NAV

Flunoxaprofen

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Flunoxaprofen
DrugBank Accession Number
DB13317
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 285.274
Monoisotopic: 285.080121413
Chemical Formula
C16H12FNO3
Synonyms
  • Flunoxaprofen
  • flunoxaprofeno
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
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AmitriptylineThe risk or severity of gastrointestinal bleeding can be increased when Amitriptyline is combined with Flunoxaprofen.
AmitriptylinoxideThe risk or severity of gastrointestinal bleeding can be increased when Amitriptylinoxide is combined with Flunoxaprofen.
AmoxapineThe risk or severity of gastrointestinal bleeding can be increased when Amoxapine is combined with Flunoxaprofen.
ButriptylineThe risk or severity of gastrointestinal bleeding can be increased when Butriptyline is combined with Flunoxaprofen.
CapecitabineCapecitabine may increase the nephrotoxic activities of Flunoxaprofen.
Food Interactions
Not Available

Products

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Categories

ATC Codes
M01AE15 — FlunoxaprofenG02CC04 — Flunoxaprofen
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenyl-1,3-oxazoles. These are aromatic heterocyclic compounds containing a 1,3-oxazole substituted at one or more positions by a phenyl group.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Azoles
Sub Class
Oxazoles
Direct Parent
Phenyl-1,3-oxazoles
Alternative Parents
Benzoxazoles / Fluorobenzenes / Aryl fluorides / Heteroaromatic compounds / Oxacyclic compounds / Monocarboxylic acids and derivatives / Carboxylic acids / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds
show 4 more
Substituents
Aromatic heteropolycyclic compound / Aryl fluoride / Aryl halide / Azacycle / Benzenoid / Benzoxazole / Carbonyl group / Carboxylic acid / Carboxylic acid derivative / Fluorobenzene
show 15 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
organofluorine compound, 1,3-benzoxazoles, monocarboxylic acid (CHEBI:76154)
Affected organisms
Not Available

Chemical Identifiers

UNII
UKU5U19W9M
CAS number
66934-18-7
InChI Key
ARPYQKTVRGFPIS-VIFPVBQESA-N
InChI
InChI=1S/C16H12FNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20)/t9-/m0/s1
IUPAC Name
(2S)-2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]propanoic acid
SMILES
C[C@H](C(O)=O)C1=CC=C2OC(=NC2=C1)C1=CC=C(F)C=C1

References

General References
Not Available
ChemSpider
62101
ChEBI
76154
ChEMBL
CHEMBL1614641
ZINC
ZINC000000000319
PharmGKB
PA166049179
Wikipedia
Flunoxaprofen

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionVaginal
Suppository
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0499 mg/mLALOGPS
logP3.14ALOGPS
logP3.67Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)4.59Chemaxon
pKa (Strongest Basic)0.12Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area63.33 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity83.92 m3·mol-1Chemaxon
Polarizability28.99 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-00xu-0960000000-beef20e71504ca15227a
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000i-0090000000-3cb026ecabdb4b890eeb
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0089-0090000000-e32dcf29e226b43b573c
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-0090000000-81696ec2db84c3d6bcfc
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0006-0090000000-eaf14044e9ad95a4c25c
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00du-1690000000-ddd8f1273cabbb483880
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-02ml-0490000000-1e14e440fb9d50215415
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-165.84222
predicted
DeepCCS 1.0 (2019)
[M+H]+168.20042
predicted
DeepCCS 1.0 (2019)
[M+Na]+175.08078
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:39 / Updated at February 21, 2021 18:54