This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Thiram
- DrugBank Accession Number
- DB13245
- Background
Thiram may be used in dermatology as a scabicide 1. Thiram is mainly used as a fungicide for plants and treatment for seeds, however, this use is being investigated for safety in many markets including Canada 2.
- Type
- Small Molecule
- Groups
- Approved, Experimental
- Structure
Structure for Thiram (DB13245)
- Weight
- Average: 240.433
Monoisotopic: 239.988331154 - Chemical Formula
- C6H12N2S4
- Synonyms
- Tetramethylthiuram disulfide
- Thiram
- Thirame
- Thiramum
- Thiuram
- Tiramo
- External IDs
- NSC-1771
- SQ 1489
- SQ-1489
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Arasan / Nomersan / Pomarsol / Rezifilm
- Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image T.R.U.E. Test Thin-Layer Rapid Use Patch Test Thiram (5.5 ug/48h) + 2,2'-Dibenzothiazyl disulfide (20 ug/48h) + 2-mercaptobenzothiazole (61 ug/48h) + 4-(Isopropylamino)diphenylamine (10 ug/48h) + Bacitracin (486 ug/48h) + Balsam of Peru (648 ug/48h) + Benzocaine (378 ug/48h) + Benzylparaben (162 ug/48h) + Bisphenol A diglycidyl ether (32 ug/48h) + Bromothalonil (4 ug/48h) + Bronopol (203 ug/48h) + Budesonide (0.8 ug/48h) + Butylparaben (162 ug/48h) + Chlorquinaldol (77 ug/48h) + Cinchocaine hydrochloride (66 ug/48h) + Cinnamaldehyde (41 ug/48h) + Cinnamyl alcohol (63 ug/48h) + Clioquinol (77 ug/48h) + Cobalt chloride hexahydrate (4 ug/48h) + Diazolidinylurea (446 ug/48h) + Potassium dichromate (15.7 ug/48h) + Dipentamethylenethiuram disulfide (5.5 ug/48h) + Diphenylguanidine (68 ug/48h) + Disperse Blue 106 (41 ug/48h) + Disulfiram (5.5 ug/48h) + Ditiocarb zinc (68 ug/48h) + Ethyl hydroxybenzoate (162 ug/48h) + Ethylenediamine (18 ug/48h) + Eugenol (41 ug/48h) + Evernia prunastri (81 ug/48h) + Formaldehyde (146 ug/48h) + Geraniol (81 ug/48h) + Hydrocortisone butyrate (16 ug/48h) + Hydroxycitronellal (63 ug/48h) + Imidurea (486 ug/48h) + Isoeugenol (17 ug/48h) + Lanolin alcohols (810 ug/48h) + Methylchloroisothiazolinone (3 ug/48h) + Methylparaben (162 ug/48h) + Morpholinylmercaptobenzothiazole (20 ug/48h) + N,N'-diphenyl-1,4-phenylenediamine (25 ug/48h) + N-Cyclohexyl-N'-phenyl-1,4-phenylenediamine (25 ug/48h) + Neomycin sulfate (486 ug/48h) + Nickel sulfate hexahydrate (36 ug/48h) + Parthenolide (2 ug/48h) + Propylparaben (162 ug/48h) + Quaternium-15 (81 ug/48h) + Rosin (972 ug/48h) + Sodium aurotiosulfate (23 ug/48h) + Tetracaine hydrochloride (66 ug/48h) + Tetramethylthiuram monosulfide (5.5 ug/48h) + Thimerosal (6 ug/48h) + Thiohexam (20 ug/48h) + Tixocortol pivalate (2 ug/48h) + Zinc dibutyldithiocarbamate (68 ug/48h) + alpha-Amyl cinnamaldehyde (17 ug/48h) + p-Phenylenediamine (65 ug/48h) + p-tert-Butylphenol-formaldehyde resin (low molecular weight) (36 ug/48h) Kit Cutaneous SmartPractice Denmark ApS 2012-03-01 Not applicable US 
Categories
- ATC Codes
- P03AA05 — Thiram
- Drug Categories
- Acids, Acyclic
- Agrochemicals
- Antiparasitic Products, Insecticides and Repellents
- Carbamates
- Cell-mediated Immunity
- Compounds used in a research, industrial, or household setting
- Dimethyldithiocarbamate
- Ectoparasiticides, Incl. Scabicides
- Ectoparasiticides, Incl. Scabicides, Insecticides and Repellents
- Fungicides, Industrial
- Increased Histamine Release
- Mutagens
- Noxae
- Pesticides
- Standardized Chemical Allergen
- Sulfur Compounds
- Sulfur Containing Products
- Thiocarbamates
- Toxic Actions
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as thiuram disulfides. These are organic disulfides that have the general structural formula RN(R')C(=S)SSC(=S)N(R\")R\"', where R-R\"'=alkyl groups.
- Kingdom
- Organic compounds
- Super Class
- Organic nitrogen compounds
- Class
- Organonitrogen compounds
- Sub Class
- Amines
- Direct Parent
- Thiuram disulfides
- Alternative Parents
- Organic disulfides / Sulfenyl compounds / Organopnictogen compounds / Hydrocarbon derivatives
- Substituents
- Aliphatic acyclic compound / Hydrocarbon derivative / Organic disulfide / Organopnictogen compound / Organosulfur compound / Sulfenyl compound / Thiuram disulfide
- Molecular Framework
- Aliphatic acyclic compounds
- External Descriptors
- organic disulfide (CHEBI:9495) / Dithiocarbamate fungicides (C11160)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 0D771IS0FH
- CAS number
- 137-26-8
- InChI Key
- KUAZQDVKQLNFPE-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H12N2S4/c1-7(2)5(9)11-12-6(10)8(3)4/h1-4H3
- IUPAC Name
- N,N-dimethyl[(dimethylcarbamothioyl)disulfanyl]carbothioamide
- SMILES
- CN(C)C(=S)SSC(=S)N(C)C
References
- General References
- Kanerva, P. Elsner, J.E. Wahlberg, H.I. Maibach (2013). Handbook of Occupational Dermatology. Springer Science & Business Media. [ISBN:3662076772]
- Re-evaluation Decision RVD2018-38, Thiram and Its Associated End-use Products [Link]
- External Links
- KEGG Drug
- D06114
- KEGG Compound
- C11160
- ChemSpider
- 5256
- BindingDB
- 43362
- 10517
- ChEBI
- 9495
- ChEMBL
- CHEMBL120563
- ZINC
- ZINC000001532176
- Wikipedia
- Thiram
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Kit Cutaneous - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.0437 mg/mL ALOGPS logP 2.18 ALOGPS logP 2.73 Chemaxon logS -3.7 ALOGPS Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 69.24 m3·mol-1 Chemaxon Polarizability 23.96 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 159.8901596 predictedDarkChem Lite v0.1.0 [M-H]- 160.1007596 predictedDarkChem Lite v0.1.0 [M-H]- 143.1438 predictedDeepCCS 1.0 (2019) [M+H]+ 145.63336 predictedDeepCCS 1.0 (2019) [M+Na]+ 153.77751 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:38 / Updated at May 27, 2021 02:58