Olaflur

Identification

Summary

Olaflur is a fluoride treatment for patients at risk of dental caries, sensitive teeth, or enamel decalcification.

Generic Name

Olaflur

DrugBank Accession Number

DB13290

Background

Olaflur which is also referred to as elmex gel is an ingredient used in toothpaste which helps in the prevention of dental caries.

Type

Small Molecule

Groups

Experimental

Structure

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MOLSDFPDBSMILESInChI

Similar Structures

Structure for Olaflur (DB13290)

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Weight

Average: 498.785
Monoisotopic: 498.457200126

Chemical Formula

C₂₇H₆₀F₂N₂O₃

Synonyms

• Olaflur

External IDs

• SK&F 38095
• SK&F-38095
• SKF-38095

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Pharmacology

Indication

Not Available

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Associated Conditions

Indication Type	Indication	Combined Product Details	Approval Level	Age Group	Patient Characteristics	Dose Form
Symptomatic treatment of	Decalcification; teeth		••• •••			•••
Prophylaxis of	Dental decay		••• •••			•••
Symptomatic treatment of	Tooth hypersensitivity		••• •••			•••

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Associated Therapies

• Fluoridation

Contraindications & Blackbox Warnings

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Pharmacodynamics

Not Available

Mechanism of action

Not Available

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Not Available

Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects

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Toxicity

Not Available

Pathways

Not Available

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Not Available

Interactions

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This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.

Not Available

Food Interactions

Not Available

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Mixture Products

Name	Ingredients	Dosage	Route	Labeller	Marketing Start	Marketing End	Region	Image
elmex Zahngel	Olaflur (3.032 g/100g) + Dectaflur (0.287 g/100g) + Sodium fluoride (2.21 g/100g)	Gel	Dental	Cp Gaba Gmb H	1986-06-03	Not applicable

Categories

ATC Codes

A01AA03 — Olaflur

• A01AA — Caries prophylactic agents
• A01A — STOMATOLOGICAL PREPARATIONS
• A01 — STOMATOLOGICAL PREPARATIONS
• A — ALIMENTARY TRACT AND METABOLISM

Drug Categories

• Alimentary Tract and Metabolism
• Amines
• Anions
• Caries Prophylactic Agents
• Cariostatic Agents
• Compounds used in a research, industrial, or household setting
• Electrolytes
• Fluorine Compounds
• Ions
• Polyamines
• Protective Agents
• Stomatological Preparations

Chemical TaxonomyProvided by Classyfire

Description

This compound belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.

Kingdom

Organic compounds

Super Class

Organic nitrogen compounds

Class

Organonitrogen compounds

Sub Class

Amines

Direct Parent

1,2-aminoalcohols

Alternative Parents

Trialkylamines / Primary alcohols / Organopnictogen compounds / Hydrocarbon derivatives

Substituents

1,2-aminoalcohol / Alcohol / Aliphatic acyclic compound / Hydrocarbon derivative / Organic oxygen compound / Organooxygen compound / Organopnictogen compound / Primary alcohol / Tertiary aliphatic amine / Tertiary amine

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Affected organisms

Not Available

Chemical Identifiers

UNII

8NY9L8837D

CAS number

6818-37-7

InChI Key

ZVVSSOQAYNYNPP-UHFFFAOYSA-N

InChI

InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H

IUPAC Name

2-({3-[bis(2-hydroxyethyl)amino]propyl}(octadecyl)amino)ethan-1-ol dihydrofluoride

SMILES

F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO

References

General References

1. AIFA Package Leaflet: ELMEX (Olaflur) dental gel [Link]

External Links

ChemSpider

21751

ChEMBL

CHEMBL2106575

Wikipedia

Olaflur

Clinical Trials

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Phase	Status	Purpose	Conditions	Count

Pharmacoeconomics

Manufacturers

Not Available

Packagers

Not Available

Dosage Forms

Form	Route	Strength
Gel	Dental
Gel	Dental

Prices

Not Available

Patents

Not Available

Properties

State

Not Available

Experimental Properties

Not Available

Predicted Properties

Property	Value	Source
Water Solubility	0.0017 mg/mL	ALOGPS
logP	6.38	ALOGPS
logP	5.75	Chemaxon
logS	-5.4	ALOGPS
pKa (Strongest Acidic)	15.12	Chemaxon
pKa (Strongest Basic)	9.72	Chemaxon
Physiological Charge	2	Chemaxon
Hydrogen Acceptor Count	5	Chemaxon
Hydrogen Donor Count	3	Chemaxon
Polar Surface Area	67.17 Å2	Chemaxon
Rotatable Bond Count	27	Chemaxon
Refractivity	140.04 m3·mol-1	Chemaxon
Polarizability	61.94 Å3	Chemaxon
Number of Rings	0	Chemaxon
Bioavailability	0	Chemaxon
Rule of Five	No	Chemaxon
Ghose Filter	No	Chemaxon
Veber's Rule	No	Chemaxon
MDDR-like Rule	No	Chemaxon

Predicted ADMET Features

Not Available

Spectra

Mass Spec (NIST)

Not Available

Spectra

Not Available

Chromatographic Properties

Collision Cross Sections (CCS)

Adduct	CCS Value (Å2)	Source type	Source
[M-H]-	211.98949	predicted	DeepCCS 1.0 (2019)
[M+H]+	214.53983	predicted	DeepCCS 1.0 (2019)
[M+Na]+	220.88274	predicted	DeepCCS 1.0 (2019)

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Drug created at June 23, 2017 20:39 / Updated at June 05, 2021 09:13