAC Name
- 4-{[4-(diethylamino)phenyl](phenyl)methylidene}-N,N-diethylcyclohexa-2,5-dien-1-iminium
- SMILES
- CCN(CC)C1=CC=C(C=C1)C(C1=CC=CC=C1)=C1C=CC(C=C1)=[N+](CC)CC
References
- General References
- Not Available
- External Links
- PubChem Compound
- 12449
- PubChem Substance
- 347827961
- ChemSpider
- 11942
- BindingDB
- 81263
- 1546367
- ChEBI
- 88176
- ChEMBL
- CHEMBL1589793
- ZINC
- ZINC000004235575
- Wikipedia
- Brilliant_Green
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Swab Topical Solution Topical Liquid Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0003 mg/mL ALOGPS logP 2.47 ALOGPS logP 2.71 Chemaxon logS -6.2 ALOGPS pKa (Strongest Basic) 5.36 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.25 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 150.57 m3·mol-1 Chemaxon Polarizability 47.39 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted 1H NMR Spectrum 1D NMR Not Applicable Predicted 13C NMR Spectrum 1D NMR Not Applicable - Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 229.3384492 predictedDarkChem Lite v0.1.0 [M+H]+ 229.7536492 predictedDarkChem Lite v0.1.0 [M+Na]+ 228.7235492 predictedDarkChem Lite v0.1.0
Drug created at December 03, 2015 16:52 / Updated at June 12, 2020 16:53