NAV

Difenpiramide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Difenpiramide
DrugBank Accession Number
DB13371
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 288.35
Monoisotopic: 288.126263143
Chemical Formula
C19H16N2O
Synonyms
Not Available
External IDs
  • NSC-305337
  • Z-876
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
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interactions in your software
AbacavirDifenpiramide may decrease the excretion rate of Abacavir which could result in a higher serum level.
AbciximabThe risk or severity of bleeding and hemorrhage can be increased when Difenpiramide is combined with Abciximab.
AcebutololDifenpiramide may decrease the antihypertensive activities of Acebutolol.
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Difenpiramide.
AcemetacinThe risk or severity of adverse effects can be increased when Difenpiramide is combined with Acemetacin.
Food Interactions
Not Available

Categories

ATC Codes
M01AB12 — Difenpiramide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as biphenyls and derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Biphenyls and derivatives
Direct Parent
Biphenyls and derivatives
Alternative Parents
Pyridines and derivatives / Heteroaromatic compounds / Propargyl-type 1,3-dipolar organic compounds / Carboximidic acids / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Hydrocarbon derivatives
Substituents
Aromatic heteromonocyclic compound / Azacycle / Biphenyl / Carboximidic acid / Carboximidic acid derivative / Heteroaromatic compound / Hydrocarbon derivative / Organic 1,3-dipolar compound / Organic nitrogen compound / Organic oxygen compound
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
monocarboxylic acid amide, pyridines, biphenyls (CHEBI:76130)
Affected organisms
Not Available

Chemical Identifiers

UNII
Q6U5F6E1QL
CAS number
51484-40-3
InChI Key
PWHROYKAGRUWDQ-UHFFFAOYSA-N
InChI
InChI=1S/C19H16N2O/c22-19(21-18-8-4-5-13-20-18)14-15-9-11-17(12-10-15)16-6-2-1-3-7-16/h1-13H,14H2,(H,20,21,22)
IUPAC Name
2-{[1,1'-biphenyl]-4-yl}-N-(pyridin-2-yl)acetamide
SMILES
O=C(CC1=CC=C(C=C1)C1=CC=CC=C1)NC1=CC=CC=N1

References

General References
Not Available
KEGG Compound
C17720
ChemSpider
90781
BindingDB
97007
ChEBI
76130
ChEMBL
CHEMBL1489662
ZINC
ZINC000000001293
Wikipedia
Difenpiramide

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00557 mg/mLALOGPS
logP3.66ALOGPS
logP4.07Chemaxon
logS-4.7ALOGPS
pKa (Strongest Acidic)12.02Chemaxon
pKa (Strongest Basic)4.04Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area41.99 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity88.94 m3·mol-1Chemaxon
Polarizability32.19 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSsplash10-014l-4930000000-bf66f721dd939320750f
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-000j-0890000000-80fac5083ff27c53416f
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-014i-0590000000-774993f382e54707b216
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0072-6960000000-b1dd154d6127a67aae02
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-02t9-0890000000-c376ddaa3eb9c70bbc16
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-014i-6910000000-2109e0d2ba851d36d4f1
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-02t9-9650000000-cd690c7dee31e5827b3f
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-187.4361058
predicted
DarkChem Lite v0.1.0
[M-H]-166.15126
predicted
DeepCCS 1.0 (2019)
[M+H]+189.0490058
predicted
DarkChem Lite v0.1.0
[M+H]+168.50926
predicted
DeepCCS 1.0 (2019)
[M+Na]+187.6064058
predicted
DarkChem Lite v0.1.0
[M+Na]+174.60243
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:40 / Updated at June 12, 2020 16:53