Artenimol

Identification

Generic Name

Artenimol

DrugBank Accession Number

DB11638

Background

Artenimol is an artemisinin derivative and antimalarial agent used in the treatment of uncomplicated Plasmodium falciparum infections ^Label. It was first authorized for market by the European Medicines Agency in October 2011 in combination with Piperaquine as the product Eurartesim. Artemisinin combination therapy is highly effective against malaria and stongly recommended by the World Health Organization ¹².

Type

Small Molecule

Groups

Approved, Experimental, Investigational

Structure

Similar Structures

Weight: Average: 284.352
Monoisotopic: 284.162373873
Chemical Formula: C₁₅H₂₄O₅

Synonyms

Artenimol
beta-Dihydroartemisinin
Dihydroartemisinin

External IDs

GNF-PF-5634

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Pharmacology

Indication

For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg ^Label. Used in combination with Piperaquine.

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Used in combination to treat	Malaria caused by plasmodium falciparum	Combination Product in combination with: Piperaquine (DB13941)	••••••••••••			••••••

Contraindications & Blackbox Warnings

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Pharmacodynamics

Artenimol is thought to form a reactive carbon radical intermediate which kills P. falciparum through alkylation of a wide array of proteins.

Mechanism of action

Artemisinins, including Artenimol which is a major active metabolite of many artemisinins, are thought to act via a common mechanism ⁴. While the exact mechanism of action is not certain, theories exist as to how artemisinins produce their antimalarial effect.

Artemisinins are believed to bind to haem within the P. falciparum parasite ^1,3. The source of this haem varies with the life stage of the parasite. When the parasite is in the early ring stage artemisinins are believed to bind haem produced by the parasite's haem biosynthesis pathway. In later stages artemisinins likely bind to haem released by haemoglobin digestion. Once bound to haem, artemisinins are thought to undergo activation involving ferrous iron via reductive scission which splits the endoperoxide bridge to produce a reactive oxygen ^2,9. This reactive oxygen is thought to undergo a subsequent intramolecular hydrogen abstraction to produce a reactive carbon radical ⁹. The carbon radical is believed to be the source of the drugs potent activity against P. falciparum by alkylating a wide array of protein targets ^5,1,9. The nature and magnitude of the effect on specific protein function as a result of this alkylation is unknown.

One target which has been the focus of research is the sarco/endoplasmic reticulum Ca2+ ATPase pump of P. falciparum ⁷. Artemisinins have been found to irreversably bind to and inhibit this protein at a binding site similar to that of Thapsigargin. The mechanism is likely the same as for other proteins, namely alkylation via the carbon radical intermediate.

Artemisinins appear to preferentially collect in infected erythrocytes, concentrating the drug by several hundred-fold compared to uninfected cells ¹⁰. This may play a role in why little alkylation is seen in uninfected erythrocytes ⁸.

Target	Actions	Organism
UActin, cytoplasmic 2	ligand	Humans
UAlpha-aminoadipic semialdehyde dehydrogenase	ligand	Humans
UAnnexin A2	ligand	Humans
UATP synthase subunit alpha, mitochondrial	ligand	Humans
UATP synthase subunit g, mitochondrial	ligand	Humans
UATP synthase subunit O, mitochondrial	ligand	Humans
UCalpastatin	ligand	Humans
UT-complex protein 1 subunit gamma	ligand	Humans
UCofilin-1	ligand	Humans
UChloride intracellular channel protein 1	ligand	Humans
UCysteine and glycine-rich protein 1	ligand	Humans
UDihydropyrimidinase-related protein 2	ligand	Humans
UDesmoplakin	ligand	Humans
UElongation factor 1-alpha 1	ligand	Humans
UAlpha-enolase	ligand	Humans
UFilamin-A	ligand	Humans
UAlpha-ketoglutarate-dependent dioxygenase FTO	ligand	Humans
UGlucose-6-phosphate 1-dehydrogenase	ligand	Humans
UGlyceraldehyde-3-phosphate dehydrogenase, testis-specific	ligand	Humans
UGlucose-6-phosphate isomerase	ligand	Humans
UHeterogeneous nuclear ribonucleoproteins A2/B1	ligand	Humans
UHeterogeneous nuclear ribonucleoprotein D0	ligand	Humans
UHeterogeneous nuclear ribonucleoprotein K	ligand	Humans
UHeterochromatin protein 1-binding protein 3	ligand	Humans
UHeat shock protein beta-1	ligand	Humans
URas GTPase-activating-like protein IQGAP1	ligand	Humans
UFar upstream element-binding protein 2	ligand	Humans
UL-lactate dehydrogenase A chain	ligand	Humans
UL-lactate dehydrogenase B chain	ligand	Humans
UGalectin-1	ligand	Humans
UMicrotubule-associated protein 4	ligand	Humans
UMalate dehydrogenase, cytoplasmic	ligand	Humans
UPuromycin-sensitive aminopeptidase	ligand	Humans
UProfilin-1	ligand	Humans
UPhosphoglycerate kinase 1	ligand	Humans
UPyruvate kinase PKM	ligand	Humans
UPeptidyl-prolyl cis-trans isomerase A	ligand	Humans
UPeroxiredoxin-1	ligand	Humans
U60S ribosomal protein L10	ligand	Humans
U60S ribosomal protein L14	ligand	Humans
U60S ribosomal protein L18	ligand	Humans
U60S ribosomal protein L23a	ligand	Humans
U60S ribosomal protein L35	ligand	Humans
U60S ribosomal protein L4	ligand	Humans
U40S ribosomal protein S13	ligand	Humans
U40S ribosomal protein S17	ligand	Humans
U40S ribosomal protein S18	ligand	Humans
U40S ribosomal protein S19	ligand	Humans
U40S ribosomal protein S28	ligand	Humans
U40S ribosomal protein S5	ligand	Humans
U40S ribosomal protein S6	ligand	Humans
U40S ribosomal protein S8	ligand	Humans
U40S ribosomal protein S9	ligand	Humans
USplicing factor 1	ligand	Humans
USplicing factor, proline- and glutamine-rich	ligand	Humans
USmall nuclear ribonucleoprotein Sm D2	ligand	Humans
USignal recognition particle 14 kDa protein	ligand	Humans
USerine/arginine-rich splicing factor 4	ligand	Humans
UTransgelin	ligand	Humans
UTransgelin-2	ligand	Humans
UTriosephosphate isomerase	ligand	Humans
UTropomyosin alpha-1 chain	ligand	Humans
UTubulin alpha-1A chain	ligand	Humans
UVimentin	ligand	Humans
UZyxin	ligand	Humans
UHeat shock cognate 71 kDa protein	ligand	Humans
UTubulin beta-6 chain	ligand	Humans
UTubulin beta-4A chain	ligand	Humans
UTubulin beta chain	ligand	Humans
UFructose-bisphosphate aldolase A	ligand	Humans
UGlyceraldehyde-3-phosphate dehydrogenase	ligand	Humans
UCytochrome c	ligand	Humans
UPhosphoglycerate mutase 1	ligand	Humans
UMyosin-9	ligand	Humans
UProtein disulfide-isomerase	ligand	Humans
UProbable ATP-dependent RNA helicase DDX5	ligand	Humans
USerine hydroxymethyltransferase, mitochondrial	ligand	Humans
USpliceosome RNA helicase DDX39B	ligand	Humans
UNucleophosmin	ligand	Humans
UTranslationally-controlled tumor protein homolog	ligand	Plasmodium falciparum (isolate 3D7)
UP-type Ca2+-transporting ATPase	antagonist	Plasmodium falciparum
UOrnithine aminotransferase	ligand	Plasmodium falciparum (isolate 3D7)
UElongation factor 1-alpha	ligand	Plasmodium falciparum (isolate K1 / Thailand)
UMultidrug resistance protein	ligand	Plasmodium falciparum (isolate FC27 / Papua New Guinea)
UElongation factor 2	ligand	Plasmodium falciparum (isolate 3D7)
UActin-1	ligand	Plasmodium falciparum (isolate HB3)
UGlyceraldehyde-3-phosphate dehydrogenase	ligand	Plasmodium falciparum (isolate 3D7)
UFructose-bisphosphate aldolase	ligand	Plasmodium falciparum
UCell division cycle protein 48 homologue,putative	ligand	Plasmodium falciparum (isolate 3D7)
UHeat shock protein 90	ligand	Plasmodium falciparum (isolate 3D7)
UEukaryotic initiation factor 4A	ligand	Plasmodium falciparum (isolate 3D7)
UPyruvate kinase	ligand	Plasmodium falciparum (isolate 3D7)
UL-lactate dehydrogenase	ligand	Plasmodium falciparum (isolate CDC / Honduras)
UProtein disulfide-isomerase	ligand	Plasmodium falciparum (isolate 3D7)
UThioredoxin-related protein, putative	ligand	Plasmodium falciparum (isolate 3D7)
USpermidine synthase	ligand	Plasmodium falciparum (isolate 3D7)
UProbable ATP-dependent 6-phosphofructokinase	ligand	Plasmodium falciparum (isolate 3D7)
UGlutamate dehydrogenase	ligand	Plasmodium falciparum (isolate 3D7)
UEndoplasmin homolog, putative	ligand	Plasmodium falciparum (isolate 3D7)
UHypoxanthine-guanine-xanthine phosphoribosyltransferase	ligand	Plasmodium falciparum (isolate FCR-3 / Gambia)
UEnolase	ligand	Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S3	ligand	Plasmodium falciparum (isolate 3D7)
UNon-SERCA-type Ca2+-transporting P-ATPase	ligand	Plasmodium falciparum (isolate 3D7)
UTubulin alpha chain	ligand	Plasmodium falciparum (isolate K1 / Thailand)
UKnob-associated histidine-rich protein	ligand	Plasmodium falciparum
US-adenosylmethionine synthase	ligand	Plasmodium falciparum (isolate 3D7)
UV-type H(+)-translocating pyrophosphatase, putative	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L4	ligand	Plasmodium falciparum (isolate 3D7)
UPhosphoethanolamine N-methyltransferase	ligand	Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S3a	ligand	Plasmodium falciparum (isolate 3D7)
UConserved Plasmodium membrane protein	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L3	ligand	Plasmodium falciparum (isolate 3D7)
UHigh molecular weight rhoptry protein 2	ligand	Plasmodium falciparum (isolate 3D7)
USerine repeat antigen 5	ligand	Plasmodium falciparum
U40S ribosomal protein S19	ligand	Plasmodium falciparum (isolate 3D7)
UGlycophorin-binding protein	ligand	Plasmodium falciparum (isolate 3D7)
UCalcium-transporting ATPase	ligand	Plasmodium falciparum (isolate K1 / Thailand)
UV-type proton ATPase catalytic subunit A	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L2	ligand	Plasmodium falciparum (isolate 3D7)
UAcyl-CoA synthetase	ligand	Plasmodium falciparum (isolate 3D7)
UPlasmepsin IV	ligand	Plasmodium falciparum (isolate 3D7)
UPlasmepsin-1	ligand	Plasmodium falciparum (isolate 3D7)
UChloroquine resistance transporter	ligand	Plasmodium falciparum
U14-3-3 protein	ligand	Plasmodium falciparum (isolate 3D7)
UIsoleucine--tRNA ligase, putative	ligand	Plasmodium falciparum (isolate 3D7)
UPlasmodium exported protein	ligand	Plasmodium falciparum (isolate 3D7)
UTubulin beta chain	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L27	ligand	Plasmodium falciparum (isolate 3D7)
USec62, putative	ligand	Plasmodium falciparum (isolate 3D7)
UAutophagy-related protein 18, putative	ligand	Plasmodium falciparum (isolate 3D7)
UMature parasite-infected erythrocyte surface antigen	ligand	Plasmodium falciparum (isolate 3D7)
UImportin-7, putative	ligand	Plasmodium falciparum (isolate 3D7)
UImportin subunit alpha	ligand	Plasmodium falciparum (isolate 3D7)
UPeptidyl-prolyl cis-trans isomerase	ligand	Plasmodium falciparum (isolate 3D7)
UDnaJ protein, putative	ligand	Plasmodium falciparum (isolate 3D7)
UMerozoite surface protein 1	ligand	Plasmodium falciparum (isolate CDC / Honduras)
UGlutamate--tRNA ligase	ligand	Plasmodium falciparum (isolate 3D7)
UT-complex protein 1 subunit eta	ligand	Plasmodium falciparum (isolate 3D7)
UPlasmepsin-2	ligand	Plasmodium falciparum
UChaperone, putative	ligand	Plasmodium falciparum (isolate 3D7)
URhoptry neck protein 3	ligand	Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S5, putative	ligand	Plasmodium falciparum (isolate 3D7)
USkeleton-binding protein 1	ligand	Plasmodium falciparum (isolate 3D7)
UPurine nucleotide phosphorylase, putative	ligand	Plasmodium falciparum (isolate 3D7)
UAdenosylhomocysteinase	ligand	Plasmodium falciparum (isolate 3D7)
UAdenosine deaminase	ligand	Plasmodium falciparum (isolate 3D7)
UMethionine--tRNA ligase	ligand	Plasmodium falciparum (isolate 3D7)
UCarbamoyl phosphate synthetase	ligand	Plasmodium falciparum (isolate 3D7)
UAspartate carbamoyltransferase	ligand	Plasmodium falciparum (isolate 3D7)
USignal recognition particle receptor, beta subunit	ligand	Plasmodium falciparum (isolate 3D7)
UParasite-infected erythrocyte surface protein	ligand	Plasmodium falciparum (isolate 3D7)
UCoatomer alpha subunit, putative	ligand	Plasmodium falciparum (isolate 3D7)
UHexokinase	ligand	Plasmodium falciparum
UProteasome subunit alpha type	ligand	Plasmodium falciparum (isolate 3D7)
UHaloacid dehalogenase-like hydrolase	ligand	Plasmodium falciparum (isolate 3D7)
UInsulinase, putative	ligand	Plasmodium falciparum (isolate 3D7)
U40S ribosomal protein S21	ligand	Plasmodium falciparum (isolate 3D7)
UUbiquitin-conjugating enzyme E2	ligand	Plasmodium falciparum (isolate 3D7)
UEukaryotic translation initiation factor 3 subunit C	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L24, putative	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L23	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L17, putative	ligand	Plasmodium falciparum (isolate 3D7)
UHAP protein	ligand	Plasmodium falciparum (isolate 3D7)
UHeat shock protein 110, putative	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L10, putative	ligand	Plasmodium falciparum (isolate 3D7)
ULysophospholipase, putative	ligand	Plasmodium falciparum (isolate 3D7)
UPolyadenylate-binding protein	ligand	Plasmodium falciparum (isolate 3D7)
UUbiquitin-60S ribosomal protein L40	ligand	Plasmodium falciparum (isolate 3D7)
UPhosphoribosylpyrophosphate synthetase	ligand	Plasmodium falciparum (isolate 3D7)
UThioredoxin peroxidase 1	ligand	Plasmodium falciparum (isolate 3D7)
UProtein transport protein SEC31	ligand	Plasmodium falciparum (isolate 3D7)
UDipeptidyl aminopeptidase 1	ligand	Plasmodium falciparum (isolate 3D7)
URing-infected erythrocyte surface antigen	ligand	Plasmodium falciparum (isolate FC27 / Papua New Guinea)
UATP-dependent RNA helicase UAP56	ligand	Plasmodium falciparum (isolate 3D7)
UCalcium-dependent protein kinase 4	ligand	Plasmodium falciparum (isolate 3D7)
UGTP-binding nuclear protein Ran	ligand	Plasmodium falciparum
UNucleoside transporter 2	ligand	Plasmodium falciparum (isolate 3D7)
UAnamorsin homolog	ligand	Plasmodium falciparum (isolate 3D7)
UGlutamine synthetase, putative	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L30e, putative	ligand	Plasmodium falciparum (isolate 3D7)
UCasein kinase 2, alpha subunit	ligand	Plasmodium falciparum (isolate 3D7)
UThreonine--tRNA ligase	ligand	Plasmodium falciparum (isolate 3D7)
UcAMP-dependent protein kinase regulatory subunit	ligand	Plasmodium falciparum (isolate 3D7)
UElongation factor 1-gamma, putative	ligand	Plasmodium falciparum (isolate 3D7)
UThioredoxin-like protein	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L21	ligand	Plasmodium falciparum (isolate 3D7)
U60S ribosomal protein L14, putative	ligand	Plasmodium falciparum (isolate 3D7)
UInner membrane complex sub-compartment protein 3	ligand	Plasmodium falciparum (isolate 3D7)
UHSP40, subfamily A, putative	ligand	Plasmodium falciparum (isolate 3D7)
UPyridoxal 5'-phosphate synthase subunit Pdx1	ligand	Plasmodium falciparum (isolate 3D7)
USerum albumin	ligand	Humans

Absorption

The reported oral bioavailability of Artenimol was reported to be 45% in healthy adults ¹¹. The observed Tmax was 1-2 h This is known to increase in malaria infected patients which could be attributed to reduced metabolism by the liver or the drug's collection in infected erythrocytes. Artenimol was obeserved to have flip-flop kinetics with an overall absorption half-life of 1.04 h. When administered with food the AUC for Artenimol increases by 144%. Cmax was observed to increase by 129% but was not found to be statistically significant. Food was observed to delay Tmax by 1 h.

Volume of distribution

Artenimol was observed to have a mean apparent volume of distribution of 0.801 L/kg in adult patients and 0.705 L/kg in pediatric patients wit P. falciparum malaria ¹¹.

Protein binding

Artenimol has been reported to be 44-93% bound to plasma proteins ^Label,11. The identity of these proteins has not been reported.

Metabolism

The primary metabolite of Artenimol is the glucuronide conjugate, α-artenimol-β-glucuronide ^Label. It is largely metabolized by UGT1A9 with some contribution by UGT2B7 ¹¹.

Hover over products below to view reaction partners

Artenimol
- α-artenimol-β-glucuronide

Route of elimination

Artenimol is eliminated via metabolism to glucuronide conjugates ^Label. There is little data on elimination of Artenimol but elimination of unchanged artemisinin compounds in feces and urine has been reported to be negligible.

Half-life

Artenimol was reported to have a half life of elimination of approximately 1 h ^Label.

Clearance

Artenimol was observed to have a mean apparent clearance of 1.340 L/h/kg in adult patients and 1.450 L/h/kg in pediatric patients with P. falciparum malaria ¹¹.

Adverse Effects

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Toxicity

In single dose studies in CD-1 male mice, Artenimol did not show signs of toxicity up to 1200 mg/kg ¹¹.

In repeated dose studies in CD-1 mice, the NOAEL for Artenimol was determined to be 200 mg/kg/day ¹¹. This value was determined to be 90 mg/kg/day in beagle dogs. The maximum tolerable dose in rats was observed to be 270 mg/kg/day. Doses of 540 mg/kg/day resulted in acute toxicity progressing to lethal effects. Toxicity was characterized by infiltration of macrophages and intracytoplasmic deposition of basophilic granular materials in macrophages consistent with phospholipidosis. Toxicity at high doses were accompanied by decreases in reticulocytes, and increases in AST and ALT.

Pathways

Not Available

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Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Drug	Interaction
Integrate drug-drug interactions in your software
Abrocitinib	The metabolism of Abrocitinib can be decreased when combined with Artenimol.
Acebutolol	The metabolism of Acebutolol can be decreased when combined with Artenimol.
Acenocoumarol	The metabolism of Acenocoumarol can be decreased when combined with Artenimol.
Acetaminophen	The metabolism of Acetaminophen can be decreased when combined with Artenimol.
Acetophenazine	The risk or severity of QTc prolongation can be increased when Artenimol is combined with Acetophenazine.

Food Interactions

Not Available

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End
Eurartesim	Artenimol (20 mg) + Piperaquine tetraphosphate (160 mg)	Tablet, film coated	Oral	Alfasigma s.p.a.	2021-01-27	Not applicable
Eurartesim	Artenimol (40 mg) + Piperaquine tetraphosphate (320 mg)	Tablet, film coated	Oral	Alfasigma s.p.a.	2021-01-27	Not applicable
EURARTESIM	Artenimol (40 MG) + Piperaquine tetraphosphate (160 320)	Tablet, film coated	Oral	Alfasigma s.p.a.	2014-07-08	Not applicable
EURARTESIM	Artenimol (20 MG) + Piperaquine tetraphosphate (160 MG)	Tablet, film coated	Oral	Alfasigma s.p.a.	2014-07-08	Not applicable
Eurartesim	Artenimol (40 mg) + Piperaquine tetraphosphate (320 mg)	Tablet, film coated	Oral	Alfasigma s.p.a.	2021-01-27	Not applicable

Chemical Identifiers

UNII: 6A9O50735X
CAS number: 71939-50-9
InChI Key: BJDCWCLMFKKGEE-ITYWPALDSA-N
InChI: InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14+,15+/m1/s1
IUPAC Name: (1S,4S,5R,8S,9R,10S,12R,13S)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-ol
SMILES: [H][C@@]1(C)CC[C@@]2([H])[C@@]([H])(C)[C@@]([H])(O)O[C@]3([H])O[C@]4(C)CC[C@]1([H])[C@]23OO4

References

General References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]
Haynes RK and Vonwiller SC: The behaviour of qinghaosu (artemisinin) in the presence of heme iron(II) and (III) Tetrahedron Lett. 1996 January 8;37(2):253-256. [Article]
Paitayatat S, Tarnchompoo B, Thebtaranonth Y, Yuthavong Y: Correlation of antimalarial activity of artemisinin derivatives with binding affinity with ferroprotoporphyrin IX. J Med Chem. 1997 Feb 28;40(5):633-8. doi: 10.1021/jm960767v. [Article]
White NJ: Clinical pharmacokinetics and pharmacodynamics of artemisinin and derivatives. Trans R Soc Trop Med Hyg. 1994 Jun;88 Suppl 1:S41-3. [Article]
Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]
Asawamahasakda W, Ittarat I, Pu YM, Ziffer H, Meshnick SR: Reaction of antimalarial endoperoxides with specific parasite proteins. Antimicrob Agents Chemother. 1994 Aug;38(8):1854-8. [Article]
Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003 Aug 21;424(6951):957-61. doi: 10.1038/nature01813. [Article]
Bhisutthibhan J, Pan XQ, Hossler PA, Walker DJ, Yowell CA, Carlton J, Dame JB, Meshnick SR: The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J Biol Chem. 1998 Jun 26;273(26):16192-8. [Article]
Olliaro PL, Haynes RK, Meunier B, Yuthavong Y: Possible modes of action of the artemisinin-type compounds. Trends Parasitol. 2001 Mar;17(3):122-6. [Article]
Gu HM, Warhurst DC, Peters W: Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro. Trans R Soc Trop Med Hyg. 1984;78(2):265-70. [Article]
EMA: Eurartesim Assessment Report [Link]
WHO: Guidelines for the Treatment of Malaria 3rd Edition [Link]
EMA Summary of Product Characteristics: Eurartesim (piperaquine tetraphosphate/artenimol) oral tablets [Link]

External Links

BindingDB: 50088446
ChEBI: 207229
ChEMBL: CHEMBL25164
ZINC: ZINC000043242043
Wikipedia: Dihydroartemisinin

FDA label

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MSDS

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Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">

Phase	Status	Purpose	Conditions	Count
4	Active Not Recruiting	Prevention	Malaria	2
4	Active Not Recruiting	Prevention	Malaria in Pregnancy	1
4	Active Not Recruiting	Prevention	Malaria / Parasitic Diseases	1
4	Completed	Not Available	Uncomplicated Malaria	1
4	Completed	Health Services Research	Healthy Subjects (HS)	1

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Tablet, film coated	Oral
Tablet, soluble	Oral

Prices

Not Available

Patents

Not Available

Properties

State

Solid

Experimental Properties

Property	Value	Source
melting point (°C)	164-165	MSDS

Predicted Properties

Property	Value	Source
logP	2.84	Chemaxon
pKa (Strongest Acidic)	12.11	Chemaxon
pKa (Strongest Basic)	-4.1	Chemaxon
Physiological Charge	0	Chemaxon
Hydrogen Acceptor Count	5	Chemaxon
Hydrogen Donor Count	1	Chemaxon
Polar Surface Area	57.15 Å²	Chemaxon
Rotatable Bond Count	0	Chemaxon
Refractivity	69.91 m³·mol^-1	Chemaxon
Polarizability	30.19 Å³	Chemaxon
Number of Rings	4	Chemaxon
Bioavailability	1	Chemaxon
Rule of Five	Yes	Chemaxon
Ghose Filter	Yes	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Spectrum	Spectrum Type	Splash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)	Predicted LC-MS/MS	splash10-000i-0090000000-1412d3d238b936ec73a6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)	Predicted LC-MS/MS	splash10-001i-0090000000-6e74ddb2006e53aa0596
Predicted MS/MS Spectrum - 20V, Positive (Annotated)	Predicted LC-MS/MS	splash10-000i-0090000000-f0a0d6214bbfd1ab8fe8
Predicted MS/MS Spectrum - 20V, Negative (Annotated)	Predicted LC-MS/MS	splash10-001i-1090000000-58eb6366b612d976e92e
Predicted MS/MS Spectrum - 40V, Positive (Annotated)	Predicted LC-MS/MS	splash10-056u-1090000000-15be1ca67e2778e6ccc3
Predicted MS/MS Spectrum - 40V, Negative (Annotated)	Predicted LC-MS/MS	splash10-0a7i-2090000000-96d83f23d29667d87ad4
Predicted 1H NMR Spectrum	1D NMR	Not Applicable
Predicted 13C NMR Spectrum	1D NMR	Not Applicable

Chromatographic Properties

Collision Cross Sections (CCS)

Not Available

Targets

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Details1. Actin, cytoplasmic 2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Ubiquitin protein ligase binding
Specific Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Gene Name: ACTG1
Uniprot ID: P63261
Uniprot Name: Actin, cytoplasmic 2
Molecular Weight: 41792.48 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details2. Alpha-aminoadipic semialdehyde dehydrogenase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: L-aminoadipate-semialdehyde dehydrogenase activity
Specific Function: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by meta...
Gene Name: ALDH7A1
Uniprot ID: P49419
Uniprot Name: Alpha-aminoadipic semialdehyde dehydrogenase
Molecular Weight: 58486.74 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details3. Annexin A2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: S100 protein binding
Specific Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress resp...
Gene Name: ANXA2
Uniprot ID: P07355
Uniprot Name: Annexin A2
Molecular Weight: 38603.63 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details4. ATP synthase subunit alpha, mitochondrial

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Transmembrane transporter activity
Specific Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport comp...
Gene Name: ATP5A1
Uniprot ID: P25705
Uniprot Name: ATP synthase subunit alpha, mitochondrial
Molecular Weight: 59750.06 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details5. ATP synthase subunit g, mitochondrial

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
Specific Function: Hydrogen ion transmembrane transporter activity
Gene Name: ATP5L
Uniprot ID: O75964
Uniprot Name: ATP synthase subunit g, mitochondrial
Molecular Weight: 11428.4 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details6. ATP synthase subunit O, mitochondrial

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
Specific Function: Atpase activity
Gene Name: ATP5O
Uniprot ID: P48047
Uniprot Name: ATP synthase subunit O, mitochondrial
Molecular Weight: 23277.12 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details7. Calpastatin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Poly(a) rna binding
Specific Function: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in liv...
Gene Name: CAST
Uniprot ID: P20810
Uniprot Name: Calpastatin
Molecular Weight: 76572.035 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details8. T-complex protein 1 subunit gamma

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Unfolded protein binding
Specific Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating tra...
Gene Name: CCT3
Uniprot ID: P49368
Uniprot Name: T-complex protein 1 subunit gamma
Molecular Weight: 60533.34 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details9. Cofilin-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role...
Gene Name: CFL1
Uniprot ID: P23528
Uniprot Name: Cofilin-1
Molecular Weight: 18502.315 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details10. Chloride intracellular channel protein 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Voltage-gated ion channel activity
Specific Function: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved ...
Gene Name: CLIC1
Uniprot ID: O00299
Uniprot Name: Chloride intracellular channel protein 1
Molecular Weight: 26922.47 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details11. Cysteine and glycine-rich protein 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Could play a role in neuronal development.
Specific Function: Rna binding
Gene Name: CSRP1
Uniprot ID: P21291
Uniprot Name: Cysteine and glycine-rich protein 1
Molecular Weight: 20567.32 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details12. Dihydropyrimidinase-related protein 2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Dihydropyrimidinase activity
Specific Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subse...
Gene Name: DPYSL2
Uniprot ID: Q16555
Uniprot Name: Dihydropyrimidinase-related protein 2
Molecular Weight: 62293.135 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details13. Desmoplakin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Specific Function: Cell adhesion molecule binding
Gene Name: DSP
Uniprot ID: P15924
Uniprot Name: Desmoplakin
Molecular Weight: 331771.16 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details14. Elongation factor 1-alpha 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Trna binding
Specific Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-sp...
Gene Name: EEF1A1
Uniprot ID: P68104
Uniprot Name: Elongation factor 1-alpha 1
Molecular Weight: 50140.565 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details15. Alpha-enolase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Transcription factor activity, sequence-specific dna binding
Specific Function: Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravas...
Gene Name: ENO1
Uniprot ID: P06733
Uniprot Name: Alpha-enolase
Molecular Weight: 47168.555 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details16. Filamin-A

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).
Specific Function: Actin filament binding
Gene Name: FLNA
Uniprot ID: P21333
Uniprot Name: Filamin-A
Molecular Weight: 280737.58 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details17. Alpha-ketoglutarate-dependent dioxygenase FTO

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Oxidative rna demethylase activity
Specific Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-m...
Gene Name: FTO
Uniprot ID: Q9C0B1
Uniprot Name: Alpha-ketoglutarate-dependent dioxygenase FTO
Molecular Weight: 58281.53 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details18. Glucose-6-phosphate 1-dehydrogenase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Protein homodimerization activity
Specific Function: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is ...
Gene Name: G6PD
Uniprot ID: P11413
Uniprot Name: Glucose-6-phosphate 1-dehydrogenase
Molecular Weight: 59256.31 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details19. Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Nadp binding
Specific Function: May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (B...
Gene Name: GAPDHS
Uniprot ID: O14556
Uniprot Name: Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
Molecular Weight: 44500.835 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details20. Glucose-6-phosphate isomerase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Ubiquitin protein ligase binding
Specific Function: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophi...
Gene Name: GPI
Uniprot ID: P06744
Uniprot Name: Glucose-6-phosphate isomerase
Molecular Weight: 63146.745 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details21. Heterogeneous nuclear ribonucleoproteins A2/B1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680).
Specific Function: G-rich strand telomeric dna binding
Gene Name: HNRNPA2B1
Uniprot ID: P22626
Uniprot Name: Heterogeneous nuclear ribonucleoproteins A2/B1
Molecular Weight: 37429.71 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details22. Heterogeneous nuclear ribonucleoprotein D0

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.
Specific Function: At dna binding
Gene Name: HNRNPD
Uniprot ID: Q14103
Uniprot Name: Heterogeneous nuclear ribonucleoprotein D0
Molecular Weight: 38434.09 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details23. Heterogeneous nuclear ribonucleoprotein K

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
Specific Function: Cadherin binding
Gene Name: HNRNPK
Uniprot ID: P61978
Uniprot Name: Heterogeneous nuclear ribonucleoprotein K
Molecular Weight: 50975.81 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details24. Heterochromatin protein 1-binding protein 3

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
Specific Function: Dna binding
Gene Name: HP1BP3
Uniprot ID: Q5SSJ5
Uniprot Name: Heterochromatin protein 1-binding protein 3
Molecular Weight: 61206.5 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details25. Heat shock protein beta-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Ubiquitin binding
Specific Function: Involved in stress resistance and actin organization.
Gene Name: HSPB1
Uniprot ID: P04792
Uniprot Name: Heat shock protein beta-1
Molecular Weight: 22782.3 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details26. Ras GTPase-activating-like protein IQGAP1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.
Specific Function: Cadherin binding
Gene Name: IQGAP1
Uniprot ID: P46940
Uniprot Name: Ras GTPase-activating-like protein IQGAP1
Molecular Weight: 189250.43 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details27. Far upstream element-binding protein 2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
Specific Function: Dna binding
Gene Name: KHSRP
Uniprot ID: Q92945
Uniprot Name: Far upstream element-binding protein 2
Molecular Weight: 73115.16 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details28. L-lactate dehydrogenase A chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Nad binding
Specific Function: Not Available
Gene Name: LDHA
Uniprot ID: P00338
Uniprot Name: L-lactate dehydrogenase A chain
Molecular Weight: 36688.465 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details29. L-lactate dehydrogenase B chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Nad binding
Specific Function: Not Available
Gene Name: LDHB
Uniprot ID: P07195
Uniprot Name: L-lactate dehydrogenase B chain
Molecular Weight: 36638.225 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details30. Galectin-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Signal transducer activity
Specific Function: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase ac...
Gene Name: LGALS1
Uniprot ID: P09382
Uniprot Name: Galectin-1
Molecular Weight: 14715.57 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details31. Microtubule-associated protein 4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Structural molecule activity
Specific Function: Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Gene Name: MAP4
Uniprot ID: P27816
Uniprot Name: Microtubule-associated protein 4
Molecular Weight: 121003.805 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details32. Malate dehydrogenase, cytoplasmic

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Nad binding
Specific Function: Not Available
Gene Name: MDH1
Uniprot ID: P40925
Uniprot Name: Malate dehydrogenase, cytoplasmic
Molecular Weight: 36425.795 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details33. Puromycin-sensitive aminopeptidase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Zinc ion binding
Specific Function: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a ...
Gene Name: NPEPPS
Uniprot ID: P55786
Uniprot Name: Puromycin-sensitive aminopeptidase
Molecular Weight: 103275.36 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details34. Profilin-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Proline-rich region binding
Specific Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2...
Gene Name: PFN1
Uniprot ID: P07737
Uniprot Name: Profilin-1
Molecular Weight: 15054.145 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details35. Phosphoglycerate kinase 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Phosphoglycerate kinase activity
Specific Function: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
Gene Name: PGK1
Uniprot ID: P00558
Uniprot Name: Phosphoglycerate kinase 1
Molecular Weight: 44614.36 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details36. Pyruvate kinase PKM

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Pyruvate kinase activity
Specific Function: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general rol...
Gene Name: PKM
Uniprot ID: P14618
Uniprot Name: Pyruvate kinase PKM
Molecular Weight: 57936.38 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details37. Peptidyl-prolyl cis-trans isomerase A

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Virion binding
Specific Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Gene Name: PPIA
Uniprot ID: P62937
Uniprot Name: Peptidyl-prolyl cis-trans isomerase A
Molecular Weight: 18012.42 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details38. Peroxiredoxin-1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Thioredoxin peroxidase activity
Specific Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating pe...
Gene Name: PRDX1
Uniprot ID: Q06830
Uniprot Name: Peroxiredoxin-1
Molecular Weight: 22110.19 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details39. 60S ribosomal protein L10

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the large ribosomal subunit.
Specific Function: Rna binding
Gene Name: RPL10
Uniprot ID: P27635
Uniprot Name: 60S ribosomal protein L10
Molecular Weight: 24603.705 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details40. 60S ribosomal protein L14

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the large ribosomal subunit.
Specific Function: Cadherin binding
Gene Name: RPL14
Uniprot ID: P50914
Uniprot Name: 60S ribosomal protein L14
Molecular Weight: 23431.68 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details41. 60S ribosomal protein L18

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the large ribosomal subunit.
Specific Function: Rna binding
Gene Name: RPL18
Uniprot ID: Q07020
Uniprot Name: 60S ribosomal protein L18
Molecular Weight: 21634.315 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details42. 60S ribosomal protein L23a

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Structural constituent of ribosome
Specific Function: This protein binds to a specific region on the 26S rRNA.
Gene Name: RPL23A
Uniprot ID: P62750
Uniprot Name: 60S ribosomal protein L23a
Molecular Weight: 17694.885 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details43. 60S ribosomal protein L35

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the large ribosomal subunit.
Specific Function: Mrna binding
Gene Name: RPL35
Uniprot ID: P42766
Uniprot Name: 60S ribosomal protein L35
Molecular Weight: 14551.37 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details44. 60S ribosomal protein L4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: RPL4
Uniprot ID: P36578
Uniprot Name: 60S ribosomal protein L4
Molecular Weight: 47696.95 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details45. 40S ribosomal protein S13

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: 5.8s rrna binding
Gene Name: RPS13
Uniprot ID: P62277
Uniprot Name: 40S ribosomal protein S13
Molecular Weight: 17222.13 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details46. 40S ribosomal protein S17

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: RPS17
Uniprot ID: P08708
Uniprot Name: 40S ribosomal protein S17
Molecular Weight: 15550.02 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details47. 40S ribosomal protein S18

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
Specific Function: Protein kinase binding
Gene Name: RPS18
Uniprot ID: P62269
Uniprot Name: 40S ribosomal protein S18
Molecular Weight: 17718.565 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details48. 40S ribosomal protein S19

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits.
Specific Function: Fibroblast growth factor binding
Gene Name: RPS19
Uniprot ID: P39019
Uniprot Name: 40S ribosomal protein S19
Molecular Weight: 16060.44 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details49. 40S ribosomal protein S28

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: RPS28
Uniprot ID: P62857
Uniprot Name: 40S ribosomal protein S28
Molecular Weight: 7840.97 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details50. 40S ribosomal protein S5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Mrna binding
Gene Name: RPS5
Uniprot ID: P46782
Uniprot Name: 40S ribosomal protein S5
Molecular Weight: 22876.165 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details51. 40S ribosomal protein S6

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Specific Function: Protein kinase binding
Gene Name: RPS6
Uniprot ID: P62753
Uniprot Name: 40S ribosomal protein S6
Molecular Weight: 28680.42 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details52. 40S ribosomal protein S8

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: RPS8
Uniprot ID: P62241
Uniprot Name: 40S ribosomal protein S8
Molecular Weight: 24205.015 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details53. 40S ribosomal protein S9

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: RPS9
Uniprot ID: P46781
Uniprot Name: 40S ribosomal protein S9
Molecular Weight: 22591.235 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details54. Splicing factor 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.
Specific Function: Identical protein binding
Gene Name: SF1
Uniprot ID: Q15637
Uniprot Name: Splicing factor 1
Molecular Weight: 68329.55 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details55. Splicing factor, proline- and glutamine-rich

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing; in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1; in vitro, stimulates dissociation of TOP1 from DNA after cleavage and enhances its jumping between separate DNA helices. The SFPQ-NONO heteromer binds DNA (PubMed:25765647). The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends; in vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. SFPQ is involved in transcriptional regulation. Functions as transcriptional activator (PubMed:25765647). Transcriptional repression is mediated by an interaction of SFPQ with SIN3A and subsequent recruitment of histone deacetylases (HDACs). The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. SFPQ isoform Long binds to the DNA binding domains (DBD) of nuclear hormone receptors, like RXRA and probably THRA, and acts as transcriptional corepressor in absence of hormone ligands. Binds the DNA sequence 5'-CTGAGTC-3' in the insulin-like growth factor response element (IGFRE) and inhibits IGF-I-stimulated transcriptional activity. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation (By similarity). Required for the assembly of nuclear speckles (PubMed:25765647).
Specific Function: Chromatin binding
Gene Name: SFPQ
Uniprot ID: P23246
Uniprot Name: Splicing factor, proline- and glutamine-rich
Molecular Weight: 76149.15 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details56. Small nuclear ribonucleoprotein Sm D2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.
Specific Function: Rna binding
Gene Name: SNRPD2
Uniprot ID: P62316
Uniprot Name: Small nuclear ribonucleoprotein Sm D2
Molecular Weight: 13526.815 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details57. Signal recognition particle 14 kDa protein

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Rna binding
Specific Function: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, con...
Gene Name: SRP14
Uniprot ID: P37108
Uniprot Name: Signal recognition particle 14 kDa protein
Molecular Weight: 14569.775 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details58. Serine/arginine-rich splicing factor 4

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.
Specific Function: Rna binding
Gene Name: SRSF4
Uniprot ID: Q08170
Uniprot Name: Serine/arginine-rich splicing factor 4
Molecular Weight: 56677.745 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details59. Transgelin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Specific Function: Actin filament binding
Gene Name: TAGLN
Uniprot ID: Q01995
Uniprot Name: Transgelin
Molecular Weight: 22610.84 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details60. Transgelin-2

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Cadherin binding
Gene Name: TAGLN2
Uniprot ID: P37802
Uniprot Name: Transgelin-2
Molecular Weight: 22391.36 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details61. Triosephosphate isomerase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Ubiquitin protein ligase binding
Specific Function: Not Available
Gene Name: TPI1
Uniprot ID: P60174
Uniprot Name: Triosephosphate isomerase
Molecular Weight: 30790.785 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details62. Tropomyosin alpha-1 chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
Specific Function: Actin binding
Gene Name: TPM1
Uniprot ID: P09493
Uniprot Name: Tropomyosin alpha-1 chain
Molecular Weight: 32708.175 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details63. Tubulin alpha-1A chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function: Gtp binding
Gene Name: TUBA1A
Uniprot ID: Q71U36
Uniprot Name: Tubulin alpha-1A chain
Molecular Weight: 50135.25 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details64. Vimentin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Structural constituent of eye lens
Specific Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, eit...
Gene Name: VIM
Uniprot ID: P08670
Uniprot Name: Vimentin
Molecular Weight: 53651.165 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details65. Zyxin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Specific Function: Rna binding
Gene Name: ZYX
Uniprot ID: Q15942
Uniprot Name: Zyxin
Molecular Weight: 61276.885 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details66. Heat shock cognate 71 kDa protein

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Unfolded protein binding
Specific Function: Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that f...
Gene Name: HSPA8
Uniprot ID: P11142
Uniprot Name: Heat shock cognate 71 kDa protein
Molecular Weight: 70897.565 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details67. Tubulin beta-6 chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Structural constituent of cytoskeleton
Specific Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene Name: TUBB6
Uniprot ID: Q9BUF5
Uniprot Name: Tubulin beta-6 chain
Molecular Weight: 49856.785 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details68. Tubulin beta-4A chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Structural constituent of cytoskeleton
Specific Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name: TUBB4A
Uniprot ID: P04350
Uniprot Name: Tubulin beta-4A chain
Molecular Weight: 49585.475 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details69. Tubulin beta chain

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Ubiquitin protein ligase binding
Specific Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Gene Name: TUBB
Uniprot ID: P07437
Uniprot Name: Tubulin beta chain
Molecular Weight: 49670.515 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details70. Fructose-bisphosphate aldolase A

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Tubulin binding
Specific Function: Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity).
Gene Name: ALDOA
Uniprot ID: P04075
Uniprot Name: Fructose-bisphosphate aldolase A
Molecular Weight: 39419.675 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details71. Glyceraldehyde-3-phosphate dehydrogenase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Peptidyl-cysteine s-nitrosylase activity
Specific Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including tran...
Gene Name: GAPDH
Uniprot ID: P04406
Uniprot Name: Glyceraldehyde-3-phosphate dehydrogenase
Molecular Weight: 36053.0 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details72. Cytochrome c

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Metal ion binding
Specific Function: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfe...
Gene Name: CYCS
Uniprot ID: P99999
Uniprot Name: Cytochrome c
Molecular Weight: 11748.69 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details73. Phosphoglycerate mutase 1

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity.
Specific Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
Gene Name: PGAM1
Uniprot ID: P18669
Uniprot Name: Phosphoglycerate mutase 1
Molecular Weight: 28803.675 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details74. Myosin-9

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10.
Specific Function: Actin binding
Gene Name: MYH9
Uniprot ID: P35579
Uniprot Name: Myosin-9
Molecular Weight: 226530.505 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details75. Protein disulfide-isomerase

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Protein heterodimerization activity
Specific Function: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attach...
Gene Name: P4HB
Uniprot ID: P07237
Uniprot Name: Protein disulfide-isomerase
Molecular Weight: 57115.795 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details76. Probable ATP-dependent RNA helicase DDX5

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Specific Function: Androgen receptor binding
Gene Name: DDX5
Uniprot ID: P17844
Uniprot Name: Probable ATP-dependent RNA helicase DDX5
Molecular Weight: 69147.585 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details77. Serine hydroxymethyltransferase, mitochondrial

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Pyridoxal phosphate binding
Specific Function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.
Gene Name: SHMT2
Uniprot ID: P34897
Uniprot Name: Serine hydroxymethyltransferase, mitochondrial
Molecular Weight: 55992.385 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details78. Spliceosome RNA helicase DDX39B

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: U6 snrna binding
Specific Function: Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically ass...
Gene Name: DDX39B
Uniprot ID: Q13838
Uniprot Name: Spliceosome RNA helicase DDX39B
Molecular Weight: 48990.945 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details79. Nucleophosmin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade (PubMed:22528486). In complex with MYC enhances the transcription of MYC target genes (PubMed:25956029).
Specific Function: Activating transcription factor binding
Gene Name: NPM1
Uniprot ID: P06748
Uniprot Name: Nucleophosmin
Molecular Weight: 32574.765 Da

References

Ravindra KC, Ho WE, Cheng C, Godoy LC, Wishnok JS, Ong CN, Wong WS, Wogan GN, Tannenbaum SR: Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21. [Article]

Details80. Translationally-controlled tumor protein homolog

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Involved in calcium binding and microtubule stabilization.
Specific Function: Calcium ion binding
Gene Name: TCTP
Uniprot ID: Q8I3Z5
Uniprot Name: Translationally-controlled tumor protein homolog
Molecular Weight: 19979.25 Da

References

Bhisutthibhan J, Pan XQ, Hossler PA, Walker DJ, Yowell CA, Carlton J, Dame JB, Meshnick SR: The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin. J Biol Chem. 1998 Jun 26;273(26):16192-8. [Article]

Details81. P-type Ca2+-transporting ATPase

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Antagonist

General Function: Not Available
Specific Function: Atp binding
Gene Name: serca
Uniprot ID: Q5R2K6
Uniprot Name: P-type Ca2+-transporting ATPase
Molecular Weight: 139413.605 Da

References

Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S: Artemisinins target the SERCA of Plasmodium falciparum. Nature. 2003 Aug 21;424(6951):957-61. doi: 10.1038/nature01813. [Article]

Details82. Ornithine aminotransferase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and of glutamate-5-semialdehyde with glutamate and alanine.
Specific Function: Identical protein binding
Gene Name: OAT
Uniprot ID: Q6LFH8
Uniprot Name: Ornithine aminotransferase
Molecular Weight: 46054.755 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details83. Elongation factor 1-alpha

Kind: Protein
Organism: Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action: Unknown
Actions: Ligand

General Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Specific Function: Gtp binding
Gene Name: MEF-1
Uniprot ID: Q00080
Uniprot Name: Elongation factor 1-alpha
Molecular Weight: 49040.52 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details84. Multidrug resistance protein

Kind: Protein
Organism: Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Pharmacological action: Unknown
Actions: Ligand

General Function: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Specific Function: Atp binding
Gene Name: MDR1
Uniprot ID: P13568
Uniprot Name: Multidrug resistance protein
Molecular Weight: 162250.55 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details85. Elongation factor 2

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Gtp binding
Gene Name: Not Available
Uniprot ID: Q8IKW5
Uniprot Name: Elongation factor 2
Molecular Weight: 93521.915 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details86. Actin-1

Kind: Protein
Organism: Plasmodium falciparum (isolate HB3)
Pharmacological action: Unknown
Actions: Ligand

General Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Actin assembles into short polymer microfilaments, these are thought to contribute to parasite gliding motility.
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: P86287
Uniprot Name: Actin-1
Molecular Weight: 41870.305 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details87. Glyceraldehyde-3-phosphate dehydrogenase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Glyceraldehyde-3-phosphate dehydrogenase (nad+) (phosphorylating) activity
Gene Name: GAPDH
Uniprot ID: Q8IKK7
Uniprot Name: Glyceraldehyde-3-phosphate dehydrogenase
Molecular Weight: 36634.97 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details88. Fructose-bisphosphate aldolase

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Fructose-bisphosphate aldolase activity
Gene Name: Not Available
Uniprot ID: P14223
Uniprot Name: Fructose-bisphosphate aldolase
Molecular Weight: 40104.68 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details89. Cell division cycle protein 48 homologue,putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: C6KT34
Uniprot Name: Cell division cycle protein 48 homologue,putative
Molecular Weight: 92386.055 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details90. Heat shock protein 90

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IC05
Uniprot Name: Heat shock protein 90
Molecular Weight: 86165.63 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details91. Eukaryotic initiation factor 4A

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: 3'-5' dna/rna helicase activity
Gene Name: H45
Uniprot ID: Q8IKF0
Uniprot Name: Eukaryotic initiation factor 4A
Molecular Weight: 45309.745 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details92. Pyruvate kinase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Kinase activity
Gene Name: Not Available
Uniprot ID: C6KTA4
Uniprot Name: Pyruvate kinase
Molecular Weight: 55660.3 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details93. L-lactate dehydrogenase

Kind: Protein
Organism: Plasmodium falciparum (isolate CDC / Honduras)
Pharmacological action: Unknown
Actions: Ligand

General Function: L-lactate dehydrogenase activity
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q27743
Uniprot Name: L-lactate dehydrogenase
Molecular Weight: 34107.505 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details94. Protein disulfide-isomerase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Protein disulfide isomerase activity
Gene Name: Not Available
Uniprot ID: C0H4Y6
Uniprot Name: Protein disulfide-isomerase
Molecular Weight: 55513.84 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details95. Thioredoxin-related protein, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Protein disulfide isomerase activity
Gene Name: Not Available
Uniprot ID: Q8IDH5
Uniprot Name: Thioredoxin-related protein, putative
Molecular Weight: 23987.805 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details96. Spermidine synthase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Spermidine synthase activity
Gene Name: Not Available
Uniprot ID: Q8II73
Uniprot Name: Spermidine synthase
Molecular Weight: 36595.23 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details97. Probable ATP-dependent 6-phosphofructokinase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Specific Function: 6-phosphofructokinase activity
Gene Name: Not Available
Uniprot ID: Q8I2Z8
Uniprot Name: Probable ATP-dependent 6-phosphofructokinase
Molecular Weight: 159450.815 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details98. Glutamate dehydrogenase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Glutamate dehydrogenase (nadp+) activity
Gene Name: Not Available
Uniprot ID: Q8ILF7
Uniprot Name: Glutamate dehydrogenase
Molecular Weight: 57342.635 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details99. Endoplasmin homolog, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8I0V4
Uniprot Name: Endoplasmin homolog, putative
Molecular Weight: 95017.4 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details100. Hypoxanthine-guanine-xanthine phosphoribosyltransferase

Kind: Protein
Organism: Plasmodium falciparum (isolate FCR-3 / Gambia)
Pharmacological action: Unknown
Actions: Ligand

General Function: Xanthine phosphoribosyltransferase activity
Specific Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Works with guanine, ...
Gene Name: LACZ
Uniprot ID: P20035
Uniprot Name: Hypoxanthine-guanine-xanthine phosphoribosyltransferase
Molecular Weight: 26348.18 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details101. Enolase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Magnesium ion binding
Gene Name: ENO
Uniprot ID: Q8IJN7
Uniprot Name: Enolase
Molecular Weight: 48677.255 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details102. 40S ribosomal protein S3

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Damaged dna binding
Gene Name: Not Available
Uniprot ID: Q8IKH8
Uniprot Name: 40S ribosomal protein S3
Molecular Weight: 24667.57 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details103. Non-SERCA-type Ca2+-transporting P-ATPase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: A0A143ZZK9
Uniprot Name: Non-SERCA-type Ca2+-transporting P-ATPase
Molecular Weight: 140260.855 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details104. Tubulin alpha chain

Kind: Protein
Organism: Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action: Unknown
Actions: Ligand

General Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function: Gtp binding
Gene Name: Not Available
Uniprot ID: P14642
Uniprot Name: Tubulin alpha chain
Molecular Weight: 50296.57 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details105. Knob-associated histidine-rich protein

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: KAHRP might mimick human histidine-rich glycoproteins to anchor host thrombospondin or a parasite analog in a binding complex with the endothelial cell receptor.
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: P13817
Uniprot Name: Knob-associated histidine-rich protein
Molecular Weight: 53191.4 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details106. S-adenosylmethionine synthase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q7K6A4
Uniprot Name: S-adenosylmethionine synthase
Molecular Weight: 44843.535 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details107. V-type H(+)-translocating pyrophosphatase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Hydrogen ion transmembrane transporter activity
Gene Name: Not Available
Uniprot ID: Q8IKR1
Uniprot Name: V-type H(+)-translocating pyrophosphatase, putative
Molecular Weight: 76415.56 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details108. 60S ribosomal protein L4

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8I431
Uniprot Name: 60S ribosomal protein L4
Molecular Weight: 46211.16 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details109. Phosphoethanolamine N-methyltransferase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Phosphoethanolamine n-methyltransferase activity
Gene Name: Not Available
Uniprot ID: Q8IDQ9
Uniprot Name: Phosphoethanolamine N-methyltransferase
Molecular Weight: 31042.865 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details110. 40S ribosomal protein S3a

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural constituent of ribosome
Gene Name: Not Available
Uniprot ID: O97313
Uniprot Name: 40S ribosomal protein S3a
Molecular Weight: 30047.235 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details111. Conserved Plasmodium membrane protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8IJT2
Uniprot Name: Conserved Plasmodium membrane protein
Molecular Weight: 78005.095 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details112. 60S ribosomal protein L3

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8IJC6
Uniprot Name: 60S ribosomal protein L3
Molecular Weight: 44220.715 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details113. High molecular weight rhoptry protein 2

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: C0H571
Uniprot Name: High molecular weight rhoptry protein 2
Molecular Weight: 162663.655 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details114. Serine repeat antigen 5

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Cysteine-type peptidase activity
Gene Name: SERA5
Uniprot ID: T1RTG8
Uniprot Name: Serine repeat antigen 5
Molecular Weight: 39765.935 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details115. 40S ribosomal protein S19

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: C0H5C2
Uniprot Name: 40S ribosomal protein S19
Molecular Weight: 16763.56 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details116. Glycophorin-binding protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Involved in erythrocyte invasion.
Specific Function: Not Available
Gene Name: GBP
Uniprot ID: Q8I6U8
Uniprot Name: Glycophorin-binding protein
Molecular Weight: 95843.285 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details117. Calcium-transporting ATPase

Kind: Protein
Organism: Plasmodium falciparum (isolate K1 / Thailand)
Pharmacological action: Unknown
Actions: Ligand

General Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.
Specific Function: Atp binding
Gene Name: ATP6
Uniprot ID: Q08853
Uniprot Name: Calcium-transporting ATPase
Molecular Weight: 139413.605 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details118. V-type proton ATPase catalytic subunit A

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Specific Function: Atp binding
Gene Name: vapA
Uniprot ID: Q76NM6
Uniprot Name: V-type proton ATPase catalytic subunit A
Molecular Weight: 68575.81 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details119. 60S ribosomal protein L2

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8I3T9
Uniprot Name: 60S ribosomal protein L2
Molecular Weight: 27999.655 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details120. Acyl-CoA synthetase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Ankyrin binding
Gene Name: ACS3
Uniprot ID: Q8I0X2
Uniprot Name: Acyl-CoA synthetase
Molecular Weight: 93865.435 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details121. Plasmepsin IV

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Aspartic-type endopeptidase activity
Gene Name: Not Available
Uniprot ID: Q8IM16
Uniprot Name: Plasmepsin IV
Molecular Weight: 51045.89 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details122. Plasmepsin-1

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation (By similarity).
Specific Function: Aspartic-type endopeptidase activity
Gene Name: Not Available
Uniprot ID: Q7KQM4
Uniprot Name: Plasmepsin-1
Molecular Weight: 51460.555 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details123. Chloroquine resistance transporter

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: May regulate endogenous transporter.
Specific Function: Drug transmembrane transporter activity
Gene Name: CRT
Uniprot ID: Q9N623
Uniprot Name: Chloroquine resistance transporter
Molecular Weight: 48674.705 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details124. 14-3-3 protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Histone binding
Gene Name: Not Available
Uniprot ID: C0H4V6
Uniprot Name: 14-3-3 protein
Molecular Weight: 30192.435 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details125. Isoleucine--tRNA ligase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Aminoacyl-trna editing activity
Gene Name: Not Available
Uniprot ID: Q8I5G6
Uniprot Name: Isoleucine--tRNA ligase, putative
Molecular Weight: 204244.265 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details126. Plasmodium exported protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: C6S3C7
Uniprot Name: Plasmodium exported protein
Molecular Weight: 36265.665 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details127. Tubulin beta chain

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Specific Function: Gtp binding
Gene Name: Not Available
Uniprot ID: Q7KQL5
Uniprot Name: Tubulin beta chain
Molecular Weight: 49750.65 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details128. 60S ribosomal protein L27

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural constituent of ribosome
Gene Name: Not Available
Uniprot ID: Q8IKM5
Uniprot Name: 60S ribosomal protein L27
Molecular Weight: 16744.955 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details129. Sec62, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Protein transporter activity
Gene Name: Not Available
Uniprot ID: Q8IL86
Uniprot Name: Sec62, putative
Molecular Weight: 43936.8 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details130. Autophagy-related protein 18, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Phosphatidylinositol-3,5-bisphosphate binding
Gene Name: Not Available
Uniprot ID: Q8IJR6
Uniprot Name: Autophagy-related protein 18, putative
Molecular Weight: 43519.065 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details131. Mature parasite-infected erythrocyte surface antigen

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8I492
Uniprot Name: Mature parasite-infected erythrocyte surface antigen
Molecular Weight: 168286.965 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details132. Importin-7, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Protein transporter activity
Gene Name: Not Available
Uniprot ID: C0H4L1
Uniprot Name: Importin-7, putative
Molecular Weight: 145507.21 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details133. Importin subunit alpha

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Nuclear import signal receptor activity
Gene Name: Not Available
Uniprot ID: Q8IAW0
Uniprot Name: Importin subunit alpha
Molecular Weight: 61157.83 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details134. Peptidyl-prolyl cis-trans isomerase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Specific Function: Cyclosporin a binding
Gene Name: Not Available
Uniprot ID: Q76NN7
Uniprot Name: Peptidyl-prolyl cis-trans isomerase
Molecular Weight: 18952.44 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details135. DnaJ protein, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Dna-directed dna polymerase activity
Gene Name: Not Available
Uniprot ID: Q8IB72
Uniprot Name: DnaJ protein, putative
Molecular Weight: 76681.32 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details136. Merozoite surface protein 1

Kind: Protein
Organism: Plasmodium falciparum (isolate CDC / Honduras)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: MSP-1
Uniprot ID: P13827
Uniprot Name: Merozoite surface protein 1
Molecular Weight: 26050.51 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details137. Glutamate--tRNA ligase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IDD3
Uniprot Name: Glutamate--tRNA ligase
Molecular Weight: 68366.905 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details138. T-complex protein 1 subunit eta

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand
Curator comments: Drug reported as binding to entire complex. Subunit is listed as a representative as no specific binding site was reported.

General Function: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: O77323
Uniprot Name: T-complex protein 1 subunit eta
Molecular Weight: 59576.67 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details139. Plasmepsin-2

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: Aspartic-type endopeptidase activity
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: P46925
Uniprot Name: Plasmepsin-2
Molecular Weight: 51489.41 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details140. Chaperone, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atpase activator activity
Gene Name: Not Available
Uniprot ID: C0H546
Uniprot Name: Chaperone, putative
Molecular Weight: 29803.79 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details141. Rhoptry neck protein 3

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Host cell surface binding
Gene Name: Not Available
Uniprot ID: Q8I4R5
Uniprot Name: Rhoptry neck protein 3
Molecular Weight: 263153.05 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details142. 40S ribosomal protein S5, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Mrna binding
Gene Name: Not Available
Uniprot ID: Q8IBN5
Uniprot Name: 40S ribosomal protein S5, putative
Molecular Weight: 21863.19 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details143. Skeleton-binding protein 1

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8I487
Uniprot Name: Skeleton-binding protein 1
Molecular Weight: 36298.62 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details144. Purine nucleotide phosphorylase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Uridine phosphorylase activity
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8I3X4
Uniprot Name: Purine nucleotide phosphorylase, putative
Molecular Weight: 26857.88 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details145. Adenosylhomocysteinase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.
Specific Function: Adenosylhomocysteinase activity
Gene Name: Not Available
Uniprot ID: P50250
Uniprot Name: Adenosylhomocysteinase
Molecular Weight: 53838.54 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details146. Adenosine deaminase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Adenosine deaminase activity
Gene Name: Not Available
Uniprot ID: Q8IJA9
Uniprot Name: Adenosine deaminase
Molecular Weight: 42465.51 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details147. Methionine--tRNA ligase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IJ60
Uniprot Name: Methionine--tRNA ligase
Molecular Weight: 104167.4 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details148. Carbamoyl phosphate synthetase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IEN3
Uniprot Name: Carbamoyl phosphate synthetase
Molecular Weight: 273435.35 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details149. Aspartate carbamoyltransferase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Amino acid binding
Gene Name: Not Available
Uniprot ID: Q8IDP8
Uniprot Name: Aspartate carbamoyltransferase
Molecular Weight: 43251.38 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details150. Signal recognition particle receptor, beta subunit

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Gtp binding
Gene Name: Not Available
Uniprot ID: Q8I4W4
Uniprot Name: Signal recognition particle receptor, beta subunit
Molecular Weight: 30623.99 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details151. Parasite-infected erythrocyte surface protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Transferase activity, transferring glycosyl groups
Gene Name: Not Available
Uniprot ID: O77361
Uniprot Name: Parasite-infected erythrocyte surface protein
Molecular Weight: 154087.705 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details152. Coatomer alpha subunit, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural molecule activity
Gene Name: Not Available
Uniprot ID: C6KSR5
Uniprot Name: Coatomer alpha subunit, putative
Molecular Weight: 176944.825 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details153. Hexokinase

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: HK
Uniprot ID: Q02155
Uniprot Name: Hexokinase
Molecular Weight: 55345.73 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details154. Proteasome subunit alpha type

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Endopeptidase activity
Gene Name: Not Available
Uniprot ID: Q8IBI3
Uniprot Name: Proteasome subunit alpha type
Molecular Weight: 28388.035 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details155. Haloacid dehalogenase-like hydrolase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Metal ion binding
Gene Name: Not Available
Uniprot ID: Q8IJ74
Uniprot Name: Haloacid dehalogenase-like hydrolase
Molecular Weight: 32841.285 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details156. Insulinase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Hydrolase activity
Gene Name: Not Available
Uniprot ID: Q8III5
Uniprot Name: Insulinase, putative
Molecular Weight: 173623.945 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details157. 40S ribosomal protein S21

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural constituent of ribosome
Gene Name: Not Available
Uniprot ID: Q8IHS5
Uniprot Name: 40S ribosomal protein S21
Molecular Weight: 9145.425 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details158. Ubiquitin-conjugating enzyme E2

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atpase activity
Gene Name: Not Available
Uniprot ID: Q8IDP1
Uniprot Name: Ubiquitin-conjugating enzyme E2
Molecular Weight: 32787.585 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details159. Eukaryotic translation initiation factor 3 subunit C

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Specific Function: Translation initiation factor activity
Gene Name: Not Available
Uniprot ID: Q8I5Y3
Uniprot Name: Eukaryotic translation initiation factor 3 subunit C
Molecular Weight: 116012.945 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details160. 60S ribosomal protein L24, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8IEM3
Uniprot Name: 60S ribosomal protein L24, putative
Molecular Weight: 19244.665 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details161. 60S ribosomal protein L23

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8IE82
Uniprot Name: 60S ribosomal protein L23
Molecular Weight: 22092.425 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details162. 60S ribosomal protein L17, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural constituent of ribosome
Gene Name: Not Available
Uniprot ID: Q8IDI5
Uniprot Name: 60S ribosomal protein L17, putative
Molecular Weight: 23414.59 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details163. HAP protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Aspartic-type endopeptidase activity
Gene Name: Not Available
Uniprot ID: Q8IM15
Uniprot Name: HAP protein
Molecular Weight: 51692.85 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details164. Heat shock protein 110, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: C0H5H0
Uniprot Name: Heat shock protein 110, putative
Molecular Weight: 108184.515 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details165. 60S ribosomal protein L10, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8ILV2
Uniprot Name: 60S ribosomal protein L10, putative
Molecular Weight: 25216.14 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details166. Lysophospholipase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Hydrolase activity
Gene Name: Not Available
Uniprot ID: Q8IM74
Uniprot Name: Lysophospholipase, putative
Molecular Weight: 43737.01 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details167. Polyadenylate-binding protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Binds the poly(A) tail of mRNA.
Specific Function: Mrna binding
Gene Name: Not Available
Uniprot ID: Q8I5H4
Uniprot Name: Polyadenylate-binding protein
Molecular Weight: 97229.36 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details168. Ubiquitin-60S ribosomal protein L40

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Metal ion binding
Gene Name: Not Available
Uniprot ID: Q8ID50
Uniprot Name: Ubiquitin-60S ribosomal protein L40
Molecular Weight: 14616.985 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details169. Phosphoribosylpyrophosphate synthetase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Magnesium ion binding
Gene Name: Not Available
Uniprot ID: Q8IE67
Uniprot Name: Phosphoribosylpyrophosphate synthetase
Molecular Weight: 49382.6 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details170. Thioredoxin peroxidase 1

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Antioxidant activity
Gene Name: TPx1
Uniprot ID: Q8IL80
Uniprot Name: Thioredoxin peroxidase 1
Molecular Weight: 21806.91 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details171. Protein transport protein SEC31

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Sec31p
Uniprot ID: O96221
Uniprot Name: Protein transport protein SEC31
Molecular Weight: 166708.21 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details172. Dipeptidyl aminopeptidase 1

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Aminopeptidase activity
Gene Name: Not Available
Uniprot ID: Q8IIJ9
Uniprot Name: Dipeptidyl aminopeptidase 1
Molecular Weight: 80411.405 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details173. Ring-infected erythrocyte surface antigen

Kind: Protein
Organism: Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Pharmacological action: Unknown
Actions: Ligand

General Function: May disrupt the normal intermolecular interactions of the cytoplasmic domain of band 3 and thereby facilitate the invagination of the red cell membrane which is necessary for the formation of the parasitophorous vacuole.
Specific Function: Not Available
Gene Name: RESA
Uniprot ID: P13830
Uniprot Name: Ring-infected erythrocyte surface antigen
Molecular Weight: 124906.19 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details174. ATP-dependent RNA helicase UAP56

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: UAP56
Uniprot ID: Q9TY94
Uniprot Name: ATP-dependent RNA helicase UAP56
Molecular Weight: 52223.26 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details175. Calcium-dependent protein kinase 4

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Calcium-dependent kinase that plays a central role in the sexual reproduction and mosquito transmission of P.falciparum. Required for cell cycle progression in the male gametocyte, an essential step in parasite transmission to the mosquito (By similarity).
Specific Function: Atp binding
Gene Name: CPK4
Uniprot ID: Q8IBS5
Uniprot Name: Calcium-dependent protein kinase 4
Molecular Weight: 60779.205 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details176. GTP-binding nuclear protein Ran

Kind: Protein
Organism: Plasmodium falciparum
Pharmacological action: Unknown
Actions: Ligand

General Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
Specific Function: Gtp binding
Gene Name: Not Available
Uniprot ID: P38545
Uniprot Name: GTP-binding nuclear protein Ran
Molecular Weight: 24875.185 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details177. Nucleoside transporter 2

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Nucleoside transmembrane transporter activity
Gene Name: Not Available
Uniprot ID: Q8IB78
Uniprot Name: Nucleoside transporter 2
Molecular Weight: 67641.47 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details178. Anamorsin homolog

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Has anti-apoptotic effects in the cell.
Specific Function: 2 iron, 2 sulfur cluster binding
Gene Name: Not Available
Uniprot ID: C0H4X5
Uniprot Name: Anamorsin homolog
Molecular Weight: 30837.715 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details179. Glutamine synthetase, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Glutamate-ammonia ligase activity
Gene Name: Not Available
Uniprot ID: C0H551
Uniprot Name: Glutamine synthetase, putative
Molecular Weight: 63230.14 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details180. 60S ribosomal protein L30e, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8IJK8
Uniprot Name: 60S ribosomal protein L30e, putative
Molecular Weight: 11774.605 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details181. Casein kinase 2, alpha subunit

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IIR9
Uniprot Name: Casein kinase 2, alpha subunit
Molecular Weight: 39889.96 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details182. Threonine--tRNA ligase

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Atp binding
Gene Name: Not Available
Uniprot ID: Q8IIA4
Uniprot Name: Threonine--tRNA ligase
Molecular Weight: 119544.87 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details183. cAMP-dependent protein kinase regulatory subunit

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Camp binding
Gene Name: PKAr
Uniprot ID: Q7KQK0
Uniprot Name: cAMP-dependent protein kinase regulatory subunit
Molecular Weight: 50832.44 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details184. Elongation factor 1-gamma, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Glutathione transferase activity
Gene Name: Not Available
Uniprot ID: Q8IDV0
Uniprot Name: Elongation factor 1-gamma, putative
Molecular Weight: 47776.84 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details185. Thioredoxin-like protein

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Nucleoside diphosphate kinase activity
Gene Name: tlp1
Uniprot ID: Q8IKL4
Uniprot Name: Thioredoxin-like protein
Molecular Weight: 14423.54 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details186. 60S ribosomal protein L21

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Structural constituent of ribosome
Gene Name: Not Available
Uniprot ID: Q8ILK3
Uniprot Name: 60S ribosomal protein L21
Molecular Weight: 18795.0 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details187. 60S ribosomal protein L14, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Rna binding
Gene Name: Not Available
Uniprot ID: Q8ILE8
Uniprot Name: 60S ribosomal protein L14, putative
Molecular Weight: 19297.13 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details188. Inner membrane complex sub-compartment protein 3

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Not Available
Gene Name: Not Available
Uniprot ID: Q8IKM6
Uniprot Name: Inner membrane complex sub-compartment protein 3
Molecular Weight: 17117.295 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details189. HSP40, subfamily A, putative

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Not Available
Specific Function: Heat shock protein binding
Gene Name: Not Available
Uniprot ID: Q8IL88
Uniprot Name: HSP40, subfamily A, putative
Molecular Weight: 48468.875 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details190. Pyridoxal 5'-phosphate synthase subunit Pdx1

Kind: Protein
Organism: Plasmodium falciparum (isolate 3D7)
Pharmacological action: Unknown
Actions: Ligand

General Function: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
Specific Function: Catalytic activity
Gene Name: pdx1
Uniprot ID: C6KT50
Uniprot Name: Pyridoxal 5'-phosphate synthase subunit Pdx1
Molecular Weight: 33013.16 Da

References

Wang J, Zhang CJ, Chia WN, Loh CC, Li Z, Lee YM, He Y, Yuan LX, Lim TK, Liu M, Liew CX, Lee YQ, Zhang J, Lu N, Lim CT, Hua ZC, Liu B, Shen HM, Tan KS, Lin Q: Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun. 2015 Dec 22;6:10111. doi: 10.1038/ncomms10111. [Article]

Details191. Serum albumin

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Ligand

General Function: Toxic substance binding
Specific Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloid...
Gene Name: ALB
Uniprot ID: P02768
Uniprot Name: Serum albumin
Molecular Weight: 69365.94 Da

References

Yang YZ, Asawamahasakda W, Meshnick SR: Alkylation of human albumin by the antimalarial artemisinin. Biochem Pharmacol. 1993 Jul 20;46(2):336-9. [Article]
Veerappan A, Eichhorn T, Zeino M, Efferth T, Schneider D: Differential interactions of the broad spectrum drugs artemisinin, dihydroartemisinin and artesunate with serum albumin. Phytomedicine. 2013 Aug 15;20(11):969-74. doi: 10.1016/j.phymed.2013.04.003. Epub 2013 May 16. [Article]

Enzymes

Details1. UDP-glucuronosyltransferase 1-9

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Retinoic acid binding
Specific Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 2 lacks trans...
Gene Name: UGT1A9
Uniprot ID: O60656
Uniprot Name: UDP-glucuronosyltransferase 1-9
Molecular Weight: 59940.495 Da

References

EMA: Eurartesim Assessment Report [Link]

Details2. UDP-glucuronosyltransferase 2B7

Kind: Protein
Organism: Humans
Pharmacological action: No
Actions: Substrate

General Function: Glucuronosyltransferase activity
Specific Function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.Its unique specificity for 3,4-catechol estrogens and estriol su...
Gene Name: UGT2B7
Uniprot ID: P16662
Uniprot Name: UDP-glucuronosyltransferase 2B7
Molecular Weight: 60694.12 Da

References

EMA: Eurartesim Assessment Report [Link]

Details3. Cytochrome P450 2D6

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor
Curator comments: Drug inhibits CYP2D6 but not strongly enough to be considered clinically relevant (<1.25 fold change in AUC)

General Function: Steroid hydroxylase activity
Specific Function: Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name: CYP2D6
Uniprot ID: P10635
Uniprot Name: Cytochrome P450 2D6
Molecular Weight: 55768.94 Da

References

EMA: Eurartesim Assessment Report [Link]

Details4. Cytochrome P450 2C19

Kind: Protein
Organism: Humans
Pharmacological action: Unknown
Actions: Inhibitor

General Function: Steroid hydroxylase activity
Specific Function: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and im...
Gene Name: CYP2C19
Uniprot ID: P33261
Uniprot Name: Cytochrome P450 2C19
Molecular Weight: 55930.545 Da

References

Ericsson T, Sundell J, Torkelsson A, Hoffmann KJ, Ashton M: Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies. Xenobiotica. 2014 Jul;44(7):615-26. doi: 10.3109/00498254.2013.878815. Epub 2014 Jan 8. [Article]
EMA: Eurartesim Assessment Report [Link]

Drug created at October 17, 2016 21:29 / Updated at November 20, 2023 20:11

Artenimol

Identification

Structure for Artenimol (DB11638)

Pharmacology

Interactions

Products

Categories

Chemical Identifiers

References

Clinical Trials

Pharmacoeconomics

Properties

Spectra

Collision Cross Sections (CCS)

Targets

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