NAV

Nicarbazin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Nicarbazin
DrugBank Accession Number
DB11434
Background

Not Available

Type
Small Molecule
Groups
Vet approved
Structure
Similar Structures
Weight
Average: 426.389
Monoisotopic: 426.128782324
Chemical Formula
C19H18N6O6
Synonyms
  • Nicarbazin
External IDs
  • MK 75
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
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Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as n-phenylureas. These are compounds containing a N-phenylurea moiety, which is structurally characterized by a phenyl group linked to one nitrogen atom of a urea group.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
N-phenylureas
Direct Parent
N-phenylureas
Alternative Parents
Nitrobenzenes / Nitroaromatic compounds / Pyrimidones / Hydropyrimidines / Heteroaromatic compounds / Ureas / Propargyl-type 1,3-dipolar organic compounds / Organic oxoazanium compounds / Azacyclic compounds / Organopnictogen compounds
show 4 more
Substituents
Allyl-type 1,3-dipolar organic compound / Aromatic heteromonocyclic compound / Azacycle / C-nitro compound / Carbonic acid derivative / Carbonyl group / Heteroaromatic compound / Hydrocarbon derivative / Hydropyrimidine / N-phenylurea
show 16 more
Molecular Framework
Not Available
External Descriptors
organic molecular entity (CHEBI:81725)
Affected organisms
Not Available

Chemical Identifiers

UNII
11P9NUA12U
CAS number
330-95-0
InChI Key
UKHWDRMMMYWSFL-UHFFFAOYSA-N
InChI
InChI=1S/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)
IUPAC Name
1,3-bis(4-nitrophenyl)urea; 4,6-dimethylpyrimidin-2-ol
SMILES
CC1=CC(C)=NC(O)=N1.[O-][N+](=O)C1=CC=C(NC(=O)NC2=CC=C(C=C2)[N+]([O-])=O)C=C1

References

General References
  1. Froyman R, Hales GB: Nicarbazin toxicity in broilers. Vet Rec. 1984 Sep 8;115(10):254-5. [Article]
  2. Bafundo KW: Effect of nicarbazin and narasin-nicarbazin combinations on broiler pigmentation. Poult Sci. 1989 Mar;68(3):374-9. [Article]
  3. Kamikura M, Eguchi H: [Analysis of nicarbazin by voltammetry]. Eisei Shikenjo Hokoku. 1983;(101):142-3. [Article]
  4. Krabel BJ, Dickson DA, Zimmermann AG, Coleman MR: Liquid chromatographic determination of nicarbazin in feeds. J AOAC Int. 2000 Sep-Oct;83(5):1027-38. [Article]
  5. BROWN HD, CUCKLER AC, SIEGEL H: 4,4'-Bisacetamidocarbanilide, a metabolite of nicarbazin. Proc Soc Exp Biol Med. 1956 Nov;93(2):248-51. [Article]
  6. Hurlbut JA, Nightengale CT, Burkepile RG: Liquid chromatographic determination of nicarbazin in feed. J Assoc Off Anal Chem. 1985 May-Jun;68(3):596-8. [Article]
  7. Murayama M, Sakurai H, Tada Y, Uchiyama S, Saito Y: [Determination of nicarbazin in imported chicken]. Eisei Shikenjo Hokoku. 1992;(110):78-9. [Article]
  8. WEISS HS: Nicarbazin induced hypercholesterolemia in the hen. Proc Soc Exp Biol Med. 1960 Jan;103:49-53. [Article]
  9. Yoder CA, Graham JK, Miller LA: Molecular effects of nicarbazin on avian reproduction. Poult Sci. 2006 Jul;85(7):1285-93. [Article]
  10. Kamikura M, Eguchi H: [Analysis of nicarbazin residue in chicken tissue (II). Colorimetric analysis of nicarbazin]. Eisei Shikenjo Hokoku. 1983;(101):143-7. [Article]
KEGG Compound
C18389
ChemSpider
9135
RxNav
1311583
ChEBI
81725
ChEMBL
CHEMBL95855
Wikipedia
Nicarbazin

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
GranuleOral
PowderOral
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0117 mg/mLALOGPS
logP2.48ALOGPS
logP3Chemaxon
logS-4.4ALOGPS
pKa (Strongest Acidic)10.77Chemaxon
pKa (Strongest Basic)-5.1Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area127.41 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity78.69 m3·mol-1Chemaxon
Polarizability26.75 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-170.7859377
predicted
DarkChem Lite v0.1.0
[M-H]-192.03731
predicted
DeepCCS 1.0 (2019)
[M+H]+186.9685566
predicted
DarkChem Lite v0.1.0
[M+H]+194.43286
predicted
DeepCCS 1.0 (2019)
[M+Na]+197.6065668
predicted
DarkChem Lite v0.1.0
[M+Na]+200.3454
predicted
DeepCCS 1.0 (2019)

Drug created at February 25, 2016 18:45 / Updated at November 25, 2020 17:34