This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- Alcuronium
- DrugBank Accession Number
- DB13648
- Background
A non-depolarizing skeletal muscle relaxant similar to tubocurarine. It is used as an anesthesia adjuvant.
- Type
- Small Molecule
- Groups
- Experimental
- Structure
Structure for Alcuronium (DB13648)
- Weight
- Average: 666.909
Monoisotopic: 666.392279706 - Chemical Formula
- C44H50N4O2
- Synonyms
- Alcuronum
- Alloferine
- Diallylnortoxiferine
- Diallyltoxiferine
- N,N'-diallyl-bis-nor-toxiferine
- N,N'-Diallylnortoxiferinium
Pharmacology
- Indication
Not Available
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Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your software1,2-Benzodiazepine The risk or severity of CNS depression can be increased when 1,2-Benzodiazepine is combined with Alcuronium. Acetazolamide The risk or severity of CNS depression can be increased when Acetazolamide is combined with Alcuronium. Acetophenazine The risk or severity of CNS depression can be increased when Acetophenazine is combined with Alcuronium. Acetyldigitoxin The risk or severity of Cardiac Arrhythmia can be increased when Alcuronium is combined with Acetyldigitoxin. Aclidinium The risk or severity of adverse effects can be increased when Aclidinium is combined with Alcuronium. - Food Interactions
- Not Available
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Product Ingredients
Ingredient UNII CAS InChI Key Alcuronium chloride 490DW6501Y 15180-03-7 CPYGBGOXCJJJGC-GKLGUMFISA-L
Categories
- ATC Codes
- M03AA01 — Alcuronium
- Drug Categories
- Adjuvants, Anesthesia
- Alkaloids
- Amines
- Anticholinergic Agents
- Benzylisoquinolines
- Central Nervous System Agents
- Central Nervous System Depressants
- Cholinergic Agents
- Curare Alkaloids
- Heterocyclic Compounds, Fused-Ring
- Isoquinolines
- Muscle Relaxants
- Muscle Relaxants, Peripherally Acting Agents
- Musculo-Skeletal System
- Neuromuscular Agents
- Neuromuscular Blocking Agents
- Neuromuscular-Blocking Agents (Nondepolarizing)
- Neurotransmitter Agents
- Nicotinic Antagonists
- Onium Compounds
- Peripheral Nervous System Agents
- Quaternary Ammonium Compounds
- Tetrahydroisoquinolines
- Toxiferine
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as strychnos alkaloids. These are alkaloids having a core structure based on the strychnan, stemmadenine (seco-curan), or the akuammicine (curan) skeleton.
- Kingdom
- Organic compounds
- Super Class
- Alkaloids and derivatives
- Class
- Strychnos alkaloids
- Sub Class
- Not Available
- Direct Parent
- Strychnos alkaloids
- Alternative Parents
- Curan alkaloids / Carbazoles / Indolizidines / Tertiary alkylarylamines / Aralkylamines / Piperidines / N-alkylpyrrolidines / Benzenoids / Tetraalkylammonium salts / Allylamines show 7 more
- Substituents
- Akuammicine-skeleton / Alcohol / Allylamine / Amine / Aralkylamine / Aromatic heteropolycyclic compound / Azacycle / Benzenoid / Carbazole / Curan skeleton show 22 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- indole alkaloid (CHEBI:55313)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- S8U3J5W06N
- CAS number
- 23214-96-2
- InChI Key
- MUQUYTSLDVKIOF-CHJKCJHBSA-N
- InChI
- InChI=1S/C44H50N4O2/c1-3-17-47-19-15-43-35-9-5-7-11-37(35)45-26-34-32-24-40-44(16-20-48(40,18-4-2)28-30(32)14-22-50)36-10-6-8-12-38(36)46(42(34)44)25-33(41(43)45)31(23-39(43)47)29(27-47)13-21-49/h3-14,25-26,31-32,39-42,49-50H,1-2,15-24,27-28H2/q+2/b29-13-,30-14-,33-25-,34-26-/t31-,32-,39-,40-,41-,42-,43+,44+,47-,48-/m0/s1
- IUPAC Name
- (1S,9Z,11S,13S,14R,17S,25Z,27S,28E,30R,33S,35S,37E,38S)-28,37-bis(2-hydroxyethylidene)-14,30-bis(prop-2-en-1-yl)-8,14,24,30-tetraazaundecacyclo[25.5.2.2^{11,14}.1^{1,8}.1^{10,17}.0^{2,7}.0^{13,17}.0^{18,23}.0^{30,33}.0^{24,35}.0^{26,38}]octatriaconta-2(7),3,5,9,18(23),19,21,25-octaene-14,30-diium
- SMILES
- [H][C@@]12C[C@@]3([H])\C(C[N@+]1(CC=C)CC[C@@]21C2=C(C=CC=C2)N2\C=C4/[C@]5([H])N(\C=C3/[C@@]12[H])C1=C(C=CC=C1)[C@@]51CC[N@@+]2(CC=C)C\C(=C\CO)[C@]4([H])C[C@@]12[H])=C/CO
References
- General References
- Not Available
- External Links
- ChemSpider
- 10308750
- 460
- ChEBI
- 55313
- ChEMBL
- CHEMBL3305985
- Wikipedia
- Alcuronium_chloride
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.000244 mg/mL ALOGPS logP 3.28 ALOGPS logP -4.3 Chemaxon logS -6.5 ALOGPS pKa (Strongest Acidic) 15.3 Chemaxon pKa (Strongest Basic) 1.52 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 46.94 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 226.64 m3·mol-1 Chemaxon Polarizability 75.98 Å3 Chemaxon Number of Rings 11 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 257.79306 predictedDeepCCS 1.0 (2019) [M+H]+ 259.5168 predictedDeepCCS 1.0 (2019) [M+Na]+ 265.84573 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:45 / Updated at June 12, 2020 16:53