NAV

Carbutamide

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Carbutamide
DrugBank Accession Number
DB13406
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
3D
Similar Structures
Weight
Average: 271.34
Monoisotopic: 271.099062593
Chemical Formula
C11H17N3O3S
Synonyms
  • Carbutamida
  • Carbutamide
  • Carbutamidum
External IDs
  • BZ 55
  • BZ-55
  • CA 1022
  • U 6987
  • U-6987
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Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
Not Available

Interactions

Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Integrate drug-drug
interactions in your software
AbataceptThe metabolism of Carbutamide can be increased when combined with Abatacept.
AbrocitinibThe metabolism of Abrocitinib can be decreased when combined with Carbutamide.
AcarboseThe risk or severity of hypoglycemia can be increased when Acarbose is combined with Carbutamide.
AcebutololThe therapeutic efficacy of Carbutamide can be increased when used in combination with Acebutolol.
AceclofenacThe protein binding of Carbutamide can be decreased when combined with Aceclofenac.
Food Interactions
Not Available

Products

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International/Other Brands
Invenol

Categories

ATC Codes
A10BB06 — Carbutamide
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Benzenesulfonamides
Direct Parent
Aminobenzenesulfonamides
Alternative Parents
Benzenesulfonyl compounds / Aniline and substituted anilines / Sulfonylureas / Organosulfonic acids and derivatives / Aminosulfonyl compounds / Organic carbonic acids and derivatives / Primary amines / Organopnictogen compounds / Organic oxides / Hydrocarbon derivatives
show 1 more
Substituents
Amine / Aminobenzenesulfonamide / Aminosulfonyl compound / Aniline or substituted anilines / Aromatic homomonocyclic compound / Benzenesulfonyl group / Carbonic acid derivative / Carbonyl group / Hydrocarbon derivative / Organic nitrogen compound
show 11 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
E3K8P4869P
CAS number
339-43-5
InChI Key
VDTNNGKXZGSZIP-UHFFFAOYSA-N
InChI
InChI=1S/C11H17N3O3S/c1-2-3-8-13-11(15)14-18(16,17)10-6-4-9(12)5-7-10/h4-7H,2-3,8,12H2,1H3,(H2,13,14,15)
IUPAC Name
1-(4-aminobenzenesulfonyl)-3-butylurea
SMILES
CCCCNC(=O)NS(=O)(=O)C1=CC=C(N)C=C1

References

General References
Not Available
ChemSpider
9189
RxNav
2068
ChEBI
135118
ChEMBL
CHEMBL448570
ZINC
ZINC000001764156
Wikipedia
Carbutamide

Clinical Trials

Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
PhaseStatusPurposeConditionsCount
Not AvailableCompletedNot AvailableType 2 Diabetes Mellitus3

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.686 mg/mLALOGPS
logP1.28ALOGPS
logP0.95Chemaxon
logS-2.6ALOGPS
pKa (Strongest Acidic)4.35Chemaxon
pKa (Strongest Basic)2.11Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area101.29 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity69.93 m3·mol-1Chemaxon
Polarizability28.43 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-05fr-7940000000-3608db4cb8905109f0b3
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0960000000-f1b0bb9d4714b159346a
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-3900000000-d80cd9f606b1dc192c37
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-0900000000-ec22f314edf2db1e74fe
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0006-9100000000-6a7e9f22acc6006fba3a
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-052g-5900000000-8d7f302208b73f03e781
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-171.2952729
predicted
DarkChem Lite v0.1.0
[M-H]-170.9655729
predicted
DarkChem Lite v0.1.0
[M-H]-163.92776
predicted
DeepCCS 1.0 (2019)
[M+H]+172.5035729
predicted
DarkChem Lite v0.1.0
[M+H]+171.9047729
predicted
DarkChem Lite v0.1.0
[M+H]+166.28575
predicted
DeepCCS 1.0 (2019)
[M+Na]+171.5491729
predicted
DarkChem Lite v0.1.0
[M+Na]+172.3789
predicted
DeepCCS 1.0 (2019)

Enzymes

Details1. Cytochrome P450 2C9
Kind
Protein
Organism
Humans
Pharmacological action
Unknown
Actions
Substrate
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. May M, Schindler C: Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016 Apr;7(2):69-83. doi: 10.1177/2042018816638050. Epub 2016 Mar 31. [Article]

Drug created at June 23, 2017 20:41 / Updated at February 21, 2021 18:54