NAV

Teclozan

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Teclozan is an antiprotozoal agent indicated in the treatment of intestinal amebiasis.

Generic Name
Teclozan
DrugBank Accession Number
DB13205
Background

Teclozan is an antiprotozoal agent employed typically as a therapy to treat protozoan infections.

Type
Small Molecule
Groups
Experimental
Structure
Similar Structures
Weight
Average: 502.25
Monoisotopic: 500.0803182
Chemical Formula
C20H28Cl4N2O4
Synonyms
  • Teclozan
  • Teclozanum
External IDs
  • BRN 2825422
  • NSC-107433
  • WIN 13,146
  • WIN AM 13146
  • WIN-13146
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Treatment ofIntestinal amebiasis••••••••••••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Categories

ATC Codes
P01AC04 — Teclozan
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Not Available
Direct Parent
Benzene and substituted derivatives
Alternative Parents
Tertiary carboxylic acid amides / Dialkyl ethers / Organopnictogen compounds / Organonitrogen compounds / Organochlorides / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds / Alkyl chlorides
Substituents
Alkyl chloride / Alkyl halide / Aromatic homomonocyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Dialkyl ether / Ether / Hydrocarbon derivative / Monocyclic benzene moiety
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
K9RIF0COUB
CAS number
5560-78-1
InChI Key
MSJLJWCAEPENBL-UHFFFAOYSA-N
InChI
InChI=1S/C20H28Cl4N2O4/c1-3-29-11-9-25(19(27)17(21)22)13-15-5-7-16(8-6-15)14-26(10-12-30-4-2)20(28)18(23)24/h5-8,17-18H,3-4,9-14H2,1-2H3
IUPAC Name
2,2-dichloro-N-[(4-{[2,2-dichloro-N-(2-ethoxyethyl)acetamido]methyl}phenyl)methyl]-N-(2-ethoxyethyl)acetamide
SMILES
CCOCCN(CC1=CC=C(CN(CCOCC)C(=O)C(Cl)Cl)C=C1)C(=O)C(Cl)Cl

References

General References
  1. Slighter RG, Yarinsky A, Drobeck HP, Bailey DM: Activity of quinfamide against natural infections of Entamoeba criceti in hamsters: a new potent agent for intestinal amoebiasis. Parasitology. 1980 Aug;81(1):157-68. [Article]
  2. INVIMA Product Authorization Renewal: Teclozan oral tablets (INVIMA 2016M-003080-R2) [Link]
KEGG Drug
D06051
ChemSpider
20418
ChEBI
135803
ChEMBL
CHEMBL1788387
ZINC
ZINC000008214685
Wikipedia
Teclozan

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SuspensionOral10 mg
SuspensionOral1 g
TabletOral500 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00142 mg/mLALOGPS
logP4.06ALOGPS
logP3.49Chemaxon
logS-5.6ALOGPS
pKa (Strongest Acidic)16.38Chemaxon
pKa (Strongest Basic)-3.8Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area59.08 Å2Chemaxon
Rotatable Bond Count14Chemaxon
Refractivity123.22 m3·mol-1Chemaxon
Polarizability50.1 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-0udi-5009000000-f10484c6d58e563a0ad1
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0000910000-9e2bac47688774e7aca4
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00mp-1003900000-3ce0e5fa58877154f88e
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0c00-2001900000-7f0f7d8ddca6eb4b24ae
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0007-5009800000-d53847c456b73e7ddb84
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0005-1529100000-dad1786a8826915abc04
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0f7k-1009200000-dce39db8f1cec246545e
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-209.25151
predicted
DeepCCS 1.0 (2019)
[M+H]+212.28032
predicted
DeepCCS 1.0 (2019)
[M+Na]+220.82487
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:37 / Updated at June 05, 2021 09:12