NAV

(+)-menthol

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
(+)-menthol
DrugBank Accession Number
DB11344
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 156.269
Monoisotopic: 156.151415264
Chemical Formula
C10H20O
Synonyms
  • (+)-(1S,2R,5S)-menthol
  • (+)-(1S,3S,4R)-menthol
  • (1S,2R,5S)-(+)-menthol
  • (1S,2R,5S)-menthol
  • D-menthol
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Used in combination for symptomatic treatment ofJoint pain••• •••
Used in combination for symptomatic treatment ofMuscle pain••• •••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
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Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Active Moieties
NameKindUNIICASInChI Key
LevomentholunknownBZ1R15MTK72216-51-5NOOLISFMXDJSKH-KXUCPTDWSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Ay Bendito - Pain Relief(+)-menthol (4 g/100g) + Camphor (6 g/100g)CreamTopicalAY BENDITO INTERNATIONAL, INC2021-01-22Not applicableUS flag
Ay Bendito - Thermoactive(+)-menthol (4 g/100g) + Camphor (6 g/100g)CreamTopicalAY BENDITO INTERNATIONAL, INC2021-01-22Not applicableUS flag
Ay Bendito - Thermoactive(+)-menthol (4 g/100g) + Camphor (6 g/100g)GelTopicalAY BENDITO INTERNATIONAL, INC2021-01-22Not applicableUS flag
Balsang Pain Relief(+)-menthol (1.5 mg/100mL) + (S)-camphor (1.5 mg/100mL) + Methyl salicylate (5 mg/100mL)SolutionTopicalGenuine Drugs2015-04-20Not applicableUS flag
BlueStop Max(+)-menthol (10 mg/1g) + Lidocaine hydrochloride (40 mg/1g)CreamTopicalClavel Corporation2023-01-10Not applicableUS flag

Categories

Drug Categories
Not Available
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as menthane monoterpenoids. These are monoterpenoids with a structure based on the o-, m-, or p-menthane backbone. P-menthane consists of the cyclohexane ring with a methyl group and a (2-methyl)-propyl group at the 1 and 4 ring position, respectively. The o- and m- menthanes are much rarer, and presumably arise by alkyl migration of p-menthanes.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Prenol lipids
Sub Class
Monoterpenoids
Direct Parent
Menthane monoterpenoids
Alternative Parents
Monocyclic monoterpenoids / Cyclohexanols / Cyclic alcohols and derivatives / Hydrocarbon derivatives
Substituents
Alcohol / Aliphatic homomonocyclic compound / Cyclic alcohol / Cyclohexanol / Hydrocarbon derivative / Monocyclic monoterpenoid / Organic oxygen compound / Organooxygen compound / P-menthane monoterpenoid / Secondary alcohol
Molecular Framework
Aliphatic homomonocyclic compounds
External Descriptors
p-menthan-3-ol (CHEBI:76306)
Affected organisms
Not Available

Chemical Identifiers

UNII
C6B1OE8P3W
CAS number
15356-60-2
InChI Key
NOOLISFMXDJSKH-AEJSXWLSSA-N
InChI
InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m0/s1
IUPAC Name
(1S,2R,5S)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol
SMILES
CC(C)[C@H]1CC[C@H](C)C[C@@H]1O

References

General References
Not Available
ChemSpider
145189
RxNav
1648123
ChEBI
76306
ChEMBL
CHEMBL2106989
ZINC
ZINC000000967511

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GelTopical
SolutionTopical
CreamTopical
PatchTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.558 mg/mLALOGPS
logP2.68ALOGPS
logP2.66Chemaxon
logS-2.4ALOGPS
pKa (Strongest Acidic)19.55Chemaxon
pKa (Strongest Basic)-0.81Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area20.23 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity47.45 m3·mol-1Chemaxon
Polarizability19.68 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-9400000000-1725adcedf912eaa92fe
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-0900000000-b6377df362903ebb5f82
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0a4i-0900000000-47694ad7d401825e6e66
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0541-9200000000-1080fe48e386942d59a2
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-1900000000-d727078dd6b1afa92c3d
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0036-9000000000-7c3553f8ea4ed276a44e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-137.3093104
predicted
DarkChem Lite v0.1.0
[M-H]-137.0062104
predicted
DarkChem Lite v0.1.0
[M-H]-146.19456
predicted
DeepCCS 1.0 (2019)
[M+H]+137.7690104
predicted
DarkChem Lite v0.1.0
[M+H]+137.9335104
predicted
DarkChem Lite v0.1.0
[M+H]+148.64532
predicted
DeepCCS 1.0 (2019)
[M+Na]+137.5408104
predicted
DarkChem Lite v0.1.0
[M+Na]+157.02116
predicted
DeepCCS 1.0 (2019)

Drug created at December 03, 2015 16:52 / Updated at September 28, 2021 21:54