Nikethamide
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This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Summary
Nikethamide is a nicotinic acid derivative indicated as a respiratory stimulant.
- Generic Name
- Nikethamide
- DrugBank Accession Number
- DB13655
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 178.235
Monoisotopic: 178.110613079 - Chemical Formula
- C10H14N2O
- Synonyms
- Nikethamide
Pharmacology
- Indication
Not Available
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- Contraindications & Blackbox Warnings
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- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs Browse all" title="About SNP Mediated Effects/ADRs" id="snp-actions-info" class="drug-info-popup" href="javascript:void(0);">
- Not Available
Interactions
- Drug Interactions Learn More" title="About Drug Interactions" id="structured-interactions-info" class="drug-info-popup" href="javascript:void(0);">
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Products
- Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.
Categories
- ATC Codes
- R07AB02 — Nikethamide
- R07AB — Respiratory stimulants
- R07A — OTHER RESPIRATORY SYSTEM PRODUCTS
- R07 — OTHER RESPIRATORY SYSTEM PRODUCTS
- R — RESPIRATORY SYSTEM
- Drug Categories
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
- Kingdom
- Organic compounds
- Super Class
- Organoheterocyclic compounds
- Class
- Pyridines and derivatives
- Sub Class
- Pyridinecarboxylic acids and derivatives
- Direct Parent
- Nicotinamides
- Alternative Parents
- Tertiary carboxylic acid amides / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives
- Substituents
- Aromatic heteromonocyclic compound / Azacycle / Carboxamide group / Carboxylic acid derivative / Heteroaromatic compound / Hydrocarbon derivative / Nicotinamide / Organic nitrogen compound / Organic oxide / Organic oxygen compound
- Molecular Framework
- Aromatic heteromonocyclic compounds
- External Descriptors
- Not Available
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 368IVD6M32
- CAS number
- 59-26-7
- InChI Key
- NCYVXEGFNDZQCU-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
- IUPAC Name
- N,N-diethylpyridine-3-carboxamide
- SMILES
- CCN(CC)C(=O)C1=CN=CC=C1
References
- General References
- FDA Thailand Product Information: Corazol (nikethamide) oral drops [Link]
- External Links
- ChemSpider
- 5296
- BindingDB
- 50248014
- 7424
- ChEBI
- 134814
- ChEMBL
- CHEMBL2104607
- ZINC
- ZINC000000001814
- Wikipedia
- Nikethamide
Clinical Trials
- Clinical Trials Learn More" title="About Clinical Trials" id="clinical-trials-info" class="drug-info-popup" href="javascript:void(0);">
Phase Status Purpose Conditions Count
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution 250 mg/1ml Suspension 250 mg/1ml - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 109.0 mg/mL ALOGPS logP 0.83 ALOGPS logP 0.77 Chemaxon logS -0.21 ALOGPS pKa (Strongest Basic) 3.61 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 33.2 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 52.27 m3·mol-1 Chemaxon Polarizability 19.56 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 145.5371213 predictedDarkChem Lite v0.1.0 [M-H]- 137.85211 predictedDeepCCS 1.0 (2019) [M+H]+ 146.4589213 predictedDarkChem Lite v0.1.0 [M+H]+ 141.24446 predictedDeepCCS 1.0 (2019) [M+Na]+ 150.34694 predictedDeepCCS 1.0 (2019)
Drug created at June 23, 2017 20:46 / Updated at May 29, 2021 18:12